ENSG00000141867

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000263377 ENSG00000141867 HEK293_OSMI2_6hA HEK293_TMG_6hB BRD4 protein_coding protein_coding 28.49727 38.25755 26.3454 6.09843 1.978335 -0.5380233 3.745712 6.4717678 0.739570 2.3608870 0.7395700 -3.1122522 0.1196958 0.1626667 0.02603333 -0.13663333 1.742347e-01 4.250884e-19 FALSE TRUE
ENST00000371835 ENSG00000141867 HEK293_OSMI2_6hA HEK293_TMG_6hB BRD4 protein_coding protein_coding 28.49727 38.25755 26.3454 6.09843 1.978335 -0.5380233 9.382898 16.2282147 6.438236 3.0427228 0.7548521 -1.3324166 0.3158917 0.4196333 0.24343333 -0.17620000 2.317623e-03 4.250884e-19 FALSE TRUE
ENST00000679869 ENSG00000141867 HEK293_OSMI2_6hA HEK293_TMG_6hB BRD4 protein_coding protein_coding 28.49727 38.25755 26.3454 6.09843 1.978335 -0.5380233 6.562158 9.7194846 5.422683 2.0212089 0.9255097 -0.8406984 0.2293042 0.2523667 0.20993333 -0.04243333 8.533905e-01 4.250884e-19 FALSE TRUE
MSTRG.16611.10 ENSG00000141867 HEK293_OSMI2_6hA HEK293_TMG_6hB BRD4 protein_coding   28.49727 38.25755 26.3454 6.09843 1.978335 -0.5380233 1.943440 0.0000000 3.030964 0.0000000 0.4676907 8.2483851 0.0767000 0.0000000 0.11613333 0.11613333 4.250884e-19 4.250884e-19 FALSE TRUE
MSTRG.16611.7 ENSG00000141867 HEK293_OSMI2_6hA HEK293_TMG_6hB BRD4 protein_coding   28.49727 38.25755 26.3454 6.09843 1.978335 -0.5380233 2.479661 0.8937341 4.592446 0.8937341 0.1329206 2.3484307 0.0969125 0.0338000 0.17616667 0.14236667 1.684240e-01 4.250884e-19 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000141867 E001 370.3451867 0.0030652454 1.146982e-09 6.625306e-08 19 15235519 15237081 1563 - 2.363 2.617 0.846
ENSG00000141867 E002 156.0374662 0.0073676697 1.390382e-04 1.968806e-03 19 15237082 15237284 203 - 1.991 2.243 0.844
ENSG00000141867 E003 99.7556304 0.0055447715 2.828906e-03 2.236617e-02 19 15237285 15237350 66 - 1.831 2.043 0.711
ENSG00000141867 E004 121.6319022 0.0038595322 4.573400e-02 1.693428e-01 19 15237351 15237389 39 - 1.970 2.112 0.475
ENSG00000141867 E005 233.0481540 0.0038429379 5.768952e-03 3.858913e-02 19 15237390 15237566 177 - 2.236 2.393 0.526
ENSG00000141867 E006 170.9751861 0.0048749164 7.223343e-03 4.568847e-02 19 15237567 15237674 108 - 2.093 2.261 0.564
ENSG00000141867 E007 224.6367439 0.0077573329 4.210876e-03 3.032537e-02 19 15237675 15237890 216 - 2.193 2.387 0.646
ENSG00000141867 E008 431.1536126 0.0007256990 1.281200e-08 5.864617e-07 19 15237891 15238445 555 - 2.494 2.666 0.571
ENSG00000141867 E009 223.6066067 0.0053610707 4.364166e-03 3.117159e-02 19 15238743 15238980 238 - 2.211 2.378 0.558
ENSG00000141867 E010 292.6337417 0.0029381811 5.612732e-02 1.939152e-01 19 15239059 15239264 206 - 2.369 2.478 0.364
