ENSG00000140443

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000649865 ENSG00000140443 HEK293_OSMI2_6hA HEK293_TMG_6hB IGF1R protein_coding protein_coding 8.843503 10.95307 9.963393 0.4773781 0.1864929 -0.1364955 1.305759 2.9112232 0.4279216 0.29599025 0.4279216 -2.7378282 0.1523875 0.26450000 0.04193333 -0.2225667 0.14914120 0.01134729 FALSE TRUE
ENST00000650285 ENSG00000140443 HEK293_OSMI2_6hA HEK293_TMG_6hB IGF1R protein_coding protein_coding 8.843503 10.95307 9.963393 0.4773781 0.1864929 -0.1364955 2.748765 2.3346529 3.6285024 0.03168157 0.3096354 0.6339704 0.3081917 0.21393333 0.36533333 0.1514000 0.07641094 0.01134729 FALSE TRUE
MSTRG.11627.5 ENSG00000140443 HEK293_OSMI2_6hA HEK293_TMG_6hB IGF1R protein_coding   8.843503 10.95307 9.963393 0.4773781 0.1864929 -0.1364955 1.536101 2.1428092 1.9655991 0.33216350 0.2298683 -0.1239302 0.1722333 0.19393333 0.19673333 0.0028000 1.00000000 0.01134729 FALSE TRUE
MSTRG.11627.6 ENSG00000140443 HEK293_OSMI2_6hA HEK293_TMG_6hB IGF1R protein_coding   8.843503 10.95307 9.963393 0.4773781 0.1864929 -0.1364955 1.506115 2.1347413 0.8893152 0.28191447 0.2509918 -1.2539049 0.1744792 0.19393333 0.08943333 -0.1045000 0.27493493 0.01134729 FALSE TRUE
MSTRG.11627.7 ENSG00000140443 HEK293_OSMI2_6hA HEK293_TMG_6hB IGF1R protein_coding   8.843503 10.95307 9.963393 0.4773781 0.1864929 -0.1364955 1.225742 0.2013839 2.8218728 0.14671239 0.2458882 3.7438188 0.1319000 0.01896667 0.28393333 0.2649667 0.01134729 0.01134729 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000140443 E001 5.6120610 0.0051922501 9.205568e-01 9.625100e-01 15 98648539 98648630 92 + 0.796 0.817 0.082
ENSG00000140443 E002 10.1174892 0.0032717423 4.491492e-01 6.651247e-01 15 98648631 98648971 341 + 0.966 1.083 0.430
ENSG00000140443 E003 21.1872187 0.0042841279 2.307824e-01 4.660520e-01 15 98648972 98649451 480 + 1.261 1.396 0.472
ENSG00000140443 E004 17.3765175 0.0018698820 1.093590e-01 2.980541e-01 15 98649452 98649581 130 + 1.311 1.219 -0.325
ENSG00000140443 E005 31.4357490 0.0074304371 3.888580e-02 1.518643e-01 15 98649582 98649675 94 + 1.568 1.455 -0.385
ENSG00000140443 E006 93.5784262 0.0019315014 4.827267e-05 8.071094e-04 15 98707562 98707830 269 + 2.041 1.913 -0.431
ENSG00000140443 E007 102.1886290 0.0004043751 4.608690e-08 1.852892e-06 15 98707831 98708107 277 + 2.090 1.939 -0.510
ENSG00000140443 E008 0.0000000       15 98734712 98734753 42 +      
ENSG00000140443 E009 0.0000000       15 98820866 98820883 18 +      
ENSG00000140443 E010 0.0000000       15 98820884 98820940 57 +      
ENSG00000140443 E011 0.1723744 0.0332793988 6.839022e-01   15 98824180 98824242 63 + 0.000 0.107 10.452
ENSG00000140443 E012 0.1308682 0.0308010913 6.854051e-01   15 98873719 98873855 137 + 0.000 0.106 10.480
ENSG00000140443 E013 0.0000000       15 98890341 98890468 128 +      
ENSG00000140443 E014 0.0000000       15 98890542 98890755 214 +      
ENSG00000140443 E015 92.3582334 0.0005056838 1.491117e-07 5.313178e-06 15 98891325 98891637 313 + 2.050 1.896 -0.519
ENSG00000140443 E016 73.5609939 0.0041376964 1.742922e-04 2.384117e-03 15 98896757 98896905 149 + 1.948 1.796 -0.510
ENSG00000140443 E017 0.3150090 0.0278703957 7.758710e-01   15 98896906 98896919 14 + 0.138 0.107 -0.430
ENSG00000140443 E018 0.0000000       15 98897286 98897488 203 +      
ENSG00000140443 E019 76.6173508 0.0005127065 2.707898e-03 2.161372e-02 15 98899477 98899621 145 + 1.931 1.849 -0.275
