ENSG00000141524

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000392467 ENSG00000141524 HEK293_OSMI2_6hA HEK293_TMG_6hB TMC6 protein_coding protein_coding 9.795122 15.77662 5.757089 0.9701257 0.4568237 -1.452787 1.0009695 1.5677899 1.3845349 0.15567738 0.25714112 -0.17812111 0.11587917 0.09896667 0.23780000 0.13883333 0.008439167 0.008439167 FALSE TRUE
ENST00000589553 ENSG00000141524 HEK293_OSMI2_6hA HEK293_TMG_6hB TMC6 protein_coding protein_coding 9.795122 15.77662 5.757089 0.9701257 0.4568237 -1.452787 0.5022876 0.5870842 0.2741309 0.06612136 0.05236751 -1.07137870 0.05362500 0.03730000 0.04926667 0.01196667 0.861207807 0.008439167 FALSE TRUE
ENST00000589933 ENSG00000141524 HEK293_OSMI2_6hA HEK293_TMG_6hB TMC6 protein_coding retained_intron 9.795122 15.77662 5.757089 0.9701257 0.4568237 -1.452787 0.9020979 1.0929261 1.0232770 0.30512007 0.23722742 -0.09410903 0.09798333 0.06843333 0.17490000 0.10646667 0.148627561 0.008439167 FALSE FALSE
ENST00000590494 ENSG00000141524 HEK293_OSMI2_6hA HEK293_TMG_6hB TMC6 protein_coding retained_intron 9.795122 15.77662 5.757089 0.9701257 0.4568237 -1.452787 0.5082295 0.6428125 0.3283005 0.37921805 0.08940995 -0.94836350 0.05330000 0.03936667 0.05516667 0.01580000 0.791231793 0.008439167   FALSE
ENST00000591436 ENSG00000141524 HEK293_OSMI2_6hA HEK293_TMG_6hB TMC6 protein_coding protein_coding 9.795122 15.77662 5.757089 0.9701257 0.4568237 -1.452787 1.1526990 1.9641572 0.5289825 0.25936207 0.17313330 -1.87292660 0.11216250 0.12763333 0.08833333 -0.03930000 0.797857926 0.008439167 FALSE TRUE
MSTRG.15169.6 ENSG00000141524 HEK293_OSMI2_6hA HEK293_TMG_6hB TMC6 protein_coding   9.795122 15.77662 5.757089 0.9701257 0.4568237 -1.452787 1.8143104 3.4698022 0.2535826 0.68118919 0.25358260 -3.72267828 0.17231667 0.22520000 0.05230000 -0.17290000 0.255343575 0.008439167 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000141524 E001 0.1426347 0.0318055564 0.113731895   17 78106864 78107396 533 - 0.213 0.000 -11.592
ENSG00000141524 E002 0.0000000       17 78107397 78107397 1 -      
ENSG00000141524 E003 3.1192034 0.0091752023 0.972607150 0.98824987 17 78107398 78107840 443 - 0.549 0.539 -0.044
ENSG00000141524 E004 2.4096845 0.0096201986 0.466712375 0.67784017 17 78107841 78109050 1210 - 0.356 0.496 0.747
ENSG00000141524 E005 25.9735061 0.0017328474 0.003585470 0.02685197 17 78109051 78112918 3868 - 1.507 1.283 -0.776
ENSG00000141524 E006 1.0773729 0.0156662487 0.187975999   17 78112919 78112920 2 - 0.463 0.219 -1.543
ENSG00000141524 E007 1.2801071 0.0137756338 0.278478344   17 78112921 78112921 1 - 0.463 0.260 -1.219
ENSG00000141524 E008 1.2801071 0.0137756338 0.278478344   17 78112922 78112924 3 - 0.463 0.260 -1.219
ENSG00000141524 E009 36.2896248 0.0012942186 0.649413865 0.80306860 17 78112925 78113075 151 - 1.507 1.472 -0.119