ENSG00000141867 E011 246.7551617 0.0060720037 4.913185e-01 6.948361e-01 19 15239392 15239522 131 - 2.321 2.393 0.240
ENSG00000141867 E012 180.4043640 0.0059976027 4.044246e-01 6.318537e-01 19 15239659 15239821 163 - 2.181 2.262 0.272
ENSG00000141867 E013 114.6248532 0.0077626454 4.918185e-01 6.952063e-01 19 15239910 15240022 113 - 2.040 2.045 0.017
ENSG00000141867 E014 67.5921752 0.0123721663 1.854759e-01 4.111860e-01 19 15242900 15243038 139 - 1.851 1.798 -0.179
ENSG00000141867 E015 3.6780481 0.0480827851 5.313884e-01 7.229901e-01 19 15243039 15243107 69 - 0.700 0.628 -0.307
ENSG00000141867 E016 4.6769858 0.1083939663 1.815329e-01 4.060223e-01 19 15243108 15243221 114 - 0.903 0.644 -1.040
ENSG00000141867 E017 76.7998430 0.0057607119 3.489286e-02 1.413215e-01 19 15243222 15243487 266 - 1.918 1.851 -0.226
ENSG00000141867 E018 93.0545610 0.0133113826 5.649288e-01 7.467438e-01 19 15244231 15244522 292 - 1.947 1.956 0.029
ENSG00000141867 E019 42.5551550 0.0010257822 7.142649e-02 2.276497e-01 19 15244523 15244600 78 - 1.517 1.666 0.511
ENSG00000141867 E020 2.6433416 0.2195387438 9.163996e-01 9.604037e-01 19 15244601 15244709 109 - 0.508 0.558 0.231
ENSG00000141867 E021 59.2120428 0.0038225379 1.664354e-01 3.857799e-01 19 15244710 15244762 53 - 1.783 1.750 -0.112
ENSG00000141867 E022 5.4837084 0.1662179791 4.867268e-01 6.917231e-01 19 15244763 15244998 236 - 0.864 0.742 -0.484
ENSG00000141867 E023 3.6988426 0.2171552935 4.716938e-01 6.813237e-01 19 15246508 15246618 111 - 0.517 0.699 0.809
ENSG00000141867 E024 68.5786607 0.5153073433 2.040102e-01 4.346459e-01 19 15247047 15247276 230 - 1.585 1.901 1.068
ENSG00000141867 E025 614.4458181 1.5720760733 4.402621e-01 6.589051e-01 19 15247277 15248793 1517 - 2.559 2.840 0.934
ENSG00000141867 E026 74.8037732 0.6568403213 4.176090e-01 6.418239e-01 19 15248794 15248823 30 - 1.749 1.900 0.511
ENSG00000141867 E027 145.3863290 1.1098495542 4.556025e-01 6.699668e-01 19 15248824 15249004 181 - 2.003 2.197 0.648
ENSG00000141867 E028 78.2164456 0.6415739237 3.629128e-01 5.980683e-01 19 15249005 15249061 57 - 1.726 1.934 0.701
ENSG00000141867 E029 158.3273017 1.1495736602 4.780947e-01 6.858662e-01 19 15249062 15249290 229 - 2.048 2.231 0.610
ENSG00000141867 E030 20.3108642 0.0293991271 4.122406e-01 6.377751e-01 19 15252992 15253750 759 - 1.344 1.286 -0.203
ENSG00000141867 E031 4.2862433 0.0078306965 9.061657e-01 9.551550e-01 19 15253751 15253783 33 - 0.662 0.714 0.217
ENSG00000141867 E032 13.6754685 0.0035232167 5.453562e-02 1.903171e-01 19 15253784 15254151 368 - 1.234 1.092 -0.507
ENSG00000141867 E033 220.0622229 0.0004733433 7.133833e-02 2.274457e-01 19 15254152 15254262 111 - 2.328 2.324 -0.015
ENSG00000141867 E034 382.1318013 0.0002396583 1.908782e-03 1.646460e-02 19 15255297 15255592 296 - 2.575 2.558 -0.056
