ENSG00000143374

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000369064 ENSG00000143374 HEK293_OSMI2_6hA HEK293_TMG_6hB TARS2 protein_coding protein_coding 67.7748 83.00268 56.81418 12.22582 2.703009 -0.5468266 35.245028 48.779906 33.851584 8.0961749 1.1352085 -0.52693326 0.51925833 0.58376667 0.59813333 0.014366667 0.965250659 0.003075421 FALSE  
ENST00000463555 ENSG00000143374 HEK293_OSMI2_6hA HEK293_TMG_6hB TARS2 protein_coding processed_transcript 67.7748 83.00268 56.81418 12.22582 2.703009 -0.5468266 5.773435 6.707861 7.019505 0.5068298 1.0846308 0.06542119 0.09156250 0.08293333 0.12250000 0.039566667 0.391131423 0.003075421 FALSE  
ENST00000606933 ENSG00000143374 HEK293_OSMI2_6hA HEK293_TMG_6hB TARS2 protein_coding protein_coding 67.7748 83.00268 56.81418 12.22582 2.703009 -0.5468266 13.790516 17.533659 6.524802 3.6431322 0.5201266 -1.42473431 0.19833333 0.20690000 0.11450000 -0.092400000 0.003075421 0.003075421 FALSE  
MSTRG.2165.1 ENSG00000143374 HEK293_OSMI2_6hA HEK293_TMG_6hB TARS2 protein_coding   67.7748 83.00268 56.81418 12.22582 2.703009 -0.5468266 3.139897 5.100662 3.894671 1.5017884 0.3826027 -0.38830926 0.05014583 0.05836667 0.06833333 0.009966667 0.861210187 0.003075421 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000143374 E001 1.963948 0.1468272229 2.552681e-01 4.938842e-01 1 150487395 150487413 19 + 0.569 0.344 -1.164
ENSG00000143374 E002 3.743205 0.0208934960 1.623309e-01 3.802469e-01 1 150487414 150487418 5 + 0.774 0.553 -0.943
ENSG00000143374 E003 4.355299 0.0067625554 2.246557e-01 4.589900e-01 1 150487419 150487419 1 + 0.805 0.628 -0.729
ENSG00000143374 E004 14.568896 0.0043667988 7.626215e-03 4.758797e-02 1 150487420 150487430 11 + 1.308 1.059 -0.887
ENSG00000143374 E005 35.090318 0.0011256976 8.595799e-05 1.317358e-03 1 150487431 150487434 4 + 1.674 1.435 -0.820
ENSG00000143374 E006 50.710523 0.0007536646 1.617540e-02 8.242924e-02 1 150487435 150487441 7 + 1.770 1.644 -0.426
ENSG00000143374 E007 295.078004 0.0021809209 9.996626e-01 1.000000e+00 1 150487442 150487516 75 + 2.447 2.443 -0.015
ENSG00000143374 E008 276.072934 0.0040855345 9.431285e-01 9.739074e-01 1 150487858 150487869 12 + 2.418 2.415 -0.009
ENSG00000143374 E009 458.426464 0.0020751977 5.821782e-01 7.584869e-01 1 150487870 150487990 121 + 2.648 2.629 -0.064
ENSG00000143374 E010 366.510935 0.0009542154 6.795108e-02 2.204789e-01 1 150487991 150488054 64 + 2.568 2.521 -0.155
ENSG00000143374 E011 3.931165 0.2053021886 4.504093e-01 6.660019e-01 1 150488055 150488632 578 + 0.770 0.612 -0.662
ENSG00000143374 E012 244.413118 0.0002645574 2.578543e-01 4.966050e-01 1 150488964 150488988 25 + 2.383 2.352 -0.103
ENSG00000143374 E013 376.818008 0.0001391206 7.940708e-01 8.927724e-01 1 150488989 150489087 99 + 2.556 2.547 -0.028
ENSG00000143374 E014 1.261991 0.1647167484 7.697375e-01   1 150489088 150489308 221 + 0.280 0.341 0.402
