ENSG00000141504

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000380466 ENSG00000141504 HEK293_OSMI2_6hA HEK293_TMG_6hB SAT2 protein_coding processed_transcript 84.89185 113.5983 45.93074 20.68336 2.240316 -1.306222 7.771454 8.455534 5.070903 1.6748580 0.6820045 -0.7365162 0.09895000 0.07676667 0.1115000 0.034733333 0.65796754 0.04284907 FALSE  
ENST00000570914 ENSG00000141504 HEK293_OSMI2_6hA HEK293_TMG_6hB SAT2 protein_coding retained_intron 84.89185 113.5983 45.93074 20.68336 2.240316 -1.306222 4.299506 2.670597 5.325817 0.8547111 0.1466365 0.9931548 0.06601250 0.02920000 0.1161667 0.086966667 0.04284907 0.04284907    
ENST00000573566 ENSG00000141504 HEK293_OSMI2_6hA HEK293_TMG_6hB SAT2 protein_coding protein_coding 84.89185 113.5983 45.93074 20.68336 2.240316 -1.306222 11.075401 15.623788 4.632934 3.2215075 0.9777001 -1.7515586 0.12245417 0.13593333 0.1005333 -0.035400000 0.67815110 0.04284907 FALSE  
ENST00000576686 ENSG00000141504 HEK293_OSMI2_6hA HEK293_TMG_6hB SAT2 protein_coding processed_transcript 84.89185 113.5983 45.93074 20.68336 2.240316 -1.306222 13.730481 20.369507 7.144775 4.3781615 1.0012752 -1.5101409 0.15514167 0.17723333 0.1546667 -0.022566667 0.84504859 0.04284907 FALSE  
ENST00000576846 ENSG00000141504 HEK293_OSMI2_6hA HEK293_TMG_6hB SAT2 protein_coding retained_intron 84.89185 113.5983 45.93074 20.68336 2.240316 -1.306222 5.384852 5.994747 4.910395 1.0496314 0.2583187 -0.2873292 0.07867500 0.06130000 0.1070000 0.045700000 0.48320671 0.04284907 FALSE  
MSTRG.13591.3 ENSG00000141504 HEK293_OSMI2_6hA HEK293_TMG_6hB SAT2 protein_coding   84.89185 113.5983 45.93074 20.68336 2.240316 -1.306222 14.045112 21.977855 6.320073 4.8998914 0.6787168 -1.7964128 0.15965833 0.18973333 0.1378667 -0.051866667 0.40892291 0.04284907 FALSE  
MSTRG.13591.7 ENSG00000141504 HEK293_OSMI2_6hA HEK293_TMG_6hB SAT2 protein_coding   84.89185 113.5983 45.93074 20.68336 2.240316 -1.306222 6.104767 7.209386 2.357269 2.4411783 0.7083959 -1.6086525 0.06410417 0.06276667 0.0529000 -0.009866667 0.91584540 0.04284907 FALSE  
MSTRG.13591.8 ENSG00000141504 HEK293_OSMI2_6hA HEK293_TMG_6hB SAT2 protein_coding   84.89185 113.5983 45.93074 20.68336 2.240316 -1.306222 14.970108 22.040436 7.687293 5.2640328 1.0477710 -1.5183840 0.17567917 0.18896667 0.1660667 -0.022900000 0.84853342 0.04284907 TRUE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000141504 E001 5.2275032 0.0065768142 4.812978e-01 6.879276e-01 17 7626234 7626236 3 - 0.681 0.777 0.392
ENSG00000141504 E002 7.5523242 0.0228057875 6.644111e-01 8.126433e-01 17 7626237 7626237 1 - 0.843 0.896 0.204
ENSG00000141504 E003 9.7912997 0.0447816382 6.263751e-01 7.881517e-01 17 7626238 7626241 4 - 0.935 0.997 0.230
ENSG00000141504 E004 16.0447742 0.0507697526 5.000370e-01 7.007766e-01 17 7626242 7626245 4 - 1.252 1.149 -0.366
ENSG00000141504 E005 250.9788869 0.0014428706 8.278565e-01 9.125357e-01 17 7626246 7626336 91 - 2.350 2.342 -0.026
