ENSG00000141219

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000268942 ENSG00000141219 HEK293_OSMI2_6hA HEK293_TMG_6hB C17orf80 protein_coding protein_coding 15.1558 5.724214 23.45621 0.5682697 0.7390882 2.032917 4.3009376 0.6012653 7.6347720 0.6012653 0.4880307 3.644603 0.23729167 0.0966000 0.325066667 0.22846667 0.256491707 0.006505224 FALSE TRUE
ENST00000426147 ENSG00000141219 HEK293_OSMI2_6hA HEK293_TMG_6hB C17orf80 protein_coding protein_coding 15.1558 5.724214 23.45621 0.5682697 0.7390882 2.032917 0.9064494 0.4998976 1.7327189 0.2048758 0.4643567 1.773061 0.05586667 0.0867000 0.074466667 -0.01223333 0.984955605 0.006505224 FALSE TRUE
ENST00000535032 ENSG00000141219 HEK293_OSMI2_6hA HEK293_TMG_6hB C17orf80 protein_coding protein_coding 15.1558 5.724214 23.45621 0.5682697 0.7390882 2.032917 7.3111519 1.8259314 12.4106936 0.5517386 0.5978523 2.758162 0.42016250 0.3082000 0.528700000 0.22050000 0.232524588 0.006505224 FALSE TRUE
ENST00000577615 ENSG00000141219 HEK293_OSMI2_6hA HEK293_TMG_6hB C17orf80 protein_coding protein_coding 15.1558 5.724214 23.45621 0.5682697 0.7390882 2.032917 0.4465748 1.1127836 0.0000000 0.5564037 0.0000000 -6.810936 0.05937083 0.2088667 0.000000000 -0.20886667 0.181220240 0.006505224 FALSE TRUE
ENST00000582793 ENSG00000141219 HEK293_OSMI2_6hA HEK293_TMG_6hB C17orf80 protein_coding protein_coding 15.1558 5.724214 23.45621 0.5682697 0.7390882 2.032917 1.0186756 1.1424662 0.1158275 0.2739904 0.1158275 -3.195206 0.14910000 0.2069667 0.004933333 -0.20203333 0.006505224 0.006505224   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000141219 E001 2.5563059 0.0904304052 0.745240745 0.86383584 17 73232233 73232432 200 + 0.511 0.463 -0.237
ENSG00000141219 E002 9.0153814 0.0113472112 0.293151278 0.53385195 17 73232433 73232464 32 + 0.949 0.831 -0.453
ENSG00000141219 E003 18.3920637 0.0023417862 0.028961755 0.12424838 17 73232465 73232489 25 + 1.234 1.028 -0.740
ENSG00000141219 E004 0.7201176 0.0686437338 0.847670855   17 73232529 73232621 93 + 0.172 0.217 0.413
ENSG00000141219 E005 0.5587019 0.4311181724 0.607801796   17 73232622 73232629 8 + 0.124 0.221 1.003
ENSG00000141219 E006 0.1779838 0.0378843066 1.000000000   17 73232630 73232636 7 + 0.065 0.000 -7.315
ENSG00000141219 E007 0.1779838 0.0378843066 1.000000000   17 73232637 73232661 25 + 0.065 0.000 -7.315
ENSG00000141219 E008 14.4885024 0.0027813041 0.103163286 0.28748767 17 73232662 73232717 56 + 1.133 0.972 -0.589
ENSG00000141219 E009 6.6057670 0.0044394439 0.001309589 0.01223314 17 73232729 73233219 491 + 0.673 1.100 1.643
ENSG00000141219 E010 38.9674769 0.0207722821 0.531162084 0.72287744 17 73233220 73233225 6 + 1.517 1.499 -0.062
ENSG00000141219 E011 71.9748282 0.0011364790 0.646941596 0.80143771 17 73233226 73233325 100 + 1.772 1.775 0.011
ENSG00000141219 E012 241.8023547 0.0038678508 0.002179740 0.01826917 17 73235476 73236022 547 + 2.310 2.224 -0.288
ENSG00000141219 E013 331.6337984 0.0045622704 0.458093215 0.67179120 17 73236023 73236995 973 + 2.431 2.428 -0.009
ENSG00000141219 E014 48.3743417 0.0009157004 0.633335598 0.79253630 17 73242244 73242351 108 + 1.603 1.599 -0.014
ENSG00000141219 E015 78.0742878 0.0007436017 0.225890353 0.46043102 17 73242896 73243003 108 + 1.814 1.780 -0.113
ENSG00000141219 E016 9.9197190 0.0032637945 0.146236668 0.35676411 17 73245168 73245344 177 + 0.909 1.100 0.707
ENSG00000141219 E017 488.4996558 0.0068241588 0.001277039 0.01198710 17 73247241 73248959 1719 + 2.571 2.684 0.374