ENSG00000140374

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000267950 ENSG00000140374 HEK293_OSMI2_6hA HEK293_TMG_6hB ETFA protein_coding nonsense_mediated_decay 115.0304 47.09135 166.6108 5.752495 9.741106 1.822728 8.370865 5.143553 4.410957 0.6431669 1.209767 -0.2212087 0.08057500 0.10946667 0.02580000 -0.083666667 0.0003742285 0.0003742285   FALSE
ENST00000433983 ENSG00000140374 HEK293_OSMI2_6hA HEK293_TMG_6hB ETFA protein_coding protein_coding 115.0304 47.09135 166.6108 5.752495 9.741106 1.822728 22.804756 10.653874 32.022975 3.1145622 1.269758 1.5868262 0.20500833 0.22186667 0.19283333 -0.029033333 0.9641257464 0.0003742285 FALSE TRUE
ENST00000559973 ENSG00000140374 HEK293_OSMI2_6hA HEK293_TMG_6hB ETFA protein_coding processed_transcript 115.0304 47.09135 166.6108 5.752495 9.741106 1.822728 38.228400 13.350666 64.213649 3.7418567 4.381770 2.2651127 0.32253333 0.28230000 0.38506667 0.102766667 0.6611525542 0.0003742285 FALSE FALSE
ENST00000560595 ENSG00000140374 HEK293_OSMI2_6hA HEK293_TMG_6hB ETFA protein_coding protein_coding 115.0304 47.09135 166.6108 5.752495 9.741106 1.822728 12.236201 5.075652 18.136277 1.3322368 2.185132 1.8351689 0.10908750 0.10436667 0.11090000 0.006533333 0.9792760619 0.0003742285 FALSE TRUE
ENST00000685548 ENSG00000140374 HEK293_OSMI2_6hA HEK293_TMG_6hB ETFA protein_coding nonsense_mediated_decay 115.0304 47.09135 166.6108 5.752495 9.741106 1.822728 18.846318 4.523450 37.675903 1.1547248 3.363554 3.0553438 0.15851250 0.09563333 0.22533333 0.129700000 0.0216477292 0.0003742285 TRUE TRUE
ENST00000688637 ENSG00000140374 HEK293_OSMI2_6hA HEK293_TMG_6hB ETFA protein_coding processed_transcript 115.0304 47.09135 166.6108 5.752495 9.741106 1.822728 8.247325 5.830829 2.257313 0.4352162 1.583984 -1.3651897 0.06472083 0.12886667 0.01283333 -0.116033333 0.2256607872 0.0003742285 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000140374 E001 3.1014675 7.549245e-03 4.116380e-06 0.0000973141 15 76188555 76188598 44 - 0.252 0.952 3.342
ENSG00000140374 E002 2.8864143 2.578283e-01 2.343464e-02 0.1073285045 15 76205902 76206041 140 - 0.301 0.877 2.712
ENSG00000140374 E003 4.9424687 1.019062e-01 8.659419e-02 0.2575648319 15 76214525 76214697 173 - 0.616 0.951 1.342
ENSG00000140374 E004 1.1002857 1.427919e-02 3.757605e-01   15 76215353 76215356 4 - 0.251 0.414 1.021
ENSG00000140374 E005 1.1002857 1.427919e-02 3.757605e-01   15 76215357 76215378 22 - 0.251 0.414 1.021
ENSG00000140374 E006 5.9277758 4.378140e-03 3.945857e-02 0.1533614018 15 76215379 76215573 195 - 0.709 0.977 1.043
ENSG00000140374 E007 13.1937714 2.319257e-03 1.719129e-01 0.3930896266 15 76215574 76216083 510 - 1.064 1.200 0.488
ENSG00000140374 E008 5.2881208 6.420299e-03 7.207935e-01 0.8486658763 15 76216084 76216129 46 - 0.771 0.720 -0.207
ENSG00000140374 E009 5.0026639 9.787718e-03 8.168470e-01 0.9063666230 15 76216130 76216249 120 - 0.725 0.762 0.147
ENSG00000140374 E010 8.3971388 9.548909e-03 9.535223e-01 0.9786838734 15 76216250 76216286 37 - 0.928 0.925 -0.011
