ENSG00000142611

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000270722 ENSG00000142611 HEK293_OSMI2_6hA HEK293_TMG_6hB PRDM16 protein_coding protein_coding 3.548513 3.183894 2.273709 0.05139759 0.1844596 -0.4839374 1.46600902 1.26349947 0.6443858 0.21174364 0.06683595 -0.9605850 0.40510417 0.39896667 0.28596667 -0.11300000 0.714568159 0.005250973 FALSE TRUE
ENST00000378389 ENSG00000142611 HEK293_OSMI2_6hA HEK293_TMG_6hB PRDM16 protein_coding processed_transcript 3.548513 3.183894 2.273709 0.05139759 0.1844596 -0.4839374 0.26353263 0.20344698 0.1182788 0.20344698 0.11827877 -0.7345953 0.07050417 0.06520000 0.05270000 -0.01250000 0.986517816 0.005250973 FALSE TRUE
ENST00000378391 ENSG00000142611 HEK293_OSMI2_6hA HEK293_TMG_6hB PRDM16 protein_coding protein_coding 3.548513 3.183894 2.273709 0.05139759 0.1844596 -0.4839374 0.05916255 0.19944208 0.0000000 0.09162022 0.00000000 -4.3884794 0.01609583 0.06176667 0.00000000 -0.06176667 0.063795959 0.005250973 FALSE TRUE
ENST00000509860 ENSG00000142611 HEK293_OSMI2_6hA HEK293_TMG_6hB PRDM16 protein_coding protein_coding 3.548513 3.183894 2.273709 0.05139759 0.1844596 -0.4839374 0.39727937 0.45662510 0.1851095 0.14558236 0.09259581 -1.2579796 0.11705000 0.14226667 0.07663333 -0.06563333 0.793123513 0.005250973 FALSE TRUE
ENST00000511072 ENSG00000142611 HEK293_OSMI2_6hA HEK293_TMG_6hB PRDM16 protein_coding protein_coding 3.548513 3.183894 2.273709 0.05139759 0.1844596 -0.4839374 0.29973309 0.39856358 0.0000000 0.20009741 0.00000000 -5.3524887 0.07744167 0.12386667 0.00000000 -0.12386667 0.310521701 0.005250973 FALSE TRUE
ENST00000514189 ENSG00000142611 HEK293_OSMI2_6hA HEK293_TMG_6hB PRDM16 protein_coding protein_coding 3.548513 3.183894 2.273709 0.05139759 0.1844596 -0.4839374 0.06165336 0.00000000 0.1678996 0.00000000 0.08538347 4.1529911 0.01737917 0.00000000 0.07373333 0.07373333 0.238768652 0.005250973 FALSE TRUE
MSTRG.157.1 ENSG00000142611 HEK293_OSMI2_6hA HEK293_TMG_6hB PRDM16 protein_coding   3.548513 3.183894 2.273709 0.05139759 0.1844596 -0.4839374 0.15029244 0.08939897 0.2135669 0.01329031 0.10881887 1.1694037 0.04631250 0.02800000 0.09670000 0.06870000 0.796359775 0.005250973 FALSE TRUE
MSTRG.157.3 ENSG00000142611 HEK293_OSMI2_6hA HEK293_TMG_6hB PRDM16 protein_coding   3.548513 3.183894 2.273709 0.05139759 0.1844596 -0.4839374 0.56189857 0.38465425 0.7651145 0.06873971 0.08858525 0.9738201 0.16491250 0.12106667 0.33460000 0.21353333 0.005250973 0.005250973 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000142611 E001 1.1210919 0.0280867112 6.196247e-01   1 3068565 3069167 603 + 0.374 0.282 -0.578
ENSG00000142611 E002 0.3336024 0.0274424043 4.607520e-01   1 3069168 3069170 3 + 0.000 0.164 11.340
ENSG00000142611 E003 1.2449456 0.0137885069 3.432163e-01   1 3069171 3069182 12 + 0.450 0.282 -0.990
ENSG00000142611 E004 3.4958752 0.0072700676 4.738894e-01 0.6827228992 1 3069183 3069196 14 + 0.707 0.599 -0.461
ENSG00000142611 E005 4.2643961 0.0069338650 4.399284e-01 0.6586553980 1 3069197 3069202 6 + 0.778 0.668 -0.451
