ENSG00000140990

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000268668 ENSG00000140990 HEK293_OSMI2_6hA HEK293_TMG_6hB NDUFB10 protein_coding protein_coding 523.081 628.6292 289.7025 117.7045 14.64132 -1.11761 438.98642 512.92583 251.58384 97.04544 13.253088 -1.027682 0.8447583 0.8153333 0.8682333 0.05290000 0.003480961 2.585752e-05 FALSE  
ENST00000543683 ENSG00000140990 HEK293_OSMI2_6hA HEK293_TMG_6hB NDUFB10 protein_coding protein_coding 523.081 628.6292 289.7025 117.7045 14.64132 -1.11761 49.29015 69.73964 23.12002 13.83572 1.709874 -1.592419 0.0868500 0.1102667 0.0797000 -0.03056667 0.066370251 2.585752e-05 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000140990 E001 24.77386 0.0025840960 8.542693e-04 8.725766e-03 16 1959515 1959537 23 + 1.038 1.377 1.204
ENSG00000140990 E002 30.27480 0.0014647032 1.053366e-03 1.031941e-02 16 1959538 1959542 5 + 1.165 1.458 1.022
ENSG00000140990 E003 34.41803 0.0011345032 3.910443e-04 4.644588e-03 16 1959543 1959543 1 + 1.217 1.515 1.033
ENSG00000140990 E004 141.59175 0.0057205755 5.812092e-02 1.985570e-01 16 1959544 1959551 8 + 1.987 2.092 0.350
ENSG00000140990 E005 195.24208 0.0010936456 1.534566e-05 3.041723e-04 16 1959552 1959557 6 + 2.080 2.241 0.538
ENSG00000140990 E006 2576.02748 0.0008483501 1.653615e-01 3.844294e-01 16 1959558 1959754 197 + 3.304 3.331 0.087
ENSG00000140990 E007 3039.20079 0.0004504928 6.553588e-02 2.150930e-01 16 1961153 1961258 106 + 3.412 3.394 -0.062
ENSG00000140990 E008 2014.93528 0.0002540025 1.613576e-03 1.442298e-02 16 1961259 1961291 33 + 3.249 3.214 -0.118
ENSG00000140990 E009 63.13847 1.9753104561 5.019107e-01 7.021340e-01 16 1961292 1961496 205 + 1.797 1.696 -0.343
ENSG00000140990 E010 2768.65812 0.0001288306 6.521710e-02 2.143730e-01 16 1961497 1961611 115 + 3.372 3.357 -0.048
ENSG00000140990 E011 1207.08239 0.0002634809 4.494214e-02 1.674648e-01 16 1961612 1961636 25 + 3.021 2.993 -0.092
ENSG00000140990 E012 365.77205 0.0010546534 2.786444e-06 6.972186e-05 16 1961637 1961796 160 + 2.366 2.506 0.467
ENSG00000140990 E013 1193.63234 0.0012749438 8.827881e-01 9.427661e-01 16 1961797 1961801 5 + 2.983 2.993 0.034
ENSG00000140990 E014 1742.45047 0.0030731716 2.315542e-01 4.669496e-01 16 1961802 1961975 174 + 3.113 3.164 0.170