ENSG00000140575

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000268182 ENSG00000140575 HEK293_OSMI2_6hA HEK293_TMG_6hB IQGAP1 protein_coding protein_coding 36.49504 19.32183 56.50288 4.77271 1.014974 1.547602 22.321616 8.760281 41.1495400 2.5470326 1.22756410 2.230532 0.5199125 0.44003333 0.728366667 0.28833333 1.106677e-03 4.320985e-20 FALSE TRUE
ENST00000559674 ENSG00000140575 HEK293_OSMI2_6hA HEK293_TMG_6hB IQGAP1 protein_coding retained_intron 36.49504 19.32183 56.50288 4.77271 1.014974 1.547602 7.964422 3.649070 12.8904333 0.3485205 1.44334594 1.817870 0.1912583 0.21176667 0.228100000 0.01633333 9.517881e-01 4.320985e-20 FALSE FALSE
ENST00000560738 ENSG00000140575 HEK293_OSMI2_6hA HEK293_TMG_6hB IQGAP1 protein_coding protein_coding 36.49504 19.32183 56.50288 4.77271 1.014974 1.547602 2.011499 4.325648 0.0000000 1.5453921 0.00000000 -8.760104 0.1093917 0.20503333 0.000000000 -0.20503333 4.320985e-20 4.320985e-20 FALSE TRUE
ENST00000561086 ENSG00000140575 HEK293_OSMI2_6hA HEK293_TMG_6hB IQGAP1 protein_coding retained_intron 36.49504 19.32183 56.50288 4.77271 1.014974 1.547602 2.106020 1.661943 0.0673376 1.4989386 0.02489504 -4.434212 0.1097833 0.07123333 0.001166667 -0.07006667 4.479480e-01 4.320985e-20 TRUE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000140575 E001 0.9770522 0.0155423968 6.801184e-01   15 90388242 90388246 5 + 0.236 0.333 0.674
ENSG00000140575 E002 10.4898618 0.0063391500 1.056990e-01 2.918529e-01 15 90388247 90388260 14 + 0.934 1.153 0.800
ENSG00000140575 E003 22.0000743 0.0015072385 6.767818e-02 2.198564e-01 15 90388261 90388276 16 + 1.246 1.430 0.642
ENSG00000140575 E004 112.2289886 0.0003648838 2.847064e-01 5.252548e-01 15 90388277 90388354 78 + 1.968 2.050 0.274
ENSG00000140575 E005 120.2942091 0.0004040017 5.628263e-01 7.453105e-01 15 90388355 90388396 42 + 2.002 2.065 0.211
ENSG00000140575 E006 138.3178830 0.0003177248 9.504400e-01 9.772312e-01 15 90390774 90390824 51 + 2.067 2.110 0.144
ENSG00000140575 E007 135.5270306 0.0003880119 7.440259e-01 8.630197e-01 15 90390825 90390873 49 + 2.061 2.090 0.098
ENSG00000140575 E008 12.2734229 0.0026807881 1.134160e-09 6.557932e-08 15 90390874 90391932 1059 + 0.820 1.439 2.241
ENSG00000140575 E009 127.0540670 0.0003503397 2.453081e-03 2.002450e-02 15 90426110 90426151 42 + 2.058 1.985 -0.246
ENSG00000140575 E010 167.9939745 0.0013637910 1.386122e-05 2.781136e-04 15 90426152 90426266 115 + 2.189 2.066 -0.409
ENSG00000140575 E011 135.2723309 0.0003270139 2.770659e-06 6.936777e-05 15 90429589 90429666 78 + 2.100 1.967 -0.448
ENSG00000140575 E012 0.0000000       15 90429667 90429849 183 +      
ENSG00000140575 E013 0.0000000       15 90431221 90431252 32 +      
ENSG00000140575 E014 151.2622764 0.0002857368 1.099577e-10 7.741851e-09 15 90433719 90433795 77 + 2.157 1.964 -0.647
ENSG00000140575 E015 142.2624113 0.0003487775 7.839255e-11 5.679547e-09 15 90439332 90439399 68 + 2.133 1.930 -0.682
ENSG00000140575 E016 158.7697423 0.0034764960 5.321375e-07 1.635050e-05 15 90440502 90440615 114 + 2.175 1.989 -0.621
