ENSG00000142599

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000377464 ENSG00000142599 HEK293_OSMI2_6hA HEK293_TMG_6hB RERE protein_coding protein_coding 12.74783 19.07001 12.86355 2.381435 1.358027 -0.5676519 5.8078624 9.5615138 3.5987980 1.0175466 0.2279985 -1.4072287 0.44110833 0.504066667 0.2851000 -0.21896667 0.001874206 0.001874206 FALSE TRUE
ENST00000400908 ENSG00000142599 HEK293_OSMI2_6hA HEK293_TMG_6hB RERE protein_coding protein_coding 12.74783 19.07001 12.86355 2.381435 1.358027 -0.5676519 4.1010707 5.5960231 4.7660607 0.8078955 0.1887146 -0.2311565 0.33418333 0.293133333 0.3773333 0.08420000 0.546709229 0.001874206 FALSE TRUE
ENST00000492766 ENSG00000142599 HEK293_OSMI2_6hA HEK293_TMG_6hB RERE protein_coding processed_transcript 12.74783 19.07001 12.86355 2.381435 1.358027 -0.5676519 0.3873665 0.1633158 0.8065783 0.1633158 0.3129933 2.2361878 0.03272083 0.007866667 0.0604000 0.05253333 0.192042138 0.001874206 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000142599 E001 0.0000000       1 8352397 8352403 7 -      
ENSG00000142599 E002 0.3032425 0.0274424043 4.669545e-01   1 8352404 8352405 2 - 0.000 0.165 9.278
ENSG00000142599 E003 66.4849611 0.0038023616 2.119796e-02 9.997781e-02 1 8352406 8352554 149 - 1.708 1.853 0.488
ENSG00000142599 E004 290.3348385 0.0021997266 7.784385e-11 5.642200e-09 1 8352555 8352908 354 - 2.281 2.503 0.739
ENSG00000142599 E005 131.1849078 0.0040940542 1.877861e-05 3.621851e-04 1 8352909 8353000 92 - 1.943 2.154 0.708
ENSG00000142599 E006 200.2449756 0.0012575989 2.317830e-12 2.240301e-10 1 8353001 8353178 178 - 2.103 2.346 0.812
ENSG00000142599 E007 517.9347908 0.0014749622 1.688737e-10 1.144233e-08 1 8353179 8353942 764 - 2.576 2.737 0.538
ENSG00000142599 E008 198.8231547 0.0025703188 3.152993e-01 5.553757e-01 1 8353943 8354092 150 - 2.243 2.289 0.153
ENSG00000142599 E009 338.6955221 0.0025694170 1.336065e-01 3.374601e-01 1 8354093 8354942 850 - 2.466 2.524 0.193
ENSG00000142599 E010 85.7132282 0.0006069088 8.291048e-01 9.133035e-01 1 8354943 8355120 178 - 1.912 1.919 0.022
ENSG00000142599 E011 62.1260215 0.0011971755 7.202543e-01 8.483544e-01 1 8355419 8355520 102 - 1.762 1.794 0.111
ENSG00000142599 E012 54.9751378 0.0046817120 7.197444e-01 8.480476e-01 1 8355521 8355599 79 - 1.707 1.743 0.122
ENSG00000142599 E013 87.0601367 0.0038063324 1.676614e-01 3.874583e-01 1 8356100 8356246 147 - 1.868 1.949 0.272
ENSG00000142599 E014 232.4694174 0.0002133817 2.192413e-02 1.023257e-01 1 8358196 8358916 721 - 2.297 2.369 0.240
ENSG00000142599 E015 135.4161256 0.0003440739 2.579578e-02 1.146574e-01 1 8359764 8359986 223 - 2.052 2.141 0.297
ENSG00000142599 E016 211.9072340 0.0003746880 9.842332e-01 9.939726e-01 1 8360112 8361157 1046 - 2.296 2.312 0.052
ENSG00000142599 E017 114.5382944 0.0006012586 9.245177e-04 9.295699e-03 1 8361158 8361459 302 - 2.104 2.002 -0.342
ENSG00000142599 E018 55.1472622 0.0077191090 6.374495e-03 4.157044e-02 1 8361460 8361490 31 - 1.829 1.666 -0.551
ENSG00000142599 E019 93.6466240 0.0018006938 2.508618e-04 3.229634e-03 1 8361763 8361876 114 - 2.041 1.902 -0.467
ENSG00000142599 E020 112.9187338 0.0008866250 7.796016e-03 4.836498e-02 1 8362683 8362844 162 - 2.086 2.003 -0.277
ENSG00000142599 E021 1.9352508 0.1505340586 3.752621e-01 6.083897e-01 1 8363710 8364055 346 - 0.565 0.381 -0.930
ENSG00000142599 E022 126.2120159 0.0003694664 2.376308e-04 3.084550e-03 1 8364056 8364255 200 - 2.150 2.045 -0.351
ENSG00000142599 E023 77.4757021 0.0007990015 2.033674e-04 2.712145e-03 1 8364746 8364838 93 - 1.962 1.820 -0.477
ENSG00000142599 E024 51.5482227 0.0013770706 3.733485e-04 4.471625e-03 1 8365812 8365854 43 - 1.807 1.640 -0.566
ENSG00000142599 E025 39.9081968 0.0011328243 9.656747e-02 2.757582e-01 1 8365855 8365875 21 - 1.646 1.565 -0.275
