ENSG00000143776

1 Isoform Switch

Summary Plot
Results

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Rows: 1-5 / 5
Columns:
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isoform_id
gene_id
condition_1
condition_2
gene_name
gene_biotype
iso_biotype
gene_overall_mean
gene_value_1
gene_value_2
gene_stderr_1
gene_stderr_2
gene_log2_fold_change
iso_overall_mean
iso_value_1
iso_value_2
iso_stderr_1
iso_stderr_2
iso_log2_fold_change
IF_overall
IF1
IF2
dIF
isoform_switch_q_value
gene_switch_q_value
PTC
codingPotential
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isoform_id	gene_id	condition_1	condition_2	gene_name	gene_biotype	iso_biotype	gene_overall_mean	gene_value_1	gene_value_2	gene_stderr_1	gene_stderr_2	gene_log2_fold_change	iso_overall_mean	iso_value_1	iso_value_2	iso_stderr_1	iso_stderr_2	iso_log2_fold_change	IF_overall	IF1	IF2	dIF	isoform_switch_q_value	gene_switch_q_value	PTC	codingPotential

ENST00000366766	ENSG00000143776	HEK293_OSMI2_6hA	HEK293_TMG_6hB	CDC42BPA	protein_coding	protein_coding	8.76248	7.27854	13.04677	1.708955	0.409611	0.841096	0.2665884	0.1703336	0.0000000	0.1703336	0.00000000	-4.172597	0.05330417	0.04336667	0.00000000	-0.04336667	8.416472e-01	2.571653e-23	FALSE	TRUE
ENST00000366767	ENSG00000143776	HEK293_OSMI2_6hA	HEK293_TMG_6hB	CDC42BPA	protein_coding	protein_coding	8.76248	7.27854	13.04677	1.708955	0.409611	0.841096	0.5498835	0.2762968	0.8492403	0.1187595	0.11554522	1.585550	0.05870833	0.04593333	0.06573333	0.01980000	7.996896e-01	2.571653e-23	FALSE	TRUE
ENST00000366769	ENSG00000143776	HEK293_OSMI2_6hA	HEK293_TMG_6hB	CDC42BPA	protein_coding	protein_coding	8.76248	7.27854	13.04677	1.708955	0.409611	0.841096	3.8204234	2.5085643	7.4096300	0.5830485	0.39931387	1.558746	0.37106250	0.34490000	0.56750000	0.22260000	2.880426e-04	2.571653e-23	FALSE	TRUE
ENST00000442054	ENSG00000143776	HEK293_OSMI2_6hA	HEK293_TMG_6hB	CDC42BPA	protein_coding	protein_coding	8.76248	7.27854	13.04677	1.708955	0.409611	0.841096	1.7699944	0.6479911	3.7977424	0.3259639	0.08460337	2.532796	0.15198333	0.07300000	0.29146667	0.21846667	3.006723e-01	2.571653e-23	FALSE	TRUE
ENST00000448940	ENSG00000143776	HEK293_OSMI2_6hA	HEK293_TMG_6hB	CDC42BPA	protein_coding	protein_coding	8.76248	7.27854	13.04677	1.708955	0.409611	0.841096	1.5867815	3.4464080	0.0000000	1.0768584	0.00000000	-8.433130	0.28871250	0.45196667	0.00000000	-0.45196667	2.571653e-23	2.571653e-23	FALSE	TRUE

Note:
- The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

All exons whithin this gene region are shown and numbering below.

All isoforms whithin this gene region are shown below.

Rows: 1-10 / 52
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groupID
featureID
exonBaseMean
dispersion
pvalue
padj
seqnames
start
end
width
strand
HEK293_TMG_6hB
HEK293_OSMI2_6hA
log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
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groupID	featureID	exonBaseMean	dispersion	pvalue	padj	seqnames	start	end	width	strand	HEK293_TMG_6hB	HEK293_OSMI2_6hA	log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB

