ENSG00000140262

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000267811 ENSG00000140262 HEK293_OSMI2_6hA HEK293_TMG_6hB TCF12 protein_coding protein_coding 6.849407 2.400142 12.31379 0.4334086 1.480366 2.354256 3.43307869 1.46543215 6.76889675 0.22075445 0.29742415 2.1999129 0.51437083 0.61810000 0.56786667 -0.05023333 9.367519e-01 2.354705e-08 FALSE TRUE
ENST00000557947 ENSG00000140262 HEK293_OSMI2_6hA HEK293_TMG_6hB TCF12 protein_coding protein_coding 6.849407 2.400142 12.31379 0.4334086 1.480366 2.354256 0.27622784 0.00000000 0.94098168 0.00000000 0.41929934 6.5713456 0.02476250 0.00000000 0.07420000 0.07420000 1.340162e-02 2.354705e-08 FALSE FALSE
ENST00000560506 ENSG00000140262 HEK293_OSMI2_6hA HEK293_TMG_6hB TCF12 protein_coding processed_transcript 6.849407 2.400142 12.31379 0.4334086 1.480366 2.354256 0.44395181 0.00000000 0.95903807 0.00000000 0.95903807 6.5984814 0.03468333 0.00000000 0.06960000 0.06960000 1.000000e+00 2.354705e-08 FALSE FALSE
ENST00000560836 ENSG00000140262 HEK293_OSMI2_6hA HEK293_TMG_6hB TCF12 protein_coding protein_coding 6.849407 2.400142 12.31379 0.4334086 1.480366 2.354256 0.06835014 0.18248252 0.00000000 0.18248252 0.00000000 -4.2666555 0.01622083 0.05923333 0.00000000 -0.05923333 6.134217e-01 2.354705e-08   FALSE
ENST00000560948 ENSG00000140262 HEK293_OSMI2_6hA HEK293_TMG_6hB TCF12 protein_coding protein_coding 6.849407 2.400142 12.31379 0.4334086 1.480366 2.354256 0.22705114 0.03880485 0.05622324 0.03880485 0.05622324 0.4403131 0.05859583 0.02433333 0.00600000 -0.01833333 8.714798e-01 2.354705e-08   FALSE
ENST00000561152 ENSG00000140262 HEK293_OSMI2_6hA HEK293_TMG_6hB TCF12 protein_coding nonsense_mediated_decay 6.849407 2.400142 12.31379 0.4334086 1.480366 2.354256 0.19972904 0.16248989 0.27697834 0.02268010 0.15527988 0.7344300 0.03907500 0.07630000 0.02006667 -0.05623333 4.474255e-01 2.354705e-08 TRUE FALSE
ENST00000561346 ENSG00000140262 HEK293_OSMI2_6hA HEK293_TMG_6hB TCF12 protein_coding processed_transcript 6.849407 2.400142 12.31379 0.4334086 1.480366 2.354256 0.82080499 0.00000000 1.82065302 0.00000000 0.22845638 7.5162146 0.06892083 0.00000000 0.14776667 0.14776667 2.354705e-08 2.354705e-08 FALSE FALSE
MSTRG.10887.4 ENSG00000140262 HEK293_OSMI2_6hA HEK293_TMG_6hB TCF12 protein_coding   6.849407 2.400142 12.31379 0.4334086 1.480366 2.354256 0.43068621 0.21182229 0.51846733 0.05779209 0.38482744 1.2524099 0.06724167 0.08503333 0.04090000 -0.04413333 6.754847e-01 2.354705e-08 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000140262 E001 0.7990684 0.0193874923 3.379500e-01   15 56918623 56918624 2 + 0.174 0.355 1.357
ENSG00000140262 E002 1.1218998 0.1776574102 6.305335e-01   15 56918625 56918643 19 + 0.261 0.355 0.623
ENSG00000140262 E003 2.2334044 0.0098888142 9.674435e-01 9.856624e-01 15 56918644 56918674 31 + 0.449 0.462 0.066
ENSG00000140262 E004 15.8172617 0.0040334398 1.182735e-01 3.130250e-01 15 56918675 56918831 157 + 1.098 1.257 0.567
ENSG00000140262 E005 15.9606500 0.0020323094 3.668543e-02 1.460465e-01 15 56918832 56918906 75 + 1.098 1.300 0.718
ENSG00000140262 E006 0.0000000       15 56919148 56919228 81 +      
ENSG00000140262 E007 2.2203325 0.0914992461 2.959644e-02 1.261518e-01 15 56919517 56919891 375 + 0.330 0.737 1.970
ENSG00000140262 E008 12.4552033 0.0026851399 5.350362e-02 1.878894e-01 15 56919892 56919901 10 + 1.002 1.208 0.745
ENSG00000140262 E009 28.3927544 0.0013781809 4.412065e-01 6.595928e-01 15 56919902 56919988 87 + 1.375 1.440 0.225
ENSG00000140262 E010 32.1075813 0.0044812034 5.726480e-01 7.521525e-01 15 56921026 56921098 73 + 1.448 1.408 -0.138
ENSG00000140262 E011 0.0000000       15 57001349 57001384 36 +      
ENSG00000140262 E012 0.0000000       15 57063748 57063749 2 +      
ENSG00000140262 E013 32.1062893 0.0012972512 4.611438e-01 6.739286e-01 15 57063750 57063823 74 + 1.447 1.398 -0.169
