ENSG00000140391

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000346495 ENSG00000140391 HEK293_OSMI2_6hA HEK293_TMG_6hB TSPAN3 protein_coding protein_coding 323.1653 223.1026 335.686 8.344842 5.876734 0.5893831 72.54363 54.30904 69.22103 4.187050 4.087521 0.3499608 0.23065417 0.2442000 0.2060333 -0.03816667 0.7292467 0.0201669 FALSE TRUE
ENST00000558394 ENSG00000140391 HEK293_OSMI2_6hA HEK293_TMG_6hB TSPAN3 protein_coding processed_transcript 323.1653 223.1026 335.686 8.344842 5.876734 0.5893831 32.51911 24.17643 21.90287 4.915608 1.972363 -0.1424190 0.09418333 0.1076333 0.0655000 -0.04213333 0.5009535 0.0201669 FALSE FALSE
ENST00000561277 ENSG00000140391 HEK293_OSMI2_6hA HEK293_TMG_6hB TSPAN3 protein_coding protein_coding 323.1653 223.1026 335.686 8.344842 5.876734 0.5893831 205.43603 135.41238 234.45885 6.034278 6.376548 0.7919301 0.63571667 0.6066333 0.6983333 0.09170000 0.0201669 0.0201669   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000140391 E001 305.703982 2.537242e-03 1.490336e-10 1.019305e-08 15 77041404 77046029 4626 - 2.381 2.580 0.665
ENSG00000140391 E002 131.798056 2.130770e-03 5.128846e-03 3.529157e-02 15 77046030 77046059 30 - 2.069 2.169 0.337
ENSG00000140391 E003 277.842093 5.331115e-03 7.050683e-01 8.387691e-01 15 77046060 77046083 24 - 2.452 2.431 -0.069
ENSG00000140391 E004 2115.164865 6.665316e-04 2.222703e-04 2.917951e-03 15 77046084 77046331 248 - 3.347 3.293 -0.181
ENSG00000140391 E005 5020.373161 2.441308e-04 1.545972e-02 7.981972e-02 15 77046332 77046927 596 - 3.708 3.687 -0.069
ENSG00000140391 E006 1383.031872 7.975864e-04 2.092656e-01 4.409913e-01 15 77052385 77052468 84 - 3.131 3.149 0.060
ENSG00000140391 E007 1812.984437 2.417922e-04 6.938510e-03 4.434604e-02 15 77052777 77052929 153 - 3.245 3.269 0.082
ENSG00000140391 E008 810.380241 1.096202e-04 3.396485e-01 5.776915e-01 15 77054178 77054180 3 - 2.903 2.910 0.024
ENSG00000140391 E009 1786.920041 6.327744e-05 6.422642e-01 7.983441e-01 15 77054181 77054279 99 - 3.253 3.244 -0.030
ENSG00000140391 E010 17.758079 3.075115e-03 6.919246e-02 2.231783e-01 15 77054280 77055788 1509 - 1.330 1.170 -0.562
ENSG00000140391 E011 1341.172488 2.795102e-04 4.903463e-02 1.772765e-01 15 77055789 77055829 41 - 3.137 3.110 -0.091
ENSG00000140391 E012 1072.091983 3.810398e-04 1.276175e-04 1.830592e-03 15 77055830 77055835 6 - 3.053 2.996 -0.190
ENSG00000140391 E013 1281.103757 4.736666e-04 4.357481e-02 1.640654e-01 15 77055836 77055863 28 - 3.119 3.088 -0.104
ENSG00000140391 E014 4.543230 1.136167e-02 4.422790e-01 6.602789e-01 15 77055864 77056063 200 - 0.800 0.688 -0.454
ENSG00000140391 E015 2175.114926 2.087176e-04 4.164753e-01 6.410267e-01 15 77056064 77056255 192 - 3.340 3.329 -0.037
ENSG00000140391 E016 10.988534 4.931059e-03 8.434055e-03 5.130737e-02 15 77069867 77070058 192 - 1.189 0.906 -1.037
ENSG00000140391 E017 789.374662 4.694167e-04 2.661843e-15 4.216811e-13 15 77070892 77071004 113 - 2.833 2.957 0.410
ENSG00000140391 E018 348.194970 9.829759e-04 1.112179e-26 6.745483e-24 15 77071005 77071122 118 - 2.402 2.658 0.854
ENSG00000140391 E019 1.499667 8.503408e-02 7.576014e-01 8.711659e-01 15 77083847 77083984 138 - 0.391 0.439 0.262