ENSG00000141401

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000269159 ENSG00000141401 HEK293_OSMI2_6hA HEK293_TMG_6hB IMPA2 protein_coding protein_coding 20.39454 25.55334 14.30155 3.763182 0.2138678 -0.8368967 6.587641 10.687185 1.157930 1.79877626 0.5936324 -3.1952053 0.31759583 0.41506667 0.08156667 -0.33350000 0.344148562 0.001486674 FALSE TRUE
ENST00000588167 ENSG00000141401 HEK293_OSMI2_6hA HEK293_TMG_6hB IMPA2 protein_coding retained_intron 20.39454 25.55334 14.30155 3.763182 0.2138678 -0.8368967 1.159722 1.313328 1.406116 0.23356737 0.1628073 0.0977691 0.06145417 0.05293333 0.09806667 0.04513333 0.269841142 0.001486674 FALSE FALSE
ENST00000588927 ENSG00000141401 HEK293_OSMI2_6hA HEK293_TMG_6hB IMPA2 protein_coding protein_coding 20.39454 25.55334 14.30155 3.763182 0.2138678 -0.8368967 8.493711 9.001027 8.091005 1.83486676 0.3530513 -0.1535906 0.40315833 0.34510000 0.56540000 0.22030000 0.001486674 0.001486674 FALSE TRUE
ENST00000589374 ENSG00000141401 HEK293_OSMI2_6hA HEK293_TMG_6hB IMPA2 protein_coding retained_intron 20.39454 25.55334 14.30155 3.763182 0.2138678 -0.8368967 1.368720 1.901834 1.666644 0.05734485 0.1694534 -0.1893808 0.06985000 0.07766667 0.11643333 0.03876667 0.479792558 0.001486674 FALSE FALSE
ENST00000590107 ENSG00000141401 HEK293_OSMI2_6hA HEK293_TMG_6hB IMPA2 protein_coding nonsense_mediated_decay 20.39454 25.55334 14.30155 3.763182 0.2138678 -0.8368967 1.219694 1.339130 0.925965 0.43143899 0.5268381 -0.5275027 0.06755833 0.05413333 0.06463333 0.01050000 1.000000000 0.001486674 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000141401 E001 0.3751086 0.0277000472 6.737132e-01   18 11981025 11981036 12 + 0.000 0.140 8.586
ENSG00000141401 E002 0.3751086 0.0277000472 6.737132e-01   18 11981037 11981130 94 + 0.000 0.140 10.576
ENSG00000141401 E003 0.3393995 0.0250202451 3.874116e-02   18 11981131 11981205 75 + 0.322 0.000 -13.197
ENSG00000141401 E004 1.0039589 0.4296112156 7.962446e-01   18 11981428 11981464 37 + 0.327 0.246 -0.563
ENSG00000141401 E005 1.5274315 0.2931867187 7.729782e-01 8.804832e-01 18 11981465 11981476 12 + 0.326 0.390 0.380
ENSG00000141401 E006 8.2627979 0.0748972283 8.172966e-01 9.065661e-01 18 11981477 11981506 30 + 0.905 0.932 0.099
ENSG00000141401 E007 11.7566822 0.0364951632 4.678124e-01 6.785806e-01 18 11981507 11981515 9 + 0.987 1.084 0.355
ENSG00000141401 E008 17.7805700 0.0204790969 2.416199e-02 1.095804e-01 18 11981516 11981526 11 + 1.012 1.281 0.963
ENSG00000141401 E009 29.8806436 0.0036176761 3.353112e-05 5.935949e-04 18 11981527 11981610 84 + 1.151 1.505 1.238
ENSG00000141401 E010 34.0241436 0.0015679934 1.069455e-08 4.985399e-07 18 11981611 11981669 59 + 1.097 1.571 1.653
ENSG00000141401 E011 33.7086754 0.0012392671 1.153317e-05 2.370037e-04 18 11981670 11981693 24 + 1.213 1.551 1.170
ENSG00000141401 E012 38.8297527 0.0010329578 1.865283e-04 2.524248e-03 18 11981694 11981765 72 + 1.339 1.597 0.888
ENSG00000141401 E013 24.5277908 0.0030891981 1.246119e-01 3.231230e-01 18 11999054 11999061 8 + 1.255 1.382 0.444
ENSG00000141401 E014 58.2625199 0.0007571541 8.550458e-01 9.276275e-01 18 11999062 11999135 74 + 1.711 1.716 0.018
ENSG00000141401 E015 68.3156617 0.0005759694 3.401549e-01 5.780832e-01 18 11999136 11999187 52 + 1.817 1.768 -0.168
ENSG00000141401 E016 2.9257195 0.0796364315 1.627093e-01 3.807865e-01 18 12008333 12008591 259 + 0.728 0.465 -1.184
ENSG00000141401 E017 55.7741654 0.0011521215 8.084049e-01 9.012281e-01 18 12009883 12009899 17 + 1.687 1.694 0.025
ENSG00000141401 E018 74.2122374 0.0005393712 6.207656e-01 7.843538e-01 18 12009900 12009930 31 + 1.803 1.820 0.060
ENSG00000141401 E019 90.4895756 0.0005053218 5.055134e-01 7.046358e-01 18 12009931 12009987 57 + 1.923 1.891 -0.109
ENSG00000141401 E020 2.4680346 0.1991506774 5.021164e-02 1.802132e-01 18 12009988 12010221 234 + 0.781 0.329 -2.152
ENSG00000141401 E021 84.7746943 0.0007056534 8.039656e-01 8.986083e-01 18 12012170 12012215 46 + 1.865 1.871 0.020
ENSG00000141401 E022 6.2718659 0.0280398504 7.934012e-01 8.923434e-01 18 12012216 12012349 134 + 0.847 0.800 -0.183
ENSG00000141401 E023 98.2140080 0.0006999280 3.383038e-01 5.764996e-01 18 12014265 12014373 109 + 1.909 1.943 0.117
ENSG00000141401 E024 1.9644276 0.0108647759 4.461607e-01 6.628380e-01 18 12017614 12018285 672 + 0.321 0.463 0.796
ENSG00000141401 E025 0.1426347 0.0317832344 1.649967e-01   18 12021702 12021822 121 + 0.190 0.000 -12.113
ENSG00000141401 E026 92.7696433 0.0006326400 9.300479e-01 9.670364e-01 18 12028043 12028151 109 + 1.911 1.910 -0.006
ENSG00000141401 E027 25.4534911 0.0247208916 2.882504e-04 3.611860e-03 18 12028152 12028607 456 + 1.601 1.229 -1.289
ENSG00000141401 E028 15.2428793 0.0487323918 1.180860e-01 3.127285e-01 18 12028608 12028841 234 + 1.294 1.079 -0.764
ENSG00000141401 E029 153.8374518 0.0003284930 3.217532e-01 5.612159e-01 18 12028842 12028993 152 + 2.157 2.121 -0.119
ENSG00000141401 E030 278.1220604 0.0004450959 9.456013e-06 1.998318e-04 18 12030343 12030877 535 + 2.460 2.358 -0.338