ENSG00000143622

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000368322 ENSG00000143622 HEK293_OSMI2_6hA HEK293_TMG_6hB RIT1 protein_coding protein_coding 12.95615 7.979727 15.56603 0.4655656 1.724439 0.9631097 2.8145742 0.7954952 3.8022631 0.7954952 0.2634563 2.2426998 0.2148542 0.09566667 0.2471667 0.151500000 3.050609e-01 9.314476e-15 FALSE TRUE
ENST00000368323 ENSG00000143622 HEK293_OSMI2_6hA HEK293_TMG_6hB RIT1 protein_coding protein_coding 12.95615 7.979727 15.56603 0.4655656 1.724439 0.9631097 3.1923418 1.6822465 4.8268333 0.1547432 0.3413712 1.5151231 0.2424750 0.21010000 0.3138667 0.103766667 1.573901e-01 9.314476e-15 FALSE TRUE
ENST00000539040 ENSG00000143622 HEK293_OSMI2_6hA HEK293_TMG_6hB RIT1 protein_coding protein_coding 12.95615 7.979727 15.56603 0.4655656 1.724439 0.9631097 3.2716070 2.8695435 2.5927521 0.7276120 0.3727823 -0.1458022 0.2651250 0.36436667 0.1651667 -0.199200000 3.523570e-01 9.314476e-15 FALSE TRUE
ENST00000609492 ENSG00000143622 HEK293_OSMI2_6hA HEK293_TMG_6hB RIT1 protein_coding protein_coding 12.95615 7.979727 15.56603 0.4655656 1.724439 0.9631097 1.1391557 0.8987621 1.9349929 0.3350443 0.4313955 1.0977903 0.0883000 0.11623333 0.1208000 0.004566667 9.482048e-01 9.314476e-15 FALSE FALSE
ENST00000650659 ENSG00000143622 HEK293_OSMI2_6hA HEK293_TMG_6hB RIT1 protein_coding retained_intron 12.95615 7.979727 15.56603 0.4655656 1.724439 0.9631097 0.7249637 1.6135634 0.1736974 0.3623205 0.1736974 -3.1437606 0.0629250 0.19950000 0.0101000 -0.189400000 2.671527e-02 9.314476e-15   FALSE
ENST00000651853 ENSG00000143622 HEK293_OSMI2_6hA HEK293_TMG_6hB RIT1 protein_coding protein_coding 12.95615 7.979727 15.56603 0.4655656 1.724439 0.9631097 1.3319196 0.0000000 1.9603507 0.0000000 0.1522754 7.6223086 0.0876375 0.00000000 0.1271000 0.127100000 9.314476e-15 9.314476e-15 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000143622 E001 66.8999540 0.0006488078 6.733590e-02 2.190942e-01 1 155897808 155898836 1029 - 1.835 1.754 -0.274
ENSG00000143622 E002 145.3276155 0.0004343687 1.148451e-08 5.308475e-07 1 155898837 155900182 1346 - 2.194 2.021 -0.578
ENSG00000143622 E003 38.0932226 0.0010695922 9.748732e-01 9.893384e-01 1 155900183 155900273 91 - 1.568 1.567 -0.001
ENSG00000143622 E004 59.6609352 0.0036274589 6.071479e-01 7.749952e-01 1 155900274 155900397 124 - 1.746 1.775 0.100
ENSG00000143622 E005 90.5732646 0.0005843096 1.759670e-01 3.984219e-01 1 155900398 155900593 196 - 1.919 1.971 0.175
ENSG00000143622 E006 38.5769515 0.0011546298 2.761120e-01 5.161242e-01 1 155900594 155900618 25 - 1.554 1.618 0.219
ENSG00000143622 E007 57.9657230 0.0009283850 4.565507e-01 6.706600e-01 1 155904311 155904373 63 - 1.735 1.771 0.123
ENSG00000143622 E008 72.2414087 0.0005943321 1.820858e-01 4.067072e-01 1 155904374 155904502 129 - 1.821 1.879 0.192
ENSG00000143622 E009 0.1308682 0.0309837691 2.417200e-01   1 155904603 155904605 3 - 0.000 0.164 11.190
ENSG00000143622 E010 0.1308682 0.0309837691 2.417200e-01   1 155904606 155904610 5 - 0.000 0.164 11.190
ENSG00000143622 E011 0.8507255 0.0273687755 1.943140e-03   1 155904612 155904730 119 - 0.000 0.519 13.505
ENSG00000143622 E012 61.0319197 0.0006635224 8.624883e-02 2.568985e-01 1 155904731 155904804 74 - 1.742 1.822 0.269
ENSG00000143622 E013 0.7143205 0.0482717755 9.638516e-02   1 155910095 155910449 355 - 0.089 0.378 2.614
ENSG00000143622 E014 51.3409826 0.0008833698 1.870485e-01 4.131083e-01 1 155910450 155910506 57 - 1.675 1.743 0.229
ENSG00000143622 E015 64.7872755 0.0043319742 5.384066e-01 7.279242e-01 1 155910656 155910804 149 - 1.807 1.779 -0.097
ENSG00000143622 E016 4.3814906 0.0852698362 6.695262e-01 8.159789e-01 1 155910805 155910877 73 - 0.681 0.756 0.309
ENSG00000143622 E017 3.3572525 0.1481098153 4.395334e-01 6.583077e-01 1 155910878 155910915 38 - 0.540 0.725 0.805
ENSG00000143622 E018 31.8447672 0.0047956771 7.898967e-01 8.905049e-01 1 155911243 155911271 29 - 1.492 1.514 0.074
ENSG00000143622 E019 37.9055908 0.0012619878 1.271763e-01 3.273599e-01 1 155911272 155911404 133 - 1.537 1.627 0.308