ENSG00000143179

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000367879 ENSG00000143179 HEK293_OSMI2_6hA HEK293_TMG_6hB UCK2 protein_coding protein_coding 44.4615 51.2356 35.26672 4.69357 1.106268 -0.5387116 32.192541 40.743776 22.322330 4.4875326 0.44487940 -0.8677999 0.71907500 0.79263333 0.6334333 -0.15920000 2.851503e-03 5.927971e-23 FALSE TRUE
ENST00000464197 ENSG00000143179 HEK293_OSMI2_6hA HEK293_TMG_6hB UCK2 protein_coding processed_transcript 44.4615 51.2356 35.26672 4.69357 1.106268 -0.5387116 6.419357 2.998136 8.704997 0.3172480 0.03158248 1.5346304 0.14736667 0.05840000 0.2473667 0.18896667 5.927971e-23 5.927971e-23 FALSE FALSE
MSTRG.2520.1 ENSG00000143179 HEK293_OSMI2_6hA HEK293_TMG_6hB UCK2 protein_coding   44.4615 51.2356 35.26672 4.69357 1.106268 -0.5387116 3.406852 4.292128 2.003316 0.5358201 0.31763058 -1.0954770 0.07624167 0.08386667 0.0564000 -0.02746667 4.922629e-01 5.927971e-23 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000143179 E001 41.5393618 0.373983249 0.392559261 0.62245521 1 165827529 165827613 85 + 1.488 1.656 0.575
ENSG00000143179 E002 152.7482715 0.168971530 0.026753171 0.11754078 1 165827614 165827804 191 + 1.841 2.267 1.427
ENSG00000143179 E003 296.0259650 0.245166276 0.276037653 0.51609203 1 165827805 165827932 128 + 2.312 2.506 0.648
ENSG00000143179 E004 4.6636055 0.021061189 0.049324822 0.17796191 1 165885142 165885379 238 + 0.885 0.652 -0.936
ENSG00000143179 E005 565.9944820 1.575985321 0.589855084 0.76362040 1 165890204 165890363 160 + 2.632 2.773 0.467
ENSG00000143179 E006 530.7473985 1.560841155 0.600764671 0.77072955 1 165891226 165891322 97 + 2.613 2.742 0.429
ENSG00000143179 E007 2.0857238 0.152045862 0.025384690 0.11339276 1 165892652 165892774 123 + 0.703 0.285 -2.127
ENSG00000143179 E008 6.9030045 0.005143372 0.217352090 0.45024938 1 165894166 165894579 414 + 0.932 0.836 -0.368
ENSG00000143179 E009 1.7549839 0.140371709 0.576043197 0.75445292 1 165895570 165895584 15 + 0.446 0.388 -0.310
ENSG00000143179 E010 2.2196421 0.062769989 0.597922584 0.76888891 1 165895585 165895641 57 + 0.509 0.461 -0.237
ENSG00000143179 E011 8.8427891 0.107051001 0.693655739 0.83144784 1 165895642 165896189 548 + 0.954 0.979 0.093
ENSG00000143179 E012 665.3364656 0.014101830 0.988567092 0.99606118 1 165896190 165896332 143 + 2.759 2.820 0.203
ENSG00000143179 E013 4.9903986 0.223727754 0.970592382 0.98715404 1 165897979 165898004 26 + 0.662 0.796 0.549
ENSG00000143179 E014 39.7886637 0.031858632 0.732454432 0.85565941 1 165902595 165903181 587 + 1.503 1.623 0.409
ENSG00000143179 E015 602.8453756 0.003301749 0.003485695 0.02625294 1 165903182 165903279 98 + 2.762 2.753 -0.028
ENSG00000143179 E016 0.8315845 0.360455572 0.717816188   1 165903993 165904167 175 + 0.281 0.230 -0.382
ENSG00000143179 E017 480.6281441 0.009405561 0.002504370 0.02035900 1 165905921 165905969 49 + 2.698 2.637 -0.206
ENSG00000143179 E018 790.6334423 0.014447176 0.010844745 0.06170718 1 165907684 165907920 237 + 2.910 2.855 -0.180
ENSG00000143179 E019 2783.6447471 0.033191750 0.643340452 0.79906095 1 165907921 165911618 3698 + 3.341 3.457 0.385