ENSG00000142230

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000270225 ENSG00000142230 HEK293_OSMI2_6hA HEK293_TMG_6hB SAE1 protein_coding protein_coding 217.2175 227.9706 204.623 27.21222 12.30649 -0.1558722 139.3419 159.92912 117.98929 18.055318 3.449136 -0.4387447 0.6394292 0.7025333 0.5789333 -0.1236 0.0126434633 0.0009010802 FALSE TRUE
ENST00000597808 ENSG00000142230 HEK293_OSMI2_6hA HEK293_TMG_6hB SAE1 protein_coding protein_coding 217.2175 227.9706 204.623 27.21222 12.30649 -0.1558722 46.5186 43.26182 66.26253 6.062314 7.642359 0.6149829 0.2217792 0.1891000 0.3220000 0.1329 0.0009010802 0.0009010802 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000142230 E001 0.8737109 2.153854e-02 3.553575e-01   19 47113274 47113353 80 + 0.342 0.183 -1.197
ENSG00000142230 E002 1.3668236 1.228034e-01 7.935623e-01   19 47113441 47113525 85 + 0.343 0.403 0.348
ENSG00000142230 E003 0.2027342 3.236554e-02 7.247812e-01   19 47125096 47125330 235 + 0.000 0.101 8.923
ENSG00000142230 E004 0.0000000       19 47130716 47130741 26 +      
ENSG00000142230 E005 0.6778738 6.093948e-01 9.123408e-01   19 47130742 47130781 40 + 0.249 0.236 -0.097
ENSG00000142230 E006 1.1894600 1.593536e-01 9.872368e-01   19 47130782 47130786 5 + 0.341 0.356 0.093
ENSG00000142230 E007 1.3618343 2.967632e-02 7.335719e-01   19 47130787 47130789 3 + 0.342 0.408 0.380
ENSG00000142230 E008 2.7005633 1.147106e-02 4.132444e-01 6.385369e-01 19 47130790 47130796 7 + 0.476 0.616 0.650
ENSG00000142230 E009 8.7483801 3.416550e-03 2.975488e-01 5.380636e-01 19 47130797 47130828 32 + 0.891 1.017 0.471
ENSG00000142230 E010 8.7671611 3.283515e-03 2.975579e-01 5.380642e-01 19 47130829 47130829 1 + 0.891 1.017 0.470
ENSG00000142230 E011 10.1948921 2.859425e-03 4.037942e-01 6.313692e-01 19 47130830 47130834 5 + 0.972 1.068 0.352
ENSG00000142230 E012 23.3708101 1.643011e-03 3.534998e-01 5.904439e-01 19 47130835 47130837 3 + 1.322 1.398 0.266
ENSG00000142230 E013 82.4835903 4.514404e-04 5.096209e-02 1.819456e-01 19 47130838 47130858 21 + 1.850 1.938 0.294
ENSG00000142230 E014 32.4138116 1.777640e-03 7.439947e-02 2.335615e-01 19 47130859 47130860 2 + 1.431 1.556 0.429
ENSG00000142230 E015 43.3478494 1.938453e-02 8.811319e-02 2.602446e-01 19 47130861 47130865 5 + 1.530 1.695 0.562
ENSG00000142230 E016 168.6934802 4.710599e-03 4.986698e-02 1.793351e-01 19 47130866 47130888 23 + 2.153 2.252 0.333
ENSG00000142230 E017 197.3997760 4.214201e-03 1.055630e-01 2.916005e-01 19 47130889 47130894 6 + 2.235 2.314 0.265
ENSG00000142230 E018 933.5322888 2.824357e-04 2.101104e-03 1.774320e-02 19 47130895 47131028 134 + 2.922 2.975 0.176
ENSG00000142230 E019 7.0751210 4.544708e-03 6.550930e-01 8.067547e-01 19 47131029 47131112 84 + 0.844 0.906 0.237
ENSG00000142230 E020 1.0933208 2.277110e-01 6.514263e-01   19 47131250 47131320 71 + 0.258 0.356 0.649
ENSG00000142230 E021 0.2922838 2.753286e-02 7.465245e-01   19 47135528 47135605 78 + 0.146 0.100 -0.617
ENSG00000142230 E022 1.5232500 1.334327e-02 9.541428e-01 9.789712e-01 19 47142511 47142611 101 + 0.414 0.408 -0.032
ENSG00000142230 E023 1424.3598579 2.869549e-04 3.060261e-01 5.466764e-01 19 47143494 47143605 112 + 3.140 3.138 -0.006
ENSG00000142230 E024 2007.0146234 3.151580e-04 4.698146e-05 7.882367e-04 19 47150202 47150375 174 + 3.308 3.275 -0.110
ENSG00000142230 E025 0.6378404 2.405125e-02 1.527374e-01   19 47151996 47152053 58 + 0.342 0.101 -2.197
ENSG00000142230 E026 1958.0152260 1.123301e-04 1.437382e-19 3.975580e-17 19 47152898 47153040 143 + 3.319 3.247 -0.241
ENSG00000142230 E027 1635.2327468 7.860529e-05 2.244132e-11 1.820856e-09 19 47155114 47155213 100 + 3.230 3.176 -0.181
ENSG00000142230 E028 0.8288081 1.892431e-02 9.694895e-01   19 47156569 47156661 93 + 0.255 0.251 -0.029
ENSG00000142230 E029 0.3032425 2.744240e-02 3.483579e-01   19 47156987 47157181 195 + 0.000 0.182 9.987
ENSG00000142230 E030 709.1058720 1.246357e-04 3.462392e-01 5.837905e-01 19 47169818 47169820 3 + 2.837 2.832 -0.019
ENSG00000142230 E031 1429.1918554 1.295761e-04 7.474340e-01 8.651606e-01 19 47169821 47169923 103 + 3.131 3.144 0.041
ENSG00000142230 E032 18.8380249 2.113784e-03 2.619216e-01 5.010229e-01 19 47180146 47180303 158 + 1.219 1.319 0.350
ENSG00000142230 E033 1635.8345054 1.948393e-04 6.715335e-02 2.187308e-01 19 47197233 47197377 145 + 3.180 3.209 0.099
ENSG00000142230 E034 1304.3298493 9.882056e-04 4.342349e-02 1.636480e-01 19 47203671 47203740 70 + 3.071 3.121 0.166
ENSG00000142230 E035 6.2523678 2.409709e-02 5.542502e-01 7.393083e-01 19 47205062 47205103 42 + 0.890 0.814 -0.294
ENSG00000142230 E036 49.3685106 1.202450e-02 9.078398e-01 9.560644e-01 19 47205104 47205129 26 + 1.665 1.692 0.090
ENSG00000142230 E037 5622.1162627 4.321974e-04 1.001593e-05 2.099661e-04 19 47209159 47210636 1478 + 3.706 3.757 0.170