ENSG00000142945

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000372224 ENSG00000142945 HEK293_OSMI2_6hA HEK293_TMG_6hB KIF2C protein_coding protein_coding 47.10988 36.87001 53.54086 1.648262 1.363687 0.5380707 35.216428 28.438108 40.707710 1.4770342 0.9924976 0.51732371 0.7468458 0.7716333 0.76073333 -0.01090000 9.669769e-01 6.826072e-27 FALSE  
ENST00000452259 ENSG00000142945 HEK293_OSMI2_6hA HEK293_TMG_6hB KIF2C protein_coding protein_coding 47.10988 36.87001 53.54086 1.648262 1.363687 0.5380707 2.228799 0.000000 5.228463 0.0000000 0.4789629 9.03299967 0.0454125 0.0000000 0.09733333 0.09733333 6.826072e-27 6.826072e-27 FALSE  
ENST00000472235 ENSG00000142945 HEK293_OSMI2_6hA HEK293_TMG_6hB KIF2C protein_coding processed_transcript 47.10988 36.87001 53.54086 1.648262 1.363687 0.5380707 3.481107 3.043486 2.873391 0.5451675 0.3749459 -0.08269071 0.0742125 0.0832000 0.05346667 -0.02973333 5.942560e-01 6.826072e-27    
MSTRG.1060.1 ENSG00000142945 HEK293_OSMI2_6hA HEK293_TMG_6hB KIF2C protein_coding   47.10988 36.87001 53.54086 1.648262 1.363687 0.5380707 4.357805 3.881749 2.471112 0.6657032 0.6320476 -0.64943179 0.0950875 0.1042333 0.04583333 -0.05840000 1.630842e-01 6.826072e-27 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000142945 E001 1.7798925 0.0108693337 6.943672e-03 4.436901e-02 1 44739750 44739817 68 + 0.598 0.131 -3.076
ENSG00000142945 E002 2.4171854 0.0108607777 6.982968e-04 7.430254e-03 1 44739818 44739824 7 + 0.712 0.131 -3.565
ENSG00000142945 E003 6.8115037 0.0084356905 9.833723e-04 9.786147e-03 1 44739825 44739836 12 + 1.033 0.619 -1.631
ENSG00000142945 E004 168.9223964 0.0005177147 6.069786e-08 2.372903e-06 1 44739837 44739952 116 + 2.286 2.152 -0.447
ENSG00000142945 E005 177.5670276 0.0002571321 6.173507e-08 2.408633e-06 1 44739953 44740002 50 + 2.303 2.178 -0.416
ENSG00000142945 E006 0.8461841 0.0172671820 2.143265e-01   1 44740003 44740042 40 + 0.340 0.131 -1.753
ENSG00000142945 E007 229.6156802 0.0003062248 2.759747e-11 2.199289e-09 1 44740913 44741007 95 + 2.417 2.278 -0.467
ENSG00000142945 E008 0.6592102 0.1261405888 9.242009e-01   1 44746406 44746759 354 + 0.204 0.230 0.226
ENSG00000142945 E009 245.0810369 0.0004550682 5.989007e-11 4.435548e-09 1 44747384 44747485 102 + 2.445 2.309 -0.455
ENSG00000142945 E010 169.2623122 0.0003735414 6.471583e-05 1.038578e-03 1 44747652 44747700 49 + 2.266 2.176 -0.299
ENSG00000142945 E011 0.6294705 0.0432897330 3.748784e-01   1 44750309 44750441 133 + 0.277 0.130 -1.346
ENSG00000142945 E012 222.7729057 0.0012120830 1.284504e-01 3.294066e-01 1 44750442 44750564 123 + 2.355 2.337 -0.059
ENSG00000142945 E013 210.9701403 0.0044136477 2.975859e-02 1.266146e-01 1 44753132 44753254 123 + 2.350 2.291 -0.198
ENSG00000142945 E014 279.8166275 0.0024104860 8.188129e-03 5.019739e-02 1 44753733 44753833 101 + 2.468 2.414 -0.181
ENSG00000142945 E015 293.6286628 0.0016250760 3.228560e-04 3.962160e-03 1 44754750 44754845 96 + 2.497 2.423 -0.248
ENSG00000142945 E016 260.0340303 0.0042075697 2.138512e-02 1.006091e-01 1 44755929 44755983 55 + 2.437 2.380 -0.189
ENSG00000142945 E017 20.9491838 0.0585177572 5.161571e-01 7.123509e-01 1 44756043 44756074 32 + 1.357 1.318 -0.138
ENSG00000142945 E018 422.0970225 0.0016801141 7.823332e-02 2.412577e-01 1 44756075 44756237 163 + 2.630 2.613 -0.056
ENSG00000142945 E019 304.9699713 0.0014058207 8.023597e-01 8.977126e-01 1 44757556 44757646 91 + 2.471 2.491 0.066
ENSG00000142945 E020 249.7394053 0.0097238701 6.335228e-01 7.926702e-01 1 44757908 44757971 64 + 2.373 2.423 0.169
ENSG00000142945 E021 265.7503061 0.0704094046 3.657452e-01 6.005518e-01 1 44758049 44758140 92 + 2.372 2.479 0.356
ENSG00000142945 E022 259.4727148 0.7763380416 3.933908e-01 6.230584e-01 1 44759206 44759348 143 + 2.310 2.511 0.668
ENSG00000142945 E023 316.1585369 0.0126774652 1.931621e-01 4.209986e-01 1 44760280 44760479 200 + 2.454 2.548 0.315
ENSG00000142945 E024 116.5414054 0.0004650954 1.349475e-01 3.396094e-01 1 44760480 44760484 5 + 2.030 2.103 0.247
ENSG00000142945 E025 241.7004366 0.0016295149 2.246744e-02 1.041232e-01 1 44760592 44760702 111 + 2.334 2.428 0.315
ENSG00000142945 E026 245.3803564 0.0019052234 2.087116e-03 1.764965e-02 1 44761916 44761983 68 + 2.328 2.448 0.400
ENSG00000142945 E027 9.9129143 0.0737901988 2.585651e-01 4.973922e-01 1 44762140 44762228 89 + 0.936 1.136 0.735
ENSG00000142945 E028 9.9343338 0.0277130132 3.140670e-02 1.315050e-01 1 44762229 44762295 67 + 0.877 1.176 1.101
ENSG00000142945 E029 10.8738918 0.0096539279 1.570908e-01 3.723699e-01 1 44762296 44762345 50 + 0.982 1.158 0.638
ENSG00000142945 E030 299.6124992 0.0009095892 3.231510e-03 2.479038e-02 1 44762346 44762451 106 + 2.427 2.524 0.323
ENSG00000142945 E031 369.2002057 0.0023467337 8.612754e-02 2.566599e-01 1 44762545 44762658 114 + 2.527 2.605 0.258
ENSG00000142945 E032 195.7876502 0.0054136116 2.119022e-01 4.439685e-01 1 44766826 44766829 4 + 2.252 2.333 0.273
ENSG00000142945 E033 378.3560964 0.0039579488 4.703089e-02 1.726119e-01 1 44766830 44766949 120 + 2.529 2.626 0.322
ENSG00000142945 E034 648.3130187 0.0018232279 2.804758e-05 5.087177e-04 1 44767097 44767767 671 + 2.747 2.873 0.419