ENSG00000141867 E035 124.5873691 0.0013431301 7.428185e-02 2.333303e-01 19 15256064 15256098 35 - 2.095 2.071 -0.078
ENSG00000141867 E036 111.6430635 0.0004444173 4.026725e-01 6.305027e-01 19 15256099 15256134 36 - 2.023 2.037 0.046
ENSG00000141867 E037 126.6799924 0.0029554471 8.256509e-01 9.113159e-01 19 15256135 15256207 73 - 2.064 2.096 0.108
ENSG00000141867 E038 117.8411040 0.0123614124 9.727445e-01 9.883299e-01 19 15256208 15256263 56 - 2.023 2.068 0.150
ENSG00000141867 E039 276.9342424 0.0058029260 1.342085e-02 7.209288e-02 19 15256964 15257173 210 - 2.459 2.400 -0.197
ENSG00000141867 E040 1.9867202 0.2304446586 3.151093e-01 5.551887e-01 19 15257174 15258201 1028 - 0.275 0.528 1.421
ENSG00000141867 E041 2.1656317 0.0440229933 4.105812e-01 6.364798e-01 19 15258889 15259793 905 - 0.370 0.549 0.919
ENSG00000141867 E042 278.0470153 0.0023363748 2.494304e-05 4.605242e-04 19 15263420 15263548 129 - 2.481 2.391 -0.300
ENSG00000141867 E043 0.4231520 0.0484483870 9.508442e-01   19 15264118 15264403 286 - 0.161 0.165 0.038
ENSG00000141867 E044 369.9103005 0.0050507317 7.864506e-05 1.223613e-03 19 15264404 15264766 363 - 2.616 2.505 -0.369
ENSG00000141867 E045 204.2885559 0.0003300596 4.461667e-07 1.400587e-05 19 15265354 15265626 273 - 2.348 2.258 -0.300
ENSG00000141867 E046 105.5402370 0.0026208009 2.767640e-04 3.496049e-03 19 15265627 15265643 17 - 2.078 1.964 -0.383
ENSG00000141867 E047 201.0159599 0.0008485124 7.662006e-11 5.570141e-09 19 15267416 15267513 98 - 2.372 2.228 -0.480
ENSG00000141867 E048 172.1454701 0.0073342543 3.548687e-06 8.581950e-05 19 15267514 15267551 38 - 2.329 2.139 -0.635
ENSG00000141867 E049 15.3489536 0.0028241932 4.352973e-04 5.083448e-03 19 15268154 15268240 87 - 1.353 1.084 -0.952
ENSG00000141867 E050 7.3548140 0.0661441505 1.119028e-01 3.022550e-01 19 15268241 15268281 41 - 1.036 0.816 -0.831
ENSG00000141867 E051 242.5078240 0.0012731816 5.893113e-17 1.167779e-14 19 15268905 15269012 108 - 2.482 2.287 -0.652
ENSG00000141867 E052 147.4532850 0.0003681004 2.082834e-16 3.819796e-14 19 15269013 15269042 30 - 2.274 2.069 -0.687
ENSG00000141867 E053 2.8871773 0.0075501303 1.186628e-01 3.136595e-01 19 15271322 15271392 71 - 0.702 0.490 -0.952
ENSG00000141867 E054 256.9560356 0.0004950053 2.943020e-22 1.132842e-19 19 15272815 15273133 319 - 2.507 2.314 -0.643
ENSG00000141867 E055 0.1308682 0.0326491905 1.000000e+00   19 15275657 15275839 183 - 0.000 0.090 9.083
ENSG00000141867 E056 0.1723744 0.0504194306 1.000000e+00   19 15280264 15280451 188 - 0.000 0.091 9.089
ENSG00000141867 E057 3.4956852 0.1912763470 2.984197e-01 5.388696e-01 19 15331836 15331907 72 - 0.745 0.536 -0.906
ENSG00000141867 E058 26.9810516 0.0018646612 2.934551e-03 2.300699e-02 19 15332290 15332579 290 - 1.523 1.358 -0.568