ENSG00000143379

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000271640 ENSG00000143379 HEK293_OSMI2_6hA HEK293_TMG_6hB SETDB1 protein_coding protein_coding 33.11852 28.35249 36.36493 2.811799 0.3830141 0.3589602 2.9689770 2.8251985 4.9075453 0.9349774 0.7275748 0.79448861 0.09153333 0.09633333 0.13483333 0.03850000 7.633589e-01 1.435342e-21 FALSE TRUE
ENST00000368962 ENSG00000143379 HEK293_OSMI2_6hA HEK293_TMG_6hB SETDB1 protein_coding protein_coding 33.11852 28.35249 36.36493 2.811799 0.3830141 0.3589602 3.6159422 1.5663783 5.2839968 0.0652187 0.1588839 1.74774350 0.10577083 0.05656667 0.14526667 0.08870000 1.973520e-04 1.435342e-21 FALSE TRUE
ENST00000497314 ENSG00000143379 HEK293_OSMI2_6hA HEK293_TMG_6hB SETDB1 protein_coding retained_intron 33.11852 28.35249 36.36493 2.811799 0.3830141 0.3589602 1.8566658 1.4684479 2.7012470 0.4872895 0.1756534 0.87487312 0.05688333 0.05576667 0.07430000 0.01853333 7.726964e-01 1.435342e-21 TRUE TRUE
ENST00000525956 ENSG00000143379 HEK293_OSMI2_6hA HEK293_TMG_6hB SETDB1 protein_coding protein_coding 33.11852 28.35249 36.36493 2.811799 0.3830141 0.3589602 2.1573657 0.4201364 4.8705535 0.4201364 0.2942556 3.50417872 0.05879167 0.01266667 0.13410000 0.12143333 9.586102e-02 1.435342e-21 FALSE FALSE
ENST00000528749 ENSG00000143379 HEK293_OSMI2_6hA HEK293_TMG_6hB SETDB1 protein_coding retained_intron 33.11852 28.35249 36.36493 2.811799 0.3830141 0.3589602 1.7590173 1.7544856 1.8525805 0.5056103 0.3785560 0.07805513 0.05376250 0.06683333 0.05076667 -0.01606667 9.513495e-01 1.435342e-21   FALSE
ENST00000533529 ENSG00000143379 HEK293_OSMI2_6hA HEK293_TMG_6hB SETDB1 protein_coding retained_intron 33.11852 28.35249 36.36493 2.811799 0.3830141 0.3589602 1.5937098 0.9121341 0.5163027 0.4599201 0.5163027 -0.80908384 0.05107500 0.03366667 0.01403333 -0.01963333 7.003585e-01 1.435342e-21 FALSE FALSE
ENST00000692314 ENSG00000143379 HEK293_OSMI2_6hA HEK293_TMG_6hB SETDB1 protein_coding protein_coding 33.11852 28.35249 36.36493 2.811799 0.3830141 0.3589602 2.3471422 4.2952533 0.0000000 0.9381141 0.0000000 -8.74995433 0.08037917 0.14776667 0.00000000 -0.14776667 1.435342e-21 1.435342e-21 FALSE TRUE
ENST00000692827 ENSG00000143379 HEK293_OSMI2_6hA HEK293_TMG_6hB SETDB1 protein_coding protein_coding 33.11852 28.35249 36.36493 2.811799 0.3830141 0.3589602 10.5417235 9.8499013 10.0436868 1.2907949 0.1210001 0.02807954 0.31549167 0.34510000 0.27623333 -0.06886667 2.648000e-01 1.435342e-21 FALSE TRUE
MSTRG.2186.9 ENSG00000143379 HEK293_OSMI2_6hA HEK293_TMG_6hB SETDB1 protein_coding   33.11852 28.35249 36.36493 2.811799 0.3830141 0.3589602 0.3420294 1.5144313 0.0000000 0.8591885 0.0000000 -7.25212735 0.01152500 0.05223333 0.00000000 -0.05223333 2.932827e-01 1.435342e-21 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000143379 E001 5.377915 0.0053268430 4.841965e-06 1.119506e-04 1 150926263 150926304 42 + 1.023 0.452 -2.383
