ENSG00000143776

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000366766 ENSG00000143776 HEK293_OSMI2_6hA HEK293_TMG_6hB CDC42BPA protein_coding protein_coding 8.76248 7.27854 13.04677 1.708955 0.409611 0.841096 0.2665884 0.1703336 0.0000000 0.1703336 0.00000000 -4.172597 0.05330417 0.04336667 0.00000000 -0.04336667 8.416472e-01 2.571653e-23 FALSE TRUE
ENST00000366767 ENSG00000143776 HEK293_OSMI2_6hA HEK293_TMG_6hB CDC42BPA protein_coding protein_coding 8.76248 7.27854 13.04677 1.708955 0.409611 0.841096 0.5498835 0.2762968 0.8492403 0.1187595 0.11554522 1.585550 0.05870833 0.04593333 0.06573333 0.01980000 7.996896e-01 2.571653e-23 FALSE TRUE
ENST00000366769 ENSG00000143776 HEK293_OSMI2_6hA HEK293_TMG_6hB CDC42BPA protein_coding protein_coding 8.76248 7.27854 13.04677 1.708955 0.409611 0.841096 3.8204234 2.5085643 7.4096300 0.5830485 0.39931387 1.558746 0.37106250 0.34490000 0.56750000 0.22260000 2.880426e-04 2.571653e-23 FALSE TRUE
ENST00000442054 ENSG00000143776 HEK293_OSMI2_6hA HEK293_TMG_6hB CDC42BPA protein_coding protein_coding 8.76248 7.27854 13.04677 1.708955 0.409611 0.841096 1.7699944 0.6479911 3.7977424 0.3259639 0.08460337 2.532796 0.15198333 0.07300000 0.29146667 0.21846667 3.006723e-01 2.571653e-23 FALSE TRUE
ENST00000448940 ENSG00000143776 HEK293_OSMI2_6hA HEK293_TMG_6hB CDC42BPA protein_coding protein_coding 8.76248 7.27854 13.04677 1.708955 0.409611 0.841096 1.5867815 3.4464080 0.0000000 1.0768584 0.00000000 -8.433130 0.28871250 0.45196667 0.00000000 -0.45196667 2.571653e-23 2.571653e-23 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000143776 E001 0.9114452 0.0282398519 4.060525e-03   1 226989865 226989865 1 - 0.000 0.512 14.176
ENSG00000143776 E002 693.0381804 0.0097746303 3.886576e-14 5.213507e-12 1 226989866 226993626 3761 - 2.647 3.029 1.272
ENSG00000143776 E003 227.4057903 0.0003643898 1.385804e-09 7.860434e-08 1 226993627 226994236 610 - 2.250 2.467 0.725
ENSG00000143776 E004 87.8364010 0.0085276048 7.457450e-03 4.682736e-02 1 226994237 226994399 163 - 1.841 2.062 0.742
ENSG00000143776 E005 82.0569685 0.0013132528 2.150310e-04 2.842028e-03 1 226994823 226994980 158 - 1.810 2.036 0.760
ENSG00000143776 E006 1.7628764 0.1229014085 5.985276e-01 7.692900e-01 1 227004055 227004993 939 - 0.377 0.513 0.705
ENSG00000143776 E007 68.2542435 0.0066646004 1.352096e-02 7.244889e-02 1 227004994 227005111 118 - 1.731 1.948 0.730
ENSG00000143776 E008 0.3088520 0.0263348112 7.224555e-01   1 227010878 227011063 186 - 0.091 0.160 0.938
ENSG00000143776 E009 66.3894579 0.0082329379 3.084209e-01 5.490138e-01 1 227016080 227016197 118 - 1.753 1.892 0.468
ENSG00000143776 E010 64.0780934 0.0061685058 5.653067e-01 7.469061e-01 1 227016927 227017050 124 - 1.754 1.865 0.376
ENSG00000143776 E011 47.7667134 0.0009428526 6.758983e-01 8.201252e-01 1 227023263 227023347 85 - 1.635 1.727 0.311
ENSG00000143776 E012 56.7974188 0.0007478347 7.607580e-01 8.730341e-01 1 227026055 227026152 98 - 1.710 1.794 0.285
ENSG00000143776 E013 150.8066370 0.0003494645 8.925634e-01 9.478864e-01 1 227028657 227029059 403 - 2.137 2.203 0.223
ENSG00000143776 E014 89.8493714 0.0004974213 8.405865e-01 9.197572e-01 1 227029060 227029250 191 - 1.916 1.979 0.211
ENSG00000143776 E015 49.9838674 0.0014144863 2.484298e-02 1.117474e-01 1 227030408 227030470 63 - 1.700 1.648 -0.178
ENSG00000143776 E016 79.7872002 0.0027775406 1.939677e-01 4.220935e-01 1 227031298 227031514 217 - 1.880 1.890 0.032
ENSG00000143776 E017 44.0672198 0.0008711705 2.009908e-01 4.309650e-01 1 227033334 227033415 82 - 1.635 1.634 -0.004
ENSG00000143776 E018 62.6033119 0.0005909562 4.760108e-01 6.842524e-01 1 227034655 227034794 140 - 1.772 1.809 0.126
