ENSG00000142949

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000372407 ENSG00000142949 HEK293_OSMI2_6hA HEK293_TMG_6hB PTPRF protein_coding protein_coding 42.48709 53.40672 34.99378 3.544966 0.6853086 -0.6097807 9.368201 14.48459 2.632756 3.046342 0.8612284 -2.4553996 0.1986917 0.2669667 0.07533333 -0.1916333 0.0300714999 6.127486e-12 FALSE TRUE
ENST00000438120 ENSG00000142949 HEK293_OSMI2_6hA HEK293_TMG_6hB PTPRF protein_coding protein_coding 42.48709 53.40672 34.99378 3.544966 0.6853086 -0.6097807 24.518854 28.09948 25.740600 2.165171 0.9321126 -0.1264509 0.5969708 0.5261333 0.73560000 0.2094667 0.0006542144 6.127486e-12 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000142949 E001 0.0000000       1 43525187 43525257 71 +      
ENSG00000142949 E002 0.0000000       1 43528562 43528656 95 +      
ENSG00000142949 E003 0.0000000       1 43528657 43528756 100 +      
ENSG00000142949 E004 1.3623117 0.0136395576 1.184333e-01   1 43530611 43530871 261 + 0.149 0.445 2.128
ENSG00000142949 E005 1.5650459 0.0125952768 7.752113e-02 2.398932e-01 1 43530872 43530875 4 + 0.149 0.483 2.322
ENSG00000142949 E006 2.0406628 0.0110301602 2.201880e-02 1.026434e-01 1 43530876 43530877 2 + 0.149 0.581 2.781
ENSG00000142949 E007 2.0406628 0.0110301602 2.201880e-02 1.026434e-01 1 43530878 43530878 1 + 0.149 0.581 2.781
ENSG00000142949 E008 2.2130371 0.0176232041 1.540994e-02 7.963249e-02 1 43530879 43530879 1 + 0.149 0.609 2.908
ENSG00000142949 E009 3.1116183 0.0076050953 1.101538e-03 1.067975e-02 1 43530880 43530882 3 + 0.149 0.747 3.490
ENSG00000142949 E010 5.6877805 0.0050224916 1.026054e-02 5.922785e-02 1 43530883 43530889 7 + 0.538 0.924 1.591
ENSG00000142949 E011 9.7432581 0.0158802028 1.720514e-03 1.516408e-02 1 43530890 43530902 13 + 0.707 1.137 1.634
ENSG00000142949 E012 17.0801332 0.0022816158 1.153829e-02 6.455809e-02 1 43530903 43530928 26 + 1.080 1.325 0.867
ENSG00000142949 E013 97.6472163 0.0004078941 3.067548e-01 5.473728e-01 1 43530929 43531090 162 + 1.946 2.003 0.189
ENSG00000142949 E014 70.4124183 0.0005689852 5.864961e-01 7.612508e-01 1 43538198 43538201 4 + 1.845 1.839 -0.021
ENSG00000142949 E015 137.0915805 0.0002824362 4.204606e-02 1.600446e-01 1 43538202 43538277 76 + 2.157 2.111 -0.153
ENSG00000142949 E016 125.1842879 0.0003936134 3.546092e-02 1.427845e-01 1 43545031 43545075 45 + 2.123 2.072 -0.171
ENSG00000142949 E017 189.4928893 0.0012760536 4.824066e-03 3.366637e-02 1 43545076 43545166 91 + 2.313 2.244 -0.229
ENSG00000142949 E018 250.3530969 0.0002598543 1.959958e-12 1.914008e-10 1 43553492 43553637 146 + 2.474 2.328 -0.488
ENSG00000142949 E019 261.9752320 0.0012856522 1.367749e-10 9.430584e-09 1 43553800 43553941 142 + 2.500 2.340 -0.535