ENSG00000140374 E011 9.4265881 1.809595e-02 2.458274e-01 0.4833971934 15 76216287 76216294 8 - 0.929 1.081 0.563
ENSG00000140374 E012 12.7160453 7.044043e-02 3.377785e-01 0.5761028819 15 76216295 76216313 19 - 1.039 1.216 0.634
ENSG00000140374 E013 12.3412966 5.380304e-02 2.376562e-01 0.4738631651 15 76216314 76216314 1 - 1.021 1.217 0.706
ENSG00000140374 E014 468.7324470 9.470092e-04 5.358699e-01 0.7262348142 15 76216315 76216467 153 - 2.626 2.615 -0.037
ENSG00000140374 E015 429.1323738 1.683273e-04 6.452690e-02 0.2128333820 15 76216468 76216482 15 - 2.594 2.560 -0.114
ENSG00000140374 E016 460.8844643 1.548482e-04 5.779872e-02 0.1978902201 15 76216483 76216538 56 - 2.625 2.591 -0.112
ENSG00000140374 E017 354.5640487 1.692552e-04 7.563407e-02 0.2360843394 15 76216539 76216558 20 - 2.512 2.476 -0.120
ENSG00000140374 E018 414.3108466 2.249680e-04 2.174018e-01 0.4502857980 15 76216559 76216597 39 - 2.575 2.552 -0.076
ENSG00000140374 E019 1.1600254 7.873785e-02 9.411241e-01   15 76217586 76217677 92 - 0.299 0.313 0.096
ENSG00000140374 E020 287.2817348 4.727336e-04 9.523293e-01 0.9781388087 15 76225849 76225856 8 - 2.410 2.410 0.003
ENSG00000140374 E021 486.8730848 5.511404e-04 2.147581e-01 0.4472155209 15 76225857 76225904 48 - 2.631 2.660 0.094
ENSG00000140374 E022 353.0045044 3.441399e-04 3.133757e-01 0.5536028252 15 76225905 76225909 5 - 2.493 2.518 0.084
ENSG00000140374 E023 409.0229078 1.368156e-03 3.248643e-01 0.5640699593 15 76225910 76225929 20 - 2.556 2.584 0.095
ENSG00000140374 E024 12.7091799 3.387919e-03 8.913763e-01 0.9473031533 15 76225930 76227137 1208 - 1.086 1.103 0.060
ENSG00000140374 E025 2.5841225 8.416784e-03 3.718212e-01 0.6054994060 15 76227138 76227230 93 - 0.471 0.622 0.700
ENSG00000140374 E026 9.0040987 1.117271e-02 1.172479e-01 0.3112305614 15 76227231 76227712 482 - 0.896 1.084 0.696
ENSG00000140374 E027 3.9726982 1.586235e-02 9.014406e-01 0.9526038868 15 76227713 76227720 8 - 0.655 0.674 0.078
ENSG00000140374 E028 7.6984951 6.735618e-02 3.110416e-01 0.5514258108 15 76227721 76227866 146 - 0.856 1.002 0.552
ENSG00000140374 E029 4.7552120 2.049411e-01 6.898358e-01 0.8289342174 15 76227867 76227897 31 - 0.700 0.794 0.381
ENSG00000140374 E030 4.1421220 1.444493e-01 3.566832e-01 0.5930974596 15 76227898 76227918 21 - 0.628 0.797 0.697
ENSG00000140374 E031 10.2403669 3.419808e-03 1.123060e-01 0.3029823780 15 76227919 76228249 331 - 0.947 1.121 0.637
ENSG00000140374 E032 0.9169527 1.561484e-02 5.549902e-01   15 76230504 76230715 212 - 0.297 0.185 -0.888
ENSG00000140374 E033 0.3393995 2.471870e-02 6.489233e-01   15 76230716 76230730 15 - 0.144 0.000 -10.913
ENSG00000140374 E034 15.1872945 1.333069e-01 8.438656e-01 0.9215363483 15 76230731 76231332 602 - 1.147 1.200 0.190
ENSG00000140374 E035 554.6924551 1.440592e-04 2.430872e-01 0.4801213858 15 76231333 76231398 66 - 2.690 2.712 0.074
