ENSG00000141564

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000306801 ENSG00000141564 HEK293_OSMI2_6hA HEK293_TMG_6hB RPTOR protein_coding protein_coding 20.05184 30.24167 11.06485 4.837704 0.2325266 -1.449727 13.650916 21.866609 9.3489782 3.0961189 0.5987000 -1.224966 0.72287917 0.72866667 0.8434 0.11473333 3.156666e-01 1.558018e-07 FALSE TRUE
ENST00000575542 ENSG00000141564 HEK293_OSMI2_6hA HEK293_TMG_6hB RPTOR protein_coding processed_transcript 20.05184 30.24167 11.06485 4.837704 0.2325266 -1.449727 2.608081 2.568576 0.0000000 0.9957318 0.0000000 -8.010431 0.09793333 0.07980000 0.0000 -0.07980000 1.558018e-07 1.558018e-07 FALSE TRUE
MSTRG.15244.9 ENSG00000141564 HEK293_OSMI2_6hA HEK293_TMG_6hB RPTOR protein_coding   20.05184 30.24167 11.06485 4.837704 0.2325266 -1.449727 1.197156 2.149889 0.5007099 0.5815545 0.1383782 -2.080381 0.05497917 0.06856667 0.0457 -0.02286667 7.343510e-01 1.558018e-07 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000141564 E001 0.5421338 0.0226886259 1.158722e-01   17 80544724 80544806 83 + 0.331 0.073 -2.646
ENSG00000141564 E002 0.5115862 0.0206066177 6.812286e-01   17 80544807 80544818 12 + 0.196 0.135 -0.648
ENSG00000141564 E003 0.5115862 0.0206066177 6.812286e-01   17 80544819 80544830 12 + 0.196 0.135 -0.648
ENSG00000141564 E004 3.4995615 0.0074243340 3.174233e-01 5.573961e-01 17 80544831 80544837 7 + 0.699 0.551 -0.646
ENSG00000141564 E005 48.6179564 0.0009410135 2.356268e-07 7.961571e-06 17 80544838 80544873 36 + 1.816 1.556 -0.885
ENSG00000141564 E006 51.7275201 0.0009910065 7.210242e-08 2.770283e-06 17 80544874 80544876 3 + 1.846 1.581 -0.897
ENSG00000141564 E007 298.0593827 0.0002298854 1.382076e-05 2.774330e-04 17 80544877 80545467 591 + 2.472 2.388 -0.281
ENSG00000141564 E008 161.5085478 0.0004172406 1.783211e-02 8.846747e-02 17 80545468 80545665 198 + 2.188 2.128 -0.199
ENSG00000141564 E009 156.3710645 0.0050305883 4.544649e-02 1.686760e-01 17 80545666 80545791 126 + 2.187 2.106 -0.272
ENSG00000141564 E010 0.3337900 0.0371054711 3.946463e-01   17 80593244 80593805 562 + 0.196 0.073 -1.646
ENSG00000141564 E011 136.3362238 0.0030163193 6.479998e-03 4.209520e-02 17 80625691 80625793 103 + 2.144 2.041 -0.344
ENSG00000141564 E012 124.3288752 0.0065853466 8.679589e-04 8.833186e-03 17 80643728 80643810 83 + 2.146 1.986 -0.537
ENSG00000141564 E013 150.0485774 0.0012947806 2.697400e-07 8.981973e-06 17 80707841 80707999 159 + 2.232 2.065 -0.558
ENSG00000141564 E014 0.3393995 0.0249830740 3.052342e-02   17 80708933 80709114 182 + 0.331 0.000 -13.534
ENSG00000141564 E015 133.6196718 0.0003187543 2.508951e-04 3.229818e-03 17 80730560 80730706 147 + 2.144 2.035 -0.363
ENSG00000141564 E016 0.0000000       17 80743287 80743427 141 +      
ENSG00000141564 E017 136.9770657 0.0016679511 1.698074e-03 1.500297e-02 17 80754010 80754185 176 + 2.152 2.050 -0.342
ENSG00000141564 E018 1.6791583 0.0120726060 4.157181e-02 1.588196e-01 17 80754186 80755098 913 + 0.000 0.451 13.541
ENSG00000141564 E019 72.7679149 0.0048806063 2.141288e-01 4.465238e-01 17 80791450 80791509 60 + 1.846 1.793 -0.179
ENSG00000141564 E020 112.7546043 0.0004723697 1.538316e-02 7.952070e-02 17 80822201 80822301 101 + 2.048 1.974 -0.250
ENSG00000141564 E021 153.7585539 0.0003051962 2.517065e-01 4.897367e-01 17 80823079 80823223 145 + 2.140 2.120 -0.068
ENSG00000141564 E022 3.5992620 0.0075434610 9.351639e-01 9.697725e-01 17 80823224 80823620 397 + 0.586 0.613 0.117
