ENSG00000143375

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000271636 ENSG00000143375 HEK293_OSMI2_6hA HEK293_TMG_6hB CGN protein_coding protein_coding 9.500203 12.19139 8.272339 0.2446938 0.3943636 -0.5589355 7.4780691 10.428365 6.4880187 0.5820540 0.24103660 -0.6838240 0.79187500 0.8564667 0.7851000 -0.07136667 6.504844e-01 3.908668e-07 FALSE TRUE
ENST00000464886 ENSG00000143375 HEK293_OSMI2_6hA HEK293_TMG_6hB CGN protein_coding retained_intron 9.500203 12.19139 8.272339 0.2446938 0.3943636 -0.5589355 0.4119034 0.000000 0.4636236 0.0000000 0.12531357 5.5656690 0.04163333 0.0000000 0.0550000 0.05500000 3.908668e-07 3.908668e-07 FALSE FALSE
ENST00000467998 ENSG00000143375 HEK293_OSMI2_6hA HEK293_TMG_6hB CGN protein_coding retained_intron 9.500203 12.19139 8.272339 0.2446938 0.3943636 -0.5589355 1.2760653 1.335279 0.8776524 0.5599836 0.04083874 -0.5998391 0.13141667 0.1085333 0.1063333 -0.00220000 9.744588e-01 3.908668e-07 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000143375 E001 0.0000000       1 151510510 151510549 40 +      
ENSG00000143375 E002 0.3641499 0.0296883190 0.62480464   1 151510936 151511000 65 + 0.162 0.090 -0.969
ENSG00000143375 E003 27.8833908 0.0014593430 0.57817346 0.75595451 1 151511387 151511515 129 + 1.456 1.417 -0.133
ENSG00000143375 E004 0.0000000       1 151515495 151515616 122 +      
ENSG00000143375 E005 175.2614879 0.0013944046 0.00533416 0.03635725 1 151518506 151519369 864 + 2.277 2.192 -0.285
ENSG00000143375 E006 36.1926860 0.0010955632 0.86173356 0.93124979 1 151519370 151519392 23 + 1.543 1.553 0.037
ENSG00000143375 E007 60.0481568 0.0008298691 0.30249327 0.54307824 1 151520166 151520266 101 + 1.795 1.747 -0.165
ENSG00000143375 E008 48.2135353 0.0043311559 0.04085419 0.15693401 1 151520414 151520483 70 + 1.745 1.626 -0.405
ENSG00000143375 E009 40.0904017 0.0021316550 0.02854883 0.12299266 1 151520596 151520619 24 + 1.669 1.540 -0.439
ENSG00000143375 E010 59.1495599 0.0053481815 0.28354651 0.52399717 1 151520620 151520691 72 + 1.792 1.731 -0.206
ENSG00000143375 E011 73.0267074 0.0024328340 0.73371882 0.85645789 1 151523434 151523561 128 + 1.854 1.836 -0.060
ENSG00000143375 E012 72.3382646 0.0015937791 0.52930712 0.72156555 1 151524226 151524358 133 + 1.817 1.845 0.096
ENSG00000143375 E013 94.3897438 0.0004420084 0.96817524 0.98595240 1 151524674 151524886 213 + 1.954 1.953 -0.005
ENSG00000143375 E014 1.2844265 0.1427389270 0.15490137   1 151525594 151525641 48 + 0.511 0.230 -1.683
ENSG00000143375 E015 83.5644709 0.0006123002 0.69433299 0.83191319 1 151525642 151525790 149 + 1.913 1.897 -0.054
ENSG00000143375 E016 69.7683636 0.0028161393 0.16223214 0.38012043 1 151526975 151527107 133 + 1.779 1.850 0.239
ENSG00000143375 E017 88.8108475 0.0045075511 0.09279362 0.26894052 1 151529350 151529559 210 + 1.873 1.958 0.288
ENSG00000143375 E018 86.5713831 0.0011435480 0.32122080 0.56073063 1 151529909 151530115 207 + 1.891 1.933 0.141
ENSG00000143375 E019 95.7611329 0.0045030839 0.18956735 0.41639155 1 151530489 151530746 258 + 1.918 1.983 0.220
ENSG00000143375 E020 72.7353640 0.0110164177 0.31892175 0.55865256 1 151532402 151532572 171 + 1.797 1.863 0.223
ENSG00000143375 E021 76.4038236 0.0008709445 0.36683211 0.60135848 1 151533975 151534136 162 + 1.888 1.849 -0.133
ENSG00000143375 E022 9.9031506 0.0875929391 0.10118794 0.28393778 1 151534140 151535041 902 + 1.161 0.916 -0.896
ENSG00000143375 E023 70.0156674 0.0005745162 0.62034133 0.78403931 1 151535042 151535131 90 + 1.811 1.833 0.074
ENSG00000143375 E024 67.6792123 0.0006099248 0.64526042 0.80036455 1 151535600 151535683 84 + 1.829 1.808 -0.069
ENSG00000143375 E025 77.0119028 0.0006292406 0.67835994 0.82169716 1 151535780 151535877 98 + 1.859 1.877 0.059
ENSG00000143375 E026 43.1650812 0.0010022968 0.35083801 0.58801827 1 151535878 151535898 21 + 1.656 1.604 -0.177
ENSG00000143375 E027 10.6736122 0.2536588045 0.32077181 0.56036736 1 151535899 151536236 338 + 1.105 1.009 -0.351
ENSG00000143375 E028 92.5464518 0.0004406956 0.69399044 0.83166705 1 151536237 151536345 109 + 1.956 1.941 -0.050
ENSG00000143375 E029 111.8622899 0.0003668416 0.53362448 0.72464546 1 151536730 151536893 164 + 2.013 2.035 0.073
ENSG00000143375 E030 412.5554112 0.0001884381 0.02345217 0.10738562 1 151537205 151538692 1488 + 2.564 2.603 0.132