ENSG00000142657

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000270776 ENSG00000142657 HEK293_OSMI2_6hA HEK293_TMG_6hB PGD protein_coding protein_coding 201.2853 258.2207 136.9781 43.3117 3.628928 -0.9146099 177.040628 232.523465 110.403613 41.219213 4.7421530 -1.074520 0.86772500 0.8973667 0.80530000 -0.09206667 0.006621858 0.000801353 FALSE  
ENST00000460189 ENSG00000142657 HEK293_OSMI2_6hA HEK293_TMG_6hB PGD protein_coding protein_coding 201.2853 258.2207 136.9781 43.3117 3.628928 -0.9146099 3.397004 1.120215 8.052516 1.120215 1.4351799 2.834633 0.02320000 0.0062000 0.05946667 0.05326667 0.115181282 0.000801353 FALSE  
MSTRG.283.10 ENSG00000142657 HEK293_OSMI2_6hA HEK293_TMG_6hB PGD protein_coding   201.2853 258.2207 136.9781 43.3117 3.628928 -0.9146099 5.184784 3.648137 9.992174 2.460482 0.9024746 1.451133 0.03245417 0.0180000 0.07336667 0.05536667 0.523743718 0.000801353 TRUE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000142657 E001 0.1308682 3.264919e-02 1.000000e+00   1 10398592 10398751 160 + 0.000 0.082 7.825
ENSG00000142657 E002 0.8216059 6.411757e-02 6.333531e-01   1 10398965 10399001 37 + 0.300 0.212 -0.659
ENSG00000142657 E003 0.6188717 2.831529e-02 3.975723e-01   1 10399002 10399002 1 + 0.300 0.151 -1.254
ENSG00000142657 E004 0.7615063 2.181245e-01 2.693294e-01   1 10399003 10399007 5 + 0.392 0.152 -1.813
ENSG00000142657 E005 0.9338807 1.020490e-01 3.632566e-01   1 10399008 10399008 1 + 0.395 0.212 -1.238
ENSG00000142657 E006 1.1118645 1.803503e-02 1.367559e-01   1 10399009 10399013 5 + 0.476 0.211 -1.670
ENSG00000142657 E007 19.7807289 1.849352e-03 2.465036e-01 4.841550e-01 1 10399014 10399043 30 + 1.341 1.248 -0.328
ENSG00000142657 E008 68.9733674 2.322786e-03 1.502834e-02 7.819352e-02 1 10399044 10399063 20 + 1.885 1.767 -0.398
ENSG00000142657 E009 117.7294919 3.938763e-03 2.034372e-01 4.338388e-01 1 10399064 10399072 9 + 2.071 2.017 -0.183
ENSG00000142657 E010 802.8658549 4.997697e-04 8.393477e-01 9.190353e-01 1 10399073 10399111 39 + 2.860 2.860 -0.003
ENSG00000142657 E011 944.1526534 1.287529e-04 5.637068e-01 7.458890e-01 1 10399112 10399125 14 + 2.933 2.928 -0.019
ENSG00000142657 E012 5.9317406 1.044258e-02 2.398915e-01 4.765197e-01 1 10399498 10399628 131 + 0.902 0.748 -0.604
ENSG00000142657 E013 963.8573425 2.035210e-04 8.796859e-01 9.410984e-01 1 10399629 10399631 3 + 2.938 2.938 0.001
ENSG00000142657 E014 1333.8824816 1.098827e-04 4.284227e-02 1.621340e-01 1 10399632 10399704 73 + 3.093 3.073 -0.069
ENSG00000142657 E015 4.4912427 3.380591e-02 7.839235e-01 8.868818e-01 1 10399705 10400008 304 + 0.652 0.701 0.207
ENSG00000142657 E016 7.6799449 4.237401e-03 5.101011e-01 7.080498e-01 1 10400376 10400392 17 + 0.953 0.874 -0.302
ENSG00000142657 E017 2187.6307572 5.904541e-05 3.657515e-07 1.173494e-05 1 10400393 10400572 180 + 3.322 3.282 -0.136
ENSG00000142657 E018 1312.8219820 8.466927e-05 7.803910e-05 1.215187e-03 1 10403071 10403136 66 + 3.102 3.061 -0.138
ENSG00000142657 E019 1862.3797134 5.282527e-05 6.405313e-05 1.029208e-03 1 10404161 10404276 116 + 3.248 3.214 -0.114
ENSG00000142657 E020 952.0786017 1.119463e-04 4.406281e-04 5.132492e-03 1 10404277 10404279 3 + 2.964 2.920 -0.146
ENSG00000142657 E021 1555.1785201 1.309722e-03 1.928801e-02 9.346423e-02 1 10408071 10408140 70 + 3.177 3.136 -0.138
ENSG00000142657 E022 1879.3229792 8.431489e-04 4.289571e-01 6.502958e-01 1 10411418 10411552 135 + 3.237 3.228 -0.029
ENSG00000142657 E023 5.3454504 3.444305e-02 2.605003e-01 4.994800e-01 1 10412834 10413061 228 + 0.874 0.700 -0.691
ENSG00000142657 E024 1956.4864772 2.828261e-04 3.379293e-01 5.762269e-01 1 10413062 10413251 190 + 3.235 3.252 0.053
ENSG00000142657 E025 3.5902376 3.273165e-01 2.173099e-01 4.501997e-01 1 10415292 10415392 101 + 0.819 0.517 -1.290
ENSG00000142657 E026 1664.5141290 1.376959e-03 1.348263e-01 3.394137e-01 1 10416987 10417117 131 + 3.149 3.189 0.133
ENSG00000142657 E027 1562.6750101 1.412294e-03 3.301595e-02 1.360923e-01 1 10417376 10417509 134 + 3.111 3.165 0.178
ENSG00000142657 E028 2.9654378 8.305067e-03 4.015318e-01 6.295582e-01 1 10418812 10418825 14 + 0.653 0.518 -0.605
ENSG00000142657 E029 694.0180778 2.405207e-03 1.593530e-01 3.757957e-01 1 10418826 10418836 11 + 2.764 2.811 0.159
ENSG00000142657 E030 1361.6526489 1.065000e-04 9.895586e-05 1.481529e-03 1 10418837 10418925 89 + 3.054 3.101 0.157
ENSG00000142657 E031 5.0433575 5.437751e-03 4.013662e-01 6.294716e-01 1 10419377 10419416 40 + 0.652 0.779 0.520
ENSG00000142657 E032 1696.5321294 1.384338e-04 5.894365e-06 1.328995e-04 1 10419417 10419539 123 + 3.147 3.199 0.171
ENSG00000142657 E033 9.8212115 2.981178e-03 8.862501e-02 2.612220e-01 1 10419540 10419629 90 + 1.113 0.930 -0.671
ENSG00000142657 E034 3377.8767318 1.391974e-04 1.656227e-06 4.423108e-05 1 10419630 10420511 882 + 3.453 3.496 0.144