ENSG00000143702

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000336415 ENSG00000143702 HEK293_OSMI2_6hA HEK293_TMG_6hB CEP170 protein_coding protein_coding 16.20862 6.98057 26.94506 1.899095 0.05520032 1.947074 1.8971261 0.7182516 3.5092071 0.34353242 0.42140970 2.2727416 0.09209167 0.0985000 0.13033333 0.03183333 0.815698703 0.005295099 FALSE TRUE
ENST00000366542 ENSG00000143702 HEK293_OSMI2_6hA HEK293_TMG_6hB CEP170 protein_coding protein_coding 16.20862 6.98057 26.94506 1.899095 0.05520032 1.947074 5.0987616 1.8394241 9.3204994 0.37648903 0.32713686 2.3348782 0.27610000 0.2823667 0.34586667 0.06350000 0.648947191 0.005295099 FALSE TRUE
ENST00000366544 ENSG00000143702 HEK293_OSMI2_6hA HEK293_TMG_6hB CEP170 protein_coding protein_coding 16.20862 6.98057 26.94506 1.899095 0.05520032 1.947074 1.8663084 0.8120343 3.8958450 0.36610658 0.56756441 2.2483643 0.08846250 0.1062000 0.14466667 0.03846667 0.792930652 0.005295099 FALSE TRUE
ENST00000451408 ENSG00000143702 HEK293_OSMI2_6hA HEK293_TMG_6hB CEP170 protein_coding processed_transcript 16.20862 6.98057 26.94506 1.899095 0.05520032 1.947074 0.7630361 0.0000000 1.4361023 0.00000000 0.73578738 7.1760258 0.04732917 0.0000000 0.05333333 0.05333333 0.497325591 0.005295099 FALSE TRUE
ENST00000468254 ENSG00000143702 HEK293_OSMI2_6hA HEK293_TMG_6hB CEP170 protein_coding processed_transcript 16.20862 6.98057 26.94506 1.899095 0.05520032 1.947074 1.1326233 0.4741680 0.6540308 0.25074266 0.04010642 0.4557423 0.15209583 0.0531000 0.02426667 -0.02883333 0.846108222 0.005295099 FALSE TRUE
MSTRG.3391.10 ENSG00000143702 HEK293_OSMI2_6hA HEK293_TMG_6hB CEP170 protein_coding   16.20862 6.98057 26.94506 1.899095 0.05520032 1.947074 1.0455722 0.3035951 1.4713491 0.03455308 0.94680016 2.2399366 0.05099167 0.0522000 0.05450000 0.00230000 0.931697406 0.005295099 FALSE TRUE
MSTRG.3391.4 ENSG00000143702 HEK293_OSMI2_6hA HEK293_TMG_6hB CEP170 protein_coding   16.20862 6.98057 26.94506 1.899095 0.05520032 1.947074 1.2937903 2.3352845 1.7436708 0.89285134 0.52805045 -0.4193850 0.13347083 0.3129000 0.06473333 -0.24816667 0.005295099 0.005295099 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000143702 E001 0.6765862 0.2606716340 4.142080e-01   1 243124428 243124428 1 - 0.234 0.000 -9.399
ENSG00000143702 E002 105.4660255 0.0041915365 1.301856e-06 3.572227e-05 1 243124429 243124892 464 - 1.881 2.135 0.852
ENSG00000143702 E003 103.2637984 0.0213166863 2.469128e-03 2.013129e-02 1 243124893 243125163 271 - 1.864 2.137 0.918
ENSG00000143702 E004 198.5186611 0.0023302179 3.930134e-05 6.784175e-04 1 243125164 243125712 549 - 2.183 2.347 0.547
ENSG00000143702 E005 44.9004220 0.0038468246 5.667168e-02 1.952557e-01 1 243125713 243125733 21 - 1.554 1.699 0.492
ENSG00000143702 E006 42.8709195 0.0037549607 3.374981e-02 1.381949e-01 1 243125734 243125788 55 - 1.530 1.689 0.542
ENSG00000143702 E007 36.9292522 0.0009754464 2.188307e-02 1.021902e-01 1 243125789 243125917 129 - 1.467 1.634 0.571
ENSG00000143702 E008 9.5705628 0.0030791580 7.000446e-03 4.464444e-02 1 243125918 243125921 4 - 0.865 1.182 1.167
ENSG00000143702 E009 28.4162105 0.0043652848 9.652770e-02 2.757009e-01 1 243125922 243125999 78 - 1.359 1.509 0.520
