ENSG00000142864

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000370990 ENSG00000142864 HEK293_OSMI2_6hA HEK293_TMG_6hB SERBP1 protein_coding protein_coding 609.3935 373.482 831.1141 66.90876 39.85553 1.153987 30.51674 41.68311 27.29791 7.311835 2.110860 -0.6104903 0.06277500 0.11196667 0.03283333 -0.07913333 9.245164e-19 2.635229e-42 FALSE TRUE
ENST00000370995 ENSG00000142864 HEK293_OSMI2_6hA HEK293_TMG_6hB SERBP1 protein_coding protein_coding 609.3935 373.482 831.1141 66.90876 39.85553 1.153987 109.65281 43.22597 156.77239 10.418374 4.147319 1.8584596 0.16719583 0.11240000 0.18910000 0.07670000 8.049047e-03 2.635229e-42 FALSE TRUE
ENST00000484880 ENSG00000142864 HEK293_OSMI2_6hA HEK293_TMG_6hB SERBP1 protein_coding processed_transcript 609.3935 373.482 831.1141 66.90876 39.85553 1.153987 178.18186 101.04251 258.80478 17.322496 15.065134 1.3568149 0.28462917 0.27193333 0.31120000 0.03926667 4.025120e-01 2.635229e-42 FALSE TRUE
ENST00000490406 ENSG00000142864 HEK293_OSMI2_6hA HEK293_TMG_6hB SERBP1 protein_coding processed_transcript 609.3935 373.482 831.1141 66.90876 39.85553 1.153987 25.41191 0.00000 49.17459 0.000000 7.704653 12.2639906 0.03008333 0.00000000 0.05863333 0.05863333 2.635229e-42 2.635229e-42   FALSE
ENST00000493607 ENSG00000142864 HEK293_OSMI2_6hA HEK293_TMG_6hB SERBP1 protein_coding processed_transcript 609.3935 373.482 831.1141 66.90876 39.85553 1.153987 131.38256 97.41722 160.63942 20.612506 8.091738 0.7215190 0.23208333 0.25686667 0.19323333 -0.06363333 5.034995e-02 2.635229e-42 FALSE FALSE
MSTRG.1374.12 ENSG00000142864 HEK293_OSMI2_6hA HEK293_TMG_6hB SERBP1 protein_coding   609.3935 373.482 831.1141 66.90876 39.85553 1.153987 41.74231 27.70617 53.76695 2.177038 3.436035 0.9562601 0.06954167 0.07843333 0.06463333 -0.01380000 8.259703e-01 2.635229e-42 FALSE FALSE
MSTRG.1374.5 ENSG00000142864 HEK293_OSMI2_6hA HEK293_TMG_6hB SERBP1 protein_coding   609.3935 373.482 831.1141 66.90876 39.85553 1.153987 66.86898 50.08545 83.87541 8.355526 2.452439 0.7437404 0.11350000 0.13516667 0.10130000 -0.03386667 1.983696e-01 2.635229e-42 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000142864 E001 1270.112335 9.923787e-03 1.942304e-13 2.281106e-11 1 67407810 67411037 3228 - 3.190 2.811 -1.261
ENSG00000142864 E002 5181.566289 5.705311e-03 3.171677e-15 4.978037e-13 1 67411038 67412866 1829 - 3.781 3.493 -0.957
ENSG00000142864 E003 3679.682226 5.160320e-04 7.795000e-03 4.836220e-02 1 67412867 67413215 349 - 3.545 3.556 0.036
ENSG00000142864 E004 1990.325997 1.648763e-03 1.809574e-04 2.459245e-03 1 67413216 67413258 43 - 3.261 3.318 0.192
ENSG00000142864 E005 1453.412990 1.877040e-03 3.205633e-03 2.463527e-02 1 67413259 67413263 5 - 3.129 3.173 0.147
ENSG00000142864 E006 3178.158612 9.455039e-04 1.146814e-13 1.410250e-11 1 67415166 67415272 107 - 3.450 3.543 0.309
ENSG00000142864 E007 2675.040058 8.563384e-04 6.149246e-16 1.064509e-13 1 67415273 67415339 67 - 3.372 3.472 0.335
ENSG00000142864 E008 4.604708 4.783041e-02 2.042320e-01 4.349644e-01 1 67417050 67417166 117 - 0.811 0.559 -1.063
ENSG00000142864 E009 6.393380 3.667446e-02 6.952169e-01 8.324106e-01 1 67419765 67420008 244 - 0.885 0.795 -0.353
ENSG00000142864 E010 5135.105504 6.799012e-05 9.755856e-24 4.325767e-21 1 67420009 67420167 159 - 3.680 3.718 0.126
ENSG00000142864 E011 2996.547399 5.637713e-04 2.708699e-01 5.108039e-01 1 67420168 67420186 19 - 3.473 3.434 -0.129
ENSG00000142864 E012 22.124250 1.271411e-01 4.767149e-01 6.848125e-01 1 67420187 67420565 379 - 1.392 1.255 -0.481
ENSG00000142864 E013 4216.931004 2.615992e-04 8.148871e-01 9.051867e-01 1 67424200 67424277 78 - 3.616 3.594 -0.073
ENSG00000142864 E014 548.491998 4.663911e-04 3.925538e-02 1.528550e-01 1 67424278 67424284 7 - 2.743 2.682 -0.203
ENSG00000142864 E015 716.941253 8.355425e-04 2.678218e-01 5.074467e-01 1 67424285 67424322 38 - 2.853 2.810 -0.144
ENSG00000142864 E016 15.584728 1.017450e-01 1.637433e-02 8.316847e-02 1 67424323 67424414 92 - 1.322 0.848 -1.726
ENSG00000142864 E017 3839.881965 2.518203e-04 3.967891e-01 6.257851e-01 1 67424888 67424959 72 - 3.579 3.547 -0.105
ENSG00000142864 E018 1158.056662 6.999179e-04 4.606675e-03 3.250859e-02 1 67424960 67424977 18 - 3.071 3.000 -0.238
ENSG00000142864 E019 4452.111540 3.166972e-04 1.037097e-01 2.883926e-01 1 67425083 67425223 141 - 3.646 3.606 -0.133
ENSG00000142864 E020 4168.457959 3.051807e-04 7.722666e-03 4.802326e-02 1 67426135 67426285 151 - 3.603 3.605 0.006
ENSG00000142864 E021 1.248530 1.382884e-02 5.698299e-01   1 67429436 67429657 222 - 0.387 0.271 -0.732
ENSG00000142864 E022 4317.748460 1.017857e-03 3.565820e-06 8.617911e-05 1 67429988 67431530 1543 - 3.601 3.648 0.156