ENSG00000142166

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000270139 ENSG00000142166 HEK293_OSMI2_6hA HEK293_TMG_6hB IFNAR1 protein_coding protein_coding 17.7035 6.976001 29.05004 1.375552 1.607482 2.056498 10.868338 4.8701550 17.288373 0.9109401 0.4824009 1.825637 0.67189583 0.7005333 0.59730000 -0.10323333 4.039283e-01 1.8329e-07 FALSE TRUE
ENST00000442071 ENSG00000142166 HEK293_OSMI2_6hA HEK293_TMG_6hB IFNAR1 protein_coding protein_coding 17.7035 6.976001 29.05004 1.375552 1.607482 2.056498 1.951121 0.0000000 4.403938 0.0000000 1.2807183 8.785923 0.06630417 0.0000000 0.15110000 0.15110000 1.832900e-07 1.8329e-07 FALSE FALSE
ENST00000652513 ENSG00000142166 HEK293_OSMI2_6hA HEK293_TMG_6hB IFNAR1 protein_coding protein_coding 17.7035 6.976001 29.05004 1.375552 1.607482 2.056498 1.835951 1.0441330 2.872164 0.2814796 0.3639638 1.451095 0.12782500 0.1443667 0.10040000 -0.04396667 6.376166e-01 1.8329e-07 FALSE TRUE
ENST00000652654 ENSG00000142166 HEK293_OSMI2_6hA HEK293_TMG_6hB IFNAR1 protein_coding nonsense_mediated_decay 17.7035 6.976001 29.05004 1.375552 1.607482 2.056498 1.667772 0.8077809 2.293904 0.4471311 0.9149975 1.494294 0.06753750 0.1206667 0.07623333 -0.04443333 1.000000e+00 1.8329e-07   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000142166 E001 0.0000000       21 33324140 33324172 33 +      
ENSG00000142166 E002 0.3336024 0.0244411696 0.0345670989   21 33324173 33324428 256 + 0.000 0.327 11.190
ENSG00000142166 E003 0.4950181 0.0217681645 0.1317296213   21 33324429 33324638 210 + 0.074 0.327 2.604
ENSG00000142166 E004 0.0000000       21 33324639 33324903 265 +      
ENSG00000142166 E005 2.1618982 0.0096765512 0.3832872894 0.614970767 21 33324904 33324969 66 + 0.426 0.581 0.755
ENSG00000142166 E006 3.3092996 0.0075286187 0.3989734805 0.627365748 21 33324970 33324971 2 + 0.555 0.693 0.604
ENSG00000142166 E007 4.2616014 0.0060068802 0.5922397785 0.765129264 21 33324972 33324972 1 + 0.655 0.740 0.355
ENSG00000142166 E008 5.7656608 0.0051582100 0.9283744961 0.966203820 21 33324973 33324974 2 + 0.791 0.782 -0.034
ENSG00000142166 E009 23.2170104 0.0015439677 0.9641338146 0.983935667 21 33324975 33325004 30 + 1.329 1.338 0.031
ENSG00000142166 E010 67.6245355 0.0006108725 0.1050009882 0.290634397 21 33325005 33325131 127 + 1.798 1.722 -0.257
ENSG00000142166 E011 125.0399249 0.0023635149 0.0288071356 0.123810244 21 33335524 33335647 124 + 2.065 1.978 -0.292
ENSG00000142166 E012 130.6908705 0.0004606569 0.0745382842 0.233891683 21 33340999 33341077 79 + 2.078 2.019 -0.198
ENSG00000142166 E013 146.2757271 0.0010058647 0.4478301728 0.664104014 21 33341078 33341174 97 + 2.116 2.095 -0.073
ENSG00000142166 E014 85.3751875 0.0080164083 0.3617136619 0.597065563 21 33343268 33343272 5 + 1.891 1.841 -0.169
ENSG00000142166 E015 165.0433739 0.0006029416 0.0247176597 0.111351755 21 33343273 33343422 150 + 2.179 2.109 -0.233
ENSG00000142166 E016 158.4564955 0.0019944254 0.1759263508 0.398355407 21 33343535 33343676 142 + 2.156 2.108 -0.160
ENSG00000142166 E017 162.5398512 0.0002945983 0.7192301182 0.847677260 21 33345246 33345360 115 + 2.156 2.149 -0.022
ENSG00000142166 E018 11.8066420 0.0031613290 0.0007041119 0.007478074 21 33348550 33349077 528 + 0.934 1.279 1.246
ENSG00000142166 E019 198.6236490 0.0003493467 0.5438398319 0.731805355 21 33349091 33349290 200 + 2.242 2.230 -0.043
ENSG00000142166 E020 177.7641291 0.0002705468 0.4863465253 0.691494763 21 33349389 33349543 155 + 2.187 2.213 0.088
ENSG00000142166 E021 187.1272538 0.0008108349 0.3206180535 0.560235984 21 33352758 33352908 151 + 2.205 2.241 0.119
ENSG00000142166 E022 178.8100178 0.0004007148 0.1611203507 0.378476261 21 33353638 33353783 146 + 2.182 2.229 0.157
ENSG00000142166 E023 97.2651692 0.0008101841 0.2602352882 0.499198186 21 33355316 33355330 15 + 1.916 1.967 0.171
ENSG00000142166 E024 1008.9787599 0.0011942665 0.0652746097 0.214503852 21 33355331 33359864 4534 + 2.936 2.966 0.099