ENSG00000143702 E010 76.1753994 0.0021128946 1.065889e-03 1.041919e-02 1 243126000 243126134 135 - 1.769 1.947 0.601
ENSG00000143702 E011 77.3426729 0.0027817189 2.302918e-02 1.060442e-01 1 243126135 243126300 166 - 1.788 1.923 0.457
ENSG00000143702 E012 39.0622345 0.0011553384 6.043231e-02 2.037967e-01 1 243126301 243126331 31 - 1.499 1.639 0.478
ENSG00000143702 E013 39.5097637 0.0011410932 9.161020e-02 2.666836e-01 1 243126332 243126344 13 - 1.506 1.634 0.435
ENSG00000143702 E014 48.0743372 0.0007960949 2.659363e-02 1.170488e-01 1 243126345 243126377 33 - 1.583 1.730 0.500
ENSG00000143702 E015 45.8469015 0.0007828907 3.849398e-02 1.508553e-01 1 243126378 243126408 31 - 1.564 1.705 0.480
ENSG00000143702 E016 58.7481560 0.0008336238 3.207105e-03 2.464435e-02 1 243126409 243126494 86 - 1.664 1.835 0.580
ENSG00000143702 E017 60.5298068 0.0006815568 1.525999e-02 7.904523e-02 1 243126495 243126612 118 - 1.684 1.828 0.487
ENSG00000143702 E018 44.4774550 0.0009576404 4.880674e-03 3.397625e-02 1 243126613 243126683 71 - 1.536 1.720 0.626
ENSG00000143702 E019 47.7041666 0.0008363752 3.460475e-01 5.836014e-01 1 243126684 243126738 55 - 1.625 1.590 -0.118
ENSG00000143702 E020 68.8711215 0.0048027806 3.982566e-01 6.268599e-01 1 243128249 243128300 52 - 1.779 1.752 -0.092
ENSG00000143702 E021 0.6600180 0.0193874923 3.278614e-01   1 243128301 243128855 555 - 0.231 0.000 -12.856
ENSG00000143702 E022 49.6750607 0.0039788391 9.088628e-02 2.653221e-01 1 243129360 243129372 13 - 1.652 1.562 -0.307
ENSG00000143702 E023 52.2771252 0.0020198559 2.051605e-01 4.361060e-01 1 243129373 243129453 81 - 1.668 1.615 -0.181
ENSG00000143702 E024 0.0000000       1 243135752 243136142 391 -      
ENSG00000143702 E025 32.7552101 0.0013289227 5.802867e-01 7.573706e-01 1 243136143 243136231 89 - 1.448 1.510 0.211
ENSG00000143702 E026 0.0000000       1 243136232 243136304 73 -      
ENSG00000143702 E027 22.3701133 0.4318141370 1.714837e-01 3.924992e-01 1 243139937 243139983 47 - 1.196 1.535 1.180
ENSG00000143702 E028 50.6544920 0.9103215132 3.536726e-01 5.905642e-01 1 243139984 243140107 124 - 1.567 1.825 0.876
ENSG00000143702 E029 3.5809536 0.2353930123 3.847370e-01 6.162665e-01 1 243140108 243140363 256 - 0.554 0.782 0.972
ENSG00000143702 E030 5.4001961 0.2155414708 8.467882e-01 9.231870e-01 1 243142286 243142315 30 - 0.738 0.793 0.218
ENSG00000143702 E031 34.6916201 0.2514193980 3.843508e-01 6.159152e-01 1 243142316 243142366 51 - 1.436 1.608 0.591
ENSG00000143702 E032 34.7861526 0.0576664583 4.507588e-01 6.662130e-01 1 243142367 243142463 97 - 1.463 1.554 0.312
ENSG00000143702 E033 63.6862316 0.0005873425 3.782633e-01 6.107475e-01 1 243156221 243156347 127 - 1.748 1.725 -0.078
ENSG00000143702 E034 71.2911204 0.0071542622 4.708194e-01 6.806964e-01 1 243156348 243156455 108 - 1.795 1.775 -0.066
ENSG00000143702 E035 2.9704655 0.0923260722 2.699897e-01 5.099613e-01 1 243156456 243156821 366 - 0.584 0.341 -1.255
ENSG00000143702 E036 1.1196869 0.0140035324 7.760325e-01   1 243163158 243163272 115 - 0.274 0.339 0.431
ENSG00000143702 E037 1.1668026 0.0139751771 5.511366e-01   1 243163273 243163340 68 - 0.313 0.202 -0.831
ENSG00000143702 E038 162.7543616 0.0248991932 8.328539e-01 9.154130e-01 1 243164284 243164918 635 - 2.138 2.160 0.073