ENSG00000143776	E001	0.9114452	0.0282398519	4.060525e-03		1	226989865	226989865	1	-	0.000	0.512	14.176
ENSG00000143776	E002	693.0381804	0.0097746303	3.886576e-14	5.213507e-12	1	226989866	226993626	3761	-	2.647	3.029	1.272
ENSG00000143776	E003	227.4057903	0.0003643898	1.385804e-09	7.860434e-08	1	226993627	226994236	610	-	2.250	2.467	0.725
ENSG00000143776	E004	87.8364010	0.0085276048	7.457450e-03	4.682736e-02	1	226994237	226994399	163	-	1.841	2.062	0.742
ENSG00000143776	E005	82.0569685	0.0013132528	2.150310e-04	2.842028e-03	1	226994823	226994980	158	-	1.810	2.036	0.760
ENSG00000143776	E006	1.7628764	0.1229014085	5.985276e-01	7.692900e-01	1	227004055	227004993	939	-	0.377	0.513	0.705
ENSG00000143776	E007	68.2542435	0.0066646004	1.352096e-02	7.244889e-02	1	227004994	227005111	118	-	1.731	1.948	0.730
ENSG00000143776	E008	0.3088520	0.0263348112	7.224555e-01		1	227010878	227011063	186	-	0.091	0.160	0.938
ENSG00000143776	E009	66.3894579	0.0082329379	3.084209e-01	5.490138e-01	1	227016080	227016197	118	-	1.753	1.892	0.468
ENSG00000143776	E010	64.0780934	0.0061685058	5.653067e-01	7.469061e-01	1	227016927	227017050	124	-	1.754	1.865	0.376
ENSG00000143776	E011	47.7667134	0.0009428526	6.758983e-01	8.201252e-01	1	227023263	227023347	85	-	1.635	1.727	0.311
ENSG00000143776	E012	56.7974188	0.0007478347	7.607580e-01	8.730341e-01	1	227026055	227026152	98	-	1.710	1.794	0.285
ENSG00000143776	E013	150.8066370	0.0003494645	8.925634e-01	9.478864e-01	1	227028657	227029059	403	-	2.137	2.203	0.223
ENSG00000143776	E014	89.8493714	0.0004974213	8.405865e-01	9.197572e-01	1	227029060	227029250	191	-	1.916	1.979	0.211
ENSG00000143776	E015	49.9838674	0.0014144863	2.484298e-02	1.117474e-01	1	227030408	227030470	63	-	1.700	1.648	-0.178
ENSG00000143776	E016	79.7872002	0.0027775406	1.939677e-01	4.220935e-01	1	227031298	227031514	217	-	1.880	1.890	0.032
ENSG00000143776	E017	44.0672198	0.0008711705	2.009908e-01	4.309650e-01	1	227033334	227033415	82	-	1.635	1.634	-0.004
ENSG00000143776	E018	62.6033119	0.0005909562	4.760108e-01	6.842524e-01	1	227034655	227034794	140	-	1.772	1.809	0.126
ENSG00000143776	E019	73.6607765	0.0006953183	1.503496e-01	3.627955e-01	1	227035471	227035607	137	-	1.849	1.855	0.023
ENSG00000143776	E020	78.2106250	0.0005484877	1.095209e-04	1.613015e-03	1	227040131	227040236	106	-	1.911	1.815	-0.322
ENSG00000143776	E021	67.2778303	0.0005833045	3.669689e-04	4.406807e-03	1	227047927	227048010	84	-	1.846	1.752	-0.318
ENSG00000143776	E022	9.2984307	0.0032430672	2.831604e-01	5.235962e-01	1	227051881	227051985	105	-	1.013	0.957	-0.210
ENSG00000143776	E023	0.0000000				1	227059213	227059372	160	-
ENSG00000143776	E024	0.0000000				1	227059373	227059389	17	-
ENSG00000143776	E025	0.0000000				1	227059390	227059411	22	-
ENSG00000143776	E026	0.1723744	0.0557156128	2.992495e-01		1	227068467	227068653	187	-	0.000	0.161	11.878
ENSG00000143776	E027	0.1426347	0.0321951114	7.895840e-01		1	227068654	227068701	48	-	0.091	0.000	-10.024
