ENSG00000141425

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000399022 ENSG00000141425 HEK293_OSMI2_6hA HEK293_TMG_6hB RPRD1A protein_coding protein_coding 63.21862 18.97814 112.6137 2.203007 3.316367 2.56834 36.6409076 8.726386 68.636651 3.18631406 2.3055574 2.9740808 0.53714583 0.45316667 0.60940000 0.15623333 7.923592e-01 1.730109e-26 FALSE TRUE
ENST00000585953 ENSG00000141425 HEK293_OSMI2_6hA HEK293_TMG_6hB RPRD1A protein_coding protein_coding 63.21862 18.97814 112.6137 2.203007 3.316367 2.56834 3.9154573 3.752941 4.878014 1.02151471 0.3428948 0.3773877 0.12200833 0.20136667 0.04350000 -0.15786667 1.045564e-02 1.730109e-26 FALSE FALSE
ENST00000588737 ENSG00000141425 HEK293_OSMI2_6hA HEK293_TMG_6hB RPRD1A protein_coding protein_coding 63.21862 18.97814 112.6137 2.203007 3.316367 2.56834 6.1786028 0.000000 11.217199 0.00000000 1.5174396 10.1327823 0.05803750 0.00000000 0.09896667 0.09896667 1.831339e-17 1.730109e-26 FALSE TRUE
ENST00000590898 ENSG00000141425 HEK293_OSMI2_6hA HEK293_TMG_6hB RPRD1A protein_coding protein_coding 63.21862 18.97814 112.6137 2.203007 3.316367 2.56834 0.7807983 1.189631 0.000000 0.09272525 0.0000000 -6.9064466 0.04557083 0.06376667 0.00000000 -0.06376667 1.730109e-26 1.730109e-26 TRUE TRUE
MSTRG.15699.14 ENSG00000141425 HEK293_OSMI2_6hA HEK293_TMG_6hB RPRD1A protein_coding   63.21862 18.97814 112.6137 2.203007 3.316367 2.56834 8.5750746 2.813111 16.439927 1.76507237 0.7138748 2.5427234 0.10324583 0.15296667 0.14606667 -0.00690000 9.092239e-01 1.730109e-26 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000141425 E001 30.5360433 0.9758466429 6.586905e-02 0.215892880 18 35978828 35984341 5514 - 1.443 0.000 -21.604
ENSG00000141425 E002 0.0000000       18 35984342 35984380 39 -      
ENSG00000141425 E003 0.0000000       18 35984381 35984386 6 -      
ENSG00000141425 E004 0.0000000       18 35984387 35984388 2 -      
ENSG00000141425 E005 1.3161915 0.1003158754 5.910603e-03   18 35984389 35984528 140 - 0.152 0.677 3.163
ENSG00000141425 E006 2.4008189 0.1929692645 1.676370e-03 0.014856031 18 35984529 35984711 183 - 0.229 0.902 3.332
ENSG00000141425 E007 1.4597360 0.2690730038 4.119018e-03 0.029832142 18 35985338 35985386 49 - 0.106 0.760 4.099
ENSG00000141425 E008 0.3032425 0.0274424043 1.123321e-02   18 35988535 35988731 197 - 0.000 0.396 19.682
ENSG00000141425 E009 0.0000000       18 35988732 35988747 16 -      
ENSG00000141425 E010 0.1426347 0.0323971505 1.000000e+00   18 35988748 35988753 6 - 0.057 0.000 -13.893
ENSG00000141425 E011 0.1426347 0.0323971505 1.000000e+00   18 35988754 35988835 82 - 0.057 0.000 -13.893
ENSG00000141425 E012 39.2150932 0.0027387279 4.515028e-04 0.005235236 18 35989824 35989885 62 - 1.427 1.673 0.840
ENSG00000141425 E013 320.7091883 0.0406611789 1.412978e-01 0.349438702 18 35989886 35990202 317 - 2.341 2.518 0.590