ENSG00000141524 E010 41.2674564 0.0009079969 0.769824315 0.87855180 17 78113076 78113147 72 - 1.524 1.541 0.058
ENSG00000141524 E011 40.2323274 0.0009029763 0.356332390 0.59282213 17 78113148 78113211 64 - 1.480 1.541 0.207
ENSG00000141524 E012 48.4307901 0.0011038282 0.677395783 0.82106807 17 78113548 78113621 74 - 1.585 1.607 0.076
ENSG00000141524 E013 30.4713448 0.0018680759 0.587798899 0.76219608 17 78113622 78113624 3 - 1.442 1.397 -0.156
ENSG00000141524 E014 5.4149060 0.2538697055 0.348627484 0.58608056 17 78113625 78113959 335 - 0.862 0.686 -0.705
ENSG00000141524 E015 33.9667155 0.0041166024 0.706405449 0.83958940 17 78117269 78117315 47 - 1.480 1.445 -0.118
ENSG00000141524 E016 32.5678118 0.0094730967 0.631999892 0.79169807 17 78117316 78117347 32 - 1.470 1.423 -0.164
ENSG00000141524 E017 58.9836393 0.0040383229 0.432558028 0.65316008 17 78117468 78117644 177 - 1.729 1.677 -0.177
ENSG00000141524 E018 46.0429360 0.0008664770 0.946431960 0.97554499 17 78117802 78117935 134 - 1.585 1.587 0.007
ENSG00000141524 E019 9.4509127 0.0869763198 0.005478967 0.03710687 17 78117936 78118172 237 - 1.255 0.791 -1.715
ENSG00000141524 E020 36.9659480 0.0010329697 0.659682495 0.80979349 17 78118971 78119046 76 - 1.471 1.500 0.099
ENSG00000141524 E021 4.3839887 0.0095101232 0.328252282 0.56727304 17 78119062 78119296 235 - 0.784 0.631 -0.635
ENSG00000141524 E022 49.1726211 0.0010685226 0.422403668 0.64542151 17 78119297 78119392 96 - 1.571 1.618 0.160
ENSG00000141524 E023 4.0203887 0.0071053194 0.385675540 0.61699733 17 78120177 78120408 232 - 0.736 0.596 -0.594
ENSG00000141524 E024 6.6852878 0.0614128240 0.282477632 0.52288894 17 78120409 78120555 147 - 0.938 0.760 -0.691
ENSG00000141524 E025 4.8962399 0.0537609054 0.479793559 0.68693036 17 78120556 78120652 97 - 0.785 0.664 -0.496
ENSG00000141524 E026 56.6835034 0.0008307144 0.388696961 0.61942696 17 78120653 78120832 180 - 1.709 1.658 -0.172
ENSG00000141524 E027 5.4194050 0.0113229897 0.385711611 0.61703030 17 78120833 78121012 180 - 0.827 0.694 -0.538
ENSG00000141524 E028 51.1831975 0.0033080476 0.720036690 0.84822169 17 78121013 78121164 152 - 1.645 1.617 -0.098
ENSG00000141524 E029 39.7620076 0.0009768903 0.762297683 0.87397769 17 78121556 78121711 156 - 1.507 1.524 0.060
ENSG00000141524 E030 0.6190593 0.0212028054 0.021513639   17 78122560 78122604 45 - 0.463 0.066 -3.536
ENSG00000141524 E031 52.1376789 0.0007400932 0.983446526 0.99352671 17 78122605 78122749 145 - 1.639 1.637 -0.005
ENSG00000141524 E032 1.0697382 0.0153311176 0.189638188   17 78122946 78123123 178 - 0.463 0.219 -1.540
ENSG00000141524 E033 64.0034790 0.0007007176 0.933157378 0.96875593 17 78123989 78124178 190 - 1.725 1.727 0.008
