ENSG00000142208

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000407796 ENSG00000142208 HEK293_OSMI2_6hA HEK293_TMG_6hB AKT1 protein_coding protein_coding 102.3438 158.4089 56.72639 24.01482 1.937496 -1.481399 25.217009 31.283731 5.51279 8.8311641 0.6207002 -2.5024045 0.2423500 0.18863333 0.09746667 -0.09116667 0.28758760 0.01258444 FALSE TRUE
ENST00000554848 ENSG00000142208 HEK293_OSMI2_6hA HEK293_TMG_6hB AKT1 protein_coding protein_coding 102.3438 158.4089 56.72639 24.01482 1.937496 -1.481399 6.372376 8.740516 9.59846 0.5664569 1.4431032 0.1349372 0.0882500 0.05816667 0.16933333 0.11116667 0.01258444 0.01258444 FALSE TRUE
ENST00000683722 ENSG00000142208 HEK293_OSMI2_6hA HEK293_TMG_6hB AKT1 protein_coding protein_coding 102.3438 158.4089 56.72639 24.01482 1.937496 -1.481399 47.971801 86.275780 26.29296 15.6072264 0.9347359 -1.7138976 0.4252958 0.53890000 0.46343333 -0.07546667 0.33000887 0.01258444 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000142208 E001 1.062294 1.1121195437 2.534698e-01   14 104768825 104769116 292 - 0.635 0.069 -4.261
ENSG00000142208 E002 1.062294 1.1121195437 2.534698e-01   14 104769117 104769348 232 - 0.635 0.069 -4.261
ENSG00000142208 E003 1.488191 0.0127154833 4.824997e-01 0.688727846 14 104769349 104769351 3 - 0.208 0.372 1.139
ENSG00000142208 E004 10.629386 0.0051108320 3.282319e-01 0.567260222 14 104769352 104769370 19 - 0.854 1.020 0.622
ENSG00000142208 E005 57.950377 0.3188988265 2.478008e-01 0.485617179 14 104769371 104769383 13 - 1.488 1.725 0.808
ENSG00000142208 E006 72.165488 0.0596879803 1.858511e-01 0.411646976 14 104769384 104769391 8 - 1.633 1.812 0.605
ENSG00000142208 E007 65.246560 0.0211870215 2.389418e-01 0.475394988 14 104769392 104769395 4 - 1.632 1.764 0.445
ENSG00000142208 E008 65.449294 0.0209978880 2.316064e-01 0.466971744 14 104769396 104769396 1 - 1.632 1.765 0.450
ENSG00000142208 E009 96.801073 0.0027776039 3.903952e-01 0.620739510 14 104769397 104769432 36 - 1.843 1.927 0.282
ENSG00000142208 E010 683.904551 0.0176354499 2.645083e-03 0.021237573 14 104769433 104769626 194 - 2.561 2.788 0.755
ENSG00000142208 E011 1367.452118 0.4479401550 2.300274e-01 0.465185338 14 104769627 104769971 345 - 2.839 3.091 0.836
ENSG00000142208 E012 915.408116 1.5452494282 4.689155e-01 0.679334388 14 104769972 104770154 183 - 2.670 2.916 0.820
ENSG00000142208 E013 405.284379 1.2656793319 4.390877e-01 0.658040566 14 104770155 104770192 38 - 2.324 2.562 0.792
ENSG00000142208 E014 733.774750 0.0839310710 1.789405e-01 0.402562274 14 104770193 104770340 148 - 2.637 2.810 0.577
ENSG00000142208 E015 620.902406 0.0001704134 9.951874e-01 0.999146954 14 104770341 104770420 80 - 2.678 2.720 0.139
ENSG00000142208 E016 23.915209 0.0033348265 4.133785e-01 0.638624796 14 104770538 104770744 207 - 1.341 1.307 -0.117
ENSG00000142208 E017 834.961839 0.0007484498 1.475851e-01 0.358836027 14 104770745 104770847 103 - 2.827 2.841 0.046
ENSG00000142208 E018 58.690879 0.0354717570 1.316369e-01 0.334394969 14 104770848 104771554 707 - 1.787 1.660 -0.432
ENSG00000142208 E019 29.402962 0.0064341444 6.580326e-01 0.808692081 14 104771555 104771721 167 - 1.398 1.398 -0.002
ENSG00000142208 E020 21.485365 0.1118787568 8.654290e-01 0.933374415 14 104771722 104771816 95 - 1.224 1.277 0.189
ENSG00000142208 E021 50.853769 0.0556458121 8.801874e-02 0.260062397 14 104771817 104772364 548 - 1.765 1.585 -0.609
ENSG00000142208 E022 770.268650 0.0044098215 9.450059e-01 0.974796115 14 104772365 104772452 88 - 2.765 2.809 0.147
ENSG00000142208 E023 766.472079 0.0021336744 3.383699e-01 0.576578745 14 104772878 104772993 116 - 2.744 2.812 0.228
ENSG00000142208 E024 844.730494 0.0011467379 5.074451e-01 0.705993101 14 104772994 104773092 99 - 2.819 2.847 0.092
