ENSG00000140463

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000268057 ENSG00000140463 HEK293_OSMI2_6hA HEK293_TMG_6hB BBS4 protein_coding protein_coding 12.19373 6.781916 17.18381 0.6223793 0.4021799 1.339999 7.6105405 4.1535068 9.915055 0.6799408 0.5524441 1.2532759 0.62897500 0.60633333 0.57850000 -0.02783333 9.436008e-01 2.123995e-07 FALSE  
ENST00000562219 ENSG00000140463 HEK293_OSMI2_6hA HEK293_TMG_6hB BBS4 protein_coding retained_intron 12.19373 6.781916 17.18381 0.6223793 0.4021799 1.339999 0.6884361 0.6200892 1.031108 0.1906719 0.1783932 0.7244917 0.06242083 0.09733333 0.05976667 -0.03756667 8.311397e-01 2.123995e-07 FALSE  
ENST00000568535 ENSG00000140463 HEK293_OSMI2_6hA HEK293_TMG_6hB BBS4 protein_coding retained_intron 12.19373 6.781916 17.18381 0.6223793 0.4021799 1.339999 1.0673133 0.9421188 1.918433 0.2513534 0.3913266 1.0182158 0.08883333 0.14173333 0.11093333 -0.03080000 9.212067e-01 2.123995e-07 FALSE  
ENST00000569151 ENSG00000140463 HEK293_OSMI2_6hA HEK293_TMG_6hB BBS4 protein_coding retained_intron 12.19373 6.781916 17.18381 0.6223793 0.4021799 1.339999 0.5760247 0.0000000 1.183610 0.0000000 0.1717336 6.8991872 0.04224583 0.00000000 0.06870000 0.06870000 2.123995e-07 2.123995e-07    
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000140463 E001 0.2027342 0.0358043249 0.227961499   15 72686179 72686185 7 + 0.000 0.168 11.134
ENSG00000140463 E002 0.2027342 0.0358043249 0.227961499   15 72686186 72686193 8 + 0.000 0.168 13.379
ENSG00000140463 E003 1.2151357 0.0514070011 0.573991401   15 72686194 72686203 10 + 0.276 0.383 0.669
ENSG00000140463 E004 1.2151357 0.0514070011 0.573991401   15 72686204 72686206 3 + 0.276 0.383 0.669
ENSG00000140463 E005 6.9669346 0.0042657791 0.549255759 0.73580766 15 72686207 72686219 13 + 0.896 0.822 -0.286
ENSG00000140463 E006 16.2105153 0.0020933892 0.162328129 0.38024602 15 72686220 72686236 17 + 1.246 1.121 -0.446
ENSG00000140463 E007 19.4109367 0.0017599788 0.173283396 0.39487287 15 72686237 72686251 15 + 1.317 1.205 -0.393
ENSG00000140463 E008 1.0179383 0.5196067364 0.636427051   15 72686252 72686389 138 + 0.224 0.389 1.097
ENSG00000140463 E009 2.5057689 0.0366313871 0.040009864 0.15473951 15 72686390 72686461 72 + 0.368 0.719 1.665
ENSG00000140463 E010 3.8503677 0.0095161334 0.131510197 0.33419310 15 72686462 72686564 103 + 0.564 0.790 0.958
ENSG00000140463 E011 0.0000000       15 72686750 72686840 91 +      
ENSG00000140463 E012 28.4409772 0.0015434743 0.426826436 0.64862906 15 72695177 72695228 52 + 1.458 1.405 -0.182
ENSG00000140463 E013 0.0000000       15 72697992 72698037 46 +      
ENSG00000140463 E014 0.3393995 0.0274424043 0.503312742   15 72704424 72704481 58 + 0.159 0.000 -13.928
ENSG00000140463 E015 23.2422861 0.0016256979 0.342178056 0.57990547 15 72709700 72709705 6 + 1.377 1.307 -0.245
ENSG00000140463 E016 38.9161730 0.0009346116 0.417304459 0.64160520 15 72709706 72709779 74 + 1.587 1.542 -0.156
