ENSG00000140534

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000268138 ENSG00000140534 HEK293_OSMI2_6hA HEK293_TMG_6hB TICRR protein_coding protein_coding 23.06752 33.3584 19.17282 3.662254 0.8653253 -0.7986675 12.618220 20.592357 12.092381 3.1588032 1.0403478 -0.7675186 0.54898750 0.61140000 0.62890000 0.01750000 0.96360041 0.01724725 FALSE TRUE
ENST00000560985 ENSG00000140534 HEK293_OSMI2_6hA HEK293_TMG_6hB TICRR protein_coding protein_coding 23.06752 33.3584 19.17282 3.662254 0.8653253 -0.7986675 5.251596 6.775191 2.244513 0.9769528 0.6536818 -1.5895738 0.21986667 0.20330000 0.12000000 -0.08330000 0.48207357 0.01724725 FALSE TRUE
ENST00000561095 ENSG00000140534 HEK293_OSMI2_6hA HEK293_TMG_6hB TICRR protein_coding nonsense_mediated_decay 23.06752 33.3584 19.17282 3.662254 0.8653253 -0.7986675 3.205455 4.086817 1.644249 0.2167239 0.4423493 -1.3083272 0.13697083 0.12540000 0.08413333 -0.04126667 0.60468074 0.01724725 TRUE TRUE
MSTRG.11502.5 ENSG00000140534 HEK293_OSMI2_6hA HEK293_TMG_6hB TICRR protein_coding   23.06752 33.3584 19.17282 3.662254 0.8653253 -0.7986675 1.855413 1.824023 2.877049 0.1427468 0.2900479 0.6545838 0.08735417 0.05713333 0.15050000 0.09336667 0.01724725 0.01724725 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000140534 E001 28.86615 0.0014273677 6.514674e-01 8.044738e-01 15 89575469 89575586 118 + 1.410 1.468 0.200
ENSG00000140534 E002 82.47148 0.0005612557 5.211642e-01 7.156732e-01 15 89575587 89575868 282 + 1.899 1.900 0.002
ENSG00000140534 E003 67.96181 0.0041257530 2.266071e-01 4.613339e-01 15 89575869 89575966 98 + 1.840 1.804 -0.120
ENSG00000140534 E004 150.70177 0.0093994912 3.251313e-03 2.491191e-02 15 89575967 89576240 274 + 2.241 2.108 -0.445
ENSG00000140534 E005 196.19625 0.0032826438 3.938779e-11 3.030789e-09 15 89582686 89582965 280 + 2.403 2.186 -0.725
ENSG00000140534 E006 55.10163 0.0129942804 1.118967e-02 6.314429e-02 15 89584286 89584288 3 + 1.825 1.668 -0.532
ENSG00000140534 E007 173.92286 0.0045001641 2.167071e-06 5.599795e-05 15 89584289 89584527 239 + 2.325 2.153 -0.575
ENSG00000140534 E008 161.87798 0.0036023139 1.063747e-04 1.575791e-03 15 89585708 89585942 235 + 2.268 2.141 -0.425
ENSG00000140534 E009 51.80495 0.0030815964 1.053554e-03 1.031941e-02 15 89592047 89592061 15 + 1.800 1.646 -0.524
ENSG00000140534 E010 110.46762 0.0045246665 2.454813e-05 4.546168e-04 15 89592062 89592176 115 + 2.129 1.961 -0.563
ENSG00000140534 E011 147.67204 0.0062924959 3.170359e-07 1.035583e-05 15 89594415 89594554 140 + 2.280 2.065 -0.720
ENSG00000140534 E012 211.56683 0.0023919417 3.074030e-13 3.477955e-11 15 89595393 89595611 219 + 2.435 2.219 -0.721
ENSG00000140534 E013 168.67466 0.0093647002 2.008725e-03 1.712376e-02 15 89599324 89599475 152 + 2.288 2.154 -0.447
ENSG00000140534 E014 142.40810 0.0083887191 1.205110e-04 1.743677e-03 15 89600585 89600685 101 + 2.239 2.065 -0.580
ENSG00000140534 E015 139.29665 0.0063995817 8.648202e-03 5.225445e-02 15 89601298 89601391 94 + 2.186 2.083 -0.346
ENSG00000140534 E016 131.17043 0.0041456364 2.338950e-01 4.696402e-01 15 89601489 89601568 80 + 2.112 2.084 -0.092
ENSG00000140534 E017 251.85013 0.0002474926 7.636758e-04 7.975507e-03 15 89601737 89601976 240 + 2.414 2.361 -0.176
ENSG00000140534 E018 167.61679 0.0094087578 4.817936e-01 6.883024e-01 15 89602796 89602892 97 + 2.215 2.195 -0.065
ENSG00000140534 E019 135.87408 0.0771830746 5.236596e-01 7.175737e-01 15 89606768 89606825 58 + 2.066 2.129 0.209
ENSG00000140534 E020 181.85126 1.2409692884 5.421369e-01 7.305886e-01 15 89608803 89608949 147 + 2.151 2.270 0.399
ENSG00000140534 E021 124.31281 0.6168195679 4.767895e-01 6.848559e-01 15 89616405 89616495 91 + 2.009 2.098 0.297
ENSG00000140534 E022 111.80814 0.2055657881 4.538441e-01 6.686142e-01 15 89618152 89618210 59 + 1.970 2.050 0.269
ENSG00000140534 E023 199.57600 0.0094404573 8.253393e-01 9.111401e-01 15 89619708 89619842 135 + 2.258 2.286 0.094
ENSG00000140534 E024 221.10736 0.0009726593 9.263312e-01 9.652781e-01 15 89621393 89621550 158 + 2.303 2.326 0.078
ENSG00000140534 E025 1300.32664 0.0059549427 3.907561e-01 6.209783e-01 15 89623623 89625399 1777 + 3.049 3.104 0.185
ENSG00000140534 E026 458.42319 0.0025187144 8.895933e-05 1.355040e-03 15 89625400 89625786 387 + 2.533 2.678 0.482
ENSG00000140534 E027 272.80721 0.0028726284 6.468661e-05 1.038404e-03 15 89625936 89626061 126 + 2.291 2.458 0.558
ENSG00000140534 E028 378.53436 0.0021438059 9.659178e-08 3.598049e-06 15 89626956 89627182 227 + 2.418 2.604 0.621
ENSG00000140534 E029 731.31434 0.0015127922 5.573463e-20 1.654724e-17 15 89627183 89628023 841 + 2.666 2.902 0.784
ENSG00000140534 E030 62.93419 0.5700860163 3.106617e-01 5.511533e-01 15 89628052 89628385 334 + 1.620 1.839 0.740
ENSG00000140534 E031 283.77360 0.4423145215 3.014925e-01 5.420093e-01 15 89629430 89633093 3664 + 2.290 2.480 0.633