ENSG00000140199

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000290209 ENSG00000140199 HEK293_OSMI2_6hA HEK293_TMG_6hB SLC12A6 protein_coding protein_coding 3.601634 3.190532 5.671722 0.1080572 0.4924886 0.8280168 2.1491125 2.0362430 3.05915263 0.35001493 0.29121691 0.5848629 0.62900417 0.64066667 0.54643333 -0.09423333 8.446944e-01 1.514841e-05 FALSE TRUE
ENST00000354181 ENSG00000140199 HEK293_OSMI2_6hA HEK293_TMG_6hB SLC12A6 protein_coding protein_coding 3.601634 3.190532 5.671722 0.1080572 0.4924886 0.8280168 0.0616392 0.2295467 0.06506517 0.08490010 0.03689317 -1.6740910 0.01986667 0.07070000 0.01093333 -0.05976667 1.253237e-01 1.514841e-05 FALSE TRUE
ENST00000559664 ENSG00000140199 HEK293_OSMI2_6hA HEK293_TMG_6hB SLC12A6 protein_coding nonsense_mediated_decay 3.601634 3.190532 5.671722 0.1080572 0.4924886 0.8280168 0.1561419 0.0000000 0.34458779 0.00000000 0.17257392 5.1480709 0.04032500 0.00000000 0.06020000 0.06020000 3.651219e-01 1.514841e-05 TRUE TRUE
ENST00000560023 ENSG00000140199 HEK293_OSMI2_6hA HEK293_TMG_6hB SLC12A6 protein_coding retained_intron 3.601634 3.190532 5.671722 0.1080572 0.4924886 0.8280168 0.2113383 0.1364140 0.61166000 0.09339056 0.36936696 2.0860720 0.04554583 0.04303333 0.09870000 0.05566667 9.198947e-01 1.514841e-05 FALSE FALSE
ENST00000560611 ENSG00000140199 HEK293_OSMI2_6hA HEK293_TMG_6hB SLC12A6 protein_coding protein_coding 3.601634 3.190532 5.671722 0.1080572 0.4924886 0.8280168 0.3259185 0.0000000 0.51805182 0.00000000 0.09438172 5.7226076 0.06820000 0.00000000 0.09376667 0.09376667 8.961738e-05 1.514841e-05 FALSE TRUE
ENST00000676379 ENSG00000140199 HEK293_OSMI2_6hA HEK293_TMG_6hB SLC12A6 protein_coding protein_coding 3.601634 3.190532 5.671722 0.1080572 0.4924886 0.8280168 0.1865033 0.3879829 0.01999142 0.07836735 0.01999142 -3.7300849 0.07153750 0.12080000 0.00400000 -0.11680000 1.514841e-05 1.514841e-05 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000140199 E001 0.0000000       15 34229784 34229995 212 -      
ENSG00000140199 E002 2.4484870 0.0157043380 1.945728e-02 9.403492e-02 15 34229996 34230035 40 - 0.314 0.725 2.023
ENSG00000140199 E003 188.5742937 0.0144286835 1.201071e-06 3.329027e-05 15 34230036 34232535 2500 - 2.120 2.424 1.015
ENSG00000140199 E004 62.0636726 0.0013223717 1.947841e-01 4.230630e-01 15 34232536 34233155 620 - 1.746 1.843 0.328
ENSG00000140199 E005 11.2821799 0.0034394868 4.495843e-01 6.653805e-01 15 34233156 34233187 32 - 1.035 1.144 0.395
ENSG00000140199 E006 16.6159590 0.0120291105 2.719006e-01 5.117759e-01 15 34233188 34233258 71 - 1.268 1.200 -0.243
ENSG00000140199 E007 11.8404429 0.0039111243 8.554726e-02 2.556090e-01 15 34233259 34233261 3 - 1.155 1.017 -0.500
