ENSG00000142173

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000300527 ENSG00000142173 HEK293_OSMI2_6hA HEK293_TMG_6hB COL6A2 protein_coding protein_coding 23.13543 31.54173 13.56748 1.555484 0.7901006 -1.216503 16.345010 24.6163809 9.4247561 1.1507373 0.5566307 -1.384147 0.70653333 0.78066667 0.69603333 -0.08463333 3.894624e-01 3.034575e-11 FALSE TRUE
MSTRG.21503.1 ENSG00000142173 HEK293_OSMI2_6hA HEK293_TMG_6hB COL6A2 protein_coding   23.13543 31.54173 13.56748 1.555484 0.7901006 -1.216503 2.046155 0.8652764 2.0839576 0.4668095 0.1767427 1.258422 0.09853333 0.02893333 0.15483333 0.12590000 4.046286e-01 3.034575e-11 FALSE TRUE
MSTRG.21503.7 ENSG00000142173 HEK293_OSMI2_6hA HEK293_TMG_6hB COL6A2 protein_coding   23.13543 31.54173 13.56748 1.555484 0.7901006 -1.216503 1.469475 3.5047759 0.0000000 0.8937221 0.0000000 -8.457289 0.05530000 0.10903333 0.00000000 -0.10903333 3.034575e-11 3.034575e-11 FALSE TRUE
MSTRG.21503.8 ENSG00000142173 HEK293_OSMI2_6hA HEK293_TMG_6hB COL6A2 protein_coding   23.13543 31.54173 13.56748 1.555484 0.7901006 -1.216503 1.099944 0.0000000 0.8491111 0.0000000 0.3485081 6.424773 0.04457083 0.00000000 0.06396667 0.06396667 6.042707e-07 3.034575e-11 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000142173 E001 0.5530924 0.0236150408 7.742587e-01   21 46098076 46098111 36 + 0.188 0.141 -0.497
ENSG00000142173 E002 0.5530924 0.0236150408 7.742587e-01   21 46098112 46098118 7 + 0.188 0.141 -0.497
ENSG00000142173 E003 60.7261387 0.0008143226 9.938192e-01 9.985524e-01 21 46098119 46098173 55 + 1.738 1.738 0.000
ENSG00000142173 E004 0.1723744 0.0326882790 1.000000e+00   21 46098797 46099147 351 + 0.000 0.076 8.387
ENSG00000142173 E005 76.1604739 0.0005720359 8.992852e-01 9.514866e-01 21 46111450 46111476 27 + 1.837 1.832 -0.018
ENSG00000142173 E006 121.9768267 0.0003456969 1.331637e-01 3.367673e-01 21 46111477 46111591 115 + 2.072 2.019 -0.178
ENSG00000142173 E007 269.5149435 0.0003072052 7.907605e-01 8.909600e-01 21 46111979 46112417 439 + 2.370 2.376 0.023
ENSG00000142173 E008 183.7594111 0.0038637276 3.853634e-01 6.167463e-01 21 46112418 46112577 160 + 2.239 2.200 -0.129
ENSG00000142173 E009 112.2845388 0.0003785971 1.693817e-02 8.522682e-02 21 46112804 46112824 21 + 2.062 1.975 -0.293
ENSG00000142173 E010 2.5147726 0.0992220258 1.941721e-01 4.223589e-01 21 46112825 46112949 125 + 0.679 0.435 -1.135
ENSG00000142173 E011 6.2136599 0.1994313435 7.772555e-01 8.830867e-01 21 46113617 46114007 391 + 0.815 0.799 -0.062
ENSG00000142173 E012 160.3672598 0.0003568131 3.827963e-01 6.145375e-01 21 46114008 46114073 66 + 2.170 2.143 -0.092
ENSG00000142173 E013 160.1505909 0.0003282523 2.779934e-02 1.207007e-01 21 46115872 46115925 54 + 2.198 2.130 -0.229
ENSG00000142173 E014 144.0629959 0.0002884573 8.559748e-03 5.187873e-02 21 46116009 46116053 45 + 2.165 2.080 -0.285
ENSG00000142173 E015 115.9482559 0.0003307571 3.055650e-02 1.290139e-01 21 46116377 46116403 27 + 2.068 1.991 -0.261
