ENSG00000141519

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000269318 ENSG00000141519 HEK293_OSMI2_6hA HEK293_TMG_6hB CCDC40 protein_coding protein_coding 4.263787 5.493633 3.196193 0.4937767 0.1869156 -0.7795228 0.9252650 1.3684297 0.6113180 0.23594811 0.071548503 -1.1496219 0.21577500 0.25913333 0.19103333 -0.06810000 0.841647177 0.003527532 FALSE TRUE
ENST00000374876 ENSG00000141519 HEK293_OSMI2_6hA HEK293_TMG_6hB CCDC40 protein_coding protein_coding 4.263787 5.493633 3.196193 0.4937767 0.1869156 -0.7795228 0.3879501 0.4670834 0.3925406 0.07468525 0.074671712 -0.2451072 0.08924167 0.08500000 0.12183333 0.03683333 0.744847850 0.003527532 FALSE TRUE
ENST00000572083 ENSG00000141519 HEK293_OSMI2_6hA HEK293_TMG_6hB CCDC40 protein_coding retained_intron 4.263787 5.493633 3.196193 0.4937767 0.1869156 -0.7795228 0.3170329 0.2016822 0.5922597 0.07359738 0.063626167 1.5084860 0.08450000 0.03880000 0.18473333 0.14593333 0.003527532 0.003527532 FALSE TRUE
ENST00000574799 ENSG00000141519 HEK293_OSMI2_6hA HEK293_TMG_6hB CCDC40 protein_coding retained_intron 4.263787 5.493633 3.196193 0.4937767 0.1869156 -0.7795228 0.3872434 0.4033658 0.4533242 0.10047285 0.008554754 0.1646033 0.09014583 0.07146667 0.14273333 0.07126667 0.277384841 0.003527532 FALSE TRUE
ENST00000574933 ENSG00000141519 HEK293_OSMI2_6hA HEK293_TMG_6hB CCDC40 protein_coding retained_intron 4.263787 5.493633 3.196193 0.4937767 0.1869156 -0.7795228 0.4320810 0.3597848 0.1759215 0.18751309 0.088262412 -0.9919920 0.09665417 0.06853333 0.05766667 -0.01086667 1.000000000 0.003527532   FALSE
ENST00000576241 ENSG00000141519 HEK293_OSMI2_6hA HEK293_TMG_6hB CCDC40 protein_coding retained_intron 4.263787 5.493633 3.196193 0.4937767 0.1869156 -0.7795228 0.5543557 0.9525612 0.2570067 0.48625754 0.257006724 -1.8500022 0.12187500 0.16076667 0.07383333 -0.08693333 0.738619853 0.003527532 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000141519 E001 2.7315882 0.016428733 0.8470570004 0.923344979 17 80036608 80036631 24 + 0.487 0.535 0.229
ENSG00000141519 E002 2.4580854 0.071514314 0.6564808401 0.807634123 17 80036632 80036635 4 + 0.407 0.514 0.543
ENSG00000141519 E003 2.7613279 0.030464870 0.4568899168 0.670930394 17 80036636 80036641 6 + 0.407 0.561 0.765
ENSG00000141519 E004 2.6950713 0.009352831 0.8544369700 0.927283958 17 80036642 80036651 10 + 0.487 0.534 0.223
ENSG00000141519 E005 3.3306988 0.008734055 0.4454492791 0.662395322 17 80036652 80036657 6 + 0.665 0.559 -0.468
ENSG00000141519 E006 3.2891926 0.007634371 0.4443458212 0.661651241 17 80036658 80036660 3 + 0.665 0.558 -0.469
ENSG00000141519 E007 3.4615670 0.007737774 0.5331648379 0.724309272 17 80036661 80036663 3 + 0.665 0.582 -0.362
ENSG00000141519 E008 4.4743283 0.006345068 0.4839349171 0.689740576 17 80036664 80036676 13 + 0.753 0.665 -0.361
ENSG00000141519 E009 6.0326672 0.004863964 0.9959019239 0.999574775 17 80036677 80036691 15 + 0.791 0.808 0.071
ENSG00000141519 E010 0.7320040 0.194123351 0.5189364827   17 80036692 80036757 66 + 0.310 0.200 -0.839
ENSG00000141519 E011 0.6378404 0.021413042 0.0492212482   17 80037952 80038028 77 + 0.407 0.080 -2.947
ENSG00000141519 E012 11.2921023 0.002987646 0.3242235079 0.563504711 17 80038123 80038186 64 + 1.111 1.027 -0.303
ENSG00000141519 E013 25.2178688 0.005394347 0.2365152955 0.472565881 17 80039812 80040004 193 + 1.429 1.355 -0.257
ENSG00000141519 E014 12.0413128 0.008880384 0.5202443461 0.715123711 17 80040005 80040040 36 + 1.013 1.101 0.322
ENSG00000141519 E015 29.8151386 0.011951863 0.9537608968 0.978793105 17 80040041 80040270 230 + 1.430 1.450 0.070
ENSG00000141519 E016 2.3215784 0.009571211 0.0204822027 0.097610413 17 80040271 80040535 265 + 0.711 0.344 -1.776
ENSG00000141519 E017 11.2173537 0.004718656 0.2048261200 0.435679131 17 80047279 80047308 30 + 0.917 1.081 0.608
ENSG00000141519 E018 13.7293320 0.003258185 0.3865079661 0.617722358 17 80047309 80047402 94 + 1.035 1.143 0.389
ENSG00000141519 E019 2.6315751 0.031540800 0.8692997527 0.935509188 17 80047403 80047454 52 + 0.487 0.534 0.227