ENSG00000140199 E008 11.8570110 0.0085630489 9.705584e-02 2.766139e-01 15 34233262 34233262 1 - 1.155 1.016 -0.503
ENSG00000140199 E009 57.9009320 0.0009335831 5.380526e-01 7.276841e-01 15 34233263 34233711 449 - 1.760 1.768 0.027
ENSG00000140199 E010 33.7029341 0.0034287132 1.908312e-01 4.179459e-01 15 34233712 34233880 169 - 1.483 1.604 0.411
ENSG00000140199 E011 19.5391493 0.0219199910 9.392567e-01 9.719127e-01 15 34233881 34233972 92 - 1.296 1.333 0.129
ENSG00000140199 E012 28.6202373 0.0016221079 1.669584e-01 3.864806e-01 15 34235181 34235314 134 - 1.414 1.540 0.432
ENSG00000140199 E013 39.4271173 0.0075094938 8.787910e-01 9.406834e-01 15 34236015 34236199 185 - 1.577 1.628 0.176
ENSG00000140199 E014 32.2807068 0.0020457901 2.126808e-01 4.448883e-01 15 34236708 34236815 108 - 1.527 1.483 -0.150
ENSG00000140199 E015 0.3032425 0.0274424043 1.310476e-01   15 34237084 34237389 306 - 0.000 0.251 11.229
ENSG00000140199 E016 0.1723744 0.0346858102 3.657453e-01   15 34237390 34237418 29 - 0.000 0.144 10.232
ENSG00000140199 E017 22.5482828 0.0024286013 9.871696e-01 9.954167e-01 15 34237419 34237480 62 - 1.347 1.383 0.125
ENSG00000140199 E018 20.0384118 0.0016503390 7.172154e-01 8.464009e-01 15 34237481 34237550 70 - 1.315 1.322 0.025
ENSG00000140199 E019 25.3591160 0.0014710105 8.822589e-01 9.424695e-01 15 34238232 34238331 100 - 1.396 1.442 0.157
ENSG00000140199 E020 22.8097071 0.0015010125 2.664166e-01 5.059185e-01 15 34238332 34238401 70 - 1.320 1.435 0.399
ENSG00000140199 E021 1.2075010 0.0184263178 9.816834e-01   15 34238402 34238710 309 - 0.315 0.338 0.149
ENSG00000140199 E022 39.1269322 0.0019853611 8.743510e-01 9.384041e-01 15 34238965 34239160 196 - 1.590 1.616 0.090
ENSG00000140199 E023 30.4149361 0.0100596484 4.910570e-01 6.947201e-01 15 34240661 34240829 169 - 1.494 1.475 -0.063
ENSG00000140199 E024 2.5235202 0.5690130981 4.789499e-01 6.864130e-01 15 34240830 34241044 215 - 0.572 0.481 -0.429
ENSG00000140199 E025 1.9943703 0.4830560734 8.854036e-01 9.441640e-01 15 34241063 34241232 170 - 0.420 0.529 0.544
ENSG00000140199 E026 28.1626107 0.0015687574 4.527938e-02 1.683005e-01 15 34241233 34241337 105 - 1.495 1.396 -0.341
ENSG00000140199 E027 0.6544085 0.0189910661 4.752173e-01   15 34241862 34242101 240 - 0.255 0.144 -1.023
ENSG00000140199 E028 30.6018532 0.0096743754 1.948145e-03 1.671837e-02 15 34242102 34242221 120 - 1.564 1.354 -0.722
ENSG00000140199 E029 22.4792476 0.0016263954 9.084851e-02 2.652746e-01 15 34243974 34244072 99 - 1.396 1.306 -0.315
ENSG00000140199 E030 22.3821932 0.0027112606 1.098556e-01 2.987925e-01 15 34245285 34245403 119 - 1.392 1.306 -0.298
ENSG00000140199 E031 29.4928657 0.0013362102 5.961342e-01 7.677889e-01 15 34245693 34245867 175 - 1.476 1.477 0.004