ENSG00000140262 E014 0.3503582 0.0270829563 3.267421e-01   15 57072653 57072714 62 + 0.066 0.213 1.941
ENSG00000140262 E015 35.0529323 0.0026991961 2.575328e-01 4.962694e-01 15 57091789 57091891 103 + 1.490 1.409 -0.280
ENSG00000140262 E016 0.0000000       15 57091892 57092023 132 +      
ENSG00000140262 E017 0.0000000       15 57109258 57109317 60 +      
ENSG00000140262 E018 0.0000000       15 57118350 57118433 84 +      
ENSG00000140262 E019 0.2027342 0.0349674640 1.115220e-01   15 57129783 57129972 190 + 0.000 0.213 10.374
ENSG00000140262 E020 0.2735028 0.0274424043 3.294994e-01   15 57134316 57134500 185 + 0.066 0.212 1.940
ENSG00000140262 E021 26.6013457 0.0014617607 8.438548e-01 9.215363e-01 15 57166402 57166466 65 + 1.353 1.376 0.077
ENSG00000140262 E022 36.7842337 0.0011263939 1.711737e-01 3.920710e-01 15 57192158 57192293 136 + 1.511 1.420 -0.315
ENSG00000140262 E023 27.5731891 0.0013743041 2.568291e-01 4.956136e-01 15 57197773 57197825 53 + 1.387 1.300 -0.302
ENSG00000140262 E024 0.0000000       15 57214079 57214396 318 +      
ENSG00000140262 E025 0.0000000       15 57219037 57219429 393 +      
ENSG00000140262 E026 0.0000000       15 57219430 57219434 5 +      
ENSG00000140262 E027 0.0000000       15 57219435 57219465 31 +      
ENSG00000140262 E028 0.0000000       15 57219466 57219590 125 +      
ENSG00000140262 E029 42.1507941 0.0009037726 3.457333e-01 5.833235e-01 15 57231152 57231257 106 + 1.561 1.505 -0.192
ENSG00000140262 E030 53.3661303 0.0007276281 4.028711e-02 1.554564e-01 15 57232291 57232430 140 + 1.671 1.553 -0.402
ENSG00000140262 E031 55.2087088 0.0007093300 9.635565e-02 2.753577e-01 15 57232712 57232856 145 + 1.682 1.590 -0.312
ENSG00000140262 E032 36.5650692 0.0010651125 2.892203e-02 1.241281e-01 15 57234043 57234107 65 + 1.520 1.364 -0.537
ENSG00000140262 E033 39.8414437 0.0011773361 3.217796e-02 1.337582e-01 15 57243472 57243550 79 + 1.555 1.409 -0.502
ENSG00000140262 E034 0.0000000       15 57243551 57243553 3 +      
ENSG00000140262 E035 0.0000000       15 57248016 57248040 25 +      
ENSG00000140262 E036 0.0000000       15 57248041 57248041 1 +      
ENSG00000140262 E037 0.0000000       15 57248042 57248081 40 +      
ENSG00000140262 E038 0.0000000       15 57251169 57251349 181 +      
ENSG00000140262 E039 36.6632182 0.0010661301 1.719005e-01 3.930716e-01 15 57251350 57251423 74 + 1.511 1.420 -0.314
ENSG00000140262 E040 0.0000000       15 57252199 57252420 222 +      
ENSG00000140262 E041 1.6480991 0.0136734378 6.216067e-01 7.848979e-01 15 57252421 57252492 72 + 0.364 0.461 0.527
ENSG00000140262 E042 63.6085213 0.0068671476 1.274564e-02 6.941962e-02 15 57253262 57253468 207 + 1.754 1.589 -0.560
ENSG00000140262 E043 48.8947460 0.0009338824 1.086379e-01 2.968164e-01 15 57262094 57262208 115 + 1.632 1.538 -0.320
ENSG00000140262 E044 57.2616506 0.0044477956 1.804751e-01 4.046050e-01 15 57263112 57263274 163 + 1.699 1.617 -0.282
ENSG00000140262 E045 25.1651460 0.0029109526 3.379381e-01 5.762361e-01 15 57273030 57273032 3 + 1.350 1.272 -0.274
ENSG00000140262 E046 69.1673178 0.0005501126 5.015542e-01 7.019279e-01 15 57273033 57273262 230 + 1.754 1.794 0.135
ENSG00000140262 E047 0.0000000       15 57281647 57281792 146 +      
ENSG00000140262 E048 0.0000000       15 57282183 57282442 260 +      
ENSG00000140262 E049 0.0000000       15 57282443 57282444 2 +      
ENSG00000140262 E050 26.7069613 0.0159798564 9.506997e-01 9.773102e-01 15 57282445 57282454 10 + 1.357 1.382 0.086
ENSG00000140262 E051 48.2807084 0.0008138812 9.675859e-01 9.856893e-01 15 57282455 57282598 144 + 1.608 1.617 0.033
ENSG00000140262 E052 371.6615096 0.0009409098 1.765068e-07 6.170216e-06 15 57286157 57289853 3697 + 2.457 2.569 0.372
ENSG00000140262 E053 0.3206185 0.0274424043 1.000000e+00   15 57290829 57291124 296 + 0.124 0.000 -9.830
ENSG00000140262 E054 1.0523622 0.0681384461 6.075163e-04   15 57299226 57299281 56 + 0.066 0.678 4.519