ENSG00000142208 E025 12.396780 0.0304067828 2.545412e-01 0.493052998 14 104773093 104773250 158 - 1.142 1.016 -0.456
ENSG00000142208 E026 1106.680004 0.0031562881 8.663431e-02 0.257617695 14 104773251 104773379 129 - 2.963 2.956 -0.024
ENSG00000142208 E027 1010.398116 0.0053682423 1.011380e-01 0.283847664 14 104773455 104773580 126 - 2.932 2.913 -0.062
ENSG00000142208 E028 52.623784 0.0990370054 1.501900e-01 0.362642162 14 104773581 104773911 331 - 1.771 1.602 -0.575
ENSG00000142208 E029 736.259627 0.0068144767 1.236343e-01 0.321473191 14 104773912 104773980 69 - 2.797 2.776 -0.071
ENSG00000142208 E030 12.818463 0.1454119915 1.912335e-01 0.418409851 14 104773981 104774055 75 - 1.216 1.007 -0.754
ENSG00000142208 E031 43.096253 0.1473750214 1.368583e-02 0.073100874 14 104774056 104774696 641 - 1.842 1.436 -1.382
ENSG00000142208 E032 30.186699 0.1401846539 6.506697e-03 0.042239558 14 104774697 104774937 241 - 1.721 1.266 -1.563
ENSG00000142208 E033 655.813743 0.0014263767 4.489221e-02 0.167339971 14 104774938 104775003 66 - 2.737 2.731 -0.022
ENSG00000142208 E034 4.750044 0.0140362104 8.925764e-02 0.262403502 14 104775004 104775075 72 - 0.854 0.625 -0.933
ENSG00000142208 E035 515.277969 0.0008825254 6.179914e-05 0.000998090 14 104775076 104775139 64 - 2.668 2.617 -0.171
ENSG00000142208 E036 673.957594 0.0025277865 3.416892e-02 0.139303051 14 104775140 104775207 68 - 2.760 2.738 -0.071
ENSG00000142208 E037 33.089990 0.1172420326 2.614598e-02 0.115774616 14 104775208 104775651 444 - 1.690 1.350 -1.165
ENSG00000142208 E038 1012.113185 0.0057235441 5.281051e-02 0.186282342 14 104775652 104775799 148 - 2.944 2.911 -0.109
ENSG00000142208 E039 10.710123 0.1385876408 5.107539e-02 0.182264319 14 104775800 104776658 859 - 1.239 0.879 -1.313
ENSG00000142208 E040 787.016471 0.0061752255 1.925111e-02 0.093330729 14 104776659 104776770 112 - 2.851 2.798 -0.176
ENSG00000142208 E041 12.806212 0.1969276296 1.578762e-01 0.373542352 14 104776771 104777568 798 - 1.236 0.993 -0.873
ENSG00000142208 E042 14.678463 0.1846148743 1.688884e-01 0.389102328 14 104777569 104778571 1003 - 1.277 1.057 -0.787
ENSG00000142208 E043 640.746555 0.0027095983 4.121765e-02 0.157910637 14 104780088 104780216 129 - 2.738 2.717 -0.070
ENSG00000142208 E044 2.533366 0.0283933022 1.297330e-01 0.331417613 14 104786291 104786367 77 - 0.671 0.430 -1.128
ENSG00000142208 E045 320.776141 0.0002276458 2.889664e-02 0.124060846 14 104792598 104792720 123 - 2.434 2.423 -0.038
ENSG00000142208 E046 71.202001 0.0067971117 8.643480e-01 0.932787056 14 104792721 104792722 2 - 1.728 1.784 0.192
ENSG00000142208 E047 13.042224 0.0044163365 2.797938e-02 0.121205300 14 104792723 104793126 404 - 1.215 1.026 -0.680
ENSG00000142208 E048 40.733085 0.0180200091 1.156102e-01 0.308490703 14 104793127 104793210 84 - 1.614 1.510 -0.356
ENSG00000142208 E049 28.033306 0.0272303282 4.511436e-02 0.167919551 14 104793211 104793304 94 - 1.504 1.331 -0.597
ENSG00000142208 E050 47.703597 0.0307547191 3.799776e-05 0.000659805 14 104793305 104794118 814 - 1.869 1.489 -1.290
ENSG00000142208 E051 14.670392 0.0110748842 3.617271e-02 0.144690001 14 104794119 104794143 25 - 1.261 1.076 -0.659
ENSG00000142208 E052 20.521204 0.0038667890 8.561832e-03 0.051880345 14 104794144 104794261 118 - 1.398 1.209 -0.662
ENSG00000142208 E053 16.234098 0.0570891310 2.156034e-03 0.018114295 14 104794262 104794528 267 - 1.436 1.044 -1.385
ENSG00000142208 E054 13.631432 0.1268771508 9.056423e-02 0.264810434 14 104794790 104795010 221 - 1.313 0.995 -1.140
ENSG00000142208 E055 9.866478 0.1771333657 2.206222e-01 0.454209264 14 104795011 104795239 229 - 1.134 0.896 -0.876
ENSG00000142208 E056 50.097742 0.0078237425 2.308956e-01 0.466188707 14 104795484 104795766 283 - 1.511 1.651 0.478