ENSG00000140750

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000289968 ENSG00000140750 HEK293_OSMI2_6hA HEK293_TMG_6hB ARHGAP17 protein_coding protein_coding 31.47973 44.35634 23.63106 6.673264 1.321226 -0.9081713 14.2700333 23.420196 9.360441 5.0362903 0.5386643 -1.322180 0.44251250 0.51536667 0.40070000 -0.11466667 5.519939e-01 9.491003e-19 FALSE TRUE
ENST00000303665 ENSG00000140750 HEK293_OSMI2_6hA HEK293_TMG_6hB ARHGAP17 protein_coding protein_coding 31.47973 44.35634 23.63106 6.673264 1.321226 -0.9081713 4.6527674 5.844146 4.363498 0.4187929 0.7382950 -0.420671 0.15577500 0.13596667 0.18333333 0.04736667 6.867503e-01 9.491003e-19 FALSE TRUE
ENST00000571843 ENSG00000140750 HEK293_OSMI2_6hA HEK293_TMG_6hB ARHGAP17 protein_coding protein_coding 31.47973 44.35634 23.63106 6.673264 1.321226 -0.9081713 5.8581388 9.494495 0.000000 2.5515127 0.0000000 -9.892466 0.15082083 0.20476667 0.00000000 -0.20476667 9.491003e-19 9.491003e-19 FALSE FALSE
ENST00000575975 ENSG00000140750 HEK293_OSMI2_6hA HEK293_TMG_6hB ARHGAP17 protein_coding processed_transcript 31.47973 44.35634 23.63106 6.673264 1.321226 -0.9081713 0.7873786 0.000000 1.417538 0.0000000 1.4175382 7.157386 0.03126667 0.00000000 0.05443333 0.05443333 8.302988e-01 9.491003e-19 FALSE TRUE
MSTRG.12303.5 ENSG00000140750 HEK293_OSMI2_6hA HEK293_TMG_6hB ARHGAP17 protein_coding   31.47973 44.35634 23.63106 6.673264 1.321226 -0.9081713 2.5830558 1.082469 4.535717 1.0824687 0.4864908 2.056916 0.10571250 0.03483333 0.19116667 0.15633333 1.565084e-01 9.491003e-19 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000140750 E001 1.5758348 0.2136674954 1.695396e-01 3.899268e-01 16 24919389 24919392 4 - 0.163 0.499 2.246
ENSG00000140750 E002 1.5758348 0.2136674954 1.695396e-01 3.899268e-01 16 24919393 24919394 2 - 0.163 0.499 2.246
ENSG00000140750 E003 1.5758348 0.2136674954 1.695396e-01 3.899268e-01 16 24919395 24919396 2 - 0.163 0.499 2.246
ENSG00000140750 E004 1.5758348 0.2136674954 1.695396e-01 3.899268e-01 16 24919397 24919397 1 - 0.163 0.499 2.246
ENSG00000140750 E005 12.1644761 0.0036875164 4.836588e-02 1.758658e-01 16 24919398 24919413 16 - 0.944 1.158 0.781
ENSG00000140750 E006 361.0992635 0.0009881970 1.162709e-08 5.368537e-07 16 24919414 24919841 428 - 2.428 2.573 0.482
ENSG00000140750 E007 191.1983854 0.0003228763 1.335716e-05 2.695927e-04 16 24919842 24919891 50 - 2.167 2.294 0.425
ENSG00000140750 E008 499.5685648 0.0001343659 2.544903e-07 8.534420e-06 16 24919892 24920247 356 - 2.609 2.700 0.302
ENSG00000140750 E009 117.9673271 0.0003940292 2.763942e-01 5.163935e-01 16 24920248 24920260 13 - 2.020 2.060 0.135
ENSG00000140750 E010 8.3845689 0.1270390261 4.111748e-01 6.369211e-01 16 24920261 24921004 744 - 0.847 0.982 0.512
ENSG00000140750 E011 40.4469049 0.0010687287 5.470259e-02 1.906647e-01 16 24927684 24927732 49 - 1.508 1.626 0.405
ENSG00000140750 E012 0.8855973 0.0201509816 9.808037e-01   16 24929613 24929660 48 - 0.283 0.280 -0.019
ENSG00000140750 E013 344.9909741 0.0047485924 3.064999e-01 5.471421e-01 16 24930784 24931160 377 - 2.485 2.525 0.133
ENSG00000140750 E014 198.7797043 0.0028635230 7.640806e-04 7.978753e-03 16 24931161 24931404 244 - 2.184 2.312 0.429
ENSG00000140750 E015 166.3433012 0.0010969846 1.978944e-03 1.692774e-02 16 24935470 24935639 170 - 2.124 2.230 0.354
ENSG00000140750 E016 11.7807276 0.1449032719 3.038470e-01 5.444381e-01 16 24935640 24936827 1188 - 0.914 1.144 0.844
ENSG00000140750 E017 203.9575007 0.0016511471 3.586809e-02 1.438665e-01 16 24939364 24939597 234 - 2.232 2.304 0.240
ENSG00000140750 E018 8.1454067 0.0573144501 9.407244e-01 9.726254e-01 16 24939598 24939921 324 - 0.942 0.925 -0.064