ENSG00000142611 E006 5.0321091 0.0092760772 9.121294e-01 0.9582046606 1 3069203 3069210 8 + 0.778 0.763 -0.060
ENSG00000142611 E007 9.2871056 0.0041215182 9.807727e-02 0.2783943226 1 3069211 3069296 86 + 1.108 0.931 -0.649
ENSG00000142611 E008 30.1160884 0.0014355830 4.712921e-02 0.1728457770 1 3186125 3186474 350 + 1.551 1.425 -0.431
ENSG00000142611 E009 0.2027342 0.0355630738 1.000000e+00   1 3186475 3186591 117 + 0.000 0.090 10.333
ENSG00000142611 E010 0.0000000       1 3237931 3238095 165 +      
ENSG00000142611 E011 13.7069961 0.0028137172 9.518131e-02 0.2732986677 1 3244087 3244131 45 + 1.240 1.087 -0.544
ENSG00000142611 E012 8.5280031 0.0254244538 2.186607e-01 0.4517941595 1 3244132 3244137 6 + 1.057 0.897 -0.596
ENSG00000142611 E013 1.3023997 0.0180317703 8.066790e-01   1 3385149 3385151 3 + 0.374 0.331 -0.253
ENSG00000142611 E014 17.0517648 0.0022978156 1.636038e-02 0.0831174848 1 3385152 3385286 135 + 1.358 1.161 -0.693
ENSG00000142611 E015 0.7735102 0.0172671820 7.570892e-01   1 3386676 3386918 243 + 0.281 0.227 -0.410
ENSG00000142611 E016 13.7124695 0.0048775581 5.503898e-02 0.1914246743 1 3396491 3396593 103 + 1.251 1.070 -0.646
ENSG00000142611 E017 26.5459624 0.0018578262 1.378038e-01 0.3441456746 1 3402791 3402998 208 + 1.472 1.370 -0.352
ENSG00000142611 E018 21.9061820 0.0032853461 8.757562e-01 0.9391428172 1 3404739 3404886 148 + 1.332 1.322 -0.037
ENSG00000142611 E019 18.0550970 0.0018740950 6.831720e-01 0.8246731796 1 3405495 3405648 154 + 1.228 1.265 0.128
ENSG00000142611 E020 82.1187020 0.0067161153 9.158252e-01 0.9600981563 1 3411384 3412800 1417 + 1.895 1.895 0.003
ENSG00000142611 E021 4.8637059 0.0598454004 4.204742e-01 0.6440244076 1 3414560 3414562 3 + 0.622 0.774 0.633
ENSG00000142611 E022 11.7970881 0.0035618252 6.454164e-01 0.8004451545 1 3414563 3414647 85 + 1.108 1.062 -0.164
ENSG00000142611 E023 17.4734295 0.0057461266 3.960720e-01 0.6252207591 1 3417828 3417997 170 + 1.283 1.208 -0.263
ENSG00000142611 E024 17.0742226 0.0144042776 6.350938e-01 0.7936203213 1 3418667 3418744 78 + 1.252 1.205 -0.168
ENSG00000142611 E025 0.2027342 0.0355630738 1.000000e+00   1 3424919 3425059 141 + 0.000 0.090 10.333
ENSG00000142611 E026 0.3032425 0.0244411696 4.620448e-01   1 3425216 3425580 365 + 0.000 0.164 11.355
ENSG00000142611 E027 28.6322790 0.0208948231 8.604533e-01 0.9305768277 1 3425581 3425750 170 + 1.447 1.433 -0.047
ENSG00000142611 E028 32.8170936 0.0048763449 7.508978e-01 0.8673112258 1 3426051 3426225 175 + 1.479 1.503 0.079
ENSG00000142611 E029 35.9519957 0.0016849128 8.456559e-01 0.9224918523 1 3430872 3431108 237 + 1.534 1.548 0.046
ENSG00000142611 E030 23.6632680 0.0015163069 9.717328e-01 0.9877569344 1 3431966 3432140 175 + 1.367 1.366 -0.005
ENSG00000142611 E031 3.3608889 0.0155606535 7.625993e-01 0.8741461811 1 3433296 3433355 60 + 0.666 0.622 -0.189
ENSG00000142611 E032 15.4444507 0.0027337426 7.084637e-01 0.8408191647 1 3433677 3433733 57 + 1.165 1.201 0.126
ENSG00000142611 E033 262.8050154 0.0004107964 1.101368e-05 0.0002281743 1 3433734 3438621 4888 + 2.334 2.422 0.296