ENSG00000140382

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000336216 ENSG00000140382 HEK293_OSMI2_6hA HEK293_TMG_6hB HMG20A protein_coding protein_coding 29.62031 20.01394 40.63963 2.297837 1.742366 1.021516 17.453036 13.683995 20.263722 1.7202590 1.3096790 0.5660676 0.60827500 0.6837667 0.49820000 -0.185566667 1.483680e-02 2.462057e-32 FALSE TRUE
ENST00000558845 ENSG00000140382 HEK293_OSMI2_6hA HEK293_TMG_6hB HMG20A protein_coding protein_coding 29.62031 20.01394 40.63963 2.297837 1.742366 1.021516 2.222048 2.441204 3.258707 0.8144662 0.4550245 0.4152295 0.07707917 0.1180000 0.08016667 -0.037833333 7.989243e-01 2.462057e-32 FALSE TRUE
ENST00000560867 ENSG00000140382 HEK293_OSMI2_6hA HEK293_TMG_6hB HMG20A protein_coding protein_coding 29.62031 20.01394 40.63963 2.297837 1.742366 1.021516 2.752586 0.000000 8.468670 0.0000000 0.7474413 9.7276941 0.07235417 0.0000000 0.20766667 0.207666667 2.462057e-32 2.462057e-32 FALSE FALSE
MSTRG.11285.2 ENSG00000140382 HEK293_OSMI2_6hA HEK293_TMG_6hB HMG20A protein_coding   29.62031 20.01394 40.63963 2.297837 1.742366 1.021516 3.338249 2.327034 4.994152 0.4132778 0.1303057 1.0984469 0.11179583 0.1153000 0.12353333 0.008233333 9.400727e-01 2.462057e-32 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000140382 E001 7.5511608 0.0392967137 0.9885441839 0.9960516838 15 77420412 77420673 262 + 0.898 0.955 0.213
ENSG00000140382 E002 8.3846709 0.2573354065 0.6503283857 0.8037807328 15 77420674 77420721 48 + 0.926 1.028 0.379
ENSG00000140382 E003 10.9730315 0.2917803576 0.5923779248 0.7651773482 15 77420722 77420737 16 + 1.026 1.133 0.387
ENSG00000140382 E004 33.0206464 0.4219912058 0.4967011986 0.6986897043 15 77420738 77420834 97 + 1.471 1.591 0.411
ENSG00000140382 E005 34.9520890 0.0583316337 0.6797065030 0.8225032082 15 77420835 77420887 53 + 1.508 1.602 0.319
ENSG00000140382 E006 38.8019618 0.0009676996 0.2962974160 0.5368436155 15 77420888 77420901 14 + 1.585 1.599 0.051
ENSG00000140382 E007 61.9165312 0.0006044299 0.0145556087 0.0764576905 15 77420902 77420920 19 + 1.799 1.761 -0.126
ENSG00000140382 E008 60.8513913 0.0006682793 0.0041755085 0.0301358849 15 77420921 77420934 14 + 1.800 1.742 -0.198
ENSG00000140382 E009 110.8051195 0.0029067276 0.0158760997 0.0813458509 15 77420935 77421004 70 + 2.044 2.022 -0.072
ENSG00000140382 E010 0.5283420 0.4400710735 0.8442789870   15 77421011 77421094 84 + 0.180 0.153 -0.283
ENSG00000140382 E011 2.7915563 0.0081577763 0.2302903703 0.4654677643 15 77447719 77447811 93 + 0.628 0.489 -0.641
ENSG00000140382 E012 0.0000000       15 77458217 77458284 68 +      
ENSG00000140382 E013 116.8091344 0.0007864139 0.0010116556 0.0099983933 15 77458404 77458453 50 + 2.071 2.033 -0.130
ENSG00000140382 E014 129.8086500 0.0006016054 0.0000193396 0.0003717146 15 77458454 77458496 43 + 2.126 2.062 -0.217
ENSG00000140382 E015 0.4820342 0.0215581387 0.1490875492   15 77458497 77458558 62 + 0.243 0.000 -9.605
ENSG00000140382 E016 154.4794367 0.0061564471 0.0174894263 0.0872534328 15 77464240 77464322 83 + 2.189 2.161 -0.093
ENSG00000140382 E017 153.1577782 0.0093885729 0.0066420256 0.0429097543 15 77464323 77464387 65 + 2.198 2.135 -0.211
ENSG00000140382 E018 1.4999724 0.2169300548 0.6307119107 0.7908445577 15 77464388 77464823 436 + 0.400 0.356 -0.252
ENSG00000140382 E019 173.0731435 0.0025466048 0.0002007203 0.0026833753 15 77467095 77467182 88 + 2.248 2.195 -0.175
ENSG00000140382 E020 209.0363348 0.0024776130 0.0065901384 0.0426524284 15 77467183 77467307 125 + 2.314 2.303 -0.034
ENSG00000140382 E021 198.3808838 0.0051072355 0.0401901657 0.1551714108 15 77470910 77471042 133 + 2.288 2.285 -0.007
ENSG00000140382 E022 103.4723645 0.0045796641 0.6237833427 0.7864580879 15 77471783 77471814 32 + 1.980 2.038 0.194
ENSG00000140382 E023 125.0771760 0.0004078727 0.4932606834 0.6961382274 15 77477555 77477630 76 + 2.065 2.119 0.182
ENSG00000140382 E024 1.8973289 0.0149470228 0.5669417009 0.7479722848 15 77478123 77478292 170 + 0.477 0.426 -0.259
ENSG00000140382 E025 1.6424194 0.0114587198 0.9158830652 0.9601230249 15 77478293 77478294 2 + 0.398 0.426 0.155
ENSG00000140382 E026 182.3487076 0.0071689172 0.9067700426 0.9554770172 15 77478295 77478510 216 + 2.217 2.297 0.268
ENSG00000140382 E027 169.7369125 0.0081150777 0.6998534114 0.8355342117 15 77479179 77479321 143 + 2.193 2.259 0.220
ENSG00000140382 E028 24.7030811 0.0482274966 0.3847908643 0.6163295350 15 77479322 77479604 283 + 1.309 1.516 0.714
ENSG00000140382 E029 13.1302523 0.0562936579 0.3709979240 0.6047317795 15 77482050 77482969 920 + 1.152 1.094 -0.206
ENSG00000140382 E030 1291.0033531 0.0295380593 0.0105946981 0.0606513878 15 77482970 77485607 2638 + 3.006 3.216 0.698