ENSG00000141524 E034 21.5024320 0.0018393386 0.602509003 0.77188768 17 78124179 78124179 1 - 1.227 1.272 0.157
ENSG00000141524 E035 5.4897704 0.1371265668 0.415156101 0.63990910 17 78124180 78124523 344 - 0.551 0.765 0.917
ENSG00000141524 E036 26.3705870 0.0018587234 0.467879898 0.67862323 17 78124524 78124557 34 - 1.302 1.360 0.203
ENSG00000141524 E037 31.0046513 0.0017678276 0.414759815 0.63964335 17 78124558 78124655 98 - 1.471 1.409 -0.212
ENSG00000141524 E038 28.6370999 0.0012677161 0.924816167 0.96472942 17 78124656 78124781 126 - 1.389 1.379 -0.035
ENSG00000141524 E039 29.1138167 0.0011975815 0.544654856 0.73236694 17 78124889 78124985 97 - 1.354 1.399 0.157
ENSG00000141524 E040 2.7593027 0.2387827408 0.742198920 0.86176750 17 78125080 78125157 78 - 0.549 0.485 -0.308
ENSG00000141524 E041 35.4335639 0.0042773594 0.186173122 0.41203979 17 78125158 78125232 75 - 1.389 1.492 0.352
ENSG00000141524 E042 28.5888162 0.0025947785 0.379203537 0.61156203 17 78125233 78125263 31 - 1.329 1.401 0.248
ENSG00000141524 E043 32.6476345 0.0082666307 0.459371176 0.67273007 17 78125726 78125753 28 - 1.390 1.455 0.224
ENSG00000141524 E044 49.4991590 0.0060260937 0.662048703 0.81112377 17 78125754 78125884 131 - 1.593 1.624 0.107
ENSG00000141524 E045 0.9271035 0.0172671820 0.471390890   17 78125885 78125922 38 - 0.356 0.219 -0.956
ENSG00000141524 E046 1.7177294 0.1342019467 0.623444728 0.78618876 17 78125923 78126064 142 - 0.462 0.362 -0.544
ENSG00000141524 E047 0.9983494 0.3032049995 0.928817661   17 78126065 78126195 131 - 0.215 0.261 0.362
ENSG00000141524 E048 1.0230998 0.1227082455 0.229287936   17 78126196 78126276 81 - 0.000 0.300 10.266
ENSG00000141524 E049 40.7733887 0.0043385644 0.825071475 0.91098066 17 78126277 78126366 90 - 1.524 1.539 0.054
ENSG00000141524 E050 36.4766641 0.0046543711 0.443252250 0.66091862 17 78126524 78126596 73 - 1.442 1.501 0.203
ENSG00000141524 E051 32.8273599 0.0013936881 0.285146380 0.52573515 17 78126597 78126648 52 - 1.378 1.457 0.274
ENSG00000141524 E052 43.8265002 0.0026305622 0.509932465 0.70795328 17 78126777 78126906 130 - 1.532 1.576 0.150
ENSG00000141524 E053 6.3769588 0.0058129903 0.020689024 0.09830094 17 78126907 78126974 68 - 1.022 0.720 -1.166
ENSG00000141524 E054 4.0509363 0.0068991887 0.190348621 0.41739501 17 78126975 78127020 46 - 0.784 0.578 -0.868
ENSG00000141524 E055 15.7239745 0.0024613846 0.006787417 0.04363985 17 78128612 78128658 47 - 0.866 1.188 1.181
ENSG00000141524 E056 27.5352642 0.0016212829 0.025125002 0.11261027 17 78128659 78128799 141 - 1.211 1.404 0.677
ENSG00000141524 E057 0.0000000       17 78130637 78130683 47 -      
ENSG00000141524 E058 0.0000000       17 78131001 78131397 397 -      
ENSG00000141524 E059 0.0000000       17 78132150 78132340 191 -      
ENSG00000141524 E060 0.0000000       17 78132341 78132407 67 -