ENSG00000142949 E020 274.7074451 0.0002461480 6.253954e-08 2.437048e-06 1 43569590 43569778 189 + 2.491 2.388 -0.344
ENSG00000142949 E021 0.0000000       1 43575910 43575927 18 +      
ENSG00000142949 E022 231.7391111 0.0031323146 5.958633e-03 3.952861e-02 1 43578810 43578920 111 + 2.404 2.325 -0.264
ENSG00000142949 E023 1.0121411 0.0212904200 2.721280e-01   1 43578921 43579175 255 + 0.149 0.357 1.644
ENSG00000142949 E024 2.4813106 0.0093753033 2.904035e-02 1.244786e-01 1 43579176 43580078 903 + 0.259 0.659 2.123
ENSG00000142949 E025 0.6894974 0.9583419518 4.935182e-01   1 43582480 43582621 142 + 0.000 0.314 13.432
ENSG00000142949 E026 1.4586385 0.0126997040 7.958329e-01 8.939474e-01 1 43583082 43583093 12 + 0.347 0.403 0.322
ENSG00000142949 E027 400.0495880 0.0001735551 3.063876e-10 1.956813e-08 1 43588731 43589000 270 + 2.652 2.553 -0.329
ENSG00000142949 E028 197.8372763 0.0017544276 7.224131e-05 1.139747e-03 1 43590972 43591020 49 + 2.353 2.241 -0.374
ENSG00000142949 E029 162.3225395 0.0039398926 6.596510e-03 4.268501e-02 1 43591021 43591052 32 + 2.259 2.161 -0.326
ENSG00000142949 E030 344.5901316 0.0015471298 9.025498e-02 2.642426e-01 1 43591053 43591449 397 + 2.545 2.515 -0.100
ENSG00000142949 E031 178.5092194 0.0003456497 1.057170e-01 2.918837e-01 1 43591450 43591553 104 + 2.258 2.230 -0.094
ENSG00000142949 E032 246.9204552 0.0016709387 6.265208e-02 2.086965e-01 1 43591812 43591948 137 + 2.405 2.365 -0.133
ENSG00000142949 E033 115.0310711 0.0016063491 2.704981e-01 5.104826e-01 1 43592457 43592462 6 + 2.067 2.041 -0.086
ENSG00000142949 E034 223.7754831 0.0008671013 3.847237e-01 6.162568e-01 1 43592463 43592601 139 + 2.343 2.336 -0.022
ENSG00000142949 E035 323.8660998 0.0002015566 3.041675e-02 1.286029e-01 1 43597748 43598053 306 + 2.516 2.489 -0.092
ENSG00000142949 E036 20.6922754 0.1195631681 7.974374e-01 8.948572e-01 1 43598074 43598719 646 + 1.236 1.370 0.469
ENSG00000142949 E037 168.5060361 0.0035288000 5.280317e-01 7.206347e-01 1 43598720 43598838 119 + 2.222 2.216 -0.022
ENSG00000142949 E038 173.9492039 0.0012353555 1.558337e-01 3.706671e-01 1 43598839 43598913 75 + 2.249 2.223 -0.089
ENSG00000142949 E039 3.4833847 0.0956249047 5.041200e-01 7.036778e-01 1 43602071 43602097 27 + 0.711 0.580 -0.563
ENSG00000142949 E040 217.4614336 0.0002379033 4.135909e-02 1.582704e-01 1 43603416 43603527 112 + 2.350 2.317 -0.111
ENSG00000142949 E041 110.4080994 0.0003717506 1.588307e-01 3.750068e-01 1 43603528 43603533 6 + 2.056 2.024 -0.106
ENSG00000142949 E042 631.3514790 0.0018011447 2.100699e-01 4.419343e-01 1 43603611 43604189 579 + 2.798 2.784 -0.049
ENSG00000142949 E043 232.2121939 0.0025210267 1.836596e-01 4.086852e-01 1 43604903 43605000 98 + 2.374 2.344 -0.102
