ENSG00000140332

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000440567 ENSG00000140332 HEK293_OSMI2_6hA HEK293_TMG_6hB TLE3 protein_coding protein_coding 35.8068 56.65468 30.30928 5.907364 1.12629 -0.9022145 2.462317 0.09692476 6.473988 0.09692476 0.8692748 5.92221352 0.09275833 0.001466667 0.21316667 0.21170000 3.617670e-06 3.61767e-06 FALSE TRUE
ENST00000451782 ENSG00000140332 HEK293_OSMI2_6hA HEK293_TMG_6hB TLE3 protein_coding protein_coding 35.8068 56.65468 30.30928 5.907364 1.12629 -0.9022145 14.021092 23.91312559 7.175321 2.45498517 0.8121978 -1.73528140 0.37312500 0.424066667 0.23540000 -0.18866667 3.150472e-03 3.61767e-06 FALSE TRUE
ENST00000557919 ENSG00000140332 HEK293_OSMI2_6hA HEK293_TMG_6hB TLE3 protein_coding nonsense_mediated_decay 35.8068 56.65468 30.30928 5.907364 1.12629 -0.9022145 1.809968 2.15801999 2.130401 0.50167414 0.2845570 -0.01849708 0.06003333 0.037100000 0.07093333 0.03383333 3.080547e-01 3.61767e-06 FALSE TRUE
ENST00000558939 ENSG00000140332 HEK293_OSMI2_6hA HEK293_TMG_6hB TLE3 protein_coding protein_coding 35.8068 56.65468 30.30928 5.907364 1.12629 -0.9022145 2.298433 2.27498849 3.503553 2.27498849 0.2379746 0.62074381 0.06963750 0.039633333 0.11646667 0.07683333 2.318669e-01 3.61767e-06 FALSE TRUE
ENST00000559608 ENSG00000140332 HEK293_OSMI2_6hA HEK293_TMG_6hB TLE3 protein_coding retained_intron 35.8068 56.65468 30.30928 5.907364 1.12629 -0.9022145 6.642928 13.47615967 2.492236 3.53086762 0.3761892 -2.43018988 0.15401250 0.230066667 0.08196667 -0.14810000 5.315285e-02 3.61767e-06   FALSE
ENST00000654081 ENSG00000140332 HEK293_OSMI2_6hA HEK293_TMG_6hB TLE3 protein_coding processed_transcript 35.8068 56.65468 30.30928 5.907364 1.12629 -0.9022145 3.591612 6.90469988 3.148419 0.69220316 0.2805054 -1.13046415 0.09935000 0.122000000 0.10376667 -0.01823333 7.441295e-01 3.61767e-06 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000140332 E001 185.2679606 0.9234109977 2.911145e-01 5.316936e-01 15 70047790 70048274 485 - 1.966 2.327 1.209
ENSG00000140332 E002 476.9810591 1.2448013937 2.917709e-01 5.324401e-01 15 70048275 70048868 594 - 2.322 2.746 1.413
ENSG00000140332 E003 211.7381615 0.9269152893 2.364716e-01 4.725120e-01 15 70048869 70048975 107 - 1.973 2.394 1.408
ENSG00000140332 E004 86.0403209 0.3928471201 1.298511e-01 3.316047e-01 15 70048976 70048976 1 - 1.612 2.002 1.317
ENSG00000140332 E005 242.9126350 1.1063756177 4.139093e-01 6.389166e-01 15 70048977 70049090 114 - 2.164 2.425 0.873
ENSG00000140332 E006 691.3428471 1.4768569111 4.451525e-01 6.621971e-01 15 70049091 70049798 708 - 2.600 2.883 0.940
ENSG00000140332 E007 100.6969333 0.5373489358 2.905183e-01 5.311722e-01 15 70049799 70049800 2 - 1.784 2.046 0.882
ENSG00000140332 E008 98.6383470 0.5324365305 2.944155e-01 5.349943e-01 15 70049801 70049801 1 - 1.778 2.036 0.869
ENSG00000140332 E009 137.5838369 0.8768853406 3.773694e-01 6.101569e-01 15 70049802 70049835 34 - 1.921 2.179 0.866