ENSG00000141564 E023 119.0965265 0.0003734728 3.680784e-01 6.024595e-01 17 80837922 80837997 76 + 2.028 2.011 -0.055
ENSG00000141564 E024 125.4351866 0.0004828493 3.399381e-01 5.778977e-01 17 80846473 80846574 102 + 2.050 2.032 -0.063
ENSG00000141564 E025 112.2950479 0.0004157407 7.196884e-01 8.480279e-01 17 80855464 80855547 84 + 1.986 1.989 0.010
ENSG00000141564 E026 154.5242290 0.0006227314 7.925754e-01 8.919119e-01 17 80857790 80857900 111 + 2.120 2.126 0.023
ENSG00000141564 E027 0.6479912 0.3317281479 4.068790e-01   17 80857901 80858124 224 + 0.000 0.238 10.949
ENSG00000141564 E028 133.7120274 0.0005642032 2.023083e-02 9.667840e-02 17 80880415 80880489 75 + 2.112 2.046 -0.221
ENSG00000141564 E029 129.1355515 0.0004229104 4.436563e-03 3.158773e-02 17 80883419 80883484 66 + 2.110 2.026 -0.283
ENSG00000141564 E030 181.6855553 0.0002770145 3.224765e-04 3.959220e-03 17 80883781 80883972 192 + 2.261 2.171 -0.301
ENSG00000141564 E031 141.5989804 0.0004137078 1.368431e-02 7.309506e-02 17 80885008 80885148 141 + 2.138 2.072 -0.222
ENSG00000141564 E032 141.1882457 0.0003366697 3.056367e-02 1.290378e-01 17 80891720 80891837 118 + 2.129 2.073 -0.188
ENSG00000141564 E033 163.5106798 0.0004691482 2.199830e-02 1.025747e-01 17 80892729 80892869 141 + 2.191 2.134 -0.189
ENSG00000141564 E034 154.8233830 0.0061834946 4.956295e-01 6.979154e-01 17 80893707 80893865 159 + 2.134 2.119 -0.050
ENSG00000141564 E035 119.0575703 0.0031739362 7.803093e-01 8.849606e-01 17 80908811 80908929 119 + 2.007 2.013 0.020
ENSG00000141564 E036 0.1723744 0.0461144062 1.000000e+00   17 80909554 80909867 314 + 0.000 0.073 9.765
ENSG00000141564 E037 122.6332666 0.0006258467 2.124298e-01 4.445876e-01 17 80922724 80922827 104 + 1.976 2.043 0.225
ENSG00000141564 E038 170.4044210 0.0003686744 4.220502e-02 1.604482e-01 17 80923490 80923673 184 + 2.104 2.190 0.286
ENSG00000141564 E039 0.3641499 0.0321043596 3.924365e-01   17 80923674 80924172 499 + 0.196 0.073 -1.644
ENSG00000141564 E040 118.4447408 0.0306019964 4.291496e-01 6.503786e-01 17 80925370 80925480 111 + 1.951 2.027 0.256
ENSG00000141564 E041 140.7956415 0.0852748156 2.937312e-01 5.343646e-01 17 80940496 80940601 106 + 1.989 2.109 0.403
ENSG00000141564 E042 0.4756169 0.0752812353 4.820419e-01   17 80945567 80945666 100 + 0.000 0.189 11.136
ENSG00000141564 E043 160.9984087 0.0002893819 1.911787e-01 4.183483e-01 17 80945667 80945781 115 + 2.098 2.160 0.205
ENSG00000141564 E044 185.6857804 0.0002498888 4.813376e-01 6.879730e-01 17 80947227 80947351 125 + 2.175 2.214 0.132
ENSG00000141564 E045 0.3503582 0.0445106184 3.947294e-01   17 80948550 80948659 110 + 0.196 0.073 -1.648
ENSG00000141564 E046 156.7012210 0.0002895978 1.759768e-01 3.984296e-01 17 80949443 80949547 105 + 2.084 2.148 0.213
ENSG00000141564 E047 177.0365541 0.0004504847 2.960043e-02 1.261582e-01 17 80957624 80957730 107 + 2.116 2.204 0.295
ENSG00000141564 E048 194.1397123 0.0097140825 4.896913e-02 1.771679e-01 17 80960078 80960205 128 + 2.130 2.248 0.394
ENSG00000141564 E049 181.2434205 0.1999228730 1.328009e-01 3.361902e-01 17 80961394 80961480 87 + 1.987 2.239 0.845
ENSG00000141564 E050 227.7034651 0.0253521608 1.815302e-02 8.953560e-02 17 80962461 80962577 117 + 2.134 2.330 0.654
ENSG00000141564 E051 230.5936297 0.0002964154 8.291367e-09 3.968616e-07 17 80962928 80963057 130 + 2.147 2.337 0.635
ENSG00000141564 E052 1257.7084005 0.0003795132 1.875728e-16 3.462411e-14 17 80964262 80966371 2110 + 2.930 3.060 0.434