ENSG00000141627

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000269445 ENSG00000141627 HEK293_OSMI2_6hA HEK293_TMG_6hB DYM protein_coding protein_coding 16.93273 12.05275 19.83089 2.527594 0.6096737 0.7179179 4.256673 3.3995124 3.927549 0.8912838 0.01594686 0.2077325 0.26035833 0.27380000 0.19840000 -0.07540000 0.27279547 0.02254006 FALSE TRUE
ENST00000442713 ENSG00000141627 HEK293_OSMI2_6hA HEK293_TMG_6hB DYM protein_coding protein_coding 16.93273 12.05275 19.83089 2.527594 0.6096737 0.7179179 1.425318 0.3571693 0.912350 0.3571693 0.91235003 1.3288690 0.08704583 0.02586667 0.04366667 0.01780000 0.99150207 0.02254006 FALSE TRUE
ENST00000577734 ENSG00000141627 HEK293_OSMI2_6hA HEK293_TMG_6hB DYM protein_coding protein_coding 16.93273 12.05275 19.83089 2.527594 0.6096737 0.7179179 2.272156 2.3869986 1.728554 0.3444288 0.19601438 -0.4633410 0.14573750 0.20730000 0.08793333 -0.11936667 0.02254006 0.02254006 FALSE FALSE
MSTRG.15787.7 ENSG00000141627 HEK293_OSMI2_6hA HEK293_TMG_6hB DYM protein_coding   16.93273 12.05275 19.83089 2.527594 0.6096737 0.7179179 5.191336 3.7265774 8.555949 0.9312516 0.34606928 1.1968957 0.29505000 0.30310000 0.43310000 0.13000000 0.24986368 0.02254006 FALSE TRUE
MSTRG.15787.8 ENSG00000141627 HEK293_OSMI2_6hA HEK293_TMG_6hB DYM protein_coding   16.93273 12.05275 19.83089 2.527594 0.6096737 0.7179179 2.323322 1.2716638 3.128263 0.6746239 0.47873352 1.2919483 0.12600833 0.09396667 0.15693333 0.06296667 0.60121921 0.02254006 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000141627 E001 17.3928244 0.0825146976 9.405380e-01 9.725421e-01 18 49036387 49041473 5087 - 1.267 1.241 -0.092
ENSG00000141627 E002 184.7536264 0.0003879356 2.605691e-15 4.131711e-13 18 49041474 49043668 2195 - 2.160 2.372 0.706
ENSG00000141627 E003 35.9129274 0.0010792569 4.321323e-01 6.528299e-01 18 49043669 49043803 135 - 1.539 1.586 0.160
ENSG00000141627 E004 35.8693494 0.0028598307 3.125278e-01 5.528584e-01 18 49043804 49043844 41 - 1.535 1.598 0.217
ENSG00000141627 E005 31.9242312 0.0011308956 5.977802e-01 7.688106e-01 18 49043845 49043846 2 - 1.525 1.492 -0.112
ENSG00000141627 E006 36.6782218 0.0010258983 8.015475e-01 8.972164e-01 18 49043847 49043853 7 - 1.562 1.577 0.051
ENSG00000141627 E007 63.0449631 0.0010016952 1.329788e-01 3.364794e-01 18 49043854 49043902 49 - 1.768 1.836 0.231
ENSG00000141627 E008 161.6281504 0.0003938004 4.513003e-07 1.414566e-05 18 49043903 49044204 302 - 2.139 2.281 0.476
ENSG00000141627 E009 2.8085187 0.0086479247 1.761515e-03 1.544097e-02 18 49093217 49093311 95 - 0.315 0.810 2.357
ENSG00000141627 E010 0.0000000       18 49097185 49097401 217 -      
ENSG00000141627 E011 96.3620823 0.0005507167 1.713285e-04 2.348992e-03 18 49097402 49097498 97 - 1.922 2.060 0.464
ENSG00000141627 E012 58.4328252 0.0041806137 2.767304e-01 5.167316e-01 18 49097499 49097515 17 - 1.742 1.804 0.209
ENSG00000141627 E013 0.3337900 0.0484245316 7.742526e-01   18 49114508 49114615 108 - 0.103 0.143 0.553
ENSG00000141627 E014 0.0000000       18 49116025 49116189 165 -      
ENSG00000141627 E015 156.0996692 0.0011437158 5.220899e-02 1.848538e-01 18 49118744 49118926 183 - 2.165 2.228 0.212
ENSG00000141627 E016 117.2978841 0.0007874349 6.304568e-01 7.907598e-01 18 49163685 49163787 103 - 2.062 2.079 0.059
ENSG00000141627 E017 0.0000000       18 49209551 49209715 165 -      
ENSG00000141627 E018 120.1642202 0.0007340287 8.305229e-01 9.140828e-01 18 49257010 49257104 95 - 2.073 2.082 0.031
ENSG00000141627 E019 127.9426670 0.0004310765 2.386654e-01 4.750900e-01 18 49258380 49258493 114 - 2.117 2.081 -0.123
ENSG00000141627 E020 118.6115892 0.0004281974 8.162718e-02 2.481037e-01 18 49272178 49272303 126 - 2.094 2.036 -0.193
ENSG00000141627 E021 149.0836213 0.0009527460 1.856612e-01 4.114034e-01 18 49281997 49282167 171 - 2.188 2.145 -0.144
ENSG00000141627 E022 58.7460228 0.0006559707 8.393999e-01 9.190432e-01 18 49282168 49282175 8 - 1.775 1.766 -0.031