ENSG00000140199 E032 19.2327590 0.0022750921 2.727929e-01 5.126087e-01 15 34250298 34250355 58 - 1.315 1.262 -0.186
ENSG00000140199 E033 25.2963425 0.0018613372 1.989110e-01 4.283421e-01 15 34250631 34250729 99 - 1.432 1.376 -0.193
ENSG00000140199 E034 30.7174035 0.0106720799 4.853168e-02 1.762536e-01 15 34250899 34251057 159 - 1.543 1.422 -0.415
ENSG00000140199 E035 32.9981739 0.0015882773 5.798920e-05 9.467313e-04 15 34252170 34252384 215 - 1.605 1.382 -0.766
ENSG00000140199 E036 28.9065073 0.0066302872 1.906077e-02 9.268842e-02 15 34254348 34254589 242 - 1.523 1.382 -0.487
ENSG00000140199 E037 14.3387967 0.4197082542 6.520442e-01 8.047803e-01 15 34255262 34255392 131 - 1.168 1.198 0.105
ENSG00000140199 E038 7.0434510 0.1762432973 4.886284e-01 6.930853e-01 15 34256229 34256283 55 - 0.853 0.968 0.434
ENSG00000140199 E039 11.7273161 0.3256170280 2.842589e-01 5.247884e-01 15 34257642 34257788 147 - 1.010 1.205 0.703
ENSG00000140199 E040 11.6142465 0.0416055049 6.609116e-01 8.105016e-01 15 34258813 34258872 60 - 1.059 1.138 0.285
ENSG00000140199 E041 11.1780812 0.0231045508 2.218348e-01 4.557268e-01 15 34258873 34258944 72 - 1.126 1.004 -0.445
ENSG00000140199 E042 5.2558420 0.0051107917 7.645844e-02 2.376529e-01 15 34260926 34260929 4 - 0.868 0.656 -0.854
ENSG00000140199 E043 9.4441881 0.0037323821 1.414908e-01 3.497176e-01 15 34260930 34260977 48 - 1.055 0.927 -0.475
ENSG00000140199 E044 12.8453480 0.0029115211 4.917861e-01 6.952006e-01 15 34260978 34261020 43 - 1.138 1.106 -0.114
ENSG00000140199 E045 12.2510544 0.0080934385 2.385950e-01 4.750167e-01 15 34275345 34275389 45 - 1.139 1.051 -0.318
ENSG00000140199 E046 0.0000000       15 34299569 34299658 90 -      
ENSG00000140199 E047 10.8908542 0.0030839986 1.990298e-02 9.553102e-02 15 34318561 34318779 219 - 1.138 0.927 -0.775
ENSG00000140199 E048 11.9798979 0.0046030596 5.854972e-01 7.606170e-01 15 34336410 34336601 192 - 1.112 1.092 -0.072
ENSG00000140199 E049 6.8711399 0.0049009807 9.575702e-01 9.806538e-01 15 34336602 34336667 66 - 0.868 0.906 0.148
ENSG00000140199 E050 4.8954780 0.0146295864 6.459162e-01 8.007726e-01 15 34336668 34336686 19 - 0.719 0.813 0.376
ENSG00000140199 E051 5.5593016 0.0054647638 8.433142e-01 9.212863e-01 15 34336687 34336752 66 - 0.781 0.838 0.222
ENSG00000140199 E052 14.5179163 0.0092099764 2.246914e-01 4.590159e-01 15 34336753 34337331 579 - 1.215 1.132 -0.298
ENSG00000140199 E053 6.6119470 0.0042016389 1.682150e-01 3.881950e-01 15 34337332 34337474 143 - 0.926 0.785 -0.544
ENSG00000140199 E054 7.8637194 0.0038193994 6.087098e-01 7.760439e-01 15 34337475 34337960 486 - 0.953 0.927 -0.097
ENSG00000140199 E055 1.3898091 0.4588066508 6.284041e-01 7.895582e-01 15 34337961 34338060 100 - 0.419 0.323 -0.560