ENSG00000141522

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000269321 ENSG00000141522 HEK293_OSMI2_6hA HEK293_TMG_6hB ARHGDIA protein_coding protein_coding 457.2328 757.9663 253.2168 186.8856 11.27741 -1.581723 377.647082 651.721267 178.23811 176.2891678 9.686719 -1.8703905 0.77624583 0.84483333 0.70330000 -0.14153333 6.691896e-02 2.307833e-07 FALSE TRUE
ENST00000580033 ENSG00000141522 HEK293_OSMI2_6hA HEK293_TMG_6hB ARHGDIA protein_coding nonsense_mediated_decay 457.2328 757.9663 253.2168 186.8856 11.27741 -1.581723 9.262401 1.907107 17.40251 0.5675683 7.499903 3.1831213 0.03261667 0.00250000 0.06963333 0.06713333 2.307833e-07 2.307833e-07   TRUE
ENST00000583111 ENSG00000141522 HEK293_OSMI2_6hA HEK293_TMG_6hB ARHGDIA protein_coding retained_intron 457.2328 757.9663 253.2168 186.8856 11.27741 -1.581723 12.489093 10.184838 19.27157 1.3317503 3.407755 0.9193834 0.04433333 0.01683333 0.07670000 0.05986667 2.792201e-02 2.307833e-07 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000141522 E001 30.262031 0.1115668495 3.509102e-01 5.880927e-01 17 81867719 81867720 2 - 1.290 1.398 0.374
ENSG00000141522 E002 2288.041744 1.7258367140 4.838761e-01 6.896799e-01 17 81867721 81867896 176 - 3.075 3.267 0.639
ENSG00000141522 E003 1730.835186 1.6488581527 4.887382e-01 6.931601e-01 17 81867897 81867919 23 - 2.969 3.144 0.582
ENSG00000141522 E004 5510.380070 2.0029613918 5.208500e-01 7.154932e-01 17 81867920 81868259 340 - 3.467 3.647 0.599
ENSG00000141522 E005 2553.431292 1.7936898758 5.362366e-01 7.264767e-01 17 81868260 81868339 80 - 3.169 3.308 0.462
ENSG00000141522 E006 1754.091769 1.6701560115 5.125109e-01 7.098649e-01 17 81868340 81868365 26 - 2.998 3.146 0.492
ENSG00000141522 E007 3067.682552 1.8140222057 4.881989e-01 6.927887e-01 17 81868366 81868505 140 - 3.198 3.395 0.652
ENSG00000141522 E008 2671.166322 0.1239286007 8.543169e-02 2.554003e-01 17 81868506 81868584 79 - 3.138 3.335 0.652
ENSG00000141522 E009 1750.353066 0.0698715938 8.855736e-02 2.611042e-01 17 81868585 81868610 26 - 2.995 3.146 0.502
ENSG00000141522 E010 1486.962449 0.0320683947 2.988710e-02 1.269990e-01 17 81868611 81868630 20 - 2.924 3.075 0.502
ENSG00000141522 E011 3354.602380 0.0001081406 3.111980e-09 1.632136e-07 17 81868631 81868869 239 - 3.368 3.420 0.175
ENSG00000141522 E012 1994.942752 0.0097160526 1.889560e-01 4.156453e-01 17 81868870 81868921 52 - 3.228 3.169 -0.196
ENSG00000141522 E013 1984.309107 0.0131388384 5.940848e-02 2.014763e-01 17 81868922 81868943 22 - 3.260 3.158 -0.340
ENSG00000141522 E014 2416.820896 0.0102791073 7.306983e-02 2.309567e-01 17 81868944 81868988 45 - 3.330 3.247 -0.276
ENSG00000141522 E015 2316.358990 0.0107424192 5.720974e-02 1.964877e-01 17 81868989 81869003 15 - 3.317 3.228 -0.299
ENSG00000141522 E016 2718.157897 0.0122813709 4.543795e-02 1.686684e-01 17 81869004 81869048 45 - 3.394 3.295 -0.331
ENSG00000141522 E017 1871.804605 0.0114560480 3.728914e-03 2.763015e-02 17 81869049 81869055 7 - 3.270 3.123 -0.488
ENSG00000141522 E018 2123.560796 0.0121723454 2.939002e-03 2.303018e-02 17 81869056 81869075 20 - 3.330 3.176 -0.511
ENSG00000141522 E019 6.596146 0.0288539602 2.805517e-04 3.534989e-03 17 81869166 81869172 7 - 1.154 0.643 -1.965
ENSG00000141522 E020 2710.122380 0.0146037292 3.021827e-02 1.279932e-01 17 81869173 81869236 64 - 3.408 3.289 -0.395
ENSG00000141522 E021 43.694277 0.1526789405 4.665496e-02 1.717066e-01 17 81869237 81869301 65 - 1.836 1.428 -1.388
ENSG00000141522 E022 29.539018 0.0729913469 3.187400e-03 2.453623e-02 17 81869302 81869329 28 - 1.702 1.247 -1.567
ENSG00000141522 E023 3395.005436 0.0192671117 1.476488e-01 3.589047e-01 17 81869330 81869406 77 - 3.479 3.394 -0.282
ENSG00000141522 E024 78.379051 0.0345741689 3.131474e-01 5.533839e-01 17 81869407 81869437 31 - 1.875 1.759 -0.390
ENSG00000141522 E025 96.811615 0.0414988384 2.303781e-01 4.655351e-01 17 81869438 81869522 85 - 1.990 1.842 -0.497
ENSG00000141522 E026 83.486351 0.0504902782 4.199093e-01 6.436118e-01 17 81869523 81869541 19 - 1.902 1.786 -0.391
ENSG00000141522 E027 3710.510873 0.0188381104 2.282088e-01 4.631789e-01 17 81869542 81869625 84 - 3.505 3.436 -0.229
ENSG00000141522 E028 12.068035 0.1090060363 2.934627e-01 5.341474e-01 17 81869626 81869740 115 - 1.174 0.955 -0.796
ENSG00000141522 E029 5510.838104 0.0202975003 8.016246e-02 2.451368e-01 17 81869741 81869957 217 - 3.708 3.600 -0.360
ENSG00000141522 E030 92.644853 0.0979586560 4.276217e-02 1.619392e-01 17 81869958 81870265 308 - 2.113 1.770 -1.155
ENSG00000141522 E031 313.550522 0.0234193800 6.577308e-01 8.084802e-01 17 81870636 81871297 662 - 2.411 2.371 -0.136
ENSG00000141522 E032 2261.143124 0.0144804634 4.258059e-02 1.614459e-01 17 81871298 81871378 81 - 3.328 3.211 -0.386