ENSG00000140443 E020 0.0000000       15 98900610 98900763 154 +      
ENSG00000140443 E021 101.2022242 0.0005352495 1.825625e-03 1.588203e-02 15 98908685 98908899 215 + 2.046 1.974 -0.240
ENSG00000140443 E022 73.5052233 0.0032081692 8.832632e-01 9.429719e-01 15 98911315 98911441 127 + 1.849 1.881 0.107
ENSG00000140443 E023 78.6835450 0.0005982189 1.158844e-01 3.089408e-01 15 98913044 98913175 132 + 1.910 1.885 -0.081
ENSG00000140443 E024 77.5897561 0.0028691483 2.923696e-01 5.330801e-01 15 98913176 98913282 107 + 1.899 1.888 -0.035
ENSG00000140443 E025 52.8116568 0.0010889202 4.056517e-02 1.562250e-01 15 98915964 98915993 30 + 1.766 1.705 -0.207
ENSG00000140443 E026 47.5529390 0.0009137740 3.402386e-02 1.389218e-01 15 98915994 98916013 20 + 1.722 1.652 -0.237
ENSG00000140443 E027 78.7785652 0.0005944622 3.690898e-01 6.033182e-01 15 98916014 98916131 118 + 1.895 1.899 0.013
ENSG00000140443 E028 0.3751086 0.0260988334 3.252494e-01   15 98916485 98916671 187 + 0.000 0.192 11.544
ENSG00000140443 E029 105.2753114 0.0016115508 5.159804e-02 1.835319e-01 15 98916672 98916876 205 + 2.042 2.007 -0.118
ENSG00000140443 E030 0.0000000       15 98916877 98916955 79 +      
ENSG00000140443 E031 132.9273739 0.0006983436 9.018567e-03 5.391036e-02 15 98922148 98922431 284 + 2.150 2.106 -0.146
ENSG00000140443 E032 0.3206185 0.0274424043 1.155323e-01   15 98923782 98923875 94 + 0.243 0.000 -12.651
ENSG00000140443 E033 90.3189241 0.0004517392 1.459779e-01 3.563450e-01 15 98923876 98924012 137 + 1.964 1.949 -0.049
ENSG00000140443 E034 65.7381975 0.0023620631 2.390745e-01 4.755448e-01 15 98924525 98924599 75 + 1.828 1.810 -0.062
ENSG00000140443 E035 68.2232165 0.0059151083 2.771345e-01 5.171847e-01 15 98924600 98924684 85 + 1.846 1.824 -0.075
ENSG00000140443 E036 27.5461369 0.0185855507 3.470010e-01 5.845237e-01 15 98929558 98929560 3 + 1.477 1.433 -0.152
ENSG00000140443 E037 76.4340045 0.0128779500 2.784208e-01 5.185425e-01 15 98929561 98929660 100 + 1.902 1.868 -0.115
ENSG00000140443 E038 62.6049920 0.0042765294 6.771343e-01 8.208918e-01 15 98930235 98930305 71 + 1.758 1.819 0.206
ENSG00000140443 E039 120.1083805 0.0004384360 1.695452e-01 3.899268e-01 15 98934824 98935053 230 + 2.079 2.073 -0.019
ENSG00000140443 E040 97.8165989 0.0004257028 8.691143e-02 2.580884e-01 15 98935316 98935426 111 + 2.001 1.980 -0.074
ENSG00000140443 E041 121.9171242 0.0025852031 2.596834e-01 4.986293e-01 15 98939201 98939360 160 + 2.085 2.078 -0.023
ENSG00000140443 E042 105.2915172 0.0007955517 3.915532e-01 6.216670e-01 15 98942923 98943052 130 + 2.013 2.021 0.028
ENSG00000140443 E043 96.2254163 0.0004409315 1.542894e-01 3.683870e-01 15 98948574 98948708 135 + 1.925 2.018 0.313
ENSG00000140443 E044 3.6474204 0.1149816802 1.931752e-01 4.210197e-01 15 98952795 98953110 316 + 0.459 0.774 1.397
ENSG00000140443 E045 167.2917637 0.0019464292 4.185452e-02 1.595766e-01 15 98957061 98957469 409 + 2.154 2.264 0.366
ENSG00000140443 E046 27.3501517 0.0024831831 2.280795e-01 4.630658e-01 15 98957470 98957474 5 + 1.371 1.495 0.429
ENSG00000140443 E047 27.3553811 0.0103974784 3.148501e-01 5.550023e-01 15 98957475 98957476 2 + 1.371 1.492 0.419
ENSG00000140443 E048 159.4240385 0.0028018161 3.228249e-01 5.621581e-01 15 98957477 98957962 486 + 2.154 2.232 0.260
ENSG00000140443 E049 1484.8094282 0.0024363903 4.888284e-09 2.466993e-07 15 98957963 98964530 6568 + 3.079 3.220 0.470