ENSG00000140332 E010 405.9606024 1.2818998205 4.135906e-01 6.387041e-01 15 70049836 70050096 261 - 2.365 2.653 0.958
ENSG00000140332 E011 296.1806896 1.1951993694 4.445527e-01 6.618128e-01 15 70050097 70050204 108 - 2.264 2.507 0.812
ENSG00000140332 E012 47.3449379 0.3036943655 2.134832e-01 4.457959e-01 15 70050205 70051390 1186 - 1.412 1.736 1.107
ENSG00000140332 E013 287.3293673 1.2018562063 4.723171e-01 6.818053e-01 15 70051391 70051467 77 - 2.271 2.489 0.725
ENSG00000140332 E014 6.1168651 0.1169503607 8.822108e-01 9.424574e-01 15 70051468 70051505 38 - 0.810 0.846 0.141
ENSG00000140332 E015 282.5030401 1.1802017012 4.469228e-01 6.633806e-01 15 70052374 70052524 151 - 2.246 2.486 0.801
ENSG00000140332 E016 24.6340756 0.3048099803 7.858270e-01 8.879954e-01 15 70052525 70053173 649 - 1.345 1.398 0.185
ENSG00000140332 E017 8.6028569 0.2096024261 7.980518e-01 8.952072e-01 15 70053174 70053226 53 - 0.964 0.956 -0.029
ENSG00000140332 E018 287.1609095 1.1990113058 4.670177e-01 6.780516e-01 15 70053227 70053374 148 - 2.267 2.490 0.743
ENSG00000140332 E019 5.2252129 0.0269478634 2.551117e-01 4.937076e-01 15 70053375 70054437 1063 - 0.577 0.836 1.078
ENSG00000140332 E020 383.1192069 0.0001795192 8.546761e-01 9.274355e-01 15 70054438 70054680 243 - 2.494 2.588 0.311
ENSG00000140332 E021 133.4622758 0.0187022083 4.288032e-01 6.501986e-01 15 70054681 70054685 5 - 2.061 2.117 0.185
ENSG00000140332 E022 1.9975817 0.2614956053 8.053599e-01 8.993527e-01 15 70054686 70055048 363 - 0.452 0.490 0.192
ENSG00000140332 E023 374.2207226 0.0245550418 1.054646e-01 2.914474e-01 15 70055049 70055296 248 - 2.550 2.543 -0.024
ENSG00000140332 E024 107.2881590 0.0247120727 5.955732e-02 2.017836e-01 15 70055297 70055298 2 - 2.035 1.992 -0.147
ENSG00000140332 E025 8.8033919 0.1691450054 2.313790e-01 4.667128e-01 15 70055299 70056297 999 - 1.036 0.921 -0.428
ENSG00000140332 E026 185.5846311 0.0180687877 8.132405e-02 2.474801e-01 15 70056298 70056374 77 - 2.247 2.240 -0.022
ENSG00000140332 E027 42.9435427 0.0028646685 3.306074e-02 1.362472e-01 15 70057459 70057473 15 - 1.645 1.612 -0.110
ENSG00000140332 E028 147.3325696 0.0050533131 1.157730e-01 3.088036e-01 15 70057474 70057519 46 - 2.122 2.155 0.111
ENSG00000140332 E029 229.7884823 0.0175840791 2.698887e-01 5.098424e-01 15 70057520 70057658 139 - 2.308 2.346 0.124
ENSG00000140332 E030 12.5298315 0.1846842417 4.856513e-01 6.910175e-01 15 70057659 70058090 432 - 1.120 1.094 -0.095
ENSG00000140332 E031 5.9680710 0.1055530144 3.788089e-01 6.112449e-01 15 70058091 70058149 59 - 0.848 0.796 -0.204
ENSG00000140332 E032 22.4438673 0.0034681097 1.267228e-02 6.913313e-02 15 70058150 70058158 9 - 1.408 1.307 -0.352
ENSG00000140332 E033 111.2202326 0.0269103228 2.092439e-01 4.409666e-01 15 70058159 70058185 27 - 2.018 2.023 0.014
ENSG00000140332 E034 247.1425247 0.0141031523 4.737791e-02 1.734551e-01 15 70058186 70058291 106 - 2.372 2.362 -0.034
