ENSG00000141298

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000269033 ENSG00000141298 HEK293_OSMI2_6hA HEK293_TMG_6hB SSH2 protein_coding protein_coding 7.082029 7.81336 5.741771 1.146383 0.2664619 -0.443782 2.2913562 2.715837 2.6556857 0.43257848 0.22185251 -0.03219276 0.34080417 0.34713333 0.46466667 0.11753333 4.318229e-01 1.865239e-13 FALSE TRUE
ENST00000324677 ENSG00000141298 HEK293_OSMI2_6hA HEK293_TMG_6hB SSH2 protein_coding protein_coding 7.082029 7.81336 5.741771 1.146383 0.2664619 -0.443782 0.4289593 0.343329 0.0000000 0.02878087 0.00000000 -5.14294040 0.06142500 0.04476667 0.00000000 -0.04476667 6.445519e-05 1.865239e-13 FALSE TRUE
ENST00000579040 ENSG00000141298 HEK293_OSMI2_6hA HEK293_TMG_6hB SSH2 protein_coding nonsense_mediated_decay 7.082029 7.81336 5.741771 1.146383 0.2664619 -0.443782 0.2777159 0.000000 0.8446419 0.00000000 0.07403892 6.41724815 0.04119167 0.00000000 0.14693333 0.14693333 1.865239e-13 1.865239e-13 FALSE TRUE
ENST00000582084 ENSG00000141298 HEK293_OSMI2_6hA HEK293_TMG_6hB SSH2 protein_coding protein_coding 7.082029 7.81336 5.741771 1.146383 0.2664619 -0.443782 1.7599016 1.973839 1.0099212 0.53696659 0.15223776 -0.95983755 0.23199583 0.24293333 0.17433333 -0.06860000 6.870441e-01 1.865239e-13   FALSE
ENST00000590153 ENSG00000141298 HEK293_OSMI2_6hA HEK293_TMG_6hB SSH2 protein_coding protein_coding 7.082029 7.81336 5.741771 1.146383 0.2664619 -0.443782 1.8718909 2.627105 0.5149042 0.22132339 0.25908000 -2.32882929 0.25348333 0.34310000 0.08993333 -0.25316667 3.631087e-01 1.865239e-13 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000141298 E001 358.2449100 1.443930669 3.321073e-01 5.709719e-01 17 29625938 29630601 4664 - 2.366 2.673 1.023
ENSG00000141298 E002 19.8953659 0.166894774 5.331320e-01 7.242942e-01 17 29630602 29630788 187 - 1.267 1.363 0.338
ENSG00000141298 E003 7.2194751 0.004837096 5.027227e-01 7.026363e-01 17 29630789 29630799 11 - 0.829 0.969 0.534
ENSG00000141298 E004 27.8478402 0.265040660 4.196612e-01 6.434131e-01 17 29630800 29631178 379 - 1.386 1.517 0.451
ENSG00000141298 E005 84.3032088 0.698026725 5.320087e-01 7.234677e-01 17 29631179 29632651 1473 - 1.891 1.962 0.241
ENSG00000141298 E006 25.8012183 0.308182571 5.842523e-01 7.598483e-01 17 29632652 29632931 280 - 1.399 1.451 0.180
ENSG00000141298 E007 56.3726093 0.079861495 8.439230e-02 2.535073e-01 17 29635968 29636802 835 - 1.816 1.695 -0.412
ENSG00000141298 E008 0.3393995 0.029098031 1.360725e-01   17 29647694 29648143 450 - 0.225 0.000 -28.348
ENSG00000141298 E009 23.3133060 0.084915515 1.302018e-02 7.053516e-02 17 29648144 29648344 201 - 1.509 1.231 -0.965
ENSG00000141298 E010 16.1772027 0.107565046 4.525820e-02 1.682496e-01 17 29650654 29650800 147 - 1.347 1.104 -0.858