ENSG00000143379 E002 11.010270 0.0028582439 1.781647e-06 4.707711e-05 1 150926305 150926329 25 + 1.257 0.832 -1.557
ENSG00000143379 E003 14.657701 0.0025986281 3.105241e-04 3.836605e-03 1 150926330 150926338 9 + 1.311 1.056 -0.907
ENSG00000143379 E004 16.343104 0.0057858060 3.320770e-04 4.058604e-03 1 150926339 150926344 6 + 1.352 1.100 -0.891
ENSG00000143379 E005 16.759241 0.0042202870 1.900778e-04 2.564555e-03 1 150926345 150926348 4 + 1.365 1.110 -0.899
ENSG00000143379 E006 2.052024 0.1680203411 2.208643e-01 4.544917e-01 1 150926349 150926362 14 + 0.609 0.345 -1.334
ENSG00000143379 E007 18.976715 0.0383223677 1.949682e-01 4.233106e-01 1 150926363 150926394 32 + 1.339 1.246 -0.325
ENSG00000143379 E008 27.594623 0.0185973149 2.681890e-01 5.078428e-01 1 150926395 150926411 17 + 1.468 1.431 -0.127
ENSG00000143379 E009 46.907378 0.0185001738 1.276391e-01 3.281068e-01 1 150926412 150926423 12 + 1.700 1.650 -0.169
ENSG00000143379 E010 82.331836 0.0259383956 7.030036e-02 2.253462e-01 1 150926424 150926463 40 + 1.961 1.876 -0.286
ENSG00000143379 E011 70.257877 0.0189664678 2.828736e-02 1.221261e-01 1 150926464 150926480 17 + 1.901 1.801 -0.336
ENSG00000143379 E012 66.416208 0.0182372016 1.584766e-02 8.123446e-02 1 150926481 150926486 6 + 1.883 1.769 -0.384
ENSG00000143379 E013 81.401274 0.0155074142 4.797288e-03 3.351254e-02 1 150926487 150926517 31 + 1.977 1.849 -0.432
ENSG00000143379 E014 10.484195 0.0238623928 2.303731e-01 4.655351e-01 1 150926518 150926531 14 + 1.091 1.009 -0.297
ENSG00000143379 E015 11.789804 0.0270561243 3.114416e-01 5.518552e-01 1 150926532 150926544 13 + 1.126 1.070 -0.201
ENSG00000143379 E016 1.987100 0.0129313260 1.422454e-01 3.507811e-01 1 150926640 150926808 169 + 0.306 0.606 1.569
ENSG00000143379 E017 194.307233 0.0160757468 1.253012e-02 6.855355e-02 1 150927704 150927841 138 + 2.332 2.246 -0.287
ENSG00000143379 E018 189.990908 0.0088893911 1.347531e-03 1.251664e-02 1 150927842 150927974 133 + 2.324 2.236 -0.294
ENSG00000143379 E019 2.184623 0.0100845779 1.229326e-01 3.203731e-01 1 150927975 150928229 255 + 0.609 0.402 -1.008
ENSG00000143379 E020 108.171582 0.0006102167 1.108877e-05 2.294259e-04 1 150929967 150929997 31 + 2.081 1.998 -0.278
ENSG00000143379 E021 172.055825 0.0033782629 6.348304e-05 1.022175e-03 1 150929998 150930118 121 + 2.278 2.200 -0.262
ENSG00000143379 E022 9.690764 0.0031881427 8.204128e-09 3.929074e-07 1 150930119 150930456 338 + 1.248 0.668 -2.190
ENSG00000143379 E023 99.642631 0.0025744416 3.585456e-05 6.280483e-04 1 150939940 150939974 35 + 2.052 1.949 -0.343
ENSG00000143379 E024 150.138925 0.0084882677 1.683840e-03 1.490434e-02 1 150941329 150941428 100 + 2.224 2.134 -0.298
ENSG00000143379 E025 190.052616 0.0077030025 8.501125e-05 1.306149e-03 1 150942563 150942688 126 + 2.339 2.222 -0.392
ENSG00000143379 E026 234.143354 0.0004451486 3.250811e-07 1.059214e-05 1 150942852 150943053 202 + 2.398 2.345 -0.178
ENSG00000143379 E027 132.863756 0.0073997840 1.567917e-02 8.065807e-02 1 150943920 150943993 74 + 2.148 2.101 -0.158