ENSG00000140575 E017 209.4925042 0.0016131953 1.775559e-09 9.879778e-08 15 90441506 90441684 179 + 2.292 2.116 -0.590
ENSG00000140575 E018 148.0577265 0.0003488960 4.933355e-12 4.501865e-10 15 90443394 90443478 85 + 2.150 1.933 -0.727
ENSG00000140575 E019 161.0594523 0.0002703618 4.765035e-10 2.941521e-08 15 90448573 90448736 164 + 2.181 2.005 -0.589
ENSG00000140575 E020 100.2812658 0.0013961566 1.834675e-03 1.594442e-02 15 90449559 90449643 85 + 1.966 1.866 -0.337
ENSG00000140575 E021 159.9220159 0.0003723307 7.497060e-03 4.701536e-02 15 90452775 90452938 164 + 2.155 2.106 -0.163
ENSG00000140575 E022 202.4230878 0.0002694889 2.350974e-06 6.012794e-05 15 90453132 90453292 161 + 2.268 2.166 -0.340
ENSG00000140575 E023 145.6501387 0.0003252098 1.037304e-02 5.973889e-02 15 90454428 90454552 125 + 2.114 2.065 -0.162
ENSG00000140575 E024 199.0393391 0.0006171195 7.374282e-05 1.159880e-03 15 90456152 90456315 164 + 2.257 2.170 -0.290
ENSG00000140575 E025 129.2341394 0.0004799127 5.758356e-02 1.973565e-01 15 90466001 90466046 46 + 2.058 2.027 -0.103
ENSG00000140575 E026 126.2996172 0.0191348369 8.247511e-01 9.107575e-01 15 90466047 90466091 45 + 2.041 2.038 -0.010
ENSG00000140575 E027 201.7196964 0.0002707912 3.132126e-02 1.312772e-01 15 90466269 90466436 168 + 2.248 2.225 -0.076
ENSG00000140575 E028 108.8890942 0.0003981592 6.742590e-02 2.192988e-01 15 90467450 90467481 32 + 1.985 1.953 -0.107
ENSG00000140575 E029 129.6605187 0.0011385742 2.221797e-02 1.033393e-01 15 90467482 90467592 111 + 2.062 2.012 -0.165
ENSG00000140575 E030 50.2966266 0.0007784928 2.772182e-01 5.172312e-01 15 90472840 90472841 2 + 1.650 1.628 -0.075
ENSG00000140575 E031 157.1213268 0.0002956388 1.707502e-01 3.914957e-01 15 90472842 90473010 169 + 2.137 2.133 -0.013
ENSG00000140575 E032 0.3503582 0.1007559984 4.252403e-01   15 90473011 90473078 68 + 0.072 0.198 1.673
ENSG00000140575 E033 0.8158242 0.0165245489 8.140288e-01   15 90473548 90473714 167 + 0.236 0.198 -0.325
ENSG00000140575 E034 138.9479996 0.0047163349 9.575013e-02 2.743428e-01 15 90473715 90473798 84 + 2.091 2.052 -0.133
ENSG00000140575 E035 0.6190593 0.0339531636 1.000000e+00   15 90473799 90473895 97 + 0.188 0.198 0.094
ENSG00000140575 E036 130.8564503 0.0018483505 5.282290e-01 7.207862e-01 15 90473896 90473967 72 + 2.051 2.065 0.047
ENSG00000140575 E037 140.0958660 0.0003353490 1.325895e-01 3.358755e-01 15 90474064 90474133 70 + 2.088 2.076 -0.039
ENSG00000140575 E038 0.8048655 0.0209344659 1.942006e-01   15 90474134 90474239 106 + 0.280 0.000 -12.002
ENSG00000140575 E039 0.4654660 0.0302357719 4.541844e-01   15 90474322 90474483 162 + 0.188 0.000 -11.264
ENSG00000140575 E040 0.1426347 0.0343409934 1.000000e+00   15 90474484 90474484 1 + 0.072 0.000 -9.678
ENSG00000140575 E041 211.0913324 0.0002695344 1.006218e-03 9.962945e-03 15 90474485 90474693 209 + 2.276 2.221 -0.183
ENSG00000140575 E042 0.0000000       15 90474694 90474857 164 +      
ENSG00000140575 E043 0.1723744 0.1812706611 1.608516e-01   15 90475689 90475754 66 + 0.000 0.198 13.000