ENSG00000141298 E011 11.2370052 0.161948046 8.429414e-02 2.533284e-01 17 29655561 29655607 47 - 1.209 0.942 -0.971
ENSG00000141298 E012 19.0899860 0.102723506 1.219324e-02 6.723392e-02 17 29666867 29666995 129 - 1.445 1.120 -1.140
ENSG00000141298 E013 14.7953389 0.053914013 1.255462e-03 1.182968e-02 17 29667130 29667223 94 - 1.357 0.994 -1.296
ENSG00000141298 E014 23.0840354 0.036679438 7.076109e-04 7.507253e-03 17 29671935 29672129 195 - 1.514 1.222 -1.015
ENSG00000141298 E015 0.1723744 0.037034843 6.512347e-01   17 29673840 29673900 61 - 0.000 0.117 27.038
ENSG00000141298 E016 6.3909587 0.060909652 1.047446e-01 2.901848e-01 17 29673901 29674159 259 - 0.946 0.774 -0.663
ENSG00000141298 E017 0.4764247 0.021768165 4.287780e-01   17 29675830 29676819 990 - 0.224 0.117 -1.136
ENSG00000141298 E018 21.6433049 0.067795256 6.145764e-03 4.044691e-02 17 29676820 29676885 66 - 1.484 1.199 -0.991
ENSG00000141298 E019 17.0821312 0.028451663 4.453750e-03 3.167955e-02 17 29677673 29677718 46 - 1.362 1.134 -0.801
ENSG00000141298 E020 14.0758816 0.029539540 1.903189e-02 9.258772e-02 17 29677719 29677738 20 - 1.261 1.075 -0.665
ENSG00000141298 E021 11.1805066 0.053155393 8.545980e-02 2.554483e-01 17 29677739 29677741 3 - 1.152 1.003 -0.539
ENSG00000141298 E022 26.0314329 0.080157448 1.861741e-02 9.111553e-02 17 29684563 29684684 122 - 1.543 1.297 -0.850
ENSG00000141298 E023 16.7738428 0.055709091 1.562957e-02 8.046788e-02 17 29695459 29695523 65 - 1.355 1.125 -0.813
ENSG00000141298 E024 15.3798789 0.036118653 8.351284e-02 2.517869e-01 17 29702959 29703062 104 - 1.271 1.154 -0.414
ENSG00000141298 E025 0.7982606 0.017286962 2.781400e-01   17 29761150 29761417 268 - 0.127 0.348 1.861
ENSG00000141298 E026 0.0000000       17 29793616 29793893 278 -      
ENSG00000141298 E027 7.2318255 0.004782818 6.719910e-01 8.175922e-01 17 29793894 29793937 44 - 0.909 0.923 0.054
ENSG00000141298 E028 0.0000000       17 29838927 29839142 216 -      
ENSG00000141298 E029 0.3150090 0.026412162 8.600948e-01   17 29848849 29848929 81 - 0.126 0.117 -0.136
ENSG00000141298 E030 6.0729473 0.007968751 1.936892e-01 4.217218e-01 17 29925217 29925276 60 - 0.704 0.939 0.921
ENSG00000141298 E031 25.0908985 0.001727480 9.916762e-08 3.681885e-06 17 29925277 29925555 279 - 1.097 1.572 1.660
ENSG00000141298 E032 0.5173834 0.373280819 8.195397e-02   17 29928282 29928584 303 - 0.309 0.000 -28.959
ENSG00000141298 E033 22.6490269 0.004827880 5.513122e-05 9.058729e-04 17 29929938 29930040 103 - 1.119 1.516 1.386
ENSG00000141298 E034 13.8403757 0.003459981 1.406804e-04 1.987749e-03 17 29930041 29930158 118 - 0.890 1.328 1.586
ENSG00000141298 E035 8.4427885 0.004121082 1.179080e-02 6.559701e-02 17 29930159 29930276 118 - 0.759 1.113 1.340