ENSG00000142188

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000420455 ENSG00000142188 HEK293_OSMI2_6hA HEK293_TMG_6hB TMEM50B protein_coding nonsense_mediated_decay 27.63776 11.18087 40.75832 1.189517 1.425186 1.865126 3.431172 1.870454 4.463657 0.2785652 0.3226756 1.25037310 0.1442667 0.1680667 0.10926667 -0.05880000 0.3024090226 0.0004363171 TRUE TRUE
ENST00000542230 ENSG00000142188 HEK293_OSMI2_6hA HEK293_TMG_6hB TMEM50B protein_coding protein_coding 27.63776 11.18087 40.75832 1.189517 1.425186 1.865126 14.504138 2.703340 24.911809 0.1077662 1.5893379 3.19926709 0.4602250 0.2476000 0.61513333 0.36753333 0.0007100721 0.0004363171 FALSE TRUE
MSTRG.21266.11 ENSG00000142188 HEK293_OSMI2_6hA HEK293_TMG_6hB TMEM50B protein_coding   27.63776 11.18087 40.75832 1.189517 1.425186 1.865126 3.734398 1.685967 3.889092 1.0311145 2.6156562 1.20103024 0.1293500 0.1345333 0.09156667 -0.04296667 0.9763418961 0.0004363171 FALSE TRUE
MSTRG.21266.4 ENSG00000142188 HEK293_OSMI2_6hA HEK293_TMG_6hB TMEM50B protein_coding   27.63776 11.18087 40.75832 1.189517 1.425186 1.865126 2.142126 2.845404 2.671917 0.5009649 0.6700429 -0.09043028 0.1024833 0.2514667 0.06533333 -0.18613333 0.0004363171 0.0004363171   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000142188 E001 2.1527205 0.0782210197 4.897064e-02 1.771696e-01 21 33432485 33432509 25 - 0.336 0.724 1.881
ENSG00000142188 E002 6.0022715 0.1375268590 5.023341e-01 7.024000e-01 21 33432510 33432540 31 - 0.738 0.914 0.690
ENSG00000142188 E003 46.6289909 0.1053683995 3.097980e-04 3.829863e-03 21 33432541 33432758 218 - 1.391 1.968 1.961
ENSG00000142188 E004 31.6135652 0.6451778554 5.195662e-02 1.842953e-01 21 33432759 33432797 39 - 1.190 1.838 2.228
ENSG00000142188 E005 19.8662252 0.4766614035 2.810700e-02 1.215858e-01 21 33432798 33432802 5 - 0.991 1.652 2.317
ENSG00000142188 E006 2.5949637 0.1582371417 6.327386e-02 2.100774e-01 21 33436883 33436883 1 - 0.391 0.775 1.761
ENSG00000142188 E007 6.6223739 0.1707426904 5.707005e-03 3.827425e-02 21 33436884 33436992 109 - 0.610 1.187 2.223
ENSG00000142188 E008 35.1452206 0.0466912611 8.234017e-07 2.397677e-05 21 33439214 33439297 84 - 1.262 1.858 2.040
ENSG00000142188 E009 6.0114220 0.0431624550 2.236036e-02 1.037717e-01 21 33447018 33447140 123 - 0.667 1.040 1.451
ENSG00000142188 E010 28.5079345 0.0279872665 2.647394e-04 3.372757e-03 21 33448782 33448879 98 - 1.272 1.662 1.344
ENSG00000142188 E011 15.1385032 0.0022560894 1.096414e-03 1.064709e-02 21 33448880 33448903 24 - 1.035 1.359 1.154
ENSG00000142188 E012 30.7012419 0.0012821905 9.826576e-03 5.737789e-02 21 33448904 33449140 237 - 1.359 1.564 0.706
ENSG00000142188 E013 39.3634780 0.0010943935 2.911575e-04 3.640230e-03 21 33449141 33449233 93 - 1.450 1.697 0.844
ENSG00000142188 E014 521.4503646 0.0057247243 3.241350e-04 3.974984e-03 21 33449234 33450520 1287 - 2.651 2.557 -0.315
ENSG00000142188 E015 45.0995733 0.0221963114 2.925029e-01 5.331694e-01 21 33450521 33450546 26 - 1.597 1.514 -0.284
ENSG00000142188 E016 170.3264593 0.0003338039 1.025490e-05 2.144198e-04 21 33450547 33450863 317 - 2.170 2.045 -0.419
ENSG00000142188 E017 2.0724661 0.0249581461 3.875909e-01 6.185798e-01 21 33453339 33453428 90 - 0.369 0.545 0.909
ENSG00000142188 E018 138.5391840 0.0140551512 5.359665e-02 1.880955e-01 21 33455727 33455784 58 - 2.075 1.987 -0.293
ENSG00000142188 E019 6.7030893 0.0042560852 9.908545e-02 2.801557e-01 21 33456004 33456097 94 - 0.753 0.989 0.905
ENSG00000142188 E020 151.7912118 0.0113062411 4.628091e-01 6.750116e-01 21 33460413 33460505 93 - 2.097 2.094 -0.011
ENSG00000142188 E021 0.7319543 0.2368970716 3.518595e-01   21 33465018 33465341 324 - 0.259 0.000 -11.213
ENSG00000142188 E022 106.7840856 0.0156681629 1.703592e-01 3.909209e-01 21 33465342 33465377 36 - 1.957 1.899 -0.192
ENSG00000142188 E023 116.8748489 0.0039409883 1.887866e-01 4.154774e-01 21 33465378 33465409 32 - 1.991 1.955 -0.121
ENSG00000142188 E024 179.2847176 0.0034539078 1.599285e-01 3.766823e-01 21 33467010 33467122 113 - 2.174 2.145 -0.098
ENSG00000142188 E025 0.5963342 0.0216979826 8.866601e-01   21 33467123 33467135 13 - 0.176 0.210 0.319
ENSG00000142188 E026 4.3668846 0.0265108703 4.780412e-02 1.745407e-01 21 33468420 33468786 367 - 0.725 0.352 -1.787
ENSG00000142188 E027 167.0566058 0.0006433237 1.571963e-02 8.079521e-02 21 33468787 33468926 140 - 2.151 2.094 -0.192
ENSG00000142188 E028 0.0000000       21 33469531 33469683 153 -      
ENSG00000142188 E029 0.1308682 0.0323624314 1.243595e-01   21 33479109 33479289 181 - 0.000 0.210 11.854
ENSG00000142188 E030 74.7088600 0.0005024012 2.322145e-01 4.677868e-01 21 33479838 33479974 137 - 1.802 1.767 -0.117