ENSG00000140463 E017 40.2657138 0.0009315013 0.407244512 0.63392547 15 72712244 72712307 64 + 1.604 1.559 -0.155
ENSG00000140463 E018 51.1493697 0.0007496290 0.023485759 0.10750174 15 72715291 72715402 112 + 1.728 1.612 -0.396
ENSG00000140463 E019 38.6641758 0.0010131468 0.003437062 0.02597535 15 72716778 72716827 50 + 1.623 1.443 -0.615
ENSG00000140463 E020 32.9737392 0.0013264472 0.456497954 0.67065368 15 72716828 72716850 23 + 1.523 1.479 -0.152
ENSG00000140463 E021 0.2027342 0.0358043249 0.227961499   15 72716851 72716851 1 + 0.000 0.168 13.379
ENSG00000140463 E022 1.0213349 0.3881215568 0.926492428   15 72717030 72717355 326 + 0.280 0.291 0.079
ENSG00000140463 E023 2.7437732 0.0078976288 0.052152845 0.18474984 15 72722789 72722793 5 + 0.636 0.288 -1.823
ENSG00000140463 E024 40.1363594 0.0011522519 0.965000303 0.98444303 15 72722794 72722829 36 + 1.590 1.596 0.023
ENSG00000140463 E025 38.5358239 0.0011561262 0.576954876 0.75509373 15 72722830 72722847 18 + 1.582 1.553 -0.100
ENSG00000140463 E026 0.3228314 0.3925088564 0.622869075   15 72722848 72722848 1 + 0.160 0.000 -12.834
ENSG00000140463 E027 76.3987534 0.0008677122 0.504865726 0.70422936 15 72724528 72724655 128 + 1.873 1.848 -0.084
ENSG00000140463 E028 0.6246688 0.0192593916 0.166309409   15 72724656 72724657 2 + 0.275 0.000 -14.958
ENSG00000140463 E029 48.3003472 0.0023854092 0.335039616 0.57360041 15 72727940 72727994 55 + 1.652 1.709 0.193
ENSG00000140463 E030 48.3707510 0.0040974862 0.609715813 0.77671860 15 72729616 72729684 69 + 1.660 1.692 0.109
ENSG00000140463 E031 61.4193188 0.0006534926 0.345052324 0.58262230 15 72731305 72731457 153 + 1.755 1.802 0.161
ENSG00000140463 E032 0.3453689 0.0274424043 0.581131805   15 72731458 72731458 1 + 0.087 0.168 1.089
ENSG00000140463 E033 22.5348038 0.0017714741 0.235572682 0.47148685 15 72731555 72731556 2 + 1.312 1.405 0.323
ENSG00000140463 E034 51.5171122 0.0009211909 0.975778140 0.98968544 15 72731557 72731681 125 + 1.695 1.697 0.008
ENSG00000140463 E035 36.4645858 0.0011083673 0.337119245 0.57552175 15 72731682 72731726 45 + 1.567 1.511 -0.191
ENSG00000140463 E036 0.4868358 0.2092932279 1.000000000   15 72735077 72735112 36 + 0.161 0.165 0.044
ENSG00000140463 E037 46.5447051 0.0009595199 0.997041786 1.00000000 15 72735113 72735182 70 + 1.650 1.654 0.014
ENSG00000140463 E038 18.8659688 0.1382336142 0.834060667 0.91605777 15 72735183 72735516 334 + 1.248 1.319 0.248
ENSG00000140463 E039 20.8623184 0.0652369270 0.123860577 0.32183813 15 72735517 72735824 308 + 1.225 1.441 0.753
ENSG00000140463 E040 81.5815294 0.0005632957 0.317820535 0.55778796 15 72735825 72735966 142 + 1.874 1.918 0.147
ENSG00000140463 E041 92.0608350 0.0013243197 0.533727224 0.72471366 15 72736762 72736963 202 + 1.952 1.931 -0.072
ENSG00000140463 E042 5.4899383 0.2661476312 0.574273108 0.75320335 15 72736964 72737092 129 + 0.848 0.591 -1.060
ENSG00000140463 E043 196.0646424 0.0004036885 0.003980212 0.02904462 15 72737478 72738475 998 + 2.243 2.318 0.251