ENSG00000141664

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000269499 ENSG00000141664 HEK293_OSMI2_6hA HEK293_TMG_6hB ZCCHC2 protein_coding protein_coding 5.167257 5.554426 5.819358 0.9340819 0.3979108 0.06710405 0.4908664 0.4189747 0.5023597 0.1064363 0.03267671 0.2562644 0.09239167 0.07360000 0.08803333 0.01443333 0.933669877 0.000668219 FALSE TRUE
ENST00000585873 ENSG00000141664 HEK293_OSMI2_6hA HEK293_TMG_6hB ZCCHC2 protein_coding nonsense_mediated_decay 5.167257 5.554426 5.819358 0.9340819 0.3979108 0.06710405 0.4052290 0.3880572 0.5612206 0.1940457 0.01385441 0.5210724 0.07316250 0.06023333 0.09743333 0.03720000 0.782502636 0.000668219 TRUE TRUE
ENST00000585949 ENSG00000141664 HEK293_OSMI2_6hA HEK293_TMG_6hB ZCCHC2 protein_coding retained_intron 5.167257 5.554426 5.819358 0.9340819 0.3979108 0.06710405 0.5539822 1.0105883 0.2377462 0.1196385 0.12214693 -2.0424659 0.12072917 0.18783333 0.04356667 -0.14426667 0.268108217 0.000668219 FALSE TRUE
ENST00000586834 ENSG00000141664 HEK293_OSMI2_6hA HEK293_TMG_6hB ZCCHC2 protein_coding protein_coding 5.167257 5.554426 5.819358 0.9340819 0.3979108 0.06710405 2.5585820 2.3682143 3.5477709 0.6106492 0.49259036 0.5810949 0.48226667 0.41053333 0.60330000 0.19276667 0.252929843 0.000668219 FALSE TRUE
ENST00000588676 ENSG00000141664 HEK293_OSMI2_6hA HEK293_TMG_6hB ZCCHC2 protein_coding protein_coding 5.167257 5.554426 5.819358 0.9340819 0.3979108 0.06710405 0.3786638 0.7969102 0.1695253 0.1461940 0.05357440 -2.1682208 0.07790417 0.14283333 0.02890000 -0.11393333 0.000668219 0.000668219 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000141664 E001 2.5347237 0.0152704391 7.105045e-01 8.421332e-01 18 62523025 62523197 173 + 0.546 0.522 -0.111
ENSG00000141664 E002 2.4119701 0.0093390265 9.382091e-02 2.708174e-01 18 62523198 62523618 421 + 0.353 0.667 1.538
ENSG00000141664 E003 1.3688489 0.0208277932 1.204381e-01   18 62523619 62523666 48 + 0.212 0.520 1.879
ENSG00000141664 E004 16.8117495 0.0019466998 1.936713e-01 4.216918e-01 18 62523667 62524157 491 + 1.170 1.327 0.551
ENSG00000141664 E005 5.4349552 0.0048754056 8.708317e-01 9.364160e-01 18 62524158 62524172 15 + 0.779 0.843 0.251
ENSG00000141664 E006 18.0664229 0.0140166492 6.756702e-01 8.199728e-01 18 62524173 62524363 191 + 1.276 1.296 0.068
ENSG00000141664 E007 17.1132664 0.0021442650 2.537373e-12 2.434487e-10 18 62524364 62525495 1132 + 0.779 1.485 2.557
ENSG00000141664 E008 0.6376527 0.0191754875 9.509095e-01   18 62526889 62526981 93 + 0.211 0.221 0.081
ENSG00000141664 E009 0.1426347 0.0316728236 4.678548e-01   18 62539514 62539680 167 + 0.118 0.000 -9.557
ENSG00000141664 E010 26.6384432 0.0117950902 1.551537e-02 8.001730e-02 18 62539681 62539792 112 + 1.503 1.360 -0.492