ENSG00000142599 E026 33.7322906 0.0010823483 2.465365e-01 4.841998e-01 1 8365876 8365879 4 - 1.558 1.501 -0.196
ENSG00000142599 E027 53.3309940 0.0036207229 4.634240e-04 5.340763e-03 1 8365880 8365974 95 - 1.827 1.646 -0.613
ENSG00000142599 E028 43.2987056 0.0011633504 6.256139e-06 1.397943e-04 1 8422727 8422789 63 - 1.765 1.532 -0.792
ENSG00000142599 E029 36.1551241 0.0009725839 1.626724e-04 2.249635e-03 1 8422790 8422807 18 - 1.676 1.468 -0.709
ENSG00000142599 E030 4.5975323 0.0065073556 4.555342e-02 1.689050e-01 1 8423167 8423247 81 - 0.890 0.627 -1.064
ENSG00000142599 E031 2.0964086 0.0989432500 6.378151e-01 7.956140e-01 1 8423248 8423560 313 - 0.515 0.423 -0.462
ENSG00000142599 E032 2.8287725 0.0082338982 7.430723e-01 8.624006e-01 1 8423561 8423666 106 - 0.512 0.577 0.300
ENSG00000142599 E033 5.2106430 0.0096094028 6.098775e-01 7.768168e-01 1 8424015 8424234 220 - 0.807 0.749 -0.230
ENSG00000142599 E034 0.4702677 0.0217681645 2.402052e-01   1 8424788 8425212 425 - 0.279 0.090 -1.968
ENSG00000142599 E035 1.3354050 0.0714877779 8.144875e-01   1 8436770 8438300 1531 - 0.371 0.335 -0.217
ENSG00000142599 E036 1.4027930 0.1873253918 5.190606e-01 7.144002e-01 1 8464970 8465924 955 - 0.451 0.327 -0.700
ENSG00000142599 E037 62.9335338 0.0006218696 1.200368e-03 1.143555e-02 1 8465925 8466023 99 - 1.869 1.737 -0.448
ENSG00000142599 E038 72.0095257 0.0006330986 3.260871e-03 2.496908e-02 1 8495063 8495150 88 - 1.912 1.800 -0.378
ENSG00000142599 E039 46.8874429 0.0008531383 1.636428e-01 3.821654e-01 1 8495151 8495162 12 - 1.696 1.636 -0.204
ENSG00000142599 E040 83.7738722 0.0004957732 1.311088e-01 3.335696e-01 1 8497405 8497529 125 - 1.938 1.891 -0.156
ENSG00000142599 E041 53.7945007 0.0013875272 6.297615e-02 2.094022e-01 1 8508627 8508675 49 - 1.771 1.690 -0.275
ENSG00000142599 E042 0.1779838 0.0348108123 2.452120e-01   1 8519710 8519792 83 - 0.162 0.000 -12.682
ENSG00000142599 E043 19.7567917 0.0181258005 3.613123e-01 5.967638e-01 1 8525759 8526039 281 - 1.346 1.267 -0.277
ENSG00000142599 E044 27.9827407 0.0015005263 3.855760e-01 6.169005e-01 1 8541214 8541223 10 - 1.468 1.422 -0.159
ENSG00000142599 E045 44.7892014 0.0007913198 1.874740e-03 1.622784e-02 1 8541224 8541318 95 - 1.734 1.582 -0.517
ENSG00000142599 E046 24.6272524 0.0034604317 1.807755e-03 1.575320e-02 1 8556475 8556475 1 - 1.519 1.304 -0.744
ENSG00000142599 E047 48.3225073 0.0008798525 2.544850e-06 6.436909e-05 1 8556476 8556571 96 - 1.807 1.579 -0.773
ENSG00000142599 E048 51.0601843 0.0009117608 3.912101e-07 1.247633e-05 1 8557418 8557523 106 - 1.839 1.599 -0.812
ENSG00000142599 E049 0.0000000       1 8590785 8590841 57 -      
ENSG00000142599 E050 34.7285172 0.0010543300 1.095990e-02 6.219276e-02 1 8614561 8614686 126 - 1.619 1.478 -0.479
ENSG00000142599 E051 43.8969597 0.0018846803 3.391705e-03 2.570923e-02 1 8624310 8624380 71 - 1.727 1.576 -0.512
ENSG00000142599 E052 75.8202725 0.0082598503 2.707033e-02 1.185177e-01 1 8655973 8656192 220 - 1.937 1.824 -0.378
ENSG00000142599 E053 60.6257292 0.0101909476 1.166958e-02 6.511245e-02 1 8656193 8656441 249 - 1.862 1.717 -0.488
ENSG00000142599 E054 2.9108302 0.0085869423 2.082807e-01 4.397664e-01 1 8703055 8703219 165 - 0.703 0.519 -0.813
ENSG00000142599 E055 0.1426347 0.0319515913 2.455441e-01   1 8753431 8753838 408 - 0.161 0.000 -12.724
ENSG00000142599 E056 2.1824602 0.0096765512 4.511219e-01 6.664307e-01 1 8792404 8792588 185 - 0.569 0.454 -0.553
ENSG00000142599 E057 34.1918716 0.0140554936 1.755750e-01 3.979178e-01 1 8817160 8817643 484 - 1.588 1.497 -0.311
ENSG00000142599 E058 0.0000000       1 8826056 8826231 176 -      
ENSG00000142599 E059 0.0000000       1 8848017 8848921 905 -