ENSG00000141736

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000269571 ENSG00000141736 HEK293_OSMI2_6hA HEK293_TMG_6hB ERBB2 protein_coding protein_coding 17.71009 25.03559 13.6767 1.742877 0.5102955 -0.8717824 4.615576 6.873626 4.177628 0.8601959 0.49048779 -0.7170354 0.26586250 0.27300000 0.30753333 0.03453333 0.90997170 0.0006355682 FALSE TRUE
ENST00000445658 ENSG00000141736 HEK293_OSMI2_6hA HEK293_TMG_6hB ERBB2 protein_coding protein_coding 17.71009 25.03559 13.6767 1.742877 0.5102955 -0.8717824 1.089354 1.792368 0.260891 0.6514383 0.08867016 -2.7341094 0.05788333 0.06903333 0.01913333 -0.04990000 0.15822932 0.0006355682 FALSE TRUE
ENST00000541774 ENSG00000141736 HEK293_OSMI2_6hA HEK293_TMG_6hB ERBB2 protein_coding protein_coding 17.71009 25.03559 13.6767 1.742877 0.5102955 -0.8717824 7.762169 10.381881 4.204819 0.5255494 0.44677598 -1.3019143 0.42831250 0.41580000 0.30803333 -0.10776667 0.33123949 0.0006355682 FALSE TRUE
ENST00000580074 ENSG00000141736 HEK293_OSMI2_6hA HEK293_TMG_6hB ERBB2 protein_coding protein_coding 17.71009 25.03559 13.6767 1.742877 0.5102955 -0.8717824 1.246427 1.877078 2.815238 0.2911306 0.50416042 0.5822184 0.07277917 0.07570000 0.20430000 0.12860000 0.01756329 0.0006355682 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000141736 E001 0.5059767 0.0215833046 0.3890489365   17 39687914 39688100 187 + 0.000 0.200 9.698
ENSG00000141736 E002 0.7076135 0.0224226385 0.7497446854   17 39688101 39688118 18 + 0.186 0.250 0.545
ENSG00000141736 E003 3.2129344 0.0075072527 0.2226874155 0.456654910 17 39688119 39688204 86 + 0.415 0.635 1.051
ENSG00000141736 E004 6.0766986 0.0053270758 0.4010746998 0.629152004 17 39688205 39688278 74 + 0.722 0.847 0.499
ENSG00000141736 E005 7.8229189 0.0142003088 0.6328577255 0.792188619 17 39688696 39688800 105 + 0.838 0.906 0.262
ENSG00000141736 E006 6.9710959 0.0045329765 0.8431584041 0.921247714 17 39693261 39693325 65 + 0.869 0.848 -0.083
ENSG00000141736 E007 2.1110715 0.0317515382 0.7324101342 0.855659415 17 39694681 39694930 250 + 0.497 0.440 -0.290
ENSG00000141736 E008 0.7063259 0.6698079412 0.2492073421   17 39694931 39694987 57 + 0.427 0.078 -3.080
ENSG00000141736 E009 12.4946636 0.0027782914 0.4179839322 0.642110297 17 39694988 39695181 194 + 1.140 1.062 -0.282
ENSG00000141736 E010 1.0293295 0.0153892664 0.7217278709   17 39699537 39699559 23 + 0.315 0.251 -0.448
ENSG00000141736 E011 1.3209931 0.0140085372 0.9218493930   17 39699560 39699587 28 + 0.315 0.337 0.134
ENSG00000141736 E012 3.6238426 0.0185899075 0.5661002145 0.747397432 17 39699976 39700023 48 + 0.564 0.670 0.463
ENSG00000141736 E013 3.7664772 0.0184522181 0.8135903166 0.904407595 17 39700024 39700036 13 + 0.623 0.670 0.201
ENSG00000141736 E014 6.1526287 0.0065364152 0.0920768815 0.267565104 17 39700037 39700063 27 + 0.623 0.881 1.047
ENSG00000141736 E015 6.2531370 0.0189329824 0.1033022321 0.287752107 17 39700064 39700073 10 + 0.623 0.889 1.078
