ENSG00000143797

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000305997 ENSG00000143797 HEK293_OSMI2_6hA HEK293_TMG_6hB MBOAT2 protein_coding protein_coding 20.14364 5.74884 34.72216 0.7247638 1.289515 2.592422 5.421214 1.5453198 8.283039 0.2428548 0.2038573 2.414690 0.26008750 0.28043333 0.23886667 -0.04156667 9.341456e-01 5.208334e-15 FALSE TRUE
ENST00000471753 ENSG00000143797 HEK293_OSMI2_6hA HEK293_TMG_6hB MBOAT2 protein_coding nonsense_mediated_decay 20.14364 5.74884 34.72216 0.7247638 1.289515 2.592422 2.279227 0.8021253 3.311316 0.4097518 0.7839440 2.031981 0.13706667 0.12530000 0.09416667 -0.03113333 1.000000e+00 5.208334e-15 TRUE TRUE
ENST00000473432 ENSG00000143797 HEK293_OSMI2_6hA HEK293_TMG_6hB MBOAT2 protein_coding retained_intron 20.14364 5.74884 34.72216 0.7247638 1.289515 2.592422 1.057297 0.5533923 2.201524 0.1291544 0.1263974 1.972829 0.06227083 0.09710000 0.06343333 -0.03366667 6.217215e-01 5.208334e-15   FALSE
ENST00000474341 ENSG00000143797 HEK293_OSMI2_6hA HEK293_TMG_6hB MBOAT2 protein_coding processed_transcript 20.14364 5.74884 34.72216 0.7247638 1.289515 2.592422 1.288895 0.0000000 5.974276 0.0000000 0.4516390 9.225033 0.03839583 0.00000000 0.17230000 0.17230000 5.208334e-15 5.208334e-15 FALSE TRUE
ENST00000494760 ENSG00000143797 HEK293_OSMI2_6hA HEK293_TMG_6hB MBOAT2 protein_coding retained_intron 20.14364 5.74884 34.72216 0.7247638 1.289515 2.592422 1.154636 0.4279644 1.680355 0.2394102 0.4813970 1.948441 0.06151667 0.06946667 0.04766667 -0.02180000 1.000000e+00 5.208334e-15 FALSE FALSE
MSTRG.17914.3 ENSG00000143797 HEK293_OSMI2_6hA HEK293_TMG_6hB MBOAT2 protein_coding   20.14364 5.74884 34.72216 0.7247638 1.289515 2.592422 4.982002 1.8018127 9.906213 0.3834111 1.1481311 2.452356 0.26142500 0.32940000 0.28850000 -0.04090000 9.696260e-01 5.208334e-15 FALSE TRUE
MSTRG.17914.4 ENSG00000143797 HEK293_OSMI2_6hA HEK293_TMG_6hB MBOAT2 protein_coding   20.14364 5.74884 34.72216 0.7247638 1.289515 2.592422 1.365086 0.2023504 1.483001 0.2023504 0.7520868 2.813696 0.07027917 0.02896667 0.04270000 0.01373333 8.506381e-01 5.208334e-15 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000143797 E001 622.5849219 0.0009796916 7.210485e-01 0.8488130779 2 8852690 8858348 5659 - 2.679 2.690 0.036
ENSG00000143797 E002 95.4953148 0.0004756932 8.316313e-04 0.0085361213 2 8858349 8858434 86 - 1.842 1.992 0.503
ENSG00000143797 E003 73.6822130 0.0005231620 2.024211e-02 0.0967186721 2 8858435 8858488 54 - 1.739 1.860 0.407
ENSG00000143797 E004 209.8887459 0.0031308781 1.454995e-02 0.0764374152 2 8858489 8858846 358 - 2.194 2.295 0.336
ENSG00000143797 E005 66.0091053 0.0005797458 8.949559e-01 0.9491949084 2 8858847 8858858 12 - 1.715 1.713 -0.006
ENSG00000143797 E006 86.9298183 0.0015539739 4.692445e-01 0.6795534161 2 8858859 8858904 46 - 1.826 1.868 0.140
ENSG00000143797 E007 94.2612748 0.0004432360 3.602032e-01 0.5958736685 2 8860613 8860694 82 - 1.860 1.907 0.159
ENSG00000143797 E008 79.6285632 0.0005830641 9.157684e-01 0.9600680387 2 8860695 8860764 70 - 1.793 1.793 0.000
ENSG00000143797 E009 14.9504719 0.0212712551 2.359403e-01 0.4719055704 2 8860765 8861142 378 - 1.067 1.212 0.519
ENSG00000143797 E010 5.2887334 0.0075687966 3.791343e-01 0.6115060551 2 8862271 8862322 52 - 0.677 0.816 0.564
ENSG00000143797 E011 2.5926961 0.0123646180 4.904731e-01 0.6943274811 2 8862323 8862325 3 - 0.447 0.577 0.624
ENSG00000143797 E012 10.2671167 0.2803987538 6.345792e-01 0.7932905530 2 8862326 8862589 264 - 0.898 1.128 0.848
ENSG00000143797 E013 106.9498439 0.0005326852 2.159783e-01 0.4486012531 2 8862590 8862722 133 - 1.911 1.970 0.196
ENSG00000143797 E014 67.5594732 0.0005346378 7.886418e-01 0.8897158756 2 8864170 8864234 65 - 1.721 1.741 0.068
ENSG00000143797 E015 86.8786719 0.0004685808 5.255476e-01 0.7188807216 2 8868446 8868549 104 - 1.837 1.812 -0.085
ENSG00000143797 E016 88.2131834 0.0012558993 3.023792e-01 0.5429706692 2 8873108 8873193 86 - 1.846 1.798 -0.162
ENSG00000143797 E017 113.1101597 0.0004545006 4.540241e-01 0.6687622136 2 8873194 8873300 107 - 1.949 1.922 -0.091
ENSG00000143797 E018 0.1614157 0.0331969761 1.000000e+00   2 8876987 8877029 43 - 0.061 0.000 -7.179
ENSG00000143797 E019 114.2024901 0.0003954472 1.305012e-02 0.0706519610 2 8877030 8877121 92 - 1.965 1.860 -0.353
ENSG00000143797 E020 111.0228878 0.0005103525 1.227939e-03 0.0116374929 2 8877122 8877213 92 - 1.960 1.816 -0.483
ENSG00000143797 E021 89.6483972 0.0005842256 4.570884e-03 0.0323196036 2 8882511 8882565 55 - 1.869 1.730 -0.471
ENSG00000143797 E022 78.6497135 0.0005601234 1.571139e-02 0.0807675347 2 8888018 8888073 56 - 1.808 1.683 -0.425
ENSG00000143797 E023 0.6151152 0.4523282416 6.761496e-01   2 8908154 8908383 230 - 0.162 0.224 0.577
ENSG00000143797 E024 94.0031354 0.0008536138 8.479790e-03 0.0515228426 2 8908621 8908716 96 - 1.885 1.757 -0.430
ENSG00000143797 E025 71.5184709 0.0006423070 1.445541e-02 0.0760826401 2 8943187 8943264 78 - 1.770 1.637 -0.454
ENSG00000143797 E026 56.3238703 0.0006365446 3.667121e-01 0.6012947795 2 8958497 8958642 146 - 1.657 1.608 -0.168
ENSG00000143797 E027 0.8096672 0.0255331279 9.326476e-01   2 8974359 8974435 77 - 0.204 0.229 0.204
ENSG00000143797 E028 27.4452477 0.0014153719 3.205925e-05 0.0005714703 2 9003540 9003750 211 - 1.272 1.585 1.081