ENSG00000140854

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000379661 ENSG00000140854 HEK293_OSMI2_6hA HEK293_TMG_6hB KATNB1 protein_coding protein_coding 57.11388 88.98777 30.85769 13.7629 0.7663258 -1.527672 35.486154 53.314310 17.705681 9.238236 0.3151619 -1.5897665 0.61817917 0.5948667 0.57450000 -0.02036667 9.096745e-01 9.668279e-29 FALSE TRUE
ENST00000563462 ENSG00000140854 HEK293_OSMI2_6hA HEK293_TMG_6hB KATNB1 protein_coding protein_coding 57.11388 88.98777 30.85769 13.7629 0.7663258 -1.527672 6.053695 10.421458 0.000000 2.046870 0.0000000 -10.0267251 0.07315833 0.1153000 0.00000000 -0.11530000 9.668279e-29 9.668279e-29 FALSE TRUE
MSTRG.12723.3 ENSG00000140854 HEK293_OSMI2_6hA HEK293_TMG_6hB KATNB1 protein_coding   57.11388 88.98777 30.85769 13.7629 0.7663258 -1.527672 5.654816 8.939266 7.428817 1.331738 1.2272285 -0.2666963 0.12701667 0.1007000 0.24096667 0.14026667 1.628427e-02 9.668279e-29 FALSE TRUE
MSTRG.12723.7 ENSG00000140854 HEK293_OSMI2_6hA HEK293_TMG_6hB KATNB1 protein_coding   57.11388 88.98777 30.85769 13.7629 0.7663258 -1.527672 4.715651 10.415355 1.519325 1.851031 0.6332819 -2.7691291 0.07263750 0.1160000 0.04846667 -0.06753333 2.935882e-01 9.668279e-29 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000140854 E001 1.332572 0.0134411540 8.847159e-01   16 57735739 57735753 15 + 0.341 0.311 -0.191
ENSG00000140854 E002 5.094610 0.0054231583 7.576534e-01 0.871199941 16 57735754 57735769 16 + 0.762 0.714 -0.194
ENSG00000140854 E003 16.264172 0.0019685979 1.684209e-02 0.084881641 16 57735770 57735790 21 + 1.328 1.108 -0.778
ENSG00000140854 E004 118.787304 0.0003990080 5.882330e-01 0.762502759 16 57735791 57735855 65 + 2.023 1.999 -0.081
ENSG00000140854 E005 1.171464 0.0894794985 1.116243e-01   16 57735856 57735863 8 + 0.000 0.374 10.289
ENSG00000140854 E006 26.087878 0.0055282778 8.314366e-04 0.008534638 16 57735864 57735930 67 + 1.092 1.417 1.144
ENSG00000140854 E007 59.500066 0.0090677660 1.954272e-02 0.094335106 16 57735931 57736116 186 + 1.573 1.739 0.564
ENSG00000140854 E008 4.036923 0.1232659341 5.831020e-01 0.759045480 16 57736763 57736878 116 + 0.531 0.649 0.530
ENSG00000140854 E009 1.234277 0.1621455347 7.832001e-01   16 57736973 57736977 5 + 0.342 0.277 -0.423
ENSG00000140854 E010 254.619858 0.0003636600 7.009511e-01 0.836231693 16 57736978 57737063 86 + 2.327 2.333 0.020
ENSG00000140854 E011 160.493754 0.0037310864 4.437939e-01 0.661195881 16 57737064 57737067 4 + 2.164 2.121 -0.145
ENSG00000140854 E012 393.019343 0.0009389960 2.190006e-01 0.452256838 16 57737068 57737191 124 + 2.547 2.508 -0.129
ENSG00000140854 E013 271.104013 0.0008660063 4.692718e-01 0.679564010 16 57737192 57737225 34 + 2.378 2.350 -0.092
ENSG00000140854 E014 262.078962 0.0002836100 3.675651e-01 0.602054454 16 57737226 57737283 58 + 2.363 2.336 -0.093
ENSG00000140854 E015 438.940741 0.0002300130 6.604884e-02 0.216219691 16 57741687 57741817 131 + 2.598 2.556 -0.141
ENSG00000140854 E016 465.589140 0.0001262227 1.937365e-02 0.093758820 16 57744394 57744511 118 + 2.630 2.582 -0.161