ENSG00000141425 E014 462.4623094 0.0323399379 6.538147e-01 0.805981183 18 35990203 35990525 323 - 2.522 2.585 0.209
ENSG00000141425 E015 237.7920713 0.0287857281 9.769645e-01 0.990252526 18 35990526 35990595 70 - 2.242 2.264 0.071
ENSG00000141425 E016 2582.2497780 0.0665406560 7.548378e-02 0.235818948 18 35990596 35993039 2444 - 3.299 3.160 -0.460
ENSG00000141425 E017 237.4202865 0.0540010302 9.600591e-03 0.056391851 18 35993040 35993101 62 - 2.279 2.009 -0.904
ENSG00000141425 E018 511.2872131 0.0408822098 2.805651e-02 0.121429239 18 35993102 35993300 199 - 2.602 2.417 -0.615
ENSG00000141425 E019 1.0235477 0.3566771668 3.840983e-01   18 35995841 35995875 35 - 0.196 0.400 1.404
ENSG00000141425 E020 39.7059506 0.0607502910 3.900287e-05 0.000674019 18 36024889 36025598 710 - 1.339 1.873 1.822
ENSG00000141425 E021 8.7444197 0.1101037717 3.854599e-02 0.150978961 18 36025599 36025600 2 - 0.788 1.151 1.354
ENSG00000141425 E022 24.4699971 0.1937028936 2.490069e-02 0.111932800 18 36025601 36025678 78 - 1.134 1.675 1.878
ENSG00000141425 E023 17.2425953 0.2197059727 1.830045e-02 0.090027451 18 36025679 36025690 12 - 0.955 1.580 2.208
ENSG00000141425 E024 202.5833077 0.1578982692 4.117102e-04 0.004843635 18 36025691 36026895 1205 - 1.940 2.679 2.467
ENSG00000141425 E025 20.4876049 0.1312859177 1.536562e-04 0.002142218 18 36026896 36026899 4 - 0.964 1.715 2.633
ENSG00000141425 E026 489.5839769 0.0004851996 6.662833e-01 0.813883988 18 36026900 36027075 176 - 2.558 2.566 0.028
ENSG00000141425 E027 384.9403851 0.0001521635 6.282067e-01 0.789362935 18 36027184 36027310 127 - 2.453 2.464 0.038
ENSG00000141425 E028 2.8727884 0.0101033745 2.057590e-01 0.436764311 18 36027311 36028190 880 - 0.450 0.674 1.036
ENSG00000141425 E029 421.1035112 0.0002052013 4.802846e-01 0.687268842 18 36030808 36030905 98 - 2.497 2.479 -0.058
ENSG00000141425 E030 465.9689388 0.0001840727 6.986645e-02 0.224535004 18 36030991 36031097 107 - 2.544 2.502 -0.139
ENSG00000141425 E031 347.8697092 0.0001550582 6.169377e-02 0.206622917 18 36033708 36033751 44 - 2.419 2.370 -0.163
ENSG00000141425 E032 365.1382230 0.0001763736 1.469025e-01 0.357859082 18 36033752 36033801 50 - 2.438 2.401 -0.124
ENSG00000141425 E033 281.1312403 0.0095875462 8.347007e-01 0.916390800 18 36033802 36033837 36 - 2.318 2.321 0.010
ENSG00000141425 E034 25.9800648 0.0209296002 9.182951e-01 0.961360188 18 36040807 36040865 59 - 1.307 1.307 0.000
ENSG00000141425 E035 0.0000000       18 36052875 36052920 46 -      
ENSG00000141425 E036 0.8327523 0.3191834488 4.886690e-02   18 36062978 36063075 98 - 0.105 0.519 3.070
ENSG00000141425 E037 0.0000000       18 36063993 36064424 432 -      
ENSG00000141425 E038 438.6248150 0.0113392843 4.419354e-01 0.660058908 18 36067254 36067576 323 - 2.506 2.540 0.115