ENSG00000143393

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000368872 ENSG00000143393 HEK293_OSMI2_6hA HEK293_TMG_6hB PI4KB protein_coding protein_coding 79.98229 105.7602 55.11028 13.21781 3.790753 -0.9402785 4.820200 5.713906 4.783315 0.5672186 0.1565750 -0.2559761 0.06767500 0.05483333 0.08723333 0.03240000 0.091344388 0.002613371 FALSE TRUE
ENST00000368874 ENSG00000143393 HEK293_OSMI2_6hA HEK293_TMG_6hB PI4KB protein_coding protein_coding 79.98229 105.7602 55.11028 13.21781 3.790753 -0.9402785 32.327824 46.753191 21.834374 6.6475163 2.0896231 -1.0981116 0.40889167 0.44000000 0.39470000 -0.04530000 0.645196249 0.002613371 FALSE TRUE
ENST00000529142 ENSG00000143393 HEK293_OSMI2_6hA HEK293_TMG_6hB PI4KB protein_coding protein_coding 79.98229 105.7602 55.11028 13.21781 3.790753 -0.9402785 15.487764 19.515896 5.174643 4.3283070 1.7996946 -1.9130721 0.16170417 0.17970000 0.09026667 -0.08943333 0.415717620 0.002613371 FALSE TRUE
MSTRG.2212.5 ENSG00000143393 HEK293_OSMI2_6hA HEK293_TMG_6hB PI4KB protein_coding   79.98229 105.7602 55.11028 13.21781 3.790753 -0.9402785 8.340093 10.931695 9.475399 1.6557107 0.2588746 -0.2060558 0.11755417 0.10256667 0.17313333 0.07056667 0.002613371 0.002613371 FALSE TRUE
MSTRG.2212.6 ENSG00000143393 HEK293_OSMI2_6hA HEK293_TMG_6hB PI4KB protein_coding   79.98229 105.7602 55.11028 13.21781 3.790753 -0.9402785 6.256857 8.701828 5.087250 1.7772960 0.3419264 -0.7732565 0.08572917 0.08053333 0.09413333 0.01360000 0.881480500 0.002613371 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000143393 E001 0.1426347 0.0313040454 1.812143e-01   1 151291797 151291803 7 - 0.175 0.000 -9.642
ENSG00000143393 E002 31.6679447 0.1711992379 6.450756e-02 2.127861e-01 1 151291804 151291936 133 - 1.209 1.551 1.186
ENSG00000143393 E003 65.1408175 0.3838932582 1.681234e-01 3.880929e-01 1 151291937 151292132 196 - 1.538 1.850 1.058
ENSG00000143393 E004 710.3057461 1.5358502820 4.592083e-01 6.726236e-01 1 151292133 151292478 346 - 2.623 2.869 0.819
ENSG00000143393 E005 686.2001759 1.5422246103 4.860393e-01 6.912557e-01 1 151292479 151292601 123 - 2.632 2.849 0.721
ENSG00000143393 E006 409.2580688 1.3491414020 4.402994e-01 6.589375e-01 1 151292602 151292622 21 - 2.390 2.629 0.796
ENSG00000143393 E007 1183.9393020 1.7180173231 4.961730e-01 6.982986e-01 1 151292623 151292954 332 - 2.860 3.087 0.753
ENSG00000143393 E008 451.4602988 1.3760611730 4.304955e-01 6.515123e-01 1 151292955 151293033 79 - 2.424 2.673 0.832
ENSG00000143393 E009 18.4220650 0.3398715420 7.875210e-01 8.890825e-01 1 151293400 151293462 63 - 1.226 1.260 0.121
ENSG00000143393 E010 49.1102990 0.0825236751 2.725504e-01 5.123855e-01 1 151293619 151294017 399 - 1.724 1.629 -0.322
ENSG00000143393 E011 319.7053081 0.0507595243 2.257881e-01 4.602798e-01 1 151294018 151294048 31 - 2.364 2.501 0.456
ENSG00000143393 E012 604.2969386 0.0001323934 8.137599e-01 9.045192e-01 1 151294049 151294138 90 - 2.714 2.753 0.127
ENSG00000143393 E013 714.7533289 0.0020513836 2.858312e-03 2.255085e-02 1 151294409 151294541 133 - 2.835 2.806 -0.096
ENSG00000143393 E014 6.0072648 0.1890832138 9.939357e-02 2.806986e-01 1 151298425 151298807 383 - 1.006 0.685 -1.248
ENSG00000143393 E015 918.2619010 0.0054056591 5.572474e-02 1.930073e-01 1 151298808 151299073 266 - 2.935 2.917 -0.062
ENSG00000143393 E016 643.9163489 0.0052546417 4.692253e-01 6.795488e-01 1 151301844 151301967 124 - 2.750 2.775 0.085
ENSG00000143393 E017 387.3232618 0.0069883591 8.915294e-01 9.474112e-01 1 151302194 151302247 54 - 2.514 2.560 0.155
ENSG00000143393 E018 416.5493180 0.0072309684 7.210190e-01 8.488083e-01 1 151302248 151302298 51 - 2.531 2.598 0.222
ENSG00000143393 E019 1.8866599 0.0423075029 8.399520e-02 2.527969e-01 1 151303354 151303540 187 - 0.600 0.313 -1.497
ENSG00000143393 E020 585.6401252 0.0033627881 4.574753e-01 6.714200e-01 1 151303541 151303650 110 - 2.710 2.734 0.082
ENSG00000143393 E021 669.9583150 0.0088835877 2.608443e-01 4.998404e-01 1 151306136 151306263 128 - 2.787 2.785 -0.007
ENSG00000143393 E022 620.6930946 0.0102160852 1.209820e-01 3.174427e-01 1 151306264 151306363 100 - 2.771 2.744 -0.090
ENSG00000143393 E023 3.3704737 0.2008906215 6.943493e-01 8.319210e-01 1 151306364 151306433 70 - 0.656 0.578 -0.344
ENSG00000143393 E024 818.6857181 0.0085254983 6.350601e-02 2.106115e-01 1 151307574 151307801 228 - 2.894 2.863 -0.105
ENSG00000143393 E025 12.6274438 0.1263694961 7.887181e-01 8.897474e-01 1 151310211 151310255 45 - 0.998 1.124 0.460
ENSG00000143393 E026 482.1321430 0.0108440534 1.056442e-01 2.917609e-01 1 151315573 151315639 67 - 2.667 2.632 -0.114
ENSG00000143393 E027 406.5006178 0.0101393062 1.396946e-01 3.470306e-01 1 151315640 151315672 33 - 2.587 2.561 -0.085
ENSG00000143393 E028 1765.2107044 0.0145852829 2.216924e-02 1.031719e-01 1 151315673 151316509 837 - 3.253 3.184 -0.227
ENSG00000143393 E029 122.5666445 0.0004469508 3.821827e-08 1.568431e-06 1 151324745 151324917 173 - 2.151 2.005 -0.491
ENSG00000143393 E030 130.0123811 0.0145715914 3.627864e-01 5.979872e-01 1 151326172 151326373 202 - 2.085 2.072 -0.044
ENSG00000143393 E031 337.8323398 0.0174403993 5.307962e-01 7.225995e-01 1 151327271 151327715 445 - 2.484 2.491 0.024