ENSG00000141627 E023 63.6564805 0.0006104852 7.969664e-01 8.945313e-01 18 49286434 49286447 14 - 1.811 1.800 -0.037
ENSG00000141627 E024 57.8061778 0.0007739263 7.636001e-01 8.748295e-01 18 49286448 49286451 4 - 1.771 1.757 -0.047
ENSG00000141627 E025 74.2519125 0.0006130837 8.229188e-01 9.096824e-01 18 49286452 49286487 36 - 1.874 1.865 -0.031
ENSG00000141627 E026 53.7883553 0.0008414974 6.631630e-01 8.118709e-01 18 49286488 49286488 1 - 1.724 1.746 0.074
ENSG00000141627 E027 58.3395096 0.0007179385 5.536605e-01 7.388478e-01 18 49286489 49286496 8 - 1.755 1.784 0.095
ENSG00000141627 E028 84.8168776 0.0004830630 2.882139e-01 5.289559e-01 18 49286497 49286613 117 - 1.944 1.902 -0.139
ENSG00000141627 E029 28.0560205 0.0013413047 1.545953e-01 3.688604e-01 18 49286614 49286616 3 - 1.497 1.401 -0.329
ENSG00000141627 E030 0.4632531 0.0245262376 1.671639e-01   18 49321125 49321377 253 - 0.255 0.000 -12.235
ENSG00000141627 E031 0.6787990 0.0563136793 9.258555e-02   18 49329573 49329707 135 - 0.316 0.000 -12.658
ENSG00000141627 E032 101.5567811 0.0006578452 6.170713e-03 4.056237e-02 18 49331864 49332006 143 - 2.039 1.937 -0.343
ENSG00000141627 E033 72.3682012 0.0024431020 4.408503e-02 1.653357e-01 18 49333728 49333853 126 - 1.891 1.793 -0.329
ENSG00000141627 E034 0.0000000       18 49359749 49359872 124 -      
ENSG00000141627 E035 56.3555545 0.0007429202 8.280449e-02 2.503357e-01 18 49363161 49363218 58 - 1.781 1.698 -0.283
ENSG00000141627 E036 39.1811530 0.0009164666 2.359139e-01 4.718844e-01 18 49363219 49363233 15 - 1.621 1.553 -0.230
ENSG00000141627 E037 0.0000000       18 49368602 49368617 16 -      
ENSG00000141627 E038 0.0000000       18 49368618 49368671 54 -      
ENSG00000141627 E039 0.1614157 0.0352617770 7.100888e-01   18 49368672 49368713 42 - 0.103 0.000 -10.652
ENSG00000141627 E040 0.0000000       18 49375648 49375724 77 -      
ENSG00000141627 E041 61.4215200 0.0009907656 1.343947e-01 3.387206e-01 18 49378567 49378622 56 - 1.813 1.743 -0.236
ENSG00000141627 E042 51.8668074 0.0007468352 4.053151e-02 1.561343e-01 18 49378623 49378658 36 - 1.754 1.651 -0.349
ENSG00000141627 E043 65.0951747 0.0009043306 9.094884e-02 2.654231e-01 18 49378659 49378700 42 - 1.842 1.766 -0.256
ENSG00000141627 E044 91.5838252 0.0008007094 1.204593e-01 3.165651e-01 18 49379665 49379745 81 - 1.981 1.921 -0.201
ENSG00000141627 E045 58.3419478 0.0007937806 7.422524e-02 2.332085e-01 18 49379746 49379758 13 - 1.798 1.714 -0.286
ENSG00000141627 E046 1.1529431 0.4160974045 6.514227e-01   18 49390720 49390812 93 - 0.257 0.446 1.150
ENSG00000141627 E047 0.3751086 0.0291284629 1.142882e-01   18 49391385 49391451 67 - 0.000 0.251 12.723
ENSG00000141627 E048 56.4185397 0.0012376306 6.157469e-02 2.063299e-01 18 49391593 49391609 17 - 1.789 1.697 -0.312
ENSG00000141627 E049 51.9243061 0.0009290922 2.624538e-01 5.016511e-01 18 49391610 49391619 10 - 1.739 1.683 -0.190
ENSG00000141627 E050 57.7257487 0.0007559220 8.859793e-02 2.611784e-01 18 49391620 49391642 23 - 1.795 1.714 -0.273
ENSG00000141627 E051 37.1091663 0.0010574259 9.876206e-02 2.796230e-01 18 49391643 49391645 3 - 1.615 1.518 -0.331
ENSG00000141627 E052 0.5283420 0.4261569637 9.310817e-01   18 49393645 49393742 98 - 0.189 0.144 -0.470
ENSG00000141627 E053 0.0000000       18 49411905 49411941 37 -      
ENSG00000141627 E054 0.0000000       18 49412967 49413132 166 -      
ENSG00000141627 E055 0.6258862 0.0193874923 1.706503e-01   18 49417935 49417938 4 - 0.103 0.336 2.134
ENSG00000141627 E056 1.1598377 0.0839824209 9.348083e-01   18 49417939 49418053 115 - 0.317 0.336 0.116
ENSG00000141627 E057 0.5587019 0.3190145817 8.843245e-01   18 49418054 49418057 4 - 0.189 0.146 -0.446
ENSG00000141627 E058 111.7632439 0.0004305942 9.665456e-04 9.644047e-03 18 49430255 49430447 193 - 2.089 1.975 -0.384
ENSG00000141627 E059 72.2785536 0.0005536112 9.473382e-01 9.759772e-01 18 49460398 49460802 405 - 1.860 1.858 -0.008
ENSG00000141627 E060 0.0000000       18 49461176 49461347 172 -