ENSG00000141736 E016 7.3119165 0.0255166850 0.4768529458 0.684882883 17 39700074 39700079 6 + 0.801 0.918 0.453
ENSG00000141736 E017 28.7004122 0.0015914234 0.9569581012 0.980351627 17 39700080 39700226 147 + 1.425 1.427 0.006
ENSG00000141736 E018 35.5720477 0.0011309180 0.6225395963 0.785543169 17 39700227 39700311 85 + 1.532 1.505 -0.093
ENSG00000141736 E019 0.1723744 0.0334737161 1.0000000000   17 39703194 39703428 235 + 0.000 0.077 10.287
ENSG00000141736 E020 0.1614157 0.0334310715 0.1710698863   17 39706749 39706897 149 + 0.186 0.000 -12.742
ENSG00000141736 E021 87.2580028 0.0005216599 0.0002965082 0.003695158 17 39706990 39707141 152 + 1.996 1.854 -0.479
ENSG00000141736 E022 1.3391092 0.0183721065 0.6475978946   17 39707142 39707204 63 + 0.415 0.335 -0.458
ENSG00000141736 E023 0.6378404 0.0246956224 0.0475233193   17 39707404 39708320 917 + 0.415 0.077 -3.034
ENSG00000141736 E024 111.7064478 0.0029068181 0.0035658979 0.026738409 17 39708321 39708534 214 + 2.088 1.964 -0.416
ENSG00000141736 E025 0.4756169 0.0250544350 0.3919058822   17 39709244 39709317 74 + 0.000 0.200 11.938
ENSG00000141736 E026 89.3172424 0.0005786570 0.0290679910 0.124549968 17 39709318 39709452 135 + 1.967 1.882 -0.286
ENSG00000141736 E027 69.4506776 0.0012585735 0.0114685602 0.064275941 17 39709813 39709881 69 + 1.882 1.768 -0.385
ENSG00000141736 E028 78.7488497 0.0098615164 0.1128740067 0.303973455 17 39710086 39710201 116 + 1.920 1.823 -0.325
ENSG00000141736 E029 54.3466629 0.0091116807 0.2521979828 0.490259735 17 39710340 39710355 16 + 1.744 1.673 -0.242
ENSG00000141736 E030 109.0530899 0.0044896265 0.0546370556 0.190518432 17 39710356 39710481 126 + 2.051 1.962 -0.299
ENSG00000141736 E031 110.0390276 0.0004564201 0.0166061525 0.083996743 17 39711928 39712047 120 + 2.053 1.969 -0.283
ENSG00000141736 E032 0.3150090 0.0274499819 0.4604357524   17 39712048 39712321 274 + 0.185 0.077 -1.448
ENSG00000141736 E033 112.0450843 0.0004137516 0.0992033433 0.280371647 17 39712322 39712448 127 + 2.043 1.986 -0.189
ENSG00000141736 E034 1.1545881 0.0144802144 0.4378925179   17 39713153 39713269 117 + 0.186 0.337 1.137
ENSG00000141736 E035 88.3558746 0.0004781602 0.7704132463 0.878903408 17 39715286 39715359 74 + 1.906 1.898 -0.026
ENSG00000141736 E036 103.5316093 0.0016757161 0.7464390132 0.864644676 17 39715446 39715536 91 + 1.952 1.968 0.055
ENSG00000141736 E037 154.6706186 0.0004157508 0.7274846690 0.852748393 17 39715740 39715939 200 + 2.128 2.144 0.053
ENSG00000141736 E038 15.4224667 0.0075133980 0.4652695802 0.676759743 17 39715940 39716300 361 + 1.216 1.148 -0.243
ENSG00000141736 E039 114.9757228 0.0018191528 0.8167891303 0.906331997 17 39716301 39716433 133 + 2.003 2.018 0.050
ENSG00000141736 E040 1.0177506 0.0162297148 0.7181787762   17 39716434 39716514 81 + 0.315 0.251 -0.450
ENSG00000141736 E041 64.0992818 0.0082757707 0.5237889542 0.717672534 17 39716515 39716550 36 + 1.791 1.755 -0.120
ENSG00000141736 E042 78.0988717 0.0020903106 0.5226452487 0.716787181 17 39716551 39716605 55 + 1.823 1.860 0.124