ENSG00000143776	E028	0.7962354	0.0408457160	3.287309e-01		1	227068702	227069776	1075	-	0.166	0.369	1.526
ENSG00000143776	E029	58.4475635	0.0006780548	5.669906e-02	1.952977e-01	1	227069777	227069853	77	-	1.763	1.741	-0.075
ENSG00000143776	E030	53.6201910	0.0007052071	7.546730e-01	8.694883e-01	1	227072208	227072299	92	-	1.698	1.752	0.182
ENSG00000143776	E031	62.8514953	0.0009598076	7.169998e-01	8.462527e-01	1	227073864	227074012	149	-	1.765	1.818	0.179
ENSG00000143776	E032	61.3335285	0.0073055331	5.481831e-02	1.909138e-01	1	227074259	227074364	106	-	1.787	1.736	-0.172
ENSG00000143776	E033	69.5978688	0.0005790826	1.833010e-03	1.593403e-02	1	227080893	227081017	125	-	1.852	1.781	-0.236
ENSG00000143776	E034	69.9272214	0.0015738943	1.170732e-06	3.256123e-05	1	227091886	227091991	106	-	1.879	1.709	-0.574
ENSG00000143776	E035	89.1376908	0.0032061036	6.046204e-05	9.798497e-04	1	227100992	227101239	248	-	1.977	1.849	-0.428
ENSG00000143776	E036	0.1779838	0.0358292264	7.888146e-01		1	227111984	227112311	328	-	0.091	0.000	-10.028
ENSG00000143776	E037	59.0327436	0.0017726838	7.200551e-03	4.558506e-02	1	227112312	227112422	111	-	1.785	1.715	-0.236
ENSG00000143776	E038	83.4935410	0.0013126160	4.563279e-04	5.280748e-03	1	227112671	227112913	243	-	1.935	1.850	-0.287
ENSG00000143776	E039	64.8874848	0.0024796044	9.490087e-07	2.712277e-05	1	227119804	227119937	134	-	1.857	1.667	-0.642
ENSG00000143776	E040	53.2717029	0.0126755118	8.130311e-03	4.992095e-02	1	227129109	227129231	123	-	1.756	1.625	-0.444
ENSG00000143776	E041	56.1608778	0.0143978844	6.766995e-03	4.354977e-02	1	227139576	227139742	167	-	1.781	1.648	-0.451
ENSG00000143776	E042	38.3541536	0.0009394407	7.579883e-06	1.648615e-04	1	227142945	227143024	80	-	1.639	1.430	-0.716
ENSG00000143776	E043	74.3289087	0.0048982167	4.581136e-06	1.067484e-04	1	227145489	227145737	249	-	1.917	1.731	-0.628
ENSG00000143776	E044	76.2591585	0.0041796475	2.985177e-06	7.403998e-05	1	227147359	227147559	201	-	1.925	1.740	-0.625
ENSG00000143776	E045	52.4963099	0.0010453983	3.041694e-06	7.520012e-05	1	227160543	227160636	94	-	1.764	1.581	-0.621
ENSG00000143776	E046	0.0000000				1	227193651	227193785	135	-
ENSG00000143776	E047	56.3759835	0.0009314535	5.836173e-09	2.877806e-07	1	227193786	227193934	149	-	1.805	1.566	-0.813
ENSG00000143776	E048	44.5625217	0.0008208763	9.157630e-10	5.393653e-08	1	227199557	227199652	96	-	1.720	1.423	-1.013
ENSG00000143776	E049	36.6838774	0.0011085421	2.592636e-09	1.389802e-07	1	227213136	227213219	84	-	1.644	1.316	-1.129
ENSG00000143776	E050	2.7794121	0.1127914458	3.883600e-01	6.191579e-01	1	227219263	227219420	158	-	0.583	0.453	-0.626
ENSG00000143776	E051	42.0716692	0.0011431938	1.000679e-10	7.095542e-09	1	227254064	227254155	92	-	1.706	1.368	-1.156
ENSG00000143776	E052	110.0794375	0.0021480335	1.571431e-11	1.308163e-09	1	227317005	227318492	1488	-	2.093	1.873	-0.740

Isoforom Switch Analysis

WANG Ziyi

Date: 19 5月 2022

ENSG00000143776

1 Isoform Switch

TableFilter v0.7.3

2 Differential Exon Usage

TableFilter v0.7.3