ENSG00000140854 E017 445.010508 0.0001597134 6.582327e-02 0.215759900 16 57750827 57750927 101 + 2.604 2.563 -0.136
ENSG00000140854 E018 277.929441 0.0001927458 9.464876e-01 0.975567573 16 57751261 57751302 42 + 2.370 2.368 -0.007
ENSG00000140854 E019 406.286809 0.0001753117 9.699044e-01 0.986793879 16 57751641 57751724 84 + 2.535 2.532 -0.010
ENSG00000140854 E020 537.094941 0.0002616085 5.003976e-01 0.701019811 16 57751940 57752055 116 + 2.666 2.649 -0.058
ENSG00000140854 E021 24.986341 0.1437943123 5.391752e-03 0.036659466 16 57752056 57752529 474 + 1.674 1.161 -1.778
ENSG00000140854 E022 381.682740 0.0009012458 8.450082e-02 0.253734052 16 57752530 57752601 72 + 2.542 2.495 -0.158
ENSG00000140854 E023 26.674202 0.2065087454 4.848940e-02 0.176177601 16 57752602 57752777 176 + 1.639 1.241 -1.373
ENSG00000140854 E024 473.686866 0.0016980651 9.371698e-01 0.970778527 16 57752778 57752928 151 + 2.601 2.598 -0.009
ENSG00000140854 E025 20.586764 0.1533088936 1.040922e-01 0.288962068 16 57752929 57753076 148 + 1.463 1.176 -1.001
ENSG00000140854 E026 457.621656 0.0008286933 6.326382e-01 0.792088522 16 57753077 57753267 191 + 2.597 2.582 -0.048
ENSG00000140854 E027 273.253114 0.0005495263 1.630193e-01 0.381238868 16 57753389 57753456 68 + 2.336 2.372 0.119
ENSG00000140854 E028 257.066756 0.0008082313 5.418402e-02 0.189511677 16 57753457 57753519 63 + 2.294 2.349 0.182
ENSG00000140854 E029 277.451743 0.0022347771 3.291648e-02 0.135837280 16 57753945 57753995 51 + 2.313 2.383 0.232
ENSG00000140854 E030 322.103091 0.0001711607 5.956283e-03 0.039524613 16 57754930 57754997 68 + 2.384 2.448 0.212
ENSG00000140854 E031 252.830809 0.0002188708 1.778454e-02 0.088310640 16 57755119 57755145 27 + 2.280 2.341 0.206
ENSG00000140854 E032 444.529051 0.0001382068 7.345276e-03 0.046299339 16 57755146 57755238 93 + 2.533 2.585 0.172
ENSG00000140854 E033 548.484846 0.0001588915 8.829326e-01 0.942801817 16 57755345 57755447 103 + 2.668 2.661 -0.022
ENSG00000140854 E034 424.646980 0.0002110739 7.538966e-01 0.869057629 16 57755448 57755494 47 + 2.561 2.550 -0.034
ENSG00000140854 E035 92.914487 0.0081627529 7.047026e-01 0.838527981 16 57755790 57755840 51 + 1.923 1.888 -0.120
ENSG00000140854 E036 461.178001 0.0001985657 6.027955e-01 0.772068274 16 57755841 57755917 77 + 2.600 2.586 -0.046
ENSG00000140854 E037 18.297004 0.0588461211 3.483083e-03 0.026237914 16 57755918 57755991 74 + 1.491 1.079 -1.446
ENSG00000140854 E038 462.680099 0.0008606760 7.946693e-01 0.893128586 16 57755992 57756066 75 + 2.597 2.587 -0.033
ENSG00000140854 E039 10.370087 0.4521944238 2.178726e-01 0.450886854 16 57756067 57756355 289 + 1.211 0.893 -1.162
ENSG00000140854 E040 492.410023 0.0001329353 4.270943e-02 0.161800781 16 57756356 57756472 117 + 2.590 2.625 0.120
ENSG00000140854 E041 20.919688 0.1073033455 1.492146e-01 0.361108653 16 57756473 57756813 341 + 1.437 1.203 -0.819
ENSG00000140854 E042 574.599357 0.0001310576 9.496023e-06 0.000200403 16 57756814 57757246 433 + 2.623 2.701 0.258