ENSG00000141664 E011 26.1698230 0.0016053782 3.666769e-02 1.460027e-01 18 62542498 62542574 77 + 1.475 1.384 -0.314
ENSG00000141664 E012 24.4550594 0.0017159474 7.473790e-03 4.690051e-02 18 62544802 62544873 72 + 1.470 1.334 -0.474
ENSG00000141664 E013 28.0213255 0.0016785069 1.329460e-02 7.161481e-02 18 62550348 62550460 113 + 1.514 1.402 -0.388
ENSG00000141664 E014 27.6159733 0.0019123322 1.089191e-01 2.972690e-01 18 62556203 62556297 95 + 1.484 1.429 -0.189
ENSG00000141664 E015 1.2014141 0.0136968632 4.335117e-01   18 62558542 62558686 145 + 0.409 0.300 -0.658
ENSG00000141664 E016 23.8045734 0.0155496704 4.403372e-01 6.589653e-01 18 62558687 62558770 84 + 1.400 1.393 -0.024
ENSG00000141664 E017 0.8377416 0.6117601055 9.281181e-01   18 62560353 62560586 234 + 0.212 0.306 0.705
ENSG00000141664 E018 19.5741545 0.0020922738 1.563015e-01 3.713272e-01 18 62560587 62560644 58 + 1.343 1.284 -0.205
ENSG00000141664 E019 29.4914887 0.0012199472 9.777395e-02 2.778646e-01 18 62563009 62563144 136 + 1.514 1.460 -0.186
ENSG00000141664 E020 27.3058904 0.0017651299 3.265958e-02 1.351120e-01 18 62564571 62564635 65 + 1.493 1.402 -0.315
ENSG00000141664 E021 32.9203201 0.0140881689 2.069617e-02 9.831840e-02 18 62565002 62565096 95 + 1.585 1.457 -0.437
ENSG00000141664 E022 35.8566584 0.0427877016 2.939977e-01 5.346193e-01 18 62570103 62570231 129 + 1.592 1.529 -0.216
ENSG00000141664 E023 78.4399867 0.0066783316 6.187611e-03 4.064671e-02 18 62574057 62574478 422 + 1.941 1.849 -0.310
ENSG00000141664 E024 45.1241329 0.0009824889 5.352439e-01 7.257514e-01 18 62574479 62574644 166 + 1.658 1.676 0.061
ENSG00000141664 E025 47.8662484 0.0146865643 2.895876e-01 5.301307e-01 18 62574645 62574926 282 + 1.704 1.676 -0.097
ENSG00000141664 E026 53.1744835 0.0130068363 8.686267e-01 9.351641e-01 18 62574927 62575297 371 + 1.715 1.757 0.142
ENSG00000141664 E027 16.6514881 0.0134442149 9.936106e-01 9.984344e-01 18 62575298 62575312 15 + 1.222 1.281 0.208
ENSG00000141664 E028 50.7652215 0.0010220756 1.917980e-01 4.191381e-01 18 62575313 62575550 238 + 1.661 1.776 0.388
ENSG00000141664 E029 36.2599347 0.5724411769 4.750171e-01 6.835936e-01 18 62576512 62576652 141 + 1.513 1.625 0.382
ENSG00000141664 E030 188.9523433 1.3647333351 3.975079e-01 6.263662e-01 18 62576653 62578579 1927 + 2.120 2.398 0.927
ENSG00000141664 E031 0.0000000       18 62581805 62581896 92 +      
ENSG00000141664 E032 2.8638166 0.0083379447 2.476488e-02 1.115053e-01 18 62584446 62584595 150 + 0.353 0.751 1.888
ENSG00000141664 E033 29.0526059 0.0139660881 3.018484e-01 5.423906e-01 18 62584596 62586729 2134 + 1.406 1.541 0.465
ENSG00000141664 E034 1.0579717 0.0327688044 3.040877e-01   18 62586849 62586907 59 + 0.212 0.423 1.395
ENSG00000141664 E035 1.6062624 0.0134504644 5.916105e-01 7.648086e-01 18 62587581 62587709 129 + 0.353 0.476 0.666