ENSG00000143374 E015 319.018703 0.0001681722 9.226625e-01 9.636489e-01 1 150490601 150490673 73 + 2.479 2.478 -0.004
ENSG00000143374 E016 277.418343 0.0007922931 1.918301e-01 4.191551e-01 1 150490674 150490725 52 + 2.443 2.405 -0.126
ENSG00000143374 E017 295.511821 0.0001807989 2.149634e-01 4.475177e-01 1 150491394 150491457 64 + 2.465 2.435 -0.103
ENSG00000143374 E018 299.364795 0.0002521223 3.357769e-02 1.376959e-01 1 150491458 150491511 54 + 2.482 2.432 -0.168
ENSG00000143374 E019 9.382730 0.1319020755 5.788779e-01 7.564213e-01 1 150491589 150491597 9 + 1.060 0.956 -0.381
ENSG00000143374 E020 342.575462 0.0001488799 3.515352e-05 6.174243e-04 1 150491598 150491662 65 + 2.565 2.478 -0.288
ENSG00000143374 E021 11.025973 0.2831393588 1.484006e-01 3.600174e-01 1 150491663 150491718 56 + 1.229 0.936 -1.061
ENSG00000143374 E022 4.263998 0.3495612619 4.774669e-02 1.744278e-01 1 150491990 150492184 195 + 0.957 0.468 -2.055
ENSG00000143374 E023 11.197602 0.2464061954 3.607147e-02 1.444041e-01 1 150492185 150492344 160 + 1.321 0.832 -1.786
ENSG00000143374 E024 12.786128 0.1957580991 3.421233e-02 1.394298e-01 1 150492345 150492410 66 + 1.359 0.909 -1.619
ENSG00000143374 E025 406.411170 0.0009746411 5.054641e-04 5.729886e-03 1 150492411 150492489 79 + 2.636 2.553 -0.277
ENSG00000143374 E026 379.589668 0.0012223430 4.328479e-04 5.057973e-03 1 150496482 150496628 147 + 2.612 2.522 -0.300
ENSG00000143374 E027 328.556757 0.0001682525 5.980276e-02 2.023407e-01 1 150496810 150496908 99 + 2.519 2.477 -0.141
ENSG00000143374 E028 691.885125 0.0013990362 4.443033e-01 6.616181e-01 1 150497530 150497747 218 + 2.828 2.809 -0.062
ENSG00000143374 E029 667.093827 0.0009011236 5.159334e-01 7.121914e-01 1 150498502 150498664 163 + 2.792 2.803 0.037
ENSG00000143374 E030 581.542657 0.0019309701 1.130961e-01 3.043341e-01 1 150498897 150499034 138 + 2.713 2.753 0.134
ENSG00000143374 E031 438.733595 0.0007909929 3.959494e-01 6.251516e-01 1 150499216 150499293 78 + 2.607 2.624 0.055
ENSG00000143374 E032 1.581324 0.0118177947 7.084799e-01 8.408192e-01 1 150504333 150504334 2 + 0.447 0.378 -0.371
ENSG00000143374 E033 484.887187 0.0001378675 1.405527e-03 1.293998e-02 1 150504335 150504435 101 + 2.625 2.678 0.175
ENSG00000143374 E034 5.017270 0.0084031006 3.296352e-01 5.685923e-01 1 150504436 150504436 1 + 0.835 0.695 -0.563
ENSG00000143374 E035 175.672166 0.0002907380 8.884122e-04 9.000944e-03 1 150504632 150504635 4 + 2.155 2.250 0.317
ENSG00000143374 E036 360.212150 0.0001780632 1.257598e-07 4.562465e-06 1 150504636 150504733 98 + 2.459 2.565 0.354
ENSG00000143374 E037 325.425583 0.0001819726 4.109084e-09 2.099961e-07 1 150504906 150504978 73 + 2.399 2.525 0.419
ENSG00000143374 E038 424.466560 0.0001794429 1.943072e-04 2.613264e-03 1 150505591 150505705 115 + 2.555 2.623 0.226
ENSG00000143374 E039 1053.488114 0.0001813985 2.586068e-03 2.087824e-02 1 150506916 150507602 687 + 2.973 3.008 0.117