ENSG00000140332 E035 3.3667154 0.0465898035 4.133934e-01 6.386377e-01 15 70058292 70058662 371 - 0.455 0.682 1.039
ENSG00000140332 E036 277.1563988 0.0050241159 4.402499e-04 5.130699e-03 15 70058663 70058815 153 - 2.441 2.404 -0.124
ENSG00000140332 E037 202.3846460 0.0023724463 2.852159e-08 1.206983e-06 15 70059410 70059460 51 - 2.341 2.251 -0.301
ENSG00000140332 E038 265.9476723 0.0081144998 7.904386e-05 1.228580e-03 15 70060530 70060649 120 - 2.452 2.369 -0.276
ENSG00000140332 E039 147.6213159 0.0074911384 1.384883e-04 1.962655e-03 15 70064454 70064470 17 - 2.202 2.111 -0.303
ENSG00000140332 E040 227.2547150 0.0068716230 3.956001e-05 6.815578e-04 15 70066014 70066122 109 - 2.385 2.300 -0.283
ENSG00000140332 E041 123.2472817 0.0132259867 1.875522e-02 9.156574e-02 15 70066123 70066143 21 - 2.097 2.052 -0.152
ENSG00000140332 E042 155.6931555 0.0298361899 1.709070e-01 3.917323e-01 15 70066144 70066215 72 - 2.175 2.161 -0.047
ENSG00000140332 E043 66.1647425 0.0563993260 5.241277e-01 7.179125e-01 15 70066216 70066218 3 - 1.783 1.805 0.076
ENSG00000140332 E044 7.9778990 0.1357969699 4.551282e-01 6.695882e-01 15 70066618 70066939 322 - 0.957 0.905 -0.196
ENSG00000140332 E045 9.5169820 0.0335245410 7.312611e-01 8.549385e-01 15 70074503 70074532 30 - 0.970 1.021 0.188
ENSG00000140332 E046 175.8557337 0.0389771480 7.120323e-02 2.271513e-01 15 70074533 70074607 75 - 2.264 2.194 -0.234
ENSG00000140332 E047 195.1792249 0.0342597066 1.560570e-02 8.038237e-02 15 70076096 70076158 63 - 2.337 2.223 -0.379
ENSG00000140332 E048 162.1362042 0.0269037277 1.861907e-03 1.613814e-02 15 70094532 70094576 45 - 2.279 2.129 -0.502
ENSG00000140332 E049 0.1723744 0.0360617952 1.000000e+00   15 70094726 70094785 60 - 0.000 0.088 8.986
ENSG00000140332 E050 0.3228314 0.3173276424 8.312837e-02   15 70095390 70095577 188 - 0.286 0.000 -12.120
ENSG00000140332 E051 181.4445163 0.0298451259 5.097603e-03 3.514637e-02 15 70095578 70095641 64 - 2.317 2.184 -0.444
ENSG00000140332 E052 1.6403264 0.1254846912 5.207106e-01 7.153965e-01 15 70095642 70095950 309 - 0.456 0.402 -0.284
ENSG00000140332 E053 159.2184406 0.0284835743 1.487720e-02 7.762182e-02 15 70096161 70096261 101 - 2.239 2.141 -0.328
ENSG00000140332 E054 1.3750059 0.0127443191 7.052247e-01   15 70096262 70096676 415 - 0.285 0.409 0.756
ENSG00000140332 E055 0.5059767 0.0214796613 3.720986e-01   15 70096677 70096752 76 - 0.000 0.224 10.571
ENSG00000140332 E056 181.3212368 0.0475063250 7.405765e-01 8.607746e-01 15 70096775 70097404 630 - 2.177 2.254 0.261
ENSG00000140332 E057 58.6752823 0.0399012254 6.551676e-01 8.068085e-01 15 70097405 70097439 35 - 1.629 1.791 0.548
ENSG00000140332 E058 111.7284560 0.0197272232 8.357457e-01 9.170189e-01 15 70097440 70097558 119 - 1.931 2.060 0.435
ENSG00000140332 E059 119.3886220 0.0083807647 6.574123e-01 8.082687e-01 15 70097559 70097657 99 - 1.957 2.090 0.447
ENSG00000140332 E060 191.0151093 0.0237691935 1.195405e-01 3.150916e-01 15 70097658 70098176 519 - 2.260 2.251 -0.031