ENSG00000143033

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000370298 ENSG00000143033 HEK293_OSMI2_6hA HEK293_TMG_6hB MTF2 protein_coding protein_coding 22.9423 5.760198 41.63975 0.7415524 1.376011 2.851615 13.739092 4.160592 25.060169 0.7370641 0.5176100 2.587648 0.62689583 0.7119 0.6023667 -0.1095333 4.251751e-01 1.24843e-12 FALSE TRUE
ENST00000473430 ENSG00000143033 HEK293_OSMI2_6hA HEK293_TMG_6hB MTF2 protein_coding processed_transcript 22.9423 5.760198 41.63975 0.7415524 1.376011 2.851615 3.133056 0.000000 6.819848 0.0000000 0.8577813 9.415710 0.08290833 0.0000 0.1635000 0.1635000 1.248430e-12 1.24843e-12 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000143033 E001 0.7860845 0.0170697610 0.426476866   1 93079235 93079246 12 + 0.232 0.000 -9.630
ENSG00000143033 E002 1.4129662 0.0344244596 0.161625598 0.379159619 1 93079247 93079249 3 + 0.357 0.000 -12.371
ENSG00000143033 E003 2.3961754 0.0907543798 0.828751076 0.913090264 1 93079250 93079257 8 + 0.452 0.395 -0.303
ENSG00000143033 E004 4.0803614 0.0114335773 0.550113573 0.736347952 1 93079258 93079269 12 + 0.614 0.506 -0.496
ENSG00000143033 E005 4.7062476 0.0130737710 0.558784317 0.742395120 1 93079270 93079282 13 + 0.629 0.734 0.439
ENSG00000143033 E006 5.2180215 0.0162078228 0.437743531 0.657035077 1 93079283 93079286 4 + 0.657 0.789 0.541
ENSG00000143033 E007 6.5004954 0.0044486550 0.856948213 0.928791262 1 93079287 93079288 2 + 0.754 0.789 0.139
ENSG00000143033 E008 31.5345763 0.0012296879 0.915031152 0.959672517 1 93079289 93079295 7 + 1.384 1.402 0.062
ENSG00000143033 E009 57.5023033 0.0011725921 0.660679629 0.810361465 1 93079296 93079309 14 + 1.643 1.625 -0.062
ENSG00000143033 E010 58.5828844 0.0020562838 0.649354866 0.803030753 1 93079310 93079310 1 + 1.651 1.632 -0.066
ENSG00000143033 E011 161.1866378 0.0002897987 0.291830600 0.532502474 1 93079311 93079531 221 + 2.088 2.057 -0.101
ENSG00000143033 E012 0.0000000       1 93080965 93081019 55 +      
ENSG00000143033 E013 61.4142391 0.0120869965 0.546944081 0.734113295 1 93110230 93110231 2 + 1.677 1.638 -0.130
ENSG00000143033 E014 70.0948114 0.0022010310 0.355973889 0.592497831 1 93110232 93110245 14 + 1.735 1.688 -0.159
ENSG00000143033 E015 60.5825108 0.0028076715 0.298483432 0.538921631 1 93110246 93110246 1 + 1.675 1.617 -0.200
ENSG00000143033 E016 105.7853819 0.0005146244 0.497762924 0.699324870 1 93110247 93110326 80 + 1.907 1.885 -0.075
ENSG00000143033 E017 138.2277098 0.0003260777 0.235853971 0.471813736 1 93110327 93110423 97 + 2.023 1.984 -0.130
ENSG00000143033 E018 65.8068816 0.0005721566 0.776512445 0.882629419 1 93110424 93110428 5 + 1.701 1.694 -0.024
ENSG00000143033 E019 110.5343627 0.0004541912 0.568052568 0.748827032 1 93110545 93110626 82 + 1.926 1.909 -0.056
ENSG00000143033 E020 2.5625650 0.0887944075 0.069861084 0.224527232 1 93110627 93110630 4 + 0.381 0.736 1.666
ENSG00000143033 E021 155.6262582 0.0015990796 0.062273509 0.207892160 1 93114688 93114783 96 + 2.080 2.007 -0.246
ENSG00000143033 E022 154.7282487 0.0005545643 0.498948659 0.700064098 1 93114988 93115088 101 + 2.069 2.052 -0.059
ENSG00000143033 E023 183.2151142 0.0088950360 0.654053816 0.806147767 1 93115470 93115618 149 + 2.142 2.121 -0.069
ENSG00000143033 E024 107.5763789 0.0005048486 0.168597684 0.388706939 1 93118345 93118440 96 + 1.919 1.863 -0.187
ENSG00000143033 E025 98.4101374 0.0006211099 0.299661856 0.540084148 1 93119333 93119401 69 + 1.878 1.836 -0.142
ENSG00000143033 E026 2.6973386 0.3016456450 0.838721918 0.918729262 1 93119402 93120274 873 + 0.484 0.396 -0.457
ENSG00000143033 E027 161.3782546 0.0002584282 0.010532823 0.060383679 1 93120549 93120672 124 + 2.097 2.007 -0.300
ENSG00000143033 E028 2.3174831 0.2293205044 0.704653685 0.838505002 1 93120673 93120676 4 + 0.427 0.502 0.381
ENSG00000143033 E029 1.4049562 0.0136968632 0.655913445 0.807285033 1 93120793 93120798 6 + 0.299 0.393 0.570
ENSG00000143033 E030 3.1411297 0.0077579222 0.860729980 0.930745679 1 93120799 93120894 96 + 0.532 0.506 -0.127
ENSG00000143033 E031 88.8231840 0.0004843109 0.044469679 0.166281439 1 93127232 93127238 7 + 1.840 1.743 -0.325
ENSG00000143033 E032 121.3334628 0.0003377099 0.045119834 0.167927976 1 93127239 93127299 61 + 1.973 1.893 -0.268
ENSG00000143033 E033 11.6523193 0.0419096996 0.130072608 0.331960574 1 93128795 93129277 483 + 0.939 1.154 0.786
ENSG00000143033 E034 146.8474743 0.0004974082 0.658548184 0.809050207 1 93129278 93129448 171 + 2.037 2.063 0.089
ENSG00000143033 E035 152.0734294 0.0003155282 0.059030706 0.200579674 1 93133703 93133808 106 + 2.044 2.122 0.261
ENSG00000143033 E036 128.0299655 0.0003245345 0.131913219 0.334821449 1 93133928 93133980 53 + 1.971 2.040 0.231
ENSG00000143033 E037 183.3488552 0.0003166255 0.262320807 0.501521023 1 93134091 93134195 105 + 2.129 2.176 0.157
ENSG00000143033 E038 7.5161872 0.1143237336 0.734261609 0.856818496 1 93134196 93134459 264 + 0.825 0.742 -0.332
ENSG00000143033 E039 878.7043929 0.0012880100 0.000136947 0.001944057 1 93136670 93139079 2410 + 2.802 2.880 0.259