ENSG00000140632

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000321919 ENSG00000140632 HEK293_OSMI2_6hA HEK293_TMG_6hB GLYR1 protein_coding protein_coding 55.9151 57.05843 64.47617 1.936365 2.727988 0.1762969 29.779622 33.38413 32.569447 1.7549601 1.6920051 -0.03563232 0.53647083 0.58450000 0.50470000 -0.07980000 1.745424e-01 6.922203e-31 FALSE TRUE
ENST00000589389 ENSG00000140632 HEK293_OSMI2_6hA HEK293_TMG_6hB GLYR1 protein_coding protein_coding 55.9151 57.05843 64.47617 1.936365 2.727988 0.1762969 4.917194 7.44308 3.390752 1.6535249 0.6862728 -1.13198285 0.09145833 0.12906667 0.05233333 -0.07673333 1.582582e-01 6.922203e-31 FALSE TRUE
ENST00000591451 ENSG00000140632 HEK293_OSMI2_6hA HEK293_TMG_6hB GLYR1 protein_coding protein_coding 55.9151 57.05843 64.47617 1.936365 2.727988 0.1762969 2.478003 0.00000 6.016527 0.0000000 0.6823066 9.23518293 0.04074167 0.00000000 0.09376667 0.09376667 2.000075e-24 6.922203e-31 FALSE TRUE
MSTRG.11991.14 ENSG00000140632 HEK293_OSMI2_6hA HEK293_TMG_6hB GLYR1 protein_coding   55.9151 57.05843 64.47617 1.936365 2.727988 0.1762969 2.895818 4.74412 0.000000 0.9066847 0.0000000 -8.89303464 0.05170833 0.08223333 0.00000000 -0.08223333 3.716145e-19 6.922203e-31 TRUE TRUE
MSTRG.11991.9 ENSG00000140632 HEK293_OSMI2_6hA HEK293_TMG_6hB GLYR1 protein_coding   55.9151 57.05843 64.47617 1.936365 2.727988 0.1762969 1.654716 0.00000 6.616361 0.0000000 0.2793030 9.37207301 0.02685000 0.00000000 0.10333333 0.10333333 6.922203e-31 6.922203e-31 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000140632 E001 0.000000       16 4803131 4803202 72 -      
ENSG00000140632 E002 46.456247 0.0180820889 9.271527e-02 2.688130e-01 16 4803203 4803253 51 - 1.580 1.729 0.505
ENSG00000140632 E003 295.612543 0.0048385943 1.584006e-05 3.128278e-04 16 4803254 4803565 312 - 2.360 2.537 0.588
ENSG00000140632 E004 187.331525 0.0049293995 1.937381e-04 2.606861e-03 16 4803566 4803682 117 - 2.172 2.338 0.554
ENSG00000140632 E005 134.987200 0.0178150669 2.558921e-01 4.946149e-01 16 4803683 4803702 20 - 2.077 2.168 0.305
ENSG00000140632 E006 118.750948 0.0137368551 6.637512e-01 8.122575e-01 16 4803703 4803707 5 - 2.055 2.089 0.112
ENSG00000140632 E007 243.717820 0.0080933291 8.479314e-01 9.238010e-01 16 4803708 4803755 48 - 2.389 2.381 -0.024
ENSG00000140632 E008 251.394013 0.0055729333 4.787641e-01 6.862932e-01 16 4803756 4803789 34 - 2.414 2.385 -0.095
ENSG00000140632 E009 889.556258 0.0002818334 1.008440e-01 2.833025e-01 16 4803790 4804148 359 - 2.932 2.956 0.078
ENSG00000140632 E010 695.016511 0.0001237329 5.534549e-11 4.124150e-09 16 4804149 4804521 373 - 2.786 2.878 0.307
ENSG00000140632 E011 921.403456 0.0001528635 1.777779e-03 1.555344e-02 16 4804522 4805048 527 - 2.940 2.979 0.131
ENSG00000140632 E012 472.959437 0.0001704043 2.811333e-03 2.225880e-02 16 4805049 4805310 262 - 2.644 2.695 0.171
ENSG00000140632 E013 351.251221 0.0001726158 1.595810e-01 3.761558e-01 16 4811170 4811294 125 - 2.559 2.532 -0.089
ENSG00000140632 E014 485.800919 0.0001864945 4.288099e-02 1.622480e-01 16 4811623 4811802 180 - 2.702 2.669 -0.112
ENSG00000140632 E015 19.417799 0.0578634234 6.163981e-01 7.813292e-01 16 4811889 4811975 87 - 1.328 1.284 -0.156