ENSG00000143776 E019 73.6607765 0.0006953183 1.503496e-01 3.627955e-01 1 227035471 227035607 137 - 1.849 1.855 0.023
ENSG00000143776 E020 78.2106250 0.0005484877 1.095209e-04 1.613015e-03 1 227040131 227040236 106 - 1.911 1.815 -0.322
ENSG00000143776 E021 67.2778303 0.0005833045 3.669689e-04 4.406807e-03 1 227047927 227048010 84 - 1.846 1.752 -0.318
ENSG00000143776 E022 9.2984307 0.0032430672 2.831604e-01 5.235962e-01 1 227051881 227051985 105 - 1.013 0.957 -0.210
ENSG00000143776 E023 0.0000000       1 227059213 227059372 160 -      
ENSG00000143776 E024 0.0000000       1 227059373 227059389 17 -      
ENSG00000143776 E025 0.0000000       1 227059390 227059411 22 -      
ENSG00000143776 E026 0.1723744 0.0557156128 2.992495e-01   1 227068467 227068653 187 - 0.000 0.161 11.878
ENSG00000143776 E027 0.1426347 0.0321951114 7.895840e-01   1 227068654 227068701 48 - 0.091 0.000 -10.024
ENSG00000143776 E028 0.7962354 0.0408457160 3.287309e-01   1 227068702 227069776 1075 - 0.166 0.369 1.526
ENSG00000143776 E029 58.4475635 0.0006780548 5.669906e-02 1.952977e-01 1 227069777 227069853 77 - 1.763 1.741 -0.075
ENSG00000143776 E030 53.6201910 0.0007052071 7.546730e-01 8.694883e-01 1 227072208 227072299 92 - 1.698 1.752 0.182
ENSG00000143776 E031 62.8514953 0.0009598076 7.169998e-01 8.462527e-01 1 227073864 227074012 149 - 1.765 1.818 0.179
ENSG00000143776 E032 61.3335285 0.0073055331 5.481831e-02 1.909138e-01 1 227074259 227074364 106 - 1.787 1.736 -0.172
ENSG00000143776 E033 69.5978688 0.0005790826 1.833010e-03 1.593403e-02 1 227080893 227081017 125 - 1.852 1.781 -0.236
ENSG00000143776 E034 69.9272214 0.0015738943 1.170732e-06 3.256123e-05 1 227091886 227091991 106 - 1.879 1.709 -0.574
ENSG00000143776 E035 89.1376908 0.0032061036 6.046204e-05 9.798497e-04 1 227100992 227101239 248 - 1.977 1.849 -0.428
ENSG00000143776 E036 0.1779838 0.0358292264 7.888146e-01   1 227111984 227112311 328 - 0.091 0.000 -10.028
ENSG00000143776 E037 59.0327436 0.0017726838 7.200551e-03 4.558506e-02 1 227112312 227112422 111 - 1.785 1.715 -0.236
ENSG00000143776 E038 83.4935410 0.0013126160 4.563279e-04 5.280748e-03 1 227112671 227112913 243 - 1.935 1.850 -0.287
ENSG00000143776 E039 64.8874848 0.0024796044 9.490087e-07 2.712277e-05 1 227119804 227119937 134 - 1.857 1.667 -0.642
ENSG00000143776 E040 53.2717029 0.0126755118 8.130311e-03 4.992095e-02 1 227129109 227129231 123 - 1.756 1.625 -0.444
ENSG00000143776 E041 56.1608778 0.0143978844 6.766995e-03 4.354977e-02 1 227139576 227139742 167 - 1.781 1.648 -0.451
ENSG00000143776 E042 38.3541536 0.0009394407 7.579883e-06 1.648615e-04 1 227142945 227143024 80 - 1.639 1.430 -0.716
ENSG00000143776 E043 74.3289087 0.0048982167 4.581136e-06 1.067484e-04 1 227145489 227145737 249 - 1.917 1.731 -0.628
ENSG00000143776 E044 76.2591585 0.0041796475 2.985177e-06 7.403998e-05 1 227147359 227147559 201 - 1.925 1.740 -0.625
ENSG00000143776 E045 52.4963099 0.0010453983 3.041694e-06 7.520012e-05 1 227160543 227160636 94 - 1.764 1.581 -0.621
ENSG00000143776 E046 0.0000000       1 227193651 227193785 135 -      
ENSG00000143776 E047 56.3759835 0.0009314535 5.836173e-09 2.877806e-07 1 227193786 227193934 149 - 1.805 1.566 -0.813
ENSG00000143776 E048 44.5625217 0.0008208763 9.157630e-10 5.393653e-08 1 227199557 227199652 96 - 1.720 1.423 -1.013
ENSG00000143776 E049 36.6838774 0.0011085421 2.592636e-09 1.389802e-07 1 227213136 227213219 84 - 1.644 1.316 -1.129
ENSG00000143776 E050 2.7794121 0.1127914458 3.883600e-01 6.191579e-01 1 227219263 227219420 158 - 0.583 0.453 -0.626
ENSG00000143776 E051 42.0716692 0.0011431938 1.000679e-10 7.095542e-09 1 227254064 227254155 92 - 1.706 1.368 -1.156
ENSG00000143776 E052 110.0794375 0.0021480335 1.571431e-11 1.308163e-09 1 227317005 227318492 1488 - 2.093 1.873 -0.740