ENSG00000140265

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000396976 ENSG00000140265 HEK293_OSMI2_6hA HEK293_TMG_6hB ZSCAN29 protein_coding protein_coding 6.298572 4.535717 8.213645 0.7388985 0.3836098 0.8552701 1.4028633 1.5902469 1.53627362 0.3830182 0.79596239 -0.04949887 0.25134167 0.33956667 0.1785000 -0.16106667 7.642184e-01 1.450069e-05 FALSE TRUE
ENST00000566849 ENSG00000140265 HEK293_OSMI2_6hA HEK293_TMG_6hB ZSCAN29 protein_coding nonsense_mediated_decay 6.298572 4.535717 8.213645 0.7388985 0.3836098 0.8552701 0.4654286 0.0000000 1.08585979 0.0000000 0.28730049 6.77591941 0.05747083 0.00000000 0.1362000 0.13620000 1.450069e-05 1.450069e-05 FALSE TRUE
ENST00000684362 ENSG00000140265 HEK293_OSMI2_6hA HEK293_TMG_6hB ZSCAN29 protein_coding protein_coding 6.298572 4.535717 8.213645 0.7388985 0.3836098 0.8552701 3.7897760 2.1143417 4.70987592 0.1280932 0.32069635 1.15173311 0.59297083 0.48610000 0.5736333 0.08753333 7.520519e-01 1.450069e-05 FALSE TRUE
MSTRG.10658.1 ENSG00000140265 HEK293_OSMI2_6hA HEK293_TMG_6hB ZSCAN29 protein_coding   6.298572 4.535717 8.213645 0.7388985 0.3836098 0.8552701 0.1091725 0.3666443 0.08513343 0.2078486 0.00608529 -1.98517835 0.02316250 0.07393333 0.0104000 -0.06353333 1.083031e-01 1.450069e-05 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000140265 E001 1.2626112 0.128311061 0.62846768   15 43358096 43358171 76 - 0.258 0.413 0.968
ENSG00000140265 E002 0.8984613 0.096748297 0.56549881   15 43358172 43358174 3 - 0.188 0.337 1.121
ENSG00000140265 E003 10.3991672 0.014181879 0.83925261 0.91897863 15 43358175 43358220 46 - 1.029 1.085 0.203
ENSG00000140265 E004 331.6663537 0.357114730 0.18181037 0.40638000 15 43358221 43360917 2697 - 2.422 2.620 0.661
ENSG00000140265 E005 32.1408538 0.174523969 0.65411359 0.80615971 15 43360918 43361017 100 - 1.507 1.529 0.075
ENSG00000140265 E006 30.7736232 0.132075136 0.32717092 0.56628608 15 43361018 43361072 55 - 1.439 1.572 0.456
ENSG00000140265 E007 29.3508903 0.085597092 0.15122563 0.36411379 15 43361073 43361161 89 - 1.381 1.588 0.710
ENSG00000140265 E008 123.7157966 0.622105599 0.35576373 0.59234338 15 43361162 43361941 780 - 2.027 2.165 0.463
ENSG00000140265 E009 0.9624527 0.848142316 0.63741221   15 43363749 43363914 166 - 0.194 0.396 1.402
ENSG00000140265 E010 41.9404763 0.064424166 0.18863002 0.41523496 15 43363915 43364125 211 - 1.643 1.611 -0.106
ENSG00000140265 E011 49.0843609 0.100150500 0.32066578 0.56028010 15 43364126 43364382 257 - 1.694 1.698 0.013
ENSG00000140265 E012 5.4391227 0.331883814 0.19210987 0.41951824 15 43364383 43364487 105 - 0.878 0.694 -0.730
ENSG00000140265 E013 96.1868947 0.533918932 0.38450346 0.61607202 15 43366110 43366774 665 - 1.931 2.044 0.379
ENSG00000140265 E014 19.5652907 0.007964514 0.86703990 0.93435780 15 43366775 43366808 34 - 1.290 1.360 0.246
ENSG00000140265 E015 39.1709111 0.001075571 0.10690103 0.29383898 15 43368923 43369127 205 - 1.620 1.597 -0.079
ENSG00000140265 E016 67.1315179 0.063947576 0.07168754 0.22819054 15 43369596 43369997 402 - 1.860 1.779 -0.272
ENSG00000140265 E017 24.0083606 0.104119326 0.00828126 0.05061903 15 43369998 43370025 28 - 1.493 1.192 -1.049
ENSG00000140265 E018 22.3584749 0.217892908 0.12116552 0.31770823 15 43370026 43370348 323 - 1.437 1.231 -0.719
ENSG00000140265 E019 46.2681906 0.250500712 0.14407989 0.35351345 15 43370558 43371043 486 - 1.741 1.542 -0.675