ENSG00000142173 E016 125.0995004 0.0003894459 5.628375e-02 1.942778e-01 21 46116651 46116677 27 + 2.094 2.027 -0.223
ENSG00000142173 E017 142.1922450 0.0032093034 2.226040e-01 4.566000e-01 21 46116770 46116814 45 + 2.136 2.087 -0.163
ENSG00000142173 E018 156.1800552 0.0010145940 2.763270e-01 5.163303e-01 21 46117400 46117453 54 + 2.167 2.131 -0.120
ENSG00000142173 E019 0.6841482 0.0919636399 3.279284e-01   21 46117454 46117521 68 + 0.320 0.142 -1.498
ENSG00000142173 E020 141.4978006 0.0004026815 7.112820e-01 8.426079e-01 21 46117874 46117936 63 + 2.105 2.093 -0.040
ENSG00000142173 E021 119.8060791 0.0006850781 2.516061e-01 4.896316e-01 21 46118614 46118676 63 + 1.992 2.036 0.149
ENSG00000142173 E022 134.9906013 0.0004374339 3.448985e-03 2.603881e-02 21 46119030 46119119 90 + 1.997 2.104 0.359
ENSG00000142173 E023 98.6629466 0.0007742008 1.507969e-03 1.367041e-02 21 46119788 46119850 63 + 1.838 1.977 0.469
ENSG00000142173 E024 83.5156209 0.0004603000 2.664230e-02 1.171852e-01 21 46120515 46120559 45 + 1.794 1.896 0.342
ENSG00000142173 E025 70.3298931 0.0005199674 1.147659e-01 3.070578e-01 21 46120560 46120577 18 + 1.738 1.816 0.263
ENSG00000142173 E026 101.8734306 0.0003890965 9.947733e-01 9.989569e-01 21 46121061 46121123 63 + 1.957 1.957 0.001
ENSG00000142173 E027 114.4835591 0.0004221328 2.588040e-01 4.976502e-01 21 46121556 46121618 63 + 2.035 1.993 -0.140
ENSG00000142173 E028 94.5255615 0.0020020116 7.055575e-01 8.390693e-01 21 46122108 46122158 51 + 1.933 1.915 -0.061
ENSG00000142173 E029 100.5939070 0.0057879677 8.777969e-01 9.401202e-01 21 46122496 46122531 36 + 1.942 1.947 0.018
ENSG00000142173 E030 112.4208311 0.0053504202 5.087082e-01 7.069645e-01 21 46122875 46122937 63 + 1.972 2.003 0.104
ENSG00000142173 E031 117.3708815 0.0043565865 3.011746e-01 5.416327e-01 21 46124651 46124713 63 + 1.979 2.028 0.163
ENSG00000142173 E032 116.7411305 0.0018809914 3.007495e-01 5.412294e-01 21 46124885 46124920 36 + 1.980 2.023 0.144
ENSG00000142173 E033 125.8084008 0.0005612101 1.280258e-01 3.286612e-01 21 46125266 46125311 46 + 2.084 2.030 -0.183
ENSG00000142173 E034 1.5179302 0.0124044474 3.894131e-02 1.520225e-01 21 46125417 46125464 48 + 0.000 0.436 11.861
ENSG00000142173 E035 243.6921695 0.0004876504 8.136217e-02 2.475441e-01 21 46125465 46125617 153 + 2.364 2.318 -0.154
ENSG00000142173 E036 491.0694230 0.0001934394 1.655964e-01 3.846819e-01 21 46125785 46126237 453 + 2.654 2.630 -0.081
ENSG00000142173 E037 159.3473194 0.0003006075 1.608738e-02 8.212120e-02 21 46126503 46126541 39 + 2.088 2.168 0.267
ENSG00000142173 E038 13.8002933 0.0359205539 7.039120e-01 8.380747e-01 21 46128903 46129195 293 + 1.089 1.126 0.135
ENSG00000142173 E039 70.0065993 0.0029487294 1.001353e-01 2.820534e-01 21 46129196 46129808 613 + 1.729 1.819 0.305
ENSG00000142173 E040 403.2948186 0.0003418713 2.345404e-08 1.012465e-06 21 46131954 46132848 895 + 2.458 2.579 0.404