ENSG00000141736 E043 0.7970432 0.0171454628 0.0140535671   17 39716974 39717319 346 + 0.496 0.077 -3.449
ENSG00000141736 E044 64.0137619 0.0006889668 0.2720339820 0.511896407 17 39717320 39717342 23 + 1.722 1.783 0.205
ENSG00000141736 E045 101.6022660 0.0004375097 0.3730437821 0.606541253 17 39717343 39717428 86 + 1.933 1.974 0.136
ENSG00000141736 E046 86.0727582 0.0005136717 0.5364788182 0.726667914 17 39717429 39717480 52 + 1.905 1.884 -0.074
ENSG00000141736 E047 0.6188717 0.0413365671 0.3367151449   17 39717481 39717657 177 + 0.315 0.143 -1.446
ENSG00000141736 E048 80.0743717 0.0005208997 0.1489669060 0.360797052 17 39719787 39719834 48 + 1.900 1.842 -0.196
ENSG00000141736 E049 5.7559082 0.0453622481 0.2342671678 0.470022645 17 39719835 39720297 463 + 0.900 0.714 -0.734
ENSG00000141736 E050 149.0945961 0.0002851704 0.3928021353 0.622662042 17 39723319 39723457 139 + 2.142 2.119 -0.077
ENSG00000141736 E051 124.8913422 0.0007460075 0.6026572137 0.771990194 17 39723538 39723624 87 + 2.032 2.054 0.076
ENSG00000141736 E052 71.9648158 0.0821493932 0.4343724544 0.654508969 17 39723625 39723660 36 + 1.755 1.827 0.244
ENSG00000141736 E053 125.9950699 0.0213277515 0.8954121894 0.949455435 17 39723912 39724010 99 + 2.051 2.050 -0.003
ENSG00000141736 E054 180.0137859 0.0003771209 0.0181743275 0.089596459 17 39724726 39724911 186 + 2.253 2.188 -0.217
ENSG00000141736 E055 158.9010285 0.0023666075 0.2565448858 0.495315025 17 39725049 39725204 156 + 2.180 2.141 -0.130
ENSG00000141736 E056 1.2794869 0.0132743653 0.9246131114   17 39725205 39725326 122 + 0.315 0.336 0.132
ENSG00000141736 E057 90.7560142 0.0026239689 0.7789682913 0.884151398 17 39725327 39725402 76 + 1.920 1.911 -0.027
ENSG00000141736 E058 1.6110641 0.0121989077 0.8085394077 0.901306231 17 39725403 39725706 304 + 0.415 0.374 -0.230
ENSG00000141736 E059 147.5312141 0.0016361832 0.2163734433 0.449130800 17 39725707 39725853 147 + 2.084 2.135 0.169
ENSG00000141736 E060 3.8053356 0.2160978520 0.4971676260 0.699020547 17 39725854 39726351 498 + 0.730 0.595 -0.570
ENSG00000141736 E061 137.2539756 0.0004143333 0.0562434283 0.194200034 17 39726562 39726659 98 + 2.038 2.110 0.239
ENSG00000141736 E062 175.6211440 0.0068713324 0.0321396788 0.133635791 17 39726815 39727003 189 + 2.113 2.222 0.363
ENSG00000141736 E063 183.8922536 0.0004697221 0.0230363695 0.106065106 17 39727295 39727547 253 + 2.161 2.236 0.250
ENSG00000141736 E064 452.2947012 0.0006460473 0.0001900341 0.002564336 17 39727689 39728347 659 + 2.541 2.625 0.280
ENSG00000141736 E065 101.4888021 0.0047320168 0.3725828324 0.606113618 17 39728348 39728385 38 + 1.922 1.969 0.156
ENSG00000141736 E066 123.9271009 0.0025490839 0.0383549849 0.150501596 17 39728386 39728481 96 + 1.976 2.069 0.310
ENSG00000141736 E067 67.2184507 0.0511328090 0.1223413473 0.319497635 17 39728482 39728662 181 + 1.657 1.818 0.547
ENSG00000141736 E068 1.7389682 0.0129229445 0.5203460215 0.715160960 17 39730023 39730538 516 + 0.315 0.440 0.718