ENSG00000141504 E006 235.5257360 0.0008189996 9.436182e-01 9.741406e-01 17 7626337 7626341 5 - 2.329 2.313 -0.056
ENSG00000141504 E007 300.6575344 0.0015858357 5.652005e-01 7.468587e-01 17 7626342 7626365 24 - 2.445 2.414 -0.104
ENSG00000141504 E008 313.2746661 0.0011748265 6.377202e-01 7.955345e-01 17 7626366 7626387 22 - 2.460 2.433 -0.090
ENSG00000141504 E009 311.7182351 0.0002531755 2.710318e-01 5.110099e-01 17 7626388 7626402 15 - 2.469 2.429 -0.132
ENSG00000141504 E010 638.5208980 0.0003237475 2.337749e-01 4.695378e-01 17 7626403 7626533 131 - 2.747 2.752 0.016
ENSG00000141504 E011 476.4941818 0.0002455439 4.113300e-03 2.979962e-02 17 7626534 7626614 81 - 2.594 2.634 0.131
ENSG00000141504 E012 23.1600060 0.1277595406 1.502487e-01 3.626600e-01 17 7626615 7626706 92 - 1.518 1.237 -0.976
ENSG00000141504 E013 17.7393451 0.0932849038 1.338979e-01 3.379146e-01 17 7626707 7626752 46 - 1.395 1.138 -0.904
ENSG00000141504 E014 286.2009768 0.0004793509 6.792028e-01 8.222255e-01 17 7626753 7626781 29 - 2.407 2.403 -0.014
ENSG00000141504 E015 255.0862868 0.0005999908 8.323804e-01 9.151938e-01 17 7626782 7626793 12 - 2.368 2.348 -0.067
ENSG00000141504 E016 53.0219173 0.0824490477 1.633573e-02 8.302209e-02 17 7626794 7626942 149 - 1.913 1.549 -1.230
ENSG00000141504 E017 40.4460549 0.0205267842 2.387198e-03 1.960543e-02 17 7626943 7626945 3 - 1.759 1.463 -1.008
ENSG00000141504 E018 42.6947717 0.0194473493 2.167297e-03 1.818864e-02 17 7626946 7626958 13 - 1.779 1.488 -0.990
ENSG00000141504 E019 68.2240002 0.0274131743 5.290411e-02 1.864898e-01 17 7626959 7627044 86 - 1.924 1.721 -0.684
ENSG00000141504 E020 40.6925211 0.0768708808 8.750503e-02 2.591022e-01 17 7627045 7627142 98 - 1.740 1.481 -0.883
ENSG00000141504 E021 430.8644789 0.0001763438 4.859855e-03 3.387020e-02 17 7627143 7627226 84 - 2.550 2.590 0.134
ENSG00000141504 E022 81.8391233 0.0376089995 2.697679e-01 5.096937e-01 17 7627227 7627362 136 - 1.958 1.821 -0.459
ENSG00000141504 E023 332.1208445 0.0002848323 1.621311e-01 3.799494e-01 17 7627363 7627414 52 - 2.454 2.471 0.055
ENSG00000141504 E024 54.5125430 0.0434583768 1.505071e-01 3.630271e-01 17 7627415 7627541 127 - 1.820 1.628 -0.650
ENSG00000141504 E025 28.3017626 0.0527409455 1.056942e-01 2.918504e-01 17 7627542 7627552 11 - 1.569 1.337 -0.798
ENSG00000141504 E026 165.3677170 0.0003159623 9.532560e-01 9.785816e-01 17 7627553 7627556 4 - 2.175 2.161 -0.046
ENSG00000141504 E027 198.7192005 0.0004084137 7.256698e-01 8.515551e-01 17 7627557 7627569 13 - 2.247 2.241 -0.020
ENSG00000141504 E028 499.6737103 0.0002057861 1.171247e-08 5.396661e-07 17 7627570 7627874 305 - 2.573 2.664 0.304
ENSG00000141504 E029 0.7076135 0.0245410637 7.398109e-01   17 7627875 7627876 2 - 0.188 0.247 0.497
ENSG00000141504 E030 0.1426347 0.0328517371 1.752173e-01   17 7630747 7630869 123 - 0.188 0.000 -10.118