ENSG00000143363

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000271620 ENSG00000143363 HEK293_OSMI2_6hA HEK293_TMG_6hB PRUNE1 protein_coding protein_coding 26.28255 29.02017 23.04114 2.862271 0.6029869 -0.3327147 9.309098 10.088389 11.272592 0.6426352 0.6307822 0.1599733 0.36150000 0.35016667 0.48870000 0.13853333 0.02975092 0.02975092 FALSE TRUE
ENST00000368934 ENSG00000143363 HEK293_OSMI2_6hA HEK293_TMG_6hB PRUNE1 protein_coding protein_coding 26.28255 29.02017 23.04114 2.862271 0.6029869 -0.3327147 2.165390 1.407788 0.000000 1.4077882 0.0000000 -7.1474982 0.07299167 0.04080000 0.00000000 -0.04080000 0.93170522 0.02975092 FALSE TRUE
ENST00000450884 ENSG00000143363 HEK293_OSMI2_6hA HEK293_TMG_6hB PRUNE1 protein_coding protein_coding 26.28255 29.02017 23.04114 2.862271 0.6029869 -0.3327147 1.519865 1.585908 1.225123 0.3176123 0.3047764 -0.3697233 0.05871250 0.05423333 0.05393333 -0.00030000 0.99971784 0.02975092 FALSE TRUE
MSTRG.2192.3 ENSG00000143363 HEK293_OSMI2_6hA HEK293_TMG_6hB PRUNE1 protein_coding   26.28255 29.02017 23.04114 2.862271 0.6029869 -0.3327147 2.979789 3.841209 2.567768 0.4035413 0.4856278 -0.5791892 0.11450417 0.13323333 0.11140000 -0.02183333 0.84479591 0.02975092 FALSE TRUE
MSTRG.2192.5 ENSG00000143363 HEK293_OSMI2_6hA HEK293_TMG_6hB PRUNE1 protein_coding   26.28255 29.02017 23.04114 2.862271 0.6029869 -0.3327147 2.988426 4.842970 3.622457 0.2039296 0.7642290 -0.4179225 0.11872917 0.16880000 0.15570000 -0.01310000 0.94641396 0.02975092 FALSE TRUE
MSTRG.2192.6 ENSG00000143363 HEK293_OSMI2_6hA HEK293_TMG_6hB PRUNE1 protein_coding   26.28255 29.02017 23.04114 2.862271 0.6029869 -0.3327147 1.989962 2.281033 1.382749 0.3085551 0.7272993 -0.7180629 0.07627083 0.08126667 0.05893333 -0.02233333 0.78357518 0.02975092 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000143363 E001 0.1308682 0.0330227586 0.677361784   1 151008412 151008419 8 + 0.000 0.104 9.562
ENSG00000143363 E002 3.5927248 0.0097969100 0.038216042 0.15015238 1 151008420 151008432 13 + 0.404 0.750 1.589
ENSG00000143363 E003 10.3441382 0.0031872758 0.007339524 0.04626996 1 151008433 151008448 16 + 0.830 1.139 1.148
ENSG00000143363 E004 10.7496067 0.0030490774 0.004273001 0.03068044 1 151008449 151008449 1 + 0.830 1.156 1.208
ENSG00000143363 E005 16.0184390 0.0025405582 0.006556375 0.04248374 1 151008450 151008460 11 + 1.041 1.301 0.929
ENSG00000143363 E006 20.1989104 0.0086882816 0.155495577 0.37016871 1 151008461 151008466 6 + 1.225 1.363 0.485
ENSG00000143363 E007 33.7219803 0.0033105660 0.195646233 0.42415870 1 151008467 151008476 10 + 1.463 1.561 0.337
ENSG00000143363 E008 34.4199202 0.0071798227 0.264185588 0.50342553 1 151008477 151008477 1 + 1.475 1.570 0.326
ENSG00000143363 E009 49.4543946 0.0013809515 0.726534552 0.85213463 1 151008478 151008481 4 + 1.669 1.699 0.099
ENSG00000143363 E010 51.6966468 0.0009076591 0.784309224 0.88710077 1 151008482 151008482 1 + 1.690 1.714 0.082
ENSG00000143363 E011 77.7923681 0.0005592467 0.682793004 0.82445366 1 151008483 151008529 47 + 1.864 1.891 0.091
ENSG00000143363 E012 168.1811339 0.0009973912 0.776615772 0.88268068 1 151008530 151008671 142 + 2.206 2.226 0.066
ENSG00000143363 E013 138.7565793 0.0013292814 0.748383352 0.86572323 1 151017812 151017904 93 + 2.136 2.136 -0.001
ENSG00000143363 E014 74.8671690 0.0005698456 0.131727306 0.33451455 1 151018467 151018556 90 + 1.897 1.845 -0.177
ENSG00000143363 E015 39.6722123 0.0011230046 0.113161611 0.30442695 1 151018557 151018559 3 + 1.640 1.560 -0.272
ENSG00000143363 E016 101.7382211 0.0004608882 0.007283185 0.04598648 1 151018560 151018669 110 + 2.048 1.962 -0.287
ENSG00000143363 E017 167.4820986 0.0003260021 0.028991755 0.12433168 1 151024611 151024741 131 + 2.243 2.192 -0.169
ENSG00000143363 E018 125.2038854 0.0007261818 0.012357651 0.06786358 1 151024742 151024795 54 + 2.129 2.056 -0.243
ENSG00000143363 E019 199.4725953 0.0002396273 0.034658024 0.14068240 1 151025515 151025673 159 + 2.313 2.270 -0.144
ENSG00000143363 E020 154.8504613 0.0004707971 0.123432419 0.32118355 1 151027233 151027327 95 + 2.197 2.162 -0.117
ENSG00000143363 E021 149.4372785 0.0003805823 0.019745954 0.09504059 1 151028786 151028944 159 + 2.200 2.141 -0.197
ENSG00000143363 E022 0.3447487 0.3053834655 0.407355298   1 151028945 151028953 9 + 0.000 0.190 11.532
ENSG00000143363 E023 7.6904416 0.0043757707 0.691106241 0.82978581 1 151031372 151031464 93 + 0.957 0.920 -0.140
ENSG00000143363 E024 1327.8542557 0.0011180906 0.003189858 0.02454816 1 151033806 151035713 1908 + 3.083 3.134 0.169