ENSG00000141519 E020 7.2169338 0.004549517 0.0001694861 0.002329447 17 80048370 80048582 213 + 1.128 0.701 -1.627
ENSG00000141519 E021 22.9626757 0.001684927 0.3913806573 0.621532099 17 80048583 80048761 179 + 1.367 1.320 -0.162
ENSG00000141519 E022 18.7233375 0.002198141 0.7844636007 0.887204473 17 80049906 80049989 84 + 1.218 1.262 0.154
ENSG00000141519 E023 27.1338877 0.001585847 0.0801073681 0.245031233 17 80050064 80050283 220 + 1.293 1.446 0.531
ENSG00000141519 E024 22.7724956 0.189062365 0.2015985806 0.431643889 17 80058494 80058651 158 + 1.147 1.385 0.835
ENSG00000141519 E025 15.2896512 0.163926360 0.2064941131 0.437522767 17 80058858 80058924 67 + 0.999 1.221 0.797
ENSG00000141519 E026 15.9998350 0.113076868 0.1970784959 0.425926987 17 80058925 80058980 56 + 1.025 1.236 0.760
ENSG00000141519 E027 16.1001759 0.023161730 0.2133147520 0.445610036 17 80065485 80065606 122 + 1.073 1.233 0.573
ENSG00000141519 E028 8.9169567 0.016638238 0.0836973994 0.252189327 17 80066083 80066770 688 + 1.076 0.884 -0.712
ENSG00000141519 E029 5.8666872 0.004915614 0.5165787469 0.712734716 17 80066874 80067504 631 + 0.711 0.822 0.444
ENSG00000141519 E030 8.9703905 0.003553913 0.5367106966 0.726848802 17 80067505 80067901 397 + 0.991 0.937 -0.202
ENSG00000141519 E031 0.0000000       17 80081443 80081545 103 +      
ENSG00000141519 E032 11.6208199 0.015221303 0.8867541404 0.944992993 17 80081546 80081789 244 + 1.056 1.052 -0.014
ENSG00000141519 E033 2.5505313 0.018161338 0.1767707545 0.399449190 17 80081790 80081875 86 + 0.309 0.581 1.438
ENSG00000141519 E034 13.6805639 0.049185344 0.8788670589 0.940690528 17 80081876 80082058 183 + 1.115 1.111 -0.014
ENSG00000141519 E035 15.7162374 0.003443022 0.2510705968 0.489124268 17 80084743 80084988 246 + 1.074 1.207 0.476
ENSG00000141519 E036 11.5331066 0.028583783 0.5243692457 0.718050958 17 80086003 80086216 214 + 0.967 1.083 0.426
ENSG00000141519 E037 8.8321479 0.003444783 0.1167302155 0.310359479 17 80086217 80087513 1297 + 1.055 0.894 -0.597
ENSG00000141519 E038 2.1070776 0.009668575 0.0449287310 0.167429547 17 80087514 80087606 93 + 0.665 0.344 -1.586
ENSG00000141519 E039 8.8390626 0.037255949 0.2765698610 0.516558478 17 80087607 80087702 96 + 0.792 0.989 0.753
ENSG00000141519 E040 8.2183787 0.061912675 0.8861737489 0.944658958 17 80087703 80087776 74 + 0.886 0.938 0.197
ENSG00000141519 E041 0.8092192 0.016813452 0.1564896458   17 80087777 80087826 50 + 0.000 0.302 12.625
ENSG00000141519 E042 1.1713439 0.015242063 0.9283827467   17 80087827 80088010 184 + 0.309 0.303 -0.040
ENSG00000141519 E043 8.7728992 0.032130270 0.5596700496 0.743032365 17 80088011 80088102 92 + 0.989 0.929 -0.227
ENSG00000141519 E044 1.0293295 0.016814468 0.7434356296   17 80088103 80088104 2 + 0.309 0.257 -0.361
ENSG00000141519 E045 3.2490914 0.007125170 0.8396841860 0.919220052 17 80088105 80088189 85 + 0.555 0.604 0.221
ENSG00000141519 E046 1.4628199 0.012702012 0.2482518037 0.486040258 17 80088190 80088212 23 + 0.181 0.416 1.635
ENSG00000141519 E047 1.7796665 0.011713596 0.0167423742 0.084519626 17 80088297 80088394 98 + 0.000 0.507 13.581
ENSG00000141519 E048 0.5059767 0.021648499 0.3752707440   17 80089574 80089763 190 + 0.000 0.205 11.979
ENSG00000141519 E049 6.7125816 0.004290343 0.2240405373 0.458234530 17 80089764 80089884 121 + 0.943 0.808 -0.517
ENSG00000141519 E050 2.5325084 0.247514410 0.4401662368 0.658845280 17 80090139 80090819 681 + 0.656 0.452 -0.943
ENSG00000141519 E051 0.3751086 0.027442404 0.6303013180   17 80092079 80092145 67 + 0.000 0.147 11.451
ENSG00000141519 E052 2.7905379 0.155288614 0.8424832395 0.920874034 17 80095263 80095267 5 + 0.558 0.548 -0.047
ENSG00000141519 E053 8.7190985 0.022625769 0.0343889085 0.139944588 17 80095268 80095451 184 + 1.112 0.868 -0.903
ENSG00000141519 E054 8.9358576 0.016677800 0.2496317496 0.487451996 17 80097245 80097403 159 + 1.036 0.915 -0.450
ENSG00000141519 E055 0.6783511 0.019258645 0.2381316379   17 80097404 80097934 531 + 0.000 0.257 12.346
ENSG00000141519 E056 15.2864031 0.035591576 0.2723599615 0.512234726 17 80099527 80100613 1087 + 1.245 1.145 -0.358