ENSG00000140632 E016 18.934597 0.0692737365 7.370554e-01 8.586272e-01 16 4811976 4812085 110 - 1.308 1.282 -0.089
ENSG00000140632 E017 462.633609 0.0001372949 3.974980e-01 6.263571e-01 16 4812086 4812248 163 - 2.670 2.656 -0.047
ENSG00000140632 E018 351.062558 0.0024619196 8.604000e-01 9.305666e-01 16 4813737 4813838 102 - 2.545 2.542 -0.011
ENSG00000140632 E019 27.832882 0.0785598855 5.892260e-01 7.631481e-01 16 4813839 4813955 117 - 1.479 1.440 -0.135
ENSG00000140632 E020 206.134969 0.0007216190 6.568668e-01 8.078846e-01 16 4814537 4814566 30 - 2.319 2.308 -0.038
ENSG00000140632 E021 241.585971 0.0031118583 6.882264e-01 8.279898e-01 16 4814567 4814629 63 - 2.372 2.389 0.056
ENSG00000140632 E022 123.789653 0.0035029721 4.067260e-01 6.335665e-01 16 4814630 4814647 18 - 2.073 2.109 0.122
ENSG00000140632 E023 251.299642 0.0024953338 8.240798e-01 9.103356e-01 16 4817598 4817652 55 - 2.394 2.402 0.027
ENSG00000140632 E024 197.270179 0.0004002744 8.958443e-01 9.496920e-01 16 4817653 4817663 11 - 2.297 2.293 -0.011
ENSG00000140632 E025 265.030690 0.0025738443 3.245950e-02 1.345859e-01 16 4817664 4817697 34 - 2.460 2.391 -0.228
ENSG00000140632 E026 18.266275 0.1096460513 6.723554e-01 8.178129e-01 16 4817698 4817923 226 - 1.289 1.272 -0.059
ENSG00000140632 E027 14.159718 0.0088815194 3.309620e-02 1.363206e-01 16 4821204 4821379 176 - 1.286 1.078 -0.740
ENSG00000140632 E028 339.171875 0.0017340572 1.007376e-02 5.847991e-02 16 4821380 4821453 74 - 2.566 2.497 -0.230
ENSG00000140632 E029 6.870481 0.0566784384 6.987791e-01 8.348313e-01 16 4821454 4821546 93 - 0.853 0.918 0.251
ENSG00000140632 E030 239.664896 0.0002327241 1.177251e-02 6.552533e-02 16 4821547 4821597 51 - 2.410 2.351 -0.196
ENSG00000140632 E031 6.338419 0.0709645930 4.581859e-01 6.718516e-01 16 4821598 4821664 67 - 0.929 0.812 -0.448
ENSG00000140632 E032 254.839955 0.0016153437 5.447201e-03 3.695215e-02 16 4822875 4822899 25 - 2.446 2.366 -0.266
ENSG00000140632 E033 264.694813 0.0002919543 1.604796e-03 1.436114e-02 16 4822900 4822931 32 - 2.459 2.387 -0.238
ENSG00000140632 E034 316.353953 0.0002355050 3.519813e-02 1.421004e-01 16 4823821 4823907 87 - 2.522 2.479 -0.143
ENSG00000140632 E035 516.985250 0.0031477181 7.575551e-04 7.921611e-03 16 4831979 4832221 243 - 2.764 2.664 -0.334
ENSG00000140632 E036 0.000000       16 4832455 4832773 319 -      
ENSG00000140632 E037 413.994292 0.0005045376 1.117252e-05 2.309617e-04 16 4832774 4832864 91 - 2.660 2.573 -0.291
ENSG00000140632 E038 314.919202 0.0047458330 1.566142e-01 3.717011e-01 16 4832865 4832912 48 - 2.526 2.471 -0.183
ENSG00000140632 E039 0.000000       16 4833120 4833200 81 -      
ENSG00000140632 E040 4.252711 0.0469485042 7.416178e-01 8.614541e-01 16 4843404 4843602 199 - 0.753 0.702 -0.209
ENSG00000140632 E041 0.000000       16 4843603 4843912 310 -      
ENSG00000140632 E042 324.320799 0.0188746982 9.706276e-01 9.871635e-01 16 4845074 4845153 80 - 2.511 2.507 -0.014
ENSG00000140632 E043 222.939956 0.0711897315 4.116589e-01 6.372742e-01 16 4846174 4846210 37 - 2.305 2.378 0.242
ENSG00000140632 E044 136.481798 1.3131435523 5.699456e-01 7.502509e-01 16 4847228 4847362 135 - 2.078 2.175 0.326