ENSG00000143379 E028 224.023490 0.0109823442 2.648997e-02 1.167335e-01 1 150944918 150945108 191 + 2.373 2.329 -0.149
ENSG00000143379 E029 19.184562 0.0025751657 2.057362e-03 1.744174e-02 1 150945109 150945320 212 + 1.384 1.203 -0.631
ENSG00000143379 E030 131.629305 0.0063786132 2.785822e-01 5.186781e-01 1 150946886 150947012 127 + 2.109 2.131 0.072
ENSG00000143379 E031 139.730695 0.0066072419 8.679959e-01 9.348485e-01 1 150949122 150949278 157 + 2.111 2.178 0.224
ENSG00000143379 E032 41.122115 0.0030411197 5.046921e-02 1.807697e-01 1 150949367 150949369 3 + 1.515 1.704 0.645
ENSG00000143379 E033 79.046520 0.0038324680 5.050159e-01 7.043289e-01 1 150949370 150949403 34 + 1.845 1.950 0.356
ENSG00000143379 E034 115.770450 0.0051610176 4.623427e-01 6.747718e-01 1 150949404 150949525 122 + 2.006 2.116 0.369
ENSG00000143379 E035 321.588559 0.0059441450 4.115434e-01 6.371987e-01 1 150950458 150951090 633 + 2.443 2.556 0.374
ENSG00000143379 E036 141.978478 0.0040233456 3.222078e-01 5.616391e-01 1 150951365 150951481 117 + 2.086 2.206 0.399
ENSG00000143379 E037 173.821509 0.0004175110 1.352805e-03 1.255396e-02 1 150959178 150959347 170 + 2.150 2.311 0.538
ENSG00000143379 E038 18.966779 0.0536302584 3.740919e-01 6.074140e-01 1 150960184 150960562 379 + 1.339 1.267 -0.252
ENSG00000143379 E039 147.810733 0.2973108583 2.003208e-01 4.301368e-01 1 150960563 150960701 139 + 2.000 2.281 0.938
ENSG00000143379 E040 299.810722 0.0118177294 5.905969e-03 3.928130e-02 1 150960702 150961191 490 + 2.350 2.565 0.719
ENSG00000143379 E041 36.297677 0.2611494336 8.981906e-02 2.634611e-01 1 150961317 150962127 811 + 1.697 1.418 -0.952
ENSG00000143379 E042 9.439902 0.0645927408 8.989705e-01 9.513336e-01 1 150962128 150962129 2 + 0.994 1.042 0.176
ENSG00000143379 E043 80.489369 0.0009195462 7.437265e-04 7.809910e-03 1 150962130 150962158 29 + 1.783 1.994 0.711
ENSG00000143379 E044 171.474441 0.0450309780 6.372656e-02 2.110832e-01 1 150962587 150962719 133 + 2.093 2.331 0.796
ENSG00000143379 E045 18.356340 0.1198753918 9.081526e-01 9.562219e-01 1 150962720 150962973 254 + 1.219 1.335 0.409
ENSG00000143379 E046 226.363780 1.3140575762 3.749550e-01 6.081360e-01 1 150962974 150963139 166 + 2.137 2.484 1.159
ENSG00000143379 E047 36.762336 0.0964411924 2.178811e-01 4.508991e-01 1 150963140 150963529 390 + 1.630 1.521 -0.370
ENSG00000143379 E048 255.791345 0.1848930820 8.104989e-02 2.469080e-01 1 150963530 150963741 212 + 2.194 2.536 1.140
ENSG00000143379 E049 5.923671 0.1016983438 4.030519e-01 6.307724e-01 1 150963742 150963851 110 + 0.730 0.922 0.753
ENSG00000143379 E050 178.225237 1.2292564249 3.655531e-01 6.003919e-01 1 150963995 150964083 89 + 2.039 2.379 1.139
ENSG00000143379 E051 96.892946 0.7909998807 3.308182e-01 5.697322e-01 1 150964247 150964249 3 + 1.813 2.101 0.969
ENSG00000143379 E052 286.706485 0.6611235040 2.639968e-01 5.032517e-01 1 150964250 150964779 530 + 2.258 2.579 1.071