ENSG00000140575 E044 187.1065370 0.0008297116 2.505005e-01 4.885217e-01 15 90476663 90476818 156 + 2.210 2.214 0.014
ENSG00000140575 E045 214.5658742 0.0003705159 1.140491e-01 3.058400e-01 15 90477067 90477230 164 + 2.272 2.268 -0.015
ENSG00000140575 E046 269.4290556 0.0008731033 8.630230e-01 9.320244e-01 15 90477665 90477889 225 + 2.360 2.395 0.115
ENSG00000140575 E047 204.8312319 0.0002512411 3.706737e-01 6.044759e-01 15 90481960 90482100 141 + 2.232 2.298 0.221
ENSG00000140575 E048 145.2194213 0.0004237521 1.758295e-01 3.982397e-01 15 90482197 90482281 85 + 2.076 2.162 0.287
ENSG00000140575 E049 1.1368026 0.3001809370 3.310160e-01   15 90482702 90482749 48 + 0.232 0.444 1.334
ENSG00000140575 E050 0.3393995 0.0250423373 7.742866e-01   15 90483205 90483360 156 + 0.134 0.000 -10.681
ENSG00000140575 E051 281.8182896 0.0007213855 7.336758e-01 8.564421e-01 15 90483361 90483593 233 + 2.374 2.421 0.158
ENSG00000140575 E052 123.8596597 0.0050295291 9.554249e-01 9.795916e-01 15 90484220 90484244 25 + 2.022 2.052 0.101
ENSG00000140575 E053 224.5207758 0.0007799512 9.150735e-01 9.596950e-01 15 90484245 90484352 108 + 2.276 2.320 0.144
ENSG00000140575 E054 201.8732308 0.0035438692 5.236028e-01 7.175349e-01 15 90486030 90486094 65 + 2.238 2.257 0.062
ENSG00000140575 E055 176.8259213 0.0019240213 8.149327e-01 9.052081e-01 15 90486095 90486132 38 + 2.178 2.213 0.115
ENSG00000140575 E056 4.0445077 0.3157435148 6.842189e-01 8.254440e-01 15 90486133 90486558 426 + 0.607 0.758 0.637
ENSG00000140575 E057 1.7836261 0.4068038239 1.216411e-01 3.184586e-01 15 90486743 90486882 140 + 0.238 0.701 2.459
ENSG00000140575 E058 1.7625166 0.0260745344 8.866159e-01 9.449064e-01 15 90486883 90486953 71 + 0.388 0.436 0.258
ENSG00000140575 E059 297.3342288 0.0019420971 4.009560e-01 6.290620e-01 15 90486954 90487089 136 + 2.394 2.460 0.219
ENSG00000140575 E060 0.5283420 0.5069772777 6.708455e-01   15 90487469 90487494 26 + 0.137 0.200 0.650
ENSG00000140575 E061 230.3054136 0.0005837033 1.401049e-01 3.476760e-01 15 90487495 90487582 88 + 2.279 2.361 0.275
ENSG00000140575 E062 382.7017302 0.0006551440 1.160698e-01 3.092847e-01 15 90491333 90491545 213 + 2.500 2.576 0.252
ENSG00000140575 E063 0.6188717 0.0295347629 3.028908e-01   15 90491546 90491671 126 + 0.134 0.333 1.678
ENSG00000140575 E064 300.7829147 0.0002336986 2.924730e-03 2.294906e-02 15 90492545 90492711 167 + 2.386 2.496 0.368
ENSG00000140575 E065 0.9997774 0.0153787590 6.705102e-01   15 90494027 90494712 686 + 0.236 0.333 0.677
ENSG00000140575 E066 232.0308652 0.0003251070 7.635455e-07 2.246882e-05 15 90494713 90494835 123 + 2.254 2.425 0.571
ENSG00000140575 E067 1.6369976 0.6652735201 7.775360e-01 8.832240e-01 15 90496714 90497231 518 + 0.318 0.530 1.145
ENSG00000140575 E068 195.9982021 0.0108808430 1.886586e-02 9.198819e-02 15 90497232 90497340 109 + 2.171 2.369 0.661
ENSG00000140575 E069 1560.2966358 0.0114968043 1.699627e-04 2.333856e-03 15 90499995 90502239 2245 + 3.060 3.286 0.752