ENSG00000142949 E044 333.6791557 0.0001541291 9.900200e-02 2.800380e-01 1 43605190 43605443 254 + 2.522 2.507 -0.053
ENSG00000142949 E045 171.5061503 0.0019733373 1.230408e-01 3.205614e-01 1 43605529 43605581 53 + 2.245 2.208 -0.123
ENSG00000142949 E046 177.8661474 0.0026516365 3.239890e-01 5.632989e-01 1 43605582 43605622 41 + 2.250 2.229 -0.070
ENSG00000142949 E047 352.4097938 0.0001600349 1.101473e-01 2.992356e-01 1 43606240 43606458 219 + 2.544 2.530 -0.047
ENSG00000142949 E048 157.6936045 0.0002915464 1.136074e-01 3.051624e-01 1 43606814 43606816 3 + 2.206 2.177 -0.097
ENSG00000142949 E049 171.3559285 0.0002979957 1.630035e-01 3.812178e-01 1 43606817 43606830 14 + 2.238 2.216 -0.074
ENSG00000142949 E050 363.2231881 0.0001796855 1.095235e-01 2.983002e-01 1 43606831 43606968 138 + 2.558 2.544 -0.046
ENSG00000142949 E051 365.2227662 0.0002533587 6.864305e-02 2.220117e-01 1 43609383 43609498 116 + 2.564 2.545 -0.063
ENSG00000142949 E052 1.3793980 0.0128892793 8.148927e-02   1 43612768 43612800 33 + 0.538 0.246 -1.682
ENSG00000142949 E053 3.6531678 0.2949855460 5.588317e-01 7.424175e-01 1 43613140 43613617 478 + 0.700 0.636 -0.271
ENSG00000142949 E054 366.7661436 0.0001984789 4.846318e-04 5.535488e-03 1 43613618 43613715 98 + 2.584 2.533 -0.169
ENSG00000142949 E055 443.1586926 0.0006299465 1.150583e-02 6.441041e-02 1 43617445 43617568 124 + 2.656 2.620 -0.121
ENSG00000142949 E056 513.6369578 0.0001573146 3.628804e-01 5.980504e-01 1 43617736 43617911 176 + 2.698 2.700 0.008
ENSG00000142949 E057 382.1649326 0.0004730932 9.627049e-01 9.833182e-01 1 43618630 43618749 120 + 2.559 2.578 0.060
ENSG00000142949 E058 399.7594843 0.0007526004 2.500595e-01 4.879966e-01 1 43619048 43619202 155 + 2.564 2.606 0.141
ENSG00000142949 E059 605.0065308 0.0001290947 1.592908e-05 3.143300e-04 1 43619288 43619573 286 + 2.716 2.801 0.282
ENSG00000142949 E060 510.6482629 0.0001275793 8.871643e-07 2.559648e-05 1 43619680 43619858 179 + 2.633 2.734 0.335
ENSG00000142949 E061 439.4456101 0.0002744230 5.767237e-03 3.858276e-02 1 43620095 43620221 127 + 2.589 2.659 0.234
ENSG00000142949 E062 7.6886180 0.0251670318 2.098705e-01 4.416829e-01 1 43620222 43620453 232 + 0.799 0.988 0.722
ENSG00000142949 E063 466.7882963 0.0014886221 7.818084e-02 2.411746e-01 1 43620454 43620579 126 + 2.620 2.682 0.207
ENSG00000142949 E064 502.8416754 0.0007020849 9.274886e-03 5.499228e-02 1 43620838 43620992 155 + 2.646 2.717 0.237
ENSG00000142949 E065 363.2921090 0.0005228444 5.051886e-06 1.161243e-04 1 43621097 43621232 136 + 2.472 2.590 0.393
ENSG00000142949 E066 2342.0452654 0.0016923723 6.448916e-14 8.321993e-12 1 43621935 43623666 1732 + 3.253 3.410 0.522