ENSG00000140750 E019 9.2163930 0.1100517129 2.607984e-01 4.998056e-01 16 24941696 24941986 291 - 1.099 0.910 -0.695
ENSG00000140750 E020 246.2497365 0.0033323331 7.116387e-01 8.428583e-01 16 24941987 24942143 157 - 2.372 2.360 -0.041
ENSG00000140750 E021 183.7932434 0.0003477037 6.207289e-01 7.843306e-01 16 24943771 24943834 64 - 2.246 2.234 -0.039
ENSG00000140750 E022 152.6185628 0.0003222603 3.811581e-01 6.131828e-01 16 24943835 24943862 28 - 2.175 2.150 -0.082
ENSG00000140750 E023 242.2735610 0.0002259583 3.896380e-01 6.201952e-01 16 24947482 24947595 114 - 2.370 2.351 -0.063
ENSG00000140750 E024 2.1660619 0.1997981972 6.516675e-01 8.045782e-01 16 24948982 24949127 146 - 0.521 0.427 -0.470
ENSG00000140750 E025 6.0979845 0.0936127677 7.287470e-02 2.305681e-01 16 24949128 24949403 276 - 1.015 0.672 -1.338
ENSG00000140750 E026 204.7426645 0.0002632898 2.592189e-02 1.150545e-01 16 24949404 24949484 81 - 2.322 2.266 -0.188
ENSG00000140750 E027 197.0828775 0.0017030551 2.039909e-01 4.346156e-01 16 24952289 24952370 82 - 2.295 2.256 -0.131
ENSG00000140750 E028 193.3511187 0.0076226975 7.624196e-01 8.740376e-01 16 24952931 24953042 112 - 2.271 2.256 -0.049
ENSG00000140750 E029 174.5527932 0.0005432970 3.821010e-01 6.139387e-01 16 24954603 24954691 89 - 2.198 2.225 0.091
ENSG00000140750 E030 136.0573296 0.0006123178 9.920583e-01 9.977444e-01 16 24954692 24954730 39 - 2.109 2.109 0.003
ENSG00000140750 E031 19.2521562 0.1900045584 3.950141e-01 6.243773e-01 16 24954731 24957536 2806 - 1.393 1.206 -0.653
ENSG00000140750 E032 188.4697509 0.0014043955 2.082615e-01 4.397526e-01 16 24959671 24959752 82 - 2.276 2.236 -0.135
ENSG00000140750 E033 107.8711800 0.0003873118 1.205716e-02 6.667479e-02 16 24959911 24959916 6 - 2.066 1.979 -0.294
ENSG00000140750 E034 173.6200349 0.0003860120 7.474061e-05 1.172981e-03 16 24959917 24959979 63 - 2.286 2.175 -0.371
ENSG00000140750 E035 0.0000000       16 24959980 24959981 2 -      
ENSG00000140750 E036 162.9926283 0.0022029458 2.761996e-03 2.194491e-02 16 24964197 24964244 48 - 2.253 2.148 -0.351
ENSG00000140750 E037 150.1398029 0.0040884448 5.038654e-03 3.484178e-02 16 24964245 24964283 39 - 2.225 2.109 -0.389
ENSG00000140750 E038 136.1949787 0.0003618708 2.345885e-03 1.935224e-02 16 24964284 24964308 25 - 2.171 2.076 -0.318
ENSG00000140750 E039 200.8794439 0.0002367498 3.224340e-05 5.742104e-04 16 24968351 24968427 77 - 2.347 2.241 -0.355
ENSG00000140750 E040 1.4066509 0.0754535022 6.275636e-01 7.889224e-01 16 24968562 24968660 99 - 0.283 0.377 0.590
ENSG00000140750 E041 215.0557617 0.0002889389 1.309572e-04 1.872803e-03 16 24968661 24968768 108 - 2.368 2.272 -0.320
ENSG00000140750 E042 97.3627846 0.0017166451 2.268495e-04 2.966600e-03 16 24968769 24968772 4 - 2.058 1.907 -0.507
ENSG00000140750 E043 168.2783202 0.0003070886 2.126926e-02 1.002139e-01 16 24970507 24970580 74 - 2.243 2.179 -0.217
ENSG00000140750 E044 0.0000000       16 24972596 24972633 38 -      
ENSG00000140750 E045 177.0641424 0.0003350854 8.233406e-01 9.098664e-01 16 24977215 24977319 105 - 2.227 2.223 -0.015
ENSG00000140750 E046 0.3206185 0.0274424043 7.050484e-02   16 24977320 24977456 137 - 0.283 0.000 -11.413
ENSG00000140750 E047 104.9911403 0.0003819092 9.982552e-01 1.000000e+00 16 24978966 24979005 40 - 1.998 2.000 0.006
ENSG00000140750 E048 5.8801992 0.0387436833 7.107182e-01 8.423157e-01 16 25013863 25013956 94 - 0.842 0.795 -0.187
ENSG00000140750 E049 119.3158180 0.0003640786 2.191078e-01 4.523461e-01 16 25015209 25015388 180 - 2.021 2.067 0.151
ENSG00000140750 E050 0.2027342 0.0344811792 1.000000e+00   16 25015501 25015666 166 - 0.000 0.089 8.327