ENSG00000140374 E036 1.1929580 1.872727e-01 1.361174e-01   15 76243170 76243267 98 - 0.201 0.499 1.870
ENSG00000140374 E037 0.3559677 5.433028e-01 8.197017e-01   15 76245212 76245248 37 - 0.148 0.000 -9.732
ENSG00000140374 E038 0.0000000       15 76274133 76274175 43 -      
ENSG00000140374 E039 1.0241679 1.537876e-02 5.561821e-01   15 76274176 76274411 236 - 0.297 0.185 -0.886
ENSG00000140374 E040 332.4626501 1.969304e-04 8.546439e-01 0.9274065611 15 76274412 76274418 7 - 2.475 2.474 -0.006
ENSG00000140374 E041 516.0791835 2.643275e-04 3.891089e-02 0.1519386605 15 76274419 76274494 76 - 2.656 2.695 0.132
ENSG00000140374 E042 0.6294705 3.000825e-02 9.719673e-01   15 76281936 76283756 1821 - 0.201 0.185 -0.154
ENSG00000140374 E043 635.2200895 4.815174e-03 5.790463e-01 0.7565424159 15 76283757 76283825 69 - 2.750 2.770 0.065
ENSG00000140374 E044 1.7345578 1.646201e-01 3.077332e-01 0.5483869344 15 76283826 76283841 16 - 0.340 0.556 1.129
ENSG00000140374 E045 2.8749311 1.020629e-02 8.333608e-01 0.9156503636 15 76284365 76284460 96 - 0.526 0.563 0.174
ENSG00000140374 E046 4.5279021 6.148436e-03 6.468986e-01 0.8014205832 15 76284805 76284852 48 - 0.692 0.761 0.283
ENSG00000140374 E047 7.7757467 4.293107e-03 4.633471e-01 0.6753735453 15 76284853 76284927 75 - 0.885 0.976 0.346
ENSG00000140374 E048 773.3753169 8.156441e-04 9.390165e-01 0.9718240328 15 76285637 76285738 102 - 2.842 2.842 0.000
ENSG00000140374 E049 558.8721536 1.730858e-04 5.251005e-01 0.7185067861 15 76286371 76286405 35 - 2.704 2.695 -0.030
ENSG00000140374 E050 635.9512631 2.703747e-04 1.505884e-01 0.3631396033 15 76286406 76286463 58 - 2.764 2.742 -0.073
ENSG00000140374 E051 447.2999377 1.633039e-04 4.854766e-02 0.1762814988 15 76286464 76286481 18 - 2.615 2.579 -0.119
ENSG00000140374 E052 2.0084925 5.250891e-02 7.644101e-01 0.8752674176 15 76286482 76287016 535 - 0.471 0.412 -0.308
ENSG00000140374 E053 1.2673108 1.294906e-02 8.932933e-01   15 76287768 76287845 78 - 0.338 0.314 -0.151
ENSG00000140374 E054 835.6266925 9.257393e-05 1.252307e-01 0.3241435531 15 76287846 76287945 100 - 2.880 2.861 -0.063
ENSG00000140374 E055 720.2088389 9.805019e-05 2.188950e-01 0.4521156953 15 76292431 76292513 83 - 2.814 2.798 -0.053
ENSG00000140374 E056 1.9427133 1.472944e-01 9.419539e-01 0.9732370369 15 76292514 76292618 105 - 0.444 0.413 -0.164
ENSG00000140374 E057 632.4317097 1.811663e-04 4.681750e-01 0.6788439514 15 76292619 76292700 82 - 2.755 2.745 -0.033
ENSG00000140374 E058 0.5173834 6.082946e-02 3.890515e-01   15 76293012 76293133 122 - 0.202 0.000 -11.058
ENSG00000140374 E059 488.9166445 1.770235e-04 2.127439e-01 0.4449579110 15 76295591 76295737 147 - 2.636 2.660 0.083
ENSG00000140374 E060 3.0407861 1.496352e-02 6.741233e-01 0.8190013326 15 76309932 76310062 131 - 0.550 0.621 0.319
ENSG00000140374 E061 0.7852767 1.691187e-02 5.383378e-01   15 76310063 76310064 2 - 0.201 0.314 0.849
ENSG00000140374 E062 289.8776043 6.499173e-04 4.731751e-03 0.0331734365 15 76311350 76311730 381 - 2.395 2.469 0.246