ENSG00000143702 E039 239.9731302 0.0002148127 2.285684e-10 1.502174e-08 1 243164919 243165988 1070 - 2.344 2.188 -0.520
ENSG00000143702 E040 46.2958690 0.0008372079 5.573295e-02 1.930200e-01 1 243165989 243166116 128 - 1.624 1.526 -0.336
ENSG00000143702 E041 0.0000000       1 243166527 243166572 46 -      
ENSG00000143702 E042 0.0000000       1 243169440 243169627 188 -      
ENSG00000143702 E043 41.4349300 0.0008671832 1.240395e-02 6.806060e-02 1 243169628 243169693 66 - 1.589 1.442 -0.504
ENSG00000143702 E044 51.6353965 0.0007960338 1.831217e-03 1.592299e-02 1 243169694 243169754 61 - 1.687 1.518 -0.576
ENSG00000143702 E045 69.3727773 0.0033157630 7.691148e-04 8.020793e-03 1 243172697 243172810 114 - 1.815 1.633 -0.617
ENSG00000143702 E046 47.2874353 0.0069393243 2.298141e-03 1.904163e-02 1 243172811 243172846 36 - 1.657 1.441 -0.739
ENSG00000143702 E047 0.0000000       1 243175023 243175188 166 -      
ENSG00000143702 E048 0.4762370 0.0217681645 1.176328e-01   1 243176702 243176816 115 - 0.070 0.339 2.754
ENSG00000143702 E049 88.6452823 0.0004997401 1.204720e-04 1.743262e-03 1 243185779 243186072 294 - 1.916 1.758 -0.533
ENSG00000143702 E050 14.8424767 0.0022081415 7.328900e-01 8.559179e-01 1 243186073 243186258 186 - 1.141 1.128 -0.046
ENSG00000143702 E051 89.7752261 0.0028331212 1.684119e-02 8.487970e-02 1 243186259 243186422 164 - 1.912 1.814 -0.331
ENSG00000143702 E052 0.3337900 0.0679055497 3.859937e-01   1 243186423 243186499 77 - 0.070 0.202 1.755
ENSG00000143702 E053 145.8508063 0.0014118343 2.102841e-09 1.153086e-07 1 243191018 243191494 477 - 2.139 1.914 -0.757
ENSG00000143702 E054 56.0319867 0.0008922344 1.701896e-03 1.502970e-02 1 243199060 243199194 135 - 1.719 1.555 -0.556
ENSG00000143702 E055 36.3243838 0.0010801733 2.990377e-02 1.270508e-01 1 243200518 243200613 96 - 1.527 1.393 -0.464
ENSG00000143702 E056 22.2596696 0.0017282881 2.466137e-01 4.843040e-01 1 243200614 243200680 67 - 1.312 1.230 -0.286
ENSG00000143702 E057 18.2196869 0.0017724353 9.461200e-03 5.578769e-02 1 243200777 243200835 59 - 1.265 1.020 -0.877
ENSG00000143702 E058 1.3502555 0.0171608615 8.098014e-03   1 243211213 243211885 673 - 0.184 0.657 2.747
ENSG00000143702 E059 13.7402378 0.0027841313 2.197580e-02 1.025020e-01 1 243211886 243211894 9 - 1.152 0.908 -0.893
ENSG00000143702 E060 46.0803876 0.0008770904 1.423993e-02 7.529792e-02 1 243211895 243211964 70 - 1.630 1.494 -0.464
ENSG00000143702 E061 0.5339515 0.9274582723 1.000000e+00   1 243221555 243221723 169 - 0.192 0.000 -10.767
ENSG00000143702 E062 63.3222935 0.0040913460 1.215572e-02 6.709312e-02 1 243221724 243221813 90 - 1.764 1.622 -0.480
ENSG00000143702 E063 63.3363115 0.0094550983 2.428167e-02 1.099630e-01 1 243225176 243225321 146 - 1.764 1.617 -0.499
ENSG00000143702 E064 0.1723744 0.1237289281 1.411630e-01   1 243253102 243253320 219 - 0.000 0.203 11.574
ENSG00000143702 E065 0.8746386 0.0190943891 1.784773e-01   1 243254351 243254470 120 - 0.184 0.442 1.747
ENSG00000143702 E066 18.8831824 0.0030982307 3.047771e-02 1.287773e-01 1 243255040 243255046 7 - 1.265 1.067 -0.708
ENSG00000143702 E067 49.3665622 0.0109353949 4.007801e-02 1.549145e-01 1